Compile Data Set for Download or QSAR
maximum 50k data
Found 226 of ic50 for UniProtKB: Q5EAD5
LigandPNGBDBM50059858((S)-2-((3Z,6E)-(2S,5S,8R)-8-Amino-2-benzyl-5-isopr...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13382(3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040692((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propyl...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against bovine type-1 geranylgeranyl transferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135353(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031179((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031169((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031167((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031170((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079803((S)-2-{[(2S,4S)-1-((E)-(2S,5R)-5-Amino-2-isopropyl...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bos taurus (bovine))
Globe Pharmaceutical R And Abbott Laboratories

LigandPNGBDBM13389(4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...)
Affinity DataIC50:  18nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13389(4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...)
Affinity DataIC50:  18nMAssay Description:Inhibition of transfer of [3H]-FPP to biotin K-ras peptide (KKSKTKCVIM) catalyzed by bovine FTaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13389(4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040689((S)-2-{(S)-2-[(S)-2-(2-Amino-3-mercapto-propylamin...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against bovine type-1 geranylgeranyl transferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031168((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040691((S)-2-{(S)-2-[(S)-2-(2-Amino-3-mercapto-propionyla...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against bovine type-1 geranylgeranyl transferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040684((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propyl...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against bovine type-1 geranylgeranyl transferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040688((S)-2-{(S)-2-[(S)-2-(3-Mercapto-propylamino)-3-met...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against bovine type-1 geranylgeranyl transferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031178((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403711(CHEMBL2092855)
Affinity DataIC50:  53nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bos taurus (bovine))
Globe Pharmaceutical R And Abbott Laboratories

LigandPNGBDBM13413(A313326 Analogue 60b)
Affinity DataIC50:  65nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369443(CHEMBL252953)
Affinity DataIC50:  67nMAssay Description:Inhibition of [3H]GGPP incorporation into recombinant human Ha-RasCVLL by Geranylgeranyl transferase from bovine brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157285(5-[(3,4-Dichloro-benzyloxy)-(3-methyl-3H-imidazol-...)
Affinity DataIC50:  72nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157237(2'',3''-Dichloro-5-[(4-cyano-benzyloxy)-(3-methyl-...)
Affinity DataIC50:  85nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031162((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  86nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153805(3'-chloro-6-(((1-((3'-chloro-5-cyanobiphenyl-2-yl)...)
Affinity DataIC50:  87nMAssay Description:Inhibition of bovine GeranylgeranyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079809((S)-2-{[(2S,4S)-1-((E)-(R)-4-Amino-5-mercapto-pent...)
Affinity DataIC50:  89nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079966((S)-2-{2-[((S)-3-Methyl-2-{2-[3-(4-nitro-benzyl)-3...)
Affinity DataIC50:  92nMAssay Description:Inhibition of [3H]GGPP incorporation into recombinant human Ha-RasCVLL by Geranylgeranyl transferase from bovine brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bos taurus (bovine))
Globe Pharmaceutical R And Abbott Laboratories

LigandPNGBDBM13414(A313326 Analogue 60c | N-(5-cyano-2-{[(4-cyanophen...)
Affinity DataIC50:  100nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031163((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079813(2-[1-[5-amino-6-sulfanyl-(5R)-hexanoyl]-4-phenoxy-...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079794(2-[1-[4-amino-5-sulfanyl-(E,4R)-2-pentenyl]-4-(4-t...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14453(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)
Affinity DataIC50:  110nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157253(5-[(4-Fluoro-3-trifluoromethyl-benzyloxy)-(3-methy...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157249(5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14450(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)
Affinity DataIC50:  140nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50079810(2-[1-[5-amino-2-isopropyl-6-sulfanyl-(2S,3E,5R)-3-...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126339(4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETH...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory activity of the compound against farnesyltransferase (FTase)More data for this Ligand-Target Pair
LigandPNGBDBM50157252(5-[(3-Fluoro-4-trifluoromethyl-benzyloxy)-(3-methy...)
Affinity DataIC50:  160nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50051826(CHEMBL27486 | [(S)-4-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  160nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079806(2-[1-[4-amino-5-sulfanyl-(E,4R)-2-pentenyl]-4-(2-p...)
Affinity DataIC50:  170nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bos taurus (bovine))
Globe Pharmaceutical R And Abbott Laboratories

LigandPNGBDBM13404(4-{[(3-chloro-4-cyanophenyl)(1-methyl-1H-imidazol-...)
Affinity DataIC50:  170nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079792(2-[1-[4-amino-5-sulfanyl-(E,4R)-2-pentenyl]-4-(4-b...)
Affinity DataIC50:  180nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157248(5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Bovine Geranyl geranyl transeferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126333(4-[Cyclohexyl-(3-methyl-3H-imidazol-4-ylmethyl)-am...)
Affinity DataIC50:  180nMAssay Description:In vitro inhibitory activity of the compound against farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50216999(CHEMBL3349357)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079811(2-[1-[4-amino-5-sulfanyl-(E,4R)-2-pentenyl]-4-(4-i...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Bos taurus (bovine))
Globe Pharmaceutical R And Abbott Laboratories

LigandPNGBDBM13412(A313326 Analogue 60a | N-(5-cyano-2-{[(4-cyanophen...)
Affinity DataIC50:  220nMAssay Description:The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153774(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methylamin...)
Affinity DataIC50:  220nMAssay Description:Inhibition of bovine GeranylgeranyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126340(4-[(3-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibitory activity of the compound against farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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