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Compile Data Set for Download or QSAR

Found 24 hits of ec50 for Inosine-5'-monophosphate dehydrogenase (IMPDH)
having polymerids = 1989 and
complexids = 50007982   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19284
PNG
(Acridone-Based Inhibitor, 4h | N-{2-[3-(dimethylsu...)
Show SMILES CN(C)S(=O)(=O)c1cccc(c1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C25H24FN3O4S/c1-25(2,15-8-7-9-16(12-15)34(32,33)29(3)4)28-24(31)18-14-22-19(13-20(18)26)23(30)17-10-5-6-11-21(17)27-22/h5-14H,1-4H3,(H,27,30)(H,28,31)
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n/an/a 7.90n/a 380n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19279
PNG
(2-fluoro-9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,1...)
Show SMILES CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1cccnc1
Show InChI InChI=1S/C22H18FN3O2/c1-22(2,13-6-5-9-24-12-13)26-21(28)15-11-19-16(10-17(15)23)20(27)14-7-3-4-8-18(14)25-19/h3-12H,1-2H3,(H,25,27)(H,26,28)
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n/an/a 11n/a 420n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19281
PNG
(2-fluoro-N-[2-(4-methanesulfonylphenyl)propan-2-yl...)
Show SMILES CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H21FN2O4S/c1-24(2,14-8-10-15(11-9-14)32(3,30)31)27-23(29)17-13-21-18(12-19(17)25)22(28)16-6-4-5-7-20(16)26-21/h4-13H,1-3H3,(H,26,28)(H,27,29)
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n/an/a 12n/a 480n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19264
PNG
((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
Show InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
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n/an/a 16n/a 540n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19280
PNG
(Acridone-Based Inhibitor, 4d | N-(2-{4-[2-(dimethy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C27H28FN3O3/c1-27(2,17-9-11-18(12-10-17)34-14-13-31(3)4)30-26(33)20-16-24-21(15-22(20)28)25(32)19-7-5-6-8-23(19)29-24/h5-12,15-16H,13-14H2,1-4H3,(H,29,32)(H,30,33)
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n/an/a 20n/a 560n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19282
PNG
(2-fluoro-N-[2-(3-methanesulfonylphenyl)propan-2-yl...)
Show SMILES CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C24H21FN2O4S/c1-24(2,14-7-6-8-15(11-14)32(3,30)31)27-23(29)17-13-21-18(12-19(17)25)22(28)16-9-4-5-10-20(16)26-21/h4-13H,1-3H3,(H,26,28)(H,27,29)
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n/an/a 12n/a 580n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19288
PNG
(Acridone-Based Inhibitor, 4l | N-{2-[2-(dimethylam...)
Show SMILES CN(C)c1cc(ccn1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C24H23FN4O2/c1-24(2,14-9-10-26-21(11-14)29(3)4)28-23(31)16-13-20-17(12-18(16)25)22(30)15-7-5-6-8-19(15)27-20/h5-13H,1-4H3,(H,27,30)(H,28,31)
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n/an/a 14n/a 640n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19283
PNG
(Acridone-Based Inhibitor, 4g | N-{2-[4-(dimethylsu...)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C25H24FN3O4S/c1-25(2,15-9-11-16(12-10-15)34(32,33)29(3)4)28-24(31)18-14-22-19(13-20(18)26)23(30)17-7-5-6-8-21(17)27-22/h5-14H,1-4H3,(H,27,30)(H,28,31)
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n/an/a 10n/a 660n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19290
PNG
(2-fluoro-N-{2-[6-(morpholin-4-yl)pyridin-3-yl]prop...)
Show SMILES CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C26H25FN4O3/c1-26(2,16-7-8-23(28-15-16)31-9-11-34-12-10-31)30-25(33)18-14-22-19(13-20(18)27)24(32)17-5-3-4-6-21(17)29-22/h3-8,13-15H,9-12H2,1-2H3,(H,29,32)(H,30,33)
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n/an/a 20n/a 660n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19286
PNG
(2-fluoro-N-[2-(6-methylpyridin-3-yl)propan-2-yl]-9...)
Show SMILES Cc1ccc(cn1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C23H20FN3O2/c1-13-8-9-14(12-25-13)23(2,3)27-22(29)16-11-20-17(10-18(16)24)21(28)15-6-4-5-7-19(15)26-20/h4-12H,1-3H3,(H,26,28)(H,27,29)
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n/an/a 23n/a 750n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19289
PNG
(Acridone-Based Inhibitor, 4m | BMS-566419 | N-{2-[...)
Show SMILES CCN1CCN(CC1)c1ccc(cn1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C28H30FN5O2/c1-4-33-11-13-34(14-12-33)25-10-9-18(17-30-25)28(2,3)32-27(36)20-16-24-21(15-22(20)29)26(35)19-7-5-6-8-23(19)31-24/h5-10,15-17H,4,11-14H2,1-3H3,(H,31,35)(H,32,36)
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n/an/a 17n/a 770n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19291
PNG
(2-fluoro-N-{2-[5-methoxy-6-(morpholin-4-yl)pyridin...)
Show SMILES COc1cc(cnc1N1CCOCC1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C27H27FN4O4/c1-27(2,16-12-23(35-3)25(29-15-16)32-8-10-36-11-9-32)31-26(34)18-14-22-19(13-20(18)28)24(33)17-6-4-5-7-21(17)30-22/h4-7,12-15H,8-11H2,1-3H3,(H,30,33)(H,31,34)
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n/an/a 20n/a 810n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19277
PNG
(2-fluoro-9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydr...)
Show SMILES CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccccc1
Show InChI InChI=1S/C23H19FN2O2/c1-23(2,14-8-4-3-5-9-14)26-22(28)16-13-20-17(12-18(16)24)21(27)15-10-6-7-11-19(15)25-20/h3-13H,1-2H3,(H,25,27)(H,26,28)
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n/an/a 11n/a 830n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19287
PNG
(Acridone-Based Inhibitor, 4k | N-{2-[6-(dimethylam...)
Show SMILES CN(C)c1ccc(cn1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C24H23FN4O2/c1-24(2,14-9-10-21(26-13-14)29(3)4)28-23(31)16-12-20-17(11-18(16)25)22(30)15-7-5-6-8-19(15)27-20/h5-13H,1-4H3,(H,27,30)(H,28,31)
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n/an/a 22n/a 850n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19292
PNG
(2-fluoro-N-{2-[5-methyl-6-(morpholin-4-yl)pyridin-...)
Show SMILES Cc1cc(cnc1N1CCOCC1)C(C)(C)NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F
Show InChI InChI=1S/C27H27FN4O3/c1-16-12-17(15-29-25(16)32-8-10-35-11-9-32)27(2,3)31-26(34)19-14-23-20(13-21(19)28)24(33)18-6-4-5-7-22(18)30-23/h4-7,12-15H,8-11H2,1-3H3,(H,30,33)(H,31,34)
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n/an/a 11n/a 870n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19285
PNG
(2-fluoro-9-oxo-N-(2-{2H,3H,4H-pyrido[3,2-b][1,4]ox...)
Show SMILES CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1cnc2NCCOc2c1
Show InChI InChI=1S/C24H21FN4O3/c1-24(2,13-9-20-22(27-12-13)26-7-8-32-20)29-23(31)15-11-19-16(10-17(15)25)21(30)14-5-3-4-6-18(14)28-19/h3-6,9-12H,7-8H2,1-2H3,(H,26,27)(H,28,30)(H,29,31)
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n/an/a 17n/a 920n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19278
PNG
(2-fluoro-9-oxo-N-[2-(pyridin-2-yl)propan-2-yl]-9,1...)
Show SMILES CC(C)(NC(=O)c1cc2[nH]c3ccccc3c(=O)c2cc1F)c1ccccn1
Show InChI InChI=1S/C22H18FN3O2/c1-22(2,19-9-5-6-10-24-19)26-21(28)14-12-18-15(11-16(14)23)20(27)13-7-3-4-8-17(13)25-18/h3-12H,1-2H3,(H,25,27)(H,26,28)
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n/an/a 29n/a 1.00E+3n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19270
PNG
(9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydroacridine...)
Show SMILES CC(C)(NC(=O)c1ccc2c(c1)[nH]c1ccccc1c2=O)c1ccccc1
Show InChI InChI=1S/C23H20N2O2/c1-23(2,16-8-4-3-5-9-16)25-22(27)15-12-13-18-20(14-15)24-19-11-7-6-10-17(19)21(18)26/h3-14H,1-2H3,(H,24,26)(H,25,27)
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n/an/a 19n/a 2.10E+3n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19274
PNG
(9-oxo-N-[2-(pyridin-2-yl)propan-2-yl]-9,10-dihydro...)
Show SMILES CC(C)(NC(=O)c1ccc2c(c1)[nH]c1ccccc1c2=O)c1ccccn1
Show InChI InChI=1S/C22H19N3O2/c1-22(2,19-9-5-6-12-23-19)25-21(27)14-10-11-16-18(13-14)24-17-8-4-3-7-15(17)20(16)26/h3-13H,1-2H3,(H,24,26)(H,25,27)
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n/an/a 53n/a 2.20E+3n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19275
PNG
(9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,10-dihydro...)
Show SMILES CC(C)(NC(=O)c1ccc2c(c1)[nH]c1ccccc1c2=O)c1cccnc1
Show InChI InChI=1S/C22H19N3O2/c1-22(2,15-6-5-11-23-13-15)25-21(27)14-9-10-17-19(12-14)24-18-8-4-3-7-16(18)20(17)26/h3-13H,1-2H3,(H,24,26)(H,25,27)
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n/an/a 42n/a 2.20E+3n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19276
PNG
(9-oxo-N-[2-(pyridin-4-yl)propan-2-yl]-9,10-dihydro...)
Show SMILES CC(C)(NC(=O)c1ccc2c(c1)[nH]c1ccccc1c2=O)c1ccncc1
Show InChI InChI=1S/C22H19N3O2/c1-22(2,15-9-11-23-12-10-15)25-21(27)14-7-8-17-19(13-14)24-18-6-4-3-5-16(18)20(17)26/h3-13H,1-2H3,(H,24,26)(H,25,27)
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n/an/a 53n/a 2.30E+3n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19269
PNG
(Acridone-Based Inhibitor, 8a | N-tert-butyl-9-oxo-...)
Show SMILES CC(C)(C)NC(=O)c1ccc2c(c1)[nH]c1ccccc1c2=O
Show InChI InChI=1S/C18H18N2O2/c1-18(2,3)20-17(22)11-8-9-13-15(10-11)19-14-7-5-4-6-12(14)16(13)21/h4-10H,1-3H3,(H,19,21)(H,20,22)
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n/an/a 59n/a 3.30E+3n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM19268
PNG
(Acridone-Based Inhibitor, 3 | ethyl 9-oxo-9,10-dih...)
Show SMILES CCOC(=O)c1ccc2c(c1)[nH]c1ccccc1c2=O
Show InChI InChI=1S/C16H13NO3/c1-2-20-16(19)10-7-8-12-14(9-10)17-13-6-4-3-5-11(13)15(12)18/h3-9H,2H2,1H3,(H,17,18)
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n/an/a 59n/a>1.00E+4n/an/a8.025



Bristol-Myers Squibb Company



Assay Description
Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...


J Med Chem 50: 3730-42 (2007)


Article DOI: 10.1021/jm070299x
BindingDB Entry DOI: 10.7270/Q2N58JPV
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50294184
PNG
(CHEMBL561640 | N-(4-chlorophenyl)-2-phenoxypropana...)
Show SMILES CC(Oc1ccccc1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C15H14ClNO2/c1-11(19-14-5-3-2-4-6-14)15(18)17-13-9-7-12(16)8-10-13/h2-11H,1H3,(H,17,18)
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n/an/an/an/a>5.00E+4n/an/an/an/a



Brandeis University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IMPDH2 expressed in Escherichia coli guaB assessed as NADH production by fluorescence assay


J Med Chem 52: 4623-30 (2009)


Article DOI: 10.1021/jm900410u
BindingDB Entry DOI: 10.7270/Q2HM59C1
More data for this
Ligand-Target Pair