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Compile Data Set for Download or QSAR

Found 3851 hits of ic50 for UniProtKB: P11309   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151989
PNG
(US8987457, 183)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F
Show InChI InChI=1/C32H34F3N5O4/c1-18-13-19(14-26(37)31(18)43-10-2-8-36)22-5-9-38-17-28(22)40-32(41)27-4-3-23(33)30(39-27)29-24(34)15-21(16-25(29)35)44-20-6-11-42-12-7-20/h3-5,9,15-20,26,31H,2,6-7,10-14,37H2,1H3,(H,40,41)/t18-,19+,26+,31-/s2
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US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151889
PNG
(US8987457, 83)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1/C28H28F3N5O2/c1-15-10-20(30)25(21(31)11-15)26-19(29)4-5-23(35-26)28(37)36-24-14-34-8-6-18(24)17-12-16(2)27(22(33)13-17)38-9-3-7-32/h4-6,8,10-11,14,16-17,22,27H,3,9,12-13,33H2,1-2H3,(H,36,37)/t16-,17+,22+,27-/s2
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US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151959
PNG
(US8987457, 153)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(F)CCOCC1
Show InChI InChI=1/C32H33F4N5O3/c1-18-13-19(14-25(38)30(18)44-10-2-8-37)21-5-9-39-17-27(21)41-31(42)26-4-3-22(33)29(40-26)28-23(34)15-20(16-24(28)35)32(36)6-11-43-12-7-32/h3-5,9,15-19,25,30H,2,6-7,10-14,38H2,1H3,(H,41,42)/t18-,19+,25+,30-/s2
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US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151905
PNG
(US8987457, 99)
Show SMILES CO[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1CCOCC1
Show InChI InChI=1/C30H33F3N4O3/c1-16-11-19(14-24(34)29(16)39-2)20-5-8-35-15-26(20)37-30(38)25-4-3-21(31)28(36-25)27-22(32)12-18(13-23(27)33)17-6-9-40-10-7-17/h3-5,8,12-13,15-17,19,24,29H,6-7,9-11,14,34H2,1-2H3,(H,37,38)/t16-,19+,24+,29-/s2
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US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151870
PNG
(US8987457, 64)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1/C25H26F2N6O2S/c1-13-10-14(11-18(29)22(13)35-9-3-7-28)15-6-8-31-12-19(15)32-24(34)21-23(30)36-25(33-21)20-16(26)4-2-5-17(20)27/h2,4-6,8,12-14,18,22H,3,9-11,29-30H2,1H3,(H,32,34)/t13-,14+,18+,22-/s2
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US Patent
n/an/a 0.0100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM238724
PNG
(US9394297, 405)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O
Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1
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US Patent
n/an/a 0.0120n/an/an/an/a7.022



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM238826
PNG
(US9394297, 513)
Show SMILES CCn1c(NC2(C)CC2)nc2c(-c3cc4C(=O)N[C@H](C)c4[nH]3)c(F)ccc2c1=O
Show InChI InChI=1S/C21H22FN5O2/c1-4-27-19(29)11-5-6-13(22)15(17(11)25-20(27)26-21(3)7-8-21)14-9-12-16(24-14)10(2)23-18(12)28/h5-6,9-10,24H,4,7-8H2,1-3H3,(H,23,28)(H,25,26)/t10-/m1/s1
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n/an/a 0.0130n/an/an/an/a7.022



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151971
PNG
(US8987457, 165)
Show SMILES COc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCC#N)[C@H](N)C1
Show InChI InChI=1/C28H28F3N5O3/c1-15-10-16(11-22(33)27(15)39-9-3-7-32)18-6-8-34-14-24(18)36-28(37)23-5-4-19(29)26(35-23)25-20(30)12-17(38-2)13-21(25)31/h4-6,8,12-16,22,27H,3,9-11,33H2,1-2H3,(H,36,37)/t15-,16+,22+,27-/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151839
PNG
(US8987457, 33)
Show SMILES CS[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C25H25F3N4OS/c1-13-10-14(11-19(29)24(13)34-2)15-8-9-30-12-21(15)32-25(33)20-7-6-18(28)23(31-20)22-16(26)4-3-5-17(22)27/h3-9,12-14,19,24H,10-11,29H2,1-2H3,(H,32,33)/t13-,14+,19+,24-/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151943
PNG
(US8987457, 137)
Show SMILES CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F
Show InChI InChI=1/C30H33F3N4O4/c1-16-11-17(12-24(34)29(16)39-2)20-5-8-35-15-26(20)37-30(38)25-4-3-21(31)28(36-25)27-22(32)13-19(14-23(27)33)41-18-6-9-40-10-7-18/h3-5,8,13-18,24,29H,6-7,9-12,34H2,1-2H3,(H,37,38)/t16-,17+,24+,29+/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151941
PNG
(US8987457, 135)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1/C25H29F2N5O4S2/c1-13-10-14(11-18(28)22(13)36-8-9-38(2,34)35)15-6-7-30-12-19(15)31-24(33)21-23(29)37-25(32-21)20-16(26)4-3-5-17(20)27/h3-7,12-14,18,22H,8-11,28-29H2,1-2H3,(H,31,33)/t13-,14+,18+,22-/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151924
PNG
(US8987457, 118)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1/C32H37F3N4O6S/c1-18-13-19(14-25(36)30(18)45-11-12-46(2,42)43)21-5-8-37-17-27(21)39-31(40)26-4-3-22(33)29(38-26)28-23(34)15-20(16-24(28)35)32(41)6-9-44-10-7-32/h3-5,8,15-19,25,30,41H,6-7,9-14,36H2,1-2H3,(H,39,40)/t18-,19+,25+,30-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151945
PNG
(US8987457, 139)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1/C31H35F3N4O5S/c1-17-12-18(13-24(35)29(17)43-10-11-44(2,41)42)20-6-9-36-16-26(20)38-30(39)25-5-4-21(32)28(37-25)27-22(33)14-19(15-23(27)34)31(40)7-3-8-31/h4-6,9,14-18,24,29,40H,3,7-8,10-13,35H2,1-2H3,(H,38,39)/t17-,18+,24+,29+/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151946
PNG
(US8987457, 140)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F
Show InChI InChI=1/C32H37F3N4O6S/c1-18-13-19(14-26(36)31(18)44-11-12-46(2,41)42)22-5-8-37-17-28(22)39-32(40)27-4-3-23(33)30(38-27)29-24(34)15-21(16-25(29)35)45-20-6-9-43-10-7-20/h3-5,8,15-20,26,31H,6-7,9-14,36H2,1-2H3,(H,39,40)/t18-,19+,26+,31+/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151947
PNG
(US8987457, 141)
Show SMILES CC(C)Oc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCS(C)(=O)=O)[C@H](N)C1
Show InChI InChI=1/C30H35F3N4O5S/c1-16(2)42-19-13-22(32)27(23(33)14-19)28-21(31)5-6-25(36-28)30(38)37-26-15-35-8-7-20(26)18-11-17(3)29(24(34)12-18)41-9-10-43(4,39)40/h5-8,13-18,24,29H,9-12,34H2,1-4H3,(H,37,38)/t17-,18+,24+,29-/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151948
PNG
(US8987457, 142)
Show SMILES CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC(C)C)cc1F
Show InChI InChI=1/C28H31F3N4O3/c1-14(2)38-17-11-20(30)25(21(31)12-17)26-19(29)5-6-23(34-26)28(36)35-24-13-33-8-7-18(24)16-9-15(3)27(37-4)22(32)10-16/h5-8,11-16,22,27H,9-10,32H2,1-4H3,(H,35,36)/t15-,16+,22+,27+/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151950
PNG
(US8987457, 144)
Show SMILES COc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCS(C)(=O)=O)[C@H](N)C1
Show InChI InChI=1/C28H31F3N4O5S/c1-15-10-16(11-22(32)27(15)40-8-9-41(3,37)38)18-6-7-33-14-24(18)35-28(36)23-5-4-19(29)26(34-23)25-20(30)12-17(39-2)13-21(25)31/h4-7,12-16,22,27H,8-11,32H2,1-3H3,(H,35,36)/t15-,16+,22+,27-/s2
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US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151952
PNG
(US8987457, 146)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1/C27H30F3N5O4S/c1-14-10-15(11-21(32)26(14)39-8-9-40(2,37)38)16-6-7-33-13-22(16)34-27(36)25-20(31)12-19(30)24(35-25)23-17(28)4-3-5-18(23)29/h3-7,12-15,21,26H,8-11,31-32H2,1-2H3,(H,34,36)/t14-,15+,21+,26-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151954
PNG
(US8987457, 148)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC(C)C)cc1F
Show InChI InChI=1/C28H31F3N6O4/c1-14(2)41-16-9-18(30)24(19(31)10-16)26-17(29)5-6-21(34-26)27(38)35-22-11-33-8-7-23(22)37-12-15(3)25(20(32)13-37)36-28(39)40-4/h5-11,14-15,20,25H,12-13,32H2,1-4H3,(H,35,38)(H,36,39)/t15-,20+,25-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151965
PNG
(US8987457, 159)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F
Show InChI InChI=1/C30H33F3N6O5/c1-16-14-39(15-22(34)27(16)38-30(41)42-2)25-5-8-35-13-24(25)37-29(40)23-4-3-19(31)28(36-23)26-20(32)11-18(12-21(26)33)44-17-6-9-43-10-7-17/h3-5,8,11-13,16-17,22,27H,6-7,9-10,14-15,34H2,1-2H3,(H,37,40)(H,38,41)/t16-,22+,27-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151967
PNG
(US8987457, 161)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1/C26H25F3N8O/c1-14-9-17(28)23(18(29)10-14)24-16(27)3-4-20(33-24)26(38)34-21-11-31-6-5-22(21)36-12-15(2)25(19(30)13-36)37-8-7-32-35-37/h3-11,15,19,25H,12-13,30H2,1-2H3,(H,34,38)/t15-,19+,25-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151862
PNG
(US8987457, 56)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1cncn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C25H23F3N8O/c1-14-10-35(11-18(29)24(14)36-13-31-12-32-36)21-7-8-30-9-20(21)34-25(37)19-6-5-17(28)23(33-19)22-15(26)3-2-4-16(22)27/h2-9,12-14,18,24H,10-11,29H2,1H3,(H,34,37)/t14-,18+,24-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151972
PNG
(US8987457, 166)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1/C27H27F3N6O2/c1-14-10-15(11-21(33)26(14)38-9-3-7-31)16-6-8-34-13-22(16)35-27(37)25-20(32)12-19(30)24(36-25)23-17(28)4-2-5-18(23)29/h2,4-6,8,12-15,21,26H,3,9-11,32-33H2,1H3,(H,35,37)/t14-,15+,21+,26-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151977
PNG
(US8987457, 171)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F
Show InChI InChI=1/C31H32F3N7O3/c1-17-12-18(13-25(35)30(17)41-9-8-37-40-41)21-4-7-36-16-27(21)39-31(42)26-3-2-22(32)29(38-26)28-23(33)14-20(15-24(28)34)44-19-5-10-43-11-6-19/h2-4,7-9,14-19,25,30H,5-6,10-13,35H2,1H3,(H,39,42)/t17-,18+,25+,30-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151980
PNG
(US8987457, 174)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1/C25H26F3N7O3/c1-12-10-35(11-17(30)21(12)34-25(37)38-2)19-6-7-31-9-18(19)32-24(36)23-16(29)8-15(28)22(33-23)20-13(26)4-3-5-14(20)27/h3-9,12,17,21H,10-11,29-30H2,1-2H3,(H,32,36)(H,34,37)/t12-,17+,21-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151982
PNG
(US8987457, 176)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1/C26H25F3N8O/c1-13-9-14(10-20(31)25(13)37-8-7-33-36-37)15-5-6-32-12-21(15)34-26(38)24-19(30)11-18(29)23(35-24)22-16(27)3-2-4-17(22)28/h2-8,11-14,20,25H,9-10,30-31H2,1H3,(H,34,38)/t13-,14+,20+,25-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151990
PNG
(US8987457, 184)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1/C31H32F3N5O3/c1-17-12-18(13-24(36)29(17)42-11-3-9-35)20-6-10-37-16-26(20)39-30(40)25-5-4-21(32)28(38-25)27-22(33)14-19(15-23(27)34)31(41)7-2-8-31/h4-6,10,14-18,24,29,41H,2-3,7-8,11-13,36H2,1H3,(H,39,40)/t17-,18+,24+,29-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151864
PNG
(US8987457, 58)
Show SMILES COC(=O)N(C)[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1/C27H29F3N6O3/c1-14-9-17(29)23(18(30)10-14)24-16(28)5-6-20(33-24)26(37)34-21-11-32-8-7-22(21)36-12-15(2)25(19(31)13-36)35(3)27(38)39-4/h5-11,15,19,25H,12-13,31H2,1-4H3,(H,34,37)/t15-,19+,25-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151879
PNG
(US8987457, 73)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1/C28H31F3N4O4S/c1-15-10-20(30)25(21(31)11-15)26-19(29)4-5-23(34-26)28(36)35-24-14-33-7-6-18(24)17-12-16(2)27(22(32)13-17)39-8-9-40(3,37)38/h4-7,10-11,14,16-17,22,27H,8-9,12-13,32H2,1-3H3,(H,35,36)/t16-,17+,22+,27-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151901
PNG
(US8987457, 95)
Show SMILES CO[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)C
Show InChI InChI=1/C28H31F3N4O2/c1-14(2)16-10-20(30)25(21(31)11-16)26-19(29)5-6-23(34-26)28(36)35-24-13-33-8-7-18(24)17-9-15(3)27(37-4)22(32)12-17/h5-8,10-11,13-15,17,22,27H,9,12,32H2,1-4H3,(H,35,36)/t15-,17+,22+,27-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151907
PNG
(US8987457, 101)
Show SMILES CO[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC(C)C)cc1F
Show InChI InChI=1/C28H31F3N4O3/c1-14(2)38-17-11-20(30)25(21(31)12-17)26-19(29)5-6-23(34-26)28(36)35-24-13-33-8-7-18(24)16-9-15(3)27(37-4)22(32)10-16/h5-8,11-16,22,27H,9-10,32H2,1-4H3,(H,35,36)/t15-,16+,22+,27-/s2
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n/an/a 0.0200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM192642
PNG
(US9187486, 87)
Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15+/s2
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n/an/a 0.0210n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay


Bioorg Med Chem Lett 26: 5580-5590 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM192574
PNG
(US9187486, 37 | US9187486, 39 | US9187486, 60)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/s2
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n/an/a 0.0240n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay


Bioorg Med Chem Lett 26: 5580-5590 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM238624
PNG
(US9394297, 284)
Show SMILES CC(C)(C)Nc1nc2c(cccc2[nH]c1=O)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C19H21N5O2/c1-19(2,3)24-16-18(26)22-13-6-4-5-10(15(13)23-16)14-9-11-12(21-14)7-8-20-17(11)25/h4-6,9,21H,7-8H2,1-3H3,(H,20,25)(H,22,26)(H,23,24)
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n/an/a 0.0282n/an/an/an/a7.022



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM238825
PNG
(US9394297, 512)
Show SMILES CCn1c(NC(C)(C)C)nc2c(-c3cc4C(=O)N[C@H](C)c4[nH]3)c(F)ccc2c1=O
Show InChI InChI=1S/C21H24FN5O2/c1-6-27-19(29)11-7-8-13(22)15(17(11)25-20(27)26-21(3,4)5)14-9-12-16(24-14)10(2)23-18(12)28/h7-10,24H,6H2,1-5H3,(H,23,28)(H,25,26)/t10-/m1/s1
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n/an/a 0.0290n/an/an/an/a7.022



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM238714
PNG
(US9394297, 378)
Show SMILES Cc1nc2ccc(F)c(-c3cc4C(=O)NC5(CC5)c4[nH]3)c2nc1NC1(C)CC1
Show InChI InChI=1S/C21H20FN5O/c1-10-18(26-20(2)5-6-20)25-16-13(23-10)4-3-12(22)15(16)14-9-11-17(24-14)21(7-8-21)27-19(11)28/h3-4,9,24H,5-8H2,1-2H3,(H,25,26)(H,27,28)
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n/an/a 0.0295n/an/an/an/a7.022



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151878
PNG
(US8987457, 72)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1/C23H25F2N7O3S/c1-11-9-32(10-14(26)18(11)31-23(34)35-2)16-6-7-28-8-15(16)29-21(33)19-20(27)36-22(30-19)17-12(24)4-3-5-13(17)25/h3-8,11,14,18H,9-10,26-27H2,1-2H3,(H,29,33)(H,31,34)/t11-,14+,18-/s2
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n/an/a 0.0300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151811
PNG
(US8987457, 5)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C25H23F3N8O/c1-14-12-35(13-18(29)24(14)36-10-9-31-34-36)21-7-8-30-11-20(21)33-25(37)19-6-5-17(28)23(32-19)22-15(26)3-2-4-16(22)27/h2-11,14,18,24H,12-13,29H2,1H3,(H,33,37)/t14-,18+,24-/s2
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n/an/a 0.0300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151936
PNG
(US8987457, 130)
Show SMILES COCCOc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCS(C)(=O)=O)[C@H](N)C1
Show InChI InChI=1/C30H35F3N4O6S/c1-17-12-18(13-24(34)29(17)43-10-11-44(3,39)40)20-6-7-35-16-26(20)37-30(38)25-5-4-21(31)28(36-25)27-22(32)14-19(15-23(27)33)42-9-8-41-2/h4-7,14-18,24,29H,8-13,34H2,1-3H3,(H,37,38)/t17-,18+,24+,29-/s2
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n/an/a 0.0300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151929
PNG
(US8987457, 123)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1Oc1ccccn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C29H26F3N5O2/c1-16-13-17(14-22(33)28(16)39-25-7-2-3-11-35-25)18-10-12-34-15-24(18)37-29(38)23-9-8-21(32)27(36-23)26-19(30)5-4-6-20(26)31/h2-12,15-17,22,28H,13-14,33H2,1H3,(H,37,38)/t16-,17+,22+,28-/s2
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n/an/a 0.0300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151944
PNG
(US8987457, 138)
Show SMILES CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1/C29H31F3N4O3/c1-15-10-16(11-22(33)27(15)39-2)18-6-9-34-14-24(18)36-28(37)23-5-4-19(30)26(35-23)25-20(31)12-17(13-21(25)32)29(38)7-3-8-29/h4-6,9,12-16,22,27,38H,3,7-8,10-11,33H2,1-2H3,(H,36,37)/t15-,16+,22+,27+/s2
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n/an/a 0.0300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151953
PNG
(US8987457, 147)
Show SMILES CC(C)Oc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H]([C@H](N)C1)n1ccnn1
Show InChI InChI=1/C28H29F3N8O2/c1-15(2)41-17-10-19(30)25(20(31)11-17)26-18(29)4-5-22(35-26)28(40)36-23-12-33-7-6-24(23)38-13-16(3)27(21(32)14-38)39-9-8-34-37-39/h4-12,15-16,21,27H,13-14,32H2,1-3H3,(H,36,40)/t16-,21+,27-/s2
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n/an/a 0.0300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151985
PNG
(US8987457, 179)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1/C31H32F3N7O3/c1-17-12-18(13-24(35)29(17)41-9-8-37-40-41)20-4-7-36-16-26(20)39-30(42)25-3-2-21(32)28(38-25)27-22(33)14-19(15-23(27)34)31(43)5-10-44-11-6-31/h2-4,7-9,14-18,24,29,43H,5-6,10-13,35H2,1H3,(H,39,42)/t17-,18+,24+,29-/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151987
PNG
(US8987457, 181)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1/C27H26F3N7O/c1-14-9-19(29)24(20(30)10-14)25-18(28)3-4-22(34-25)27(38)35-23-13-32-6-5-17(23)16-11-15(2)26(21(31)12-16)37-8-7-33-36-37/h3-10,13,15-16,21,26H,11-12,31H2,1-2H3,(H,35,38)/t15-,16+,21+,26-/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151999
PNG
(US8987457, 193)
Show SMILES COc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H]([C@H](N)C1)n1ccnn1
Show InChI InChI=1/C26H25F3N8O2/c1-14-12-36(13-19(30)25(14)37-8-7-32-35-37)22-5-6-31-11-21(22)34-26(38)20-4-3-16(27)24(33-20)23-17(28)9-15(39-2)10-18(23)29/h3-11,14,19,25H,12-13,30H2,1-2H3,(H,34,38)/t14-,19+,25-/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151867
PNG
(US8987457, 61)
Show SMILES COC(=O)N(C)[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C26H27F3N6O3/c1-14-12-35(13-18(30)24(14)34(2)26(37)38-3)21-9-10-31-11-20(21)33-25(36)19-8-7-17(29)23(32-19)22-15(27)5-4-6-16(22)28/h4-11,14,18,24H,12-13,30H2,1-3H3,(H,33,36)/t14-,18+,24-/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151868
PNG
(US8987457, 62)
Show SMILES CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1/C26H27F3N4O2/c1-13-8-18(28)23(19(29)9-13)24-17(27)4-5-21(32-24)26(34)33-22-12-31-7-6-16(22)15-10-14(2)25(35-3)20(30)11-15/h4-9,12,14-15,20,25H,10-11,30H2,1-3H3,(H,33,34)/t14-,15+,20+,25+/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151872
PNG
(US8987457, 66)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1cc(CO)nn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C26H25F3N8O2/c1-14-10-36(12-19(30)25(14)37-11-15(13-38)34-35-37)22-7-8-31-9-21(22)33-26(39)20-6-5-18(29)24(32-20)23-16(27)3-2-4-17(23)28/h2-9,11,14,19,25,38H,10,12-13,30H2,1H3,(H,33,39)/t14-,19+,25-/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151855
PNG
(US8987457, 49)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1cncn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C26H24F3N7O/c1-14-9-15(10-20(30)25(14)36-13-32-12-33-36)16-7-8-31-11-22(16)35-26(37)21-6-5-19(29)24(34-21)23-17(27)3-2-4-18(23)28/h2-8,11-15,20,25H,9-10,30H2,1H3,(H,35,37)/t14-,15+,20+,25-/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM151886
PNG
(US8987457, 80)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1/C26H27F3N6O3/c1-13-8-16(28)22(17(29)9-13)24-15(27)4-5-19(32-24)25(36)33-20-10-31-7-6-21(20)35-11-14(2)23(18(30)12-35)34-26(37)38-3/h4-10,14,18,23H,11-12,30H2,1-3H3,(H,33,36)(H,34,37)/t14-,18+,23-/s2
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Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
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