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Compile Data Set for Download or QSAR

Found 1 hit of ec50 for Phosphodiesterase 3
having polymerids = 1570,1571,49000915 and
complexids = 50000730   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (Human))
BDBM50176998
PNG
(CHEMBL3814434)
Show SMILES O=C(Cc1cccnc1)Nc1ccc(cc1)C1=NNC(=O)CC1
Show InChI InChI=1S/C17H16N4O2/c22-16-8-7-15(20-21-16)13-3-5-14(6-4-13)19-17(23)10-12-2-1-9-18-11-12/h1-6,9,11H,7-8,10H2,(H,19,23)(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.00E+3n/an/an/an/a



Swiss Federal Institute of Technology (ETH)

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3B expressed in insect Sf9 cells assessed as residual cAMP level after 30 mins by HTRF assay


J Med Chem 59: 4077-86 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01849
BindingDB Entry DOI: 10.7270/Q2FN184P
More data for this
Ligand-Target Pair