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Compile Data Set for Download or QSAR

Found 80 hits of ec50 for UniProtKB: P42338   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420309
PNG
(CHEMBL2089120)
Show SMILES Cc1c(Cl)cccc1Cn1c(N)nc(=O)c2sc(nc12)N1CCOCC1
Show InChI InChI=1S/C17H18ClN5O2S/c1-10-11(3-2-4-12(10)18)9-23-14-13(15(24)21-16(23)19)26-17(20-14)22-5-7-25-8-6-22/h2-4H,5-9H2,1H3,(H2,19,21,24)
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n/an/an/an/a 3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylation


ACS Med Chem Lett 3: 524-529 (2012)


Article DOI: 10.1021/ml300045b
BindingDB Entry DOI: 10.7270/Q2J967PT
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501398
PNG
(CHEMBL4082978)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1
Show InChI InChI=1S/C17H14Cl2FN9O/c1-6(24-14-11(19)13(21)26-17(22)27-14)15-25-12-8(4-7(20)5-9(12)18)16(30)29(15)10-2-3-23-28-10/h2-6H,1H3,(H,23,28)(H5,21,22,24,26,27)/t6-/m0/s1
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n/an/an/an/a 3.40n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrs


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501408
PNG
(CHEMBL4081433)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(Cl)cc(F)cc3c(=O)n2-c2cc[nH]n2)n1
Show InChI InChI=1S/C20H16ClFN10O/c21-12-6-9(22)5-10-15(12)28-18(32(19(10)33)13-3-4-26-31-13)14(8-1-2-8)27-17-11(7-23)16(24)29-20(25)30-17/h3-6,8,14H,1-2H2,(H,26,31)(H5,24,25,27,29,30)/t14-/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501405
PNG
(CHEMBL4074361)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1-c1cc[nH]n1
Show InChI InChI=1S/C17H15Cl2N9O/c1-7(23-14-12(19)13(20)25-17(21)26-14)15-24-9-4-2-3-8(18)11(9)16(29)28(15)10-5-6-22-27-10/h2-7H,1H3,(H,22,27)(H5,20,21,23,25,26)/t7-/m0/s1
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n/an/an/an/a 4.20n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501398
PNG
(CHEMBL4082978)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1
Show InChI InChI=1S/C17H14Cl2FN9O/c1-6(24-14-11(19)13(21)26-17(22)27-14)15-25-12-8(4-7(20)5-9(12)18)16(30)29(15)10-2-3-23-28-10/h2-6H,1H3,(H,23,28)(H5,21,22,24,26,27)/t6-/m0/s1
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n/an/an/an/a 5.40n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrs


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501398
PNG
(CHEMBL4082978)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1
Show InChI InChI=1S/C17H14Cl2FN9O/c1-6(24-14-11(19)13(21)26-17(22)27-14)15-25-12-8(4-7(20)5-9(12)18)16(30)29(15)10-2-3-23-28-10/h2-6H,1H3,(H,23,28)(H5,21,22,24,26,27)/t6-/m0/s1
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n/an/an/an/a 5.70n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrs


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420311
PNG
(CHEMBL2089114)
Show SMILES Cc1c(Cl)cccc1Cn1c(CO)nc(=O)c2sc(nc12)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c1-11-12(3-2-4-13(11)19)9-23-14(10-24)20-17(25)15-16(23)21-18(27-15)22-5-7-26-8-6-22/h2-4,24H,5-10H2,1H3
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n/an/an/an/a 6n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylation


ACS Med Chem Lett 3: 524-529 (2012)


Article DOI: 10.1021/ml300045b
BindingDB Entry DOI: 10.7270/Q2J967PT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420310
PNG
(CHEMBL2089116)
Show SMILES COc1nc(=O)c2sc(nc2n1Cc1cccc(Cl)c1C)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c1-11-12(4-3-5-13(11)19)10-23-15-14(16(24)21-17(23)25-2)27-18(20-15)22-6-8-26-9-7-22/h3-5H,6-10H2,1-2H3
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n/an/an/an/a 6n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylation


ACS Med Chem Lett 3: 524-529 (2012)


Article DOI: 10.1021/ml300045b
BindingDB Entry DOI: 10.7270/Q2J967PT
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420315
PNG
(CHEMBL2089106)
Show SMILES Cc1nc(=O)c2sc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C19H19F3N4O2S/c1-11-13(4-3-5-14(11)19(20,21)22)10-26-12(2)23-17(27)15-16(26)24-18(29-15)25-6-8-28-9-7-25/h3-5H,6-10H2,1-2H3
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n/an/an/an/a 6.30n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501398
PNG
(CHEMBL4082978)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1
Show InChI InChI=1S/C17H14Cl2FN9O/c1-6(24-14-11(19)13(21)26-17(22)27-14)15-25-12-8(4-7(20)5-9(12)18)16(30)29(15)10-2-3-23-28-10/h2-6H,1H3,(H,23,28)(H5,21,22,24,26,27)/t6-/m0/s1
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n/an/an/an/a 7.30n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in PTEN-deficient human LNCaP cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrs


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501410
PNG
(CHEMBL4101102)
Show SMILES Nc1nc(N)c(Cl)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2-c2cc[nH]n2)n1
Show InChI InChI=1S/C19H17Cl2N9O/c20-9-2-1-3-10-12(9)18(31)30(11-6-7-24-29-11)17(25-10)14(8-4-5-8)26-16-13(21)15(22)27-19(23)28-16/h1-3,6-8,14H,4-5H2,(H,24,29)(H5,22,23,26,27,28)/t14-/m0/s1
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n/an/an/an/a 7.60n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420312
PNG
(CHEMBL2089109)
Show SMILES Cc1c(Cn2c(nc(=O)c3sc(nc23)N2CCOCC2)C2CC2)cccc1C(F)(F)F
Show InChI InChI=1S/C21H21F3N4O2S/c1-12-14(3-2-4-15(12)21(22,23)24)11-28-17(13-5-6-13)25-19(29)16-18(28)26-20(31-16)27-7-9-30-10-8-27/h2-4,13H,5-11H2,1H3
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n/an/an/an/a 9n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylation


ACS Med Chem Lett 3: 524-529 (2012)


Article DOI: 10.1021/ml300045b
BindingDB Entry DOI: 10.7270/Q2J967PT
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM92862
PNG
(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Show SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
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n/an/an/an/a 15n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assay


Eur J Med Chem 158: 707-719 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM92862
PNG
(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Show SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
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n/an/an/an/a 15n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-beta (unknown origin) after 40 mins by Kinase-Glo assay


Eur J Med Chem 157: 37-49 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501415
PNG
(CHEMBL4085918)
Show SMILES C[C@H](Nc1nc(N)nc(C(F)F)c1C#N)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1
Show InChI InChI=1S/C19H13ClF3N9O/c1-7(27-16-10(6-24)14(15(22)23)29-19(25)30-16)17-28-13-9(4-8(21)5-11(13)20)18(33)32(17)12-2-3-26-31-12/h2-5,7,15H,1H3,(H,26,31)(H3,25,27,29,30)/t7-/m0/s1
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n/an/an/an/a 15n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420313
PNG
(CHEMBL2089108)
Show SMILES CCc1nc(=O)c2sc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C20H21F3N4O2S/c1-3-15-24-18(28)16-17(25-19(30-16)26-7-9-29-10-8-26)27(15)11-13-5-4-6-14(12(13)2)20(21,22)23/h4-6H,3,7-11H2,1-2H3
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n/an/an/an/a 16n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylation


ACS Med Chem Lett 3: 524-529 (2012)


Article DOI: 10.1021/ml300045b
BindingDB Entry DOI: 10.7270/Q2J967PT
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420315
PNG
(CHEMBL2089106)
Show SMILES Cc1nc(=O)c2sc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C19H19F3N4O2S/c1-11-13(4-3-5-14(11)19(20,21)22)10-26-12(2)23-17(27)15-16(26)24-18(29-15)25-6-8-28-9-7-25/h3-5H,6-10H2,1-2H3
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n/an/an/an/a 16n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420314
PNG
(CHEMBL2089107)
Show SMILES Cc1nc(=O)c2sc(nc2n1Cc1cccc(Cl)c1C)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O2S/c1-11-13(4-3-5-14(11)19)10-23-12(2)20-17(24)15-16(23)21-18(26-15)22-6-8-25-9-7-22/h3-5H,6-10H2,1-2H3
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n/an/an/an/a 19n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylation


ACS Med Chem Lett 3: 524-529 (2012)


Article DOI: 10.1021/ml300045b
BindingDB Entry DOI: 10.7270/Q2J967PT
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501398
PNG
(CHEMBL4082978)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1
Show InChI InChI=1S/C17H14Cl2FN9O/c1-6(24-14-11(19)13(21)26-17(22)27-14)15-25-12-8(4-7(20)5-9(12)18)16(30)29(15)10-2-3-23-28-10/h2-6H,1H3,(H,23,28)(H5,21,22,24,26,27)/t6-/m0/s1
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n/an/an/an/a 20n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50420315
PNG
(CHEMBL2089106)
Show SMILES Cc1nc(=O)c2sc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C19H19F3N4O2S/c1-11-13(4-3-5-14(11)19(20,21)22)10-26-12(2)23-17(27)15-16(26)24-18(29-15)25-6-8-28-9-7-25/h3-5H,6-10H2,1-2H3
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n/an/an/an/a 24n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylation


ACS Med Chem Lett 3: 524-529 (2012)


Article DOI: 10.1021/ml300045b
BindingDB Entry DOI: 10.7270/Q2J967PT
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489455
PNG
(CHEMBL2322337)
Show SMILES Cc1c(Cc2cnn3c(O)cc(nc23)-c2ccncc2)cccc1C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O/c1-12-14(3-2-4-16(12)20(21,22)23)9-15-11-25-27-18(28)10-17(26-19(15)27)13-5-7-24-8-6-13/h2-8,10-11,28H,9H2,1H3
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n/an/an/an/a 25n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489445
PNG
(CHEMBL2322331)
Show SMILES Cc1nn2c(O)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C20H21F3N4O2/c1-12-14(4-3-5-16(12)20(21,22)23)10-15-13(2)25-27-18(28)11-17(24-19(15)27)26-6-8-29-9-7-26/h3-5,11,28H,6-10H2,1-2H3
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n/an/an/an/a 32n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501416
PNG
(CHEMBL4102306)
Show SMILES Nc1nc(N[C@@H](C2CC2)c2nc3c(Cl)cc(F)cc3c(=O)n2-c2cc[nH]n2)c(C#N)c(n1)C(F)F
Show InChI InChI=1S/C21H15ClF3N9O/c22-12-6-9(23)5-10-15(12)30-19(34(20(10)35)13-3-4-28-33-13)14(8-1-2-8)29-18-11(7-26)16(17(24)25)31-21(27)32-18/h3-6,8,14,17H,1-2H2,(H,28,33)(H3,27,29,31,32)/t14-/m0/s1
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n/an/an/an/a 42n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50315213
PNG
(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)
Show SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
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n/an/an/an/a 44n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assay


Eur J Med Chem 158: 707-719 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50315213
PNG
(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)
Show SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
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n/an/an/an/a 44n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-beta (unknown origin) after 40 mins by Kinase-Glo assay


Eur J Med Chem 157: 37-49 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50501413
PNG
(CHEMBL4079545)
Show SMILES Nc1nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2-c2cc[nH]n2)c(C#N)c(n1)C(F)F
Show InChI InChI=1S/C21H16ClF2N9O/c22-11-2-1-3-12-14(11)20(34)33(13-6-7-27-32-13)19(28-12)15(9-4-5-9)29-18-10(8-25)16(17(23)24)30-21(26)31-18/h1-3,6-7,9,15,17H,4-5H2,(H,27,32)(H3,26,29,30,31)/t15-/m0/s1
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n/an/an/an/a 45n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assay


J Med Chem 60: 1555-1567 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489446
PNG
(CHEMBL2322336)
Show SMILES Cc1c(Cc2cnn3c(O)cc(nc23)N2CCOCC2)cccc1C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O2/c1-12-13(3-2-4-15(12)19(20,21)22)9-14-11-23-26-17(27)10-16(24-18(14)26)25-5-7-28-8-6-25/h2-4,10-11,27H,5-9H2,1H3
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n/an/an/an/a 63n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489452
PNG
(CHEMBL2322344)
Show SMILES COc1nn2c(O)cc(nc2c1Cc1cccc(Cl)c1Cl)-c1ccncc1
Show InChI InChI=1S/C19H14Cl2N4O2/c1-27-19-13(9-12-3-2-4-14(20)17(12)21)18-23-15(10-16(26)25(18)24-19)11-5-7-22-8-6-11/h2-8,10,26H,9H2,1H3
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n/an/an/an/a 158n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489441
PNG
(CHEMBL2322352)
Show SMILES Cc1nn2c(N)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C20H22F3N5O/c1-12-14(4-3-5-16(12)20(21,22)23)10-15-13(2)26-28-17(24)11-18(25-19(15)28)27-6-8-29-9-7-27/h3-5,11H,6-10,24H2,1-2H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489440
PNG
(CHEMBL2322349)
Show SMILES Cc1nn2c(cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C21H21F3N4O3/c1-12-14(4-3-5-16(12)21(22,23)24)10-15-13(2)26-28-17(20(29)30)11-18(25-19(15)28)27-6-8-31-9-7-27/h3-5,11H,6-10H2,1-2H3,(H,29,30)
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489460
PNG
(CHEMBL2322332)
Show SMILES Cc1nn2c(O)cc(nc2c1Cc1cccc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C22H22N4O2/c1-15-19(13-17-7-4-6-16-5-2-3-8-18(16)17)22-23-20(14-21(27)26(22)24-15)25-9-11-28-12-10-25/h2-8,14,27H,9-13H2,1H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489446
PNG
(CHEMBL2322336)
Show SMILES Cc1c(Cc2cnn3c(O)cc(nc23)N2CCOCC2)cccc1C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O2/c1-12-13(3-2-4-15(12)19(20,21)22)9-14-11-23-26-17(27)10-16(24-18(14)26)25-5-7-28-8-6-25/h2-4,10-11,27H,5-9H2,1H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489437
PNG
(CHEMBL2322356)
Show SMILES Cc1nn2c(NC(N)=O)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C21H23F3N6O2/c1-12-14(4-3-5-16(12)21(22,23)24)10-15-13(2)28-30-18(27-20(25)31)11-17(26-19(15)30)29-6-8-32-9-7-29/h3-5,11H,6-10H2,1-2H3,(H3,25,27,31)
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n/an/an/an/a 1.26E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489445
PNG
(CHEMBL2322331)
Show SMILES Cc1nn2c(O)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C20H21F3N4O2/c1-12-14(4-3-5-16(12)20(21,22)23)10-15-13(2)25-27-18(28)11-17(24-19(15)27)26-6-8-29-9-7-26/h3-5,11,28H,6-10H2,1-2H3
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n/an/an/an/a 1.59E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489438
PNG
(CHEMBL2322345)
Show SMILES Nc1nn2c(O)cc(nc2c1Cc1cccc(Cl)c1Cl)C1CCOCC1
Show InChI InChI=1S/C18H18Cl2N4O2/c19-13-3-1-2-11(16(13)20)8-12-17(21)23-24-15(25)9-14(22-18(12)24)10-4-6-26-7-5-10/h1-3,9-10,25H,4-8H2,(H2,21,23)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489436
PNG
(CHEMBL2322350)
Show SMILES Cc1nn2c(cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C21H22F3N5O2/c1-12-14(4-3-5-16(12)21(22,23)24)10-15-13(2)27-29-17(19(25)30)11-18(26-20(15)29)28-6-8-31-9-7-28/h3-5,11H,6-10H2,1-2H3,(H2,25,30)
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489440
PNG
(CHEMBL2322349)
Show SMILES Cc1nn2c(cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1)C(O)=O
Show InChI InChI=1S/C21H21F3N4O3/c1-12-14(4-3-5-16(12)21(22,23)24)10-15-13(2)26-28-17(20(29)30)11-18(25-19(15)28)27-6-8-31-9-7-27/h3-5,11H,6-10H2,1-2H3,(H,29,30)
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n/an/an/an/a 3.16E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489455
PNG
(CHEMBL2322337)
Show SMILES Cc1c(Cc2cnn3c(O)cc(nc23)-c2ccncc2)cccc1C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O/c1-12-14(3-2-4-16(12)20(21,22)23)9-15-11-25-27-18(28)10-17(26-19(15)27)13-5-7-24-8-6-13/h2-8,10-11,28H,9H2,1H3
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n/an/an/an/a 3.16E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489446
PNG
(CHEMBL2322336)
Show SMILES Cc1c(Cc2cnn3c(O)cc(nc23)N2CCOCC2)cccc1C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O2/c1-12-13(3-2-4-15(12)19(20,21)22)9-14-11-23-26-17(27)10-16(24-18(14)26)25-5-7-28-8-6-25/h2-4,10-11,27H,5-9H2,1H3
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n/an/an/an/a 3.16E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50468940
PNG
(CHEMBL4291904)
Show SMILES Fc1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H12BrFN2O2/c23-15-12-18-17(11-14(15)13-5-1-2-6-16(13)24)25-21(19-7-3-9-27-19)22(26-18)20-8-4-10-28-20/h1-12H
PDB
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n/an/an/an/a 3.34E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-beta (unknown origin) after 40 mins by Kinase-Glo assay


Eur J Med Chem 157: 37-49 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489460
PNG
(CHEMBL2322332)
Show SMILES Cc1nn2c(O)cc(nc2c1Cc1cccc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C22H22N4O2/c1-15-19(13-17-7-4-6-16-5-2-3-8-18(16)17)22-23-20(14-21(27)26(22)24-15)25-9-11-28-12-10-25/h2-8,14,27H,9-13H2,1H3
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n/an/an/an/a 3.98E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489439
PNG
(CHEMBL2322340)
Show SMILES Oc1cc(nc2c(Cc3cccc(Cl)c3Cl)c(nn12)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C18H15Cl2F3N4O2/c19-12-3-1-2-10(15(12)20)8-11-16(18(21,22)23)25-27-14(28)9-13(24-17(11)27)26-4-6-29-7-5-26/h1-3,9,28H,4-8H2
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n/an/an/an/a 5.01E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489445
PNG
(CHEMBL2322331)
Show SMILES Cc1nn2c(O)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C20H21F3N4O2/c1-12-14(4-3-5-16(12)20(21,22)23)10-15-13(2)25-27-18(28)11-17(24-19(15)27)26-6-8-29-9-7-26/h3-5,11,28H,6-10H2,1-2H3
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n/an/an/an/a 5.01E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50467448
PNG
(CHEMBL4280001)
Show SMILES Oc1ccc(-c2n[nH]cc2-c2ccc(Cl)c(Cl)c2)c(O)c1O
Show InChI InChI=1S/C15H10Cl2N2O3/c16-10-3-1-7(5-11(10)17)9-6-18-19-13(9)8-2-4-12(20)15(22)14(8)21/h1-6,20-22H,(H,18,19)
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n/an/an/an/a 5.70E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assay


Eur J Med Chem 158: 707-719 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489449
PNG
(CHEMBL2322333)
Show SMILES Cc1nn2c(O)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)C1CCOCC1
Show InChI InChI=1S/C21H22F3N3O2/c1-12-15(4-3-5-17(12)21(22,23)24)10-16-13(2)26-27-19(28)11-18(25-20(16)27)14-6-8-29-9-7-14/h3-5,11,14,28H,6-10H2,1-2H3
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489438
PNG
(CHEMBL2322345)
Show SMILES Nc1nn2c(O)cc(nc2c1Cc1cccc(Cl)c1Cl)C1CCOCC1
Show InChI InChI=1S/C18H18Cl2N4O2/c19-13-3-1-2-11(16(13)20)8-12-17(21)23-24-15(25)9-14(22-18(12)24)10-4-6-26-7-5-10/h1-3,9-10,25H,4-8H2,(H2,21,23)
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489452
PNG
(CHEMBL2322344)
Show SMILES COc1nn2c(O)cc(nc2c1Cc1cccc(Cl)c1Cl)-c1ccncc1
Show InChI InChI=1S/C19H14Cl2N4O2/c1-27-19-13(9-12-3-2-4-14(20)17(12)21)18-23-15(10-16(26)25(18)24-19)11-5-7-22-8-6-11/h2-8,10,26H,9H2,1H3
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n/an/an/an/a 1.26E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serum


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489441
PNG
(CHEMBL2322352)
Show SMILES Cc1nn2c(N)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C20H22F3N5O/c1-12-14(4-3-5-16(12)20(21,22)23)10-15-13(2)26-28-17(24)11-18(25-19(15)28)27-6-8-29-9-7-27/h3-5,11H,6-10,24H2,1-2H3
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n/an/an/an/a 1.26E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489437
PNG
(CHEMBL2322356)
Show SMILES Cc1nn2c(NC(N)=O)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C21H23F3N6O2/c1-12-14(4-3-5-16(12)21(22,23)24)10-15-13(2)28-30-18(27-20(25)31)11-17(26-19(15)30)29-6-8-32-9-7-29/h3-5,11H,6-10H2,1-2H3,(H3,25,27,31)
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n/an/an/an/a 1.26E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50489441
PNG
(CHEMBL2322352)
Show SMILES Cc1nn2c(N)cc(nc2c1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C20H22F3N5O/c1-12-14(4-3-5-16(12)20(21,22)23)10-15-13(2)26-28-17(24)11-18(25-19(15)28)27-6-8-29-9-7-27/h3-5,11H,6-10,24H2,1-2H3
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n/an/an/an/a 1.26E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta human in PTEN wild type HCC1954 cells assessed as cell growth inhibition


ACS Med Chem Lett 4: 230-4 (2013)

More data for this
Ligand-Target Pair
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