Compile Data Set for Download or QSAR

Found 221 hits of ec50 for UniProtKB: A0A024RB59   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289541 (8-((1,4-Oxazepan-4-yl)methyl)-6-(4-methoxybenzyl)t...) Show SMILES COc1ccc(Cn2c3sc(CN4CCCOCC4)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C21H23N5O3S/c1-28-16-5-3-15(4-6-16)12-25-20-18(19-22-14-23-26(19)21(25)27)11-17(30-20)13-24-7-2-9-29-10-8-24/h3-6,11,14H,2,7-10,12-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289543 (6-(4-Methoxybenzyl)-8-(morpholinomethyl)thieno[3,2...) Show SMILES COc1ccc(Cn2c3sc(CN4CCOCC4)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C20H21N5O3S/c1-27-15-4-2-14(3-5-15)11-24-19-17(18-21-13-22-25(18)20(24)26)10-16(29-19)12-23-6-8-28-9-7-23/h2-5,10,13H,6-9,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289545 (8-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...) Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H25N5O3S/c1-14-9-25(10-15(2)30-14)12-18-8-19-20-23-13-24-27(20)22(28)26(21(19)31-18)11-16-4-6-17(29-3)7-5-16/h4-8,13-15H,9-12H2,1-3H3/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289546 (8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...) Show SMILES CCN1CCN(Cc2cc3c4ncnn4c(=O)n(Cc4ccc(OC)cc4)c3s2)CC1=O Show InChI InChI=1S/C22H24N6O3S/c1-3-26-9-8-25(13-19(26)29)12-17-10-18-20-23-14-24-28(20)22(30)27(21(18)32-17)11-15-4-6-16(31-2)7-5-15/h4-7,10,14H,3,8-9,11-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289547 (6-(4-Methoxybenzyl)-8-((4-(methylsulfonyl)piperazi...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)S(C)(=O)=O)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C21H24N6O4S2/c1-31-16-5-3-15(4-6-16)12-26-20-18(19-22-14-23-27(19)21(26)28)11-17(32-20)13-24-7-9-25(10-8-24)33(2,29)30/h3-6,11,14H,7-10,12-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289548 (8-(2,2-Dimethylmorpholino)methyl)-6-(4-methoxybenz...) Show SMILES COc1ccc(Cn2c3sc(CN4CCOC(C)(C)C4)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H25N5O3S/c1-22(2)13-25(8-9-30-22)12-17-10-18-19-23-14-24-27(19)21(28)26(20(18)31-17)11-15-4-6-16(29-3)7-5-15/h4-7,10,14H,8-9,11-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289549 (8-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-6-(...) Show SMILES COc1ccc(Cn2c3sc(CN4CC5CC4CO5)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C21H21N5O3S/c1-28-15-4-2-13(3-5-15)8-25-20-18(19-22-12-23-26(19)21(25)27)7-17(30-20)10-24-9-16-6-14(24)11-29-16/h2-5,7,12,14,16H,6,8-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289550 (8-(7-Oxa-2-azaspiro[3.5]nonan-2-ylmethyl)-6-(4-met...) Show SMILES COc1ccc(Cn2c3sc(CN4CC5(C4)CCOCC5)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H25N5O3S/c1-30-17-4-2-16(3-5-17)11-27-21-19(20-24-15-25-28(20)22(27)29)10-18(32-21)12-26-13-23(14-26)6-8-31-9-7-23/h2-5,10,15H,6-9,11-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289551 (8-(2-Oxa-7-azaspiro[3.5]nonan-7-ylmethyl)-6-(4-met...) Show SMILES COc1ccc(Cn2c3sc(CN4CCC5(COC5)CC4)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H25N5O3S/c1-30-17-4-2-16(3-5-17)11-27-21-19(20-24-15-25-28(20)22(27)29)10-18(32-21)12-26-8-6-23(7-9-26)13-31-14-23/h2-5,10,15H,6-9,11-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289552 (7-((6-(4-Methoxybenzyl)-5-oxo-5,6-dihydrothieno[3,...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN5C(COC5=O)C4)cc3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H22N6O4S/c1-31-16-4-2-14(3-5-16)9-27-20-18(19-23-13-24-28(19)21(27)29)8-17(33-20)11-25-6-7-26-15(10-25)12-32-22(26)30/h2-5,8,13,15H,6-7,9-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289553 (6-(4-Methoxybenzyl)-8-(1-methyl-3-(trifluoromethyl...) Show SMILES COc1ccc(Cn2c3sc(cc3c3ncnn3c2=O)-c2cc(nn2C)C(F)(F)F)cc1 Show InChI InChI=1S/C20H15F3N6O2S/c1-27-14(8-16(26-27)20(21,22)23)15-7-13-17-24-10-25-29(17)19(30)28(18(13)32-15)9-11-3-5-12(31-2)6-4-11/h3-8,10H,9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289556 (6-(4-Methoxybenzyl)-9-methyl-8-(morpholinomethyl)t...) Show SMILES COc1ccc(Cn2c3sc(CN4CCOCC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C21H23N5O3S/c1-14-17(12-24-7-9-29-10-8-24)30-20-18(14)19-22-13-23-26(19)21(27)25(20)11-15-3-5-16(28-2)6-4-15/h3-6,13H,7-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289557 (8-((Dimethylamino)methyl)-6-(4-methoxybenzyl)-9-me...) Show SMILES COc1ccc(Cn2c3sc(CN(C)C)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C19H21N5O2S/c1-12-15(10-22(2)3)27-18-16(12)17-20-11-21-24(17)19(25)23(18)9-13-5-7-14(26-4)8-6-13/h5-8,11H,9-10H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289558 (8-((Cyclopropyl(methyl)amino)methyl)-6-(4-methoxyb...) Show SMILES COc1ccc(Cn2c3sc(CN(C)C4CC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C21H23N5O2S/c1-13-17(11-24(2)15-6-7-15)29-20-18(13)19-22-12-23-26(19)21(27)25(20)10-14-4-8-16(28-3)9-5-14/h4-5,8-9,12,15H,6-7,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289559 (8-((4-Hydroxypiperidin-1-yl)methyl)-6-(4-methoxybe...) Show SMILES COc1ccc(Cn2c3sc(CN4CCC(O)CC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H25N5O3S/c1-14-18(12-25-9-7-16(28)8-10-25)31-21-19(14)20-23-13-24-27(20)22(29)26(21)11-15-3-5-17(30-2)6-4-15/h3-6,13,16,28H,7-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289560 (8-((Benzyl(2-hydroxyethyl)amino)methyl)-6-(4-metho...) Show SMILES COc1ccc(Cn2c3sc(CN(CCO)Cc4ccccc4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C26H27N5O3S/c1-18-22(16-29(12-13-32)14-19-6-4-3-5-7-19)35-25-23(18)24-27-17-28-31(24)26(33)30(25)15-20-8-10-21(34-2)11-9-20/h3-11,17,32H,12-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289562 (6-(4-Methoxybenzyl)-9-methyl-8-((((3-methyloxetan-...) Show SMILES COc1ccc(Cn2c3sc(CNCC4(C)COC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H25N5O3S/c1-14-17(8-23-10-22(2)11-30-12-22)31-20-18(14)19-24-13-25-27(19)21(28)26(20)9-15-4-6-16(29-3)7-5-15/h4-7,13,23H,8-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289563 (8-((4-Acetylpiperazin-1-yl)methyl)-6-(4-methoxyben...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)C(C)=O)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H26N6O3S/c1-15-19(13-26-8-10-27(11-9-26)16(2)30)33-22-20(15)21-24-14-25-29(21)23(31)28(22)12-17-4-6-18(32-3)7-5-17/h4-7,14H,8-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289564 (6-(4-Methoxybenzyl)-9-methyl-8-(((pyridin-3-ylmeth...) Show SMILES COc1ccc(Cn2c3sc(CNCc4cccnc4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H22N6O2S/c1-15-19(12-25-11-17-4-3-9-24-10-17)32-22-20(15)21-26-14-27-29(21)23(30)28(22)13-16-5-7-18(31-2)8-6-16/h3-10,14,25H,11-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289565 (6-(4-Methoxybenzyl)-9-methyl-8-((3-oxopiperazin-1-...) Show SMILES COc1ccc(Cn2c3sc(CN4CCNC(=O)C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C21H22N6O3S/c1-13-16(10-25-8-7-22-17(28)11-25)31-20-18(13)19-23-12-24-27(19)21(29)26(20)9-14-3-5-15(30-2)6-4-14/h3-6,12H,7-11H2,1-2H3,(H,22,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289566 (6-(4-Methoxybenzyl)-9-methyl-8-((methyl((tetrahydr...) Show SMILES COc1ccc(Cn2c3sc(CN(C)CC4CCCO4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H27N5O3S/c1-15-19(13-26(2)12-18-5-4-10-31-18)32-22-20(15)21-24-14-25-28(21)23(29)27(22)11-16-6-8-17(30-3)9-7-16/h6-9,14,18H,4-5,10-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289567 (8-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-6-(4-me...) Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H27N5O3S/c1-14-9-26(10-15(2)31-14)12-19-16(3)20-21-24-13-25-28(21)23(29)27(22(20)32-19)11-17-5-7-18(30-4)8-6-17/h5-8,13-15H,9-12H2,1-4H3/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289568 (8-(Isoindolin-2-ylmethyl)-6-(4-methoxybenzyl)-9-me...) Show SMILES COc1ccc(Cn2c3sc(CN4Cc5ccccc5C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C25H23N5O2S/c1-16-21(14-28-12-18-5-3-4-6-19(18)13-28)33-24-22(16)23-26-15-27-30(23)25(31)29(24)11-17-7-9-20(32-2)10-8-17/h3-10,15H,11-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289569 (8-((Cyclopropylamino)methyl)-6-(4-methoxybenzyl)-9...) Show SMILES COc1ccc(Cn2c3sc(CNC4CC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C20H21N5O2S/c1-12-16(9-21-14-5-6-14)28-19-17(12)18-22-11-23-25(18)20(26)24(19)10-13-3-7-15(27-2)8-4-13/h3-4,7-8,11,14,21H,5-6,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289570 ((S)-6-(4-Methoxybenzyl)-8-((2-(methoxymethyl)pyrro...) Show SMILES COC[C@@H]1CCCN1Cc1sc2n(Cc3ccc(OC)cc3)c(=O)n3ncnc3c2c1C Show InChI InChI=1S/C23H27N5O3S/c1-15-19(12-26-10-4-5-17(26)13-30-2)32-22-20(15)21-24-14-25-28(21)23(29)27(22)11-16-6-8-18(31-3)9-7-16/h6-9,14,17H,4-5,10-13H2,1-3H3/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289571 (6-(4-Methoxybenzyl)-9-methyl-8-((methyl((tetrahydr...) Show SMILES COc1ccc(Cn2c3sc(CN(C)CC4CCOC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H27N5O3S/c1-15-19(12-26(2)10-17-8-9-31-13-17)32-22-20(15)21-24-14-25-28(21)23(29)27(22)11-16-4-6-18(30-3)7-5-16/h4-7,14,17H,8-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289572 (2-(((6-(4-Methoxybenzyl)-9-methyl-5-oxo-5,6-dihydr...) Show SMILES COc1ccc(Cn2c3sc(CN(C)CC(=O)N(C)C)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H26N6O3S/c1-14-17(11-26(4)12-18(29)25(2)3)32-21-19(14)20-23-13-24-28(20)22(30)27(21)10-15-6-8-16(31-5)9-7-15/h6-9,13H,10-12H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289573 (8-((1,4-Oxazepan-4-yl)methyl)-6-(4-methoxybenzyl)-...) Show SMILES COc1ccc(Cn2c3sc(CN4CCCOCC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H25N5O3S/c1-15-18(13-25-8-3-10-30-11-9-25)31-21-19(15)20-23-14-24-27(20)22(28)26(21)12-16-4-6-17(29-2)7-5-16/h4-7,14H,3,8-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289574 (6-(4-Methoxybenzyl)-9-methyl-8-((4-methylpiperazin...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)CC4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H26N6O2S/c1-15-18(13-26-10-8-25(2)9-11-26)31-21-19(15)20-23-14-24-28(20)22(29)27(21)12-16-4-6-17(30-3)7-5-16/h4-7,14H,8-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289575 (6-(4-Methoxybenzyl)-9-methyl-8-((4-(methylsulfonyl...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)S(C)(=O)=O)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H26N6O4S2/c1-15-18(13-25-8-10-26(11-9-25)34(3,30)31)33-21-19(15)20-23-14-24-28(20)22(29)27(21)12-16-4-6-17(32-2)7-5-16/h4-7,14H,8-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289576 (8-((4-Isopropylpiperazin-1-yl)methyl)-6-(4-methoxy...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN(CC4)C(C)C)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C24H30N6O2S/c1-16(2)28-11-9-27(10-12-28)14-20-17(3)21-22-25-15-26-30(22)24(31)29(23(21)33-20)13-18-5-7-19(32-4)8-6-18/h5-8,15-16H,9-14H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289577 (8-(2-Oxa-5-azabicyclo[2.2.1]heptan-5-ylmethyl)-6-(...) Show SMILES COc1ccc(Cn2c3sc(CN4CC5CC4CO5)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H23N5O3S/c1-13-18(10-25-9-17-7-15(25)11-30-17)31-21-19(13)20-23-12-24-27(20)22(28)26(21)8-14-3-5-16(29-2)6-4-14/h3-6,12,15,17H,7-11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289578 (8-((4-Ethyl-3-oxopiperazin-1-yl)methyl)-6-(4-metho...) Show SMILES CCN1CCN(Cc2sc3n(Cc4ccc(OC)cc4)c(=O)n4ncnc4c3c2C)CC1=O Show InChI InChI=1S/C23H26N6O3S/c1-4-27-10-9-26(13-19(27)30)12-18-15(2)20-21-24-14-25-29(21)23(31)28(22(20)33-18)11-16-5-7-17(32-3)8-6-16/h5-8,14H,4,9-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289579 (8-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-6-(4...) Show SMILES COc1ccc(Cn2c3sc(CN4CC5CCC(C4)O5)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H25N5O3S/c1-14-19(12-26-10-17-7-8-18(11-26)31-17)32-22-20(14)21-24-13-25-28(21)23(29)27(22)9-15-3-5-16(30-2)6-4-15/h3-6,13,17-18H,7-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289580 (8-((2-Ethylmorpholino)methyl)-6-(4-methoxybenzyl)-...) Show SMILES CCC1CN(Cc2sc3n(Cc4ccc(OC)cc4)c(=O)n4ncnc4c3c2C)CCO1 Show InChI InChI=1S/C23H27N5O3S/c1-4-17-12-26(9-10-31-17)13-19-15(2)20-21-24-14-25-28(21)23(29)27(22(20)32-19)11-16-5-7-18(30-3)8-6-16/h5-8,14,17H,4,9-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289581 (8-((2,2-Dimethylmorpholino)methyl)-6-(4-methoxyben...) Show SMILES COc1ccc(Cn2c3sc(CN4CCOC(C)(C)C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H27N5O3S/c1-15-18(12-26-9-10-31-23(2,3)13-26)32-21-19(15)20-24-14-25-28(20)22(29)27(21)11-16-5-7-17(30-4)8-6-16/h5-8,14H,9-13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289582 (6-(4-Methoxybenzyl)-9-methyl-8-((2-methylmorpholin...) Show SMILES COc1ccc(Cn2c3sc(CN4CCOC(C)C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H25N5O3S/c1-14-10-25(8-9-30-14)12-18-15(2)19-20-23-13-24-27(20)22(28)26(21(19)31-18)11-16-4-6-17(29-3)7-5-16/h4-7,13-14H,8-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289583 (6-(4-Methoxybenzyl)-9-methyl-8-((3-methylmorpholin...) Show SMILES COc1ccc(Cn2c3sc(CN4CCOCC4C)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H25N5O3S/c1-14-12-30-9-8-25(14)11-18-15(2)19-20-23-13-24-27(20)22(28)26(21(19)31-18)10-16-4-6-17(29-3)7-5-16/h4-7,13-14H,8-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289585 (8-((3,4-Dimethylpiperazin-1-yl)methyl)-6-(4-methox...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)C(C)C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H28N6O2S/c1-15-11-27(10-9-26(15)3)13-19-16(2)20-21-24-14-25-29(21)23(30)28(22(20)32-19)12-17-5-7-18(31-4)8-6-17/h5-8,14-15H,9-13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289586 (6-(4-Methoxybenzyl)-9-methyl-8-((3,3,4-trimethylpi...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN(C)C(C)(C)C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C24H30N6O2S/c1-16-19(13-28-11-10-27(4)24(2,3)14-28)33-22-20(16)21-25-15-26-30(21)23(31)29(22)12-17-6-8-18(32-5)9-7-17/h6-9,15H,10-14H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289587 ((S)-8-((Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)me...) Show SMILES COc1ccc(Cn2c3sc(CN4CCN5CCC[C@H]5C4)c(C)c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C24H28N6O2S/c1-16-20(14-27-10-11-28-9-3-4-18(28)13-27)33-23-21(16)22-25-15-26-30(22)24(31)29(23)12-17-5-7-19(32-2)8-6-17/h5-8,15,18H,3-4,9-14H2,1-2H3/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289592 (US10092575, Example 80 | US10376514, Example 80 | ...) Show SMILES COc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C23H25N5O4S/c1-23(2,3)32-22(30)26-10-9-16-17(12-26)33-20-18(16)19-24-13-25-28(19)21(29)27(20)11-14-5-7-15(31-4)8-6-14/h5-8,13H,9-12H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289602 (6-(4-Methoxybenzyl)-6,8,10,11-tetrahydro-5H-pyrano...) Show SMILES COc1ccc(Cn2c3sc4COCCc4c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C18H16N4O3S/c1-24-12-4-2-11(3-5-12)8-21-17-15(13-6-7-25-9-14(13)26-17)16-19-10-20-22(16)18(21)23/h2-5,10H,6-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289615 (6-(4-Chlorobenzyl)-9-(cyclopropylmethyl)-8,9,10,11...) Show SMILES Clc1ccc(Cn2c3sc4CN(CC5CC5)CCc4c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C21H20ClN5OS/c22-15-5-3-14(4-6-15)10-26-20-18(19-23-12-24-27(19)21(26)28)16-7-8-25(9-13-1-2-13)11-17(16)29-20/h3-6,12-13H,1-2,7-11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289616 (2-(((2S,6R)-2,6-Dimethylmorpholino)methyl)-4-(4-me...) Show SMILES COc1ccc(Cn2c3sc(CN4C[C@H](C)O[C@H](C)C4)cc3c3ccnn3c2=O)cc1 Show InChI InChI=1S/C23H26N4O3S/c1-15-11-25(12-16(2)30-15)14-19-10-20-21-8-9-24-27(21)23(28)26(22(20)31-19)13-17-4-6-18(29-3)7-5-17/h4-10,15-16H,11-14H2,1-3H3/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289617 (6-(4-Chlorobenzyl)-9-((tetrahydro-2H-pyran-4-yl)me...) Show SMILES Clc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C23H24ClN5O2S/c24-17-3-1-15(2-4-17)12-28-22-20(21-25-14-26-29(21)23(28)30)18-5-8-27(13-19(18)32-22)11-16-6-9-31-10-7-16/h1-4,14,16H,5-13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289618 (6-(4-Chlorobenzyl)-9-(oxetan-3-yl)-8,9,10,11-tetra...) Show SMILES Clc1ccc(Cn2c3sc4CN(CCc4c3c3ncnn3c2=O)C2COC2)cc1 Show InChI InChI=1S/C20H18ClN5O2S/c21-13-3-1-12(2-4-13)7-25-19-17(18-22-11-23-26(18)20(25)27)15-5-6-24(8-16(15)29-19)14-9-28-10-14/h1-4,11,14H,5-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289620 (6-(4-Methoxybenzyl)-9-((5-methyl-1,3,4-thiadiazol-...) Show SMILES COc1ccc(Cn2c3sc4CN(Cc5nnc(C)s5)CCc4c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H21N7O2S2/c1-13-25-26-18(32-13)11-27-8-7-16-17(10-27)33-21-19(16)20-23-12-24-29(20)22(30)28(21)9-14-3-5-15(31-2)6-4-14/h3-6,12H,7-11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289621 (6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...) Show SMILES COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C24H27N5O3S/c1-31-18-4-2-16(3-5-18)13-28-23-21(22-25-15-26-29(22)24(28)30)19-6-9-27(14-20(19)33-23)12-17-7-10-32-11-8-17/h2-5,15,17H,6-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair				3D Structure (crystal)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM289622 (9-(Cyclopropylmethyl)-6-(4-methoxybenzyl)-8,9,10,1...) Show SMILES COc1ccc(Cn2c3sc4CN(CC5CC5)CCc4c3c3ncnn3c2=O)cc1 Show InChI InChI=1S/C22H23N5O2S/c1-29-16-6-4-15(5-7-16)11-26-21-19(20-23-13-24-27(20)22(26)28)17-8-9-25(10-14-2-3-14)12-18(17)30-21/h4-7,13-14H,2-3,8-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	25
Dart NeuroScience (Cayman) Ltd US Patent					Assay Description The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...				US Patent US10092575 (2018) BindingDB Entry DOI: 10.7270/Q2514181
					More data for this Ligand-Target Pair

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