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Compile Data Set for Download or QSAR

Found 6 hits of ec50 for UniProtKB: A0A024R720   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50315213
PNG
(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)
Show SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
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n/an/an/an/a 51n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma (unknown origin) after 40 mins by Kinase-Glo assay


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50315213
PNG
(2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...)
Show SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2
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n/an/an/an/a 51n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assay


Eur J Med Chem 158: 707-719 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.002
BindingDB Entry DOI: 10.7270/Q2PK0JVH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM92862
PNG
(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Show SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
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n/an/an/an/a 67n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assay


Eur J Med Chem 158: 707-719 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.002
BindingDB Entry DOI: 10.7270/Q2PK0JVH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM92862
PNG
(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)
Show SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
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n/an/an/an/a 67n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma (unknown origin) after 40 mins by Kinase-Glo assay


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50468940
PNG
(CHEMBL4291904)
Show SMILES Fc1ccccc1-c1cc2nc(-c3ccco3)c(nc2cc1Br)-c1ccco1
Show InChI InChI=1S/C22H12BrFN2O2/c23-15-12-18-17(11-14(15)13-5-1-2-6-16(13)24)25-21(19-7-3-9-27-19)22(26-18)20-8-4-10-28-20/h1-12H
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n/an/an/an/a 9.89E+3n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma (unknown origin) after 40 mins by Kinase-Glo assay


Eur J Med Chem 157: 37-49 (2018)


Article DOI: 10.1016/j.ejmech.2018.07.061
BindingDB Entry DOI: 10.7270/Q2ZC85KT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50467448
PNG
(CHEMBL4280001)
Show SMILES Oc1ccc(-c2n[nH]cc2-c2ccc(Cl)c(Cl)c2)c(O)c1O
Show InChI InChI=1S/C15H10Cl2N2O3/c16-10-3-1-7(5-11(10)17)9-6-18-19-13(9)8-2-4-12(20)15(22)14(8)21/h1-6,20-22H,(H,18,19)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Chongqing University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assay


Eur J Med Chem 158: 707-719 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.002
BindingDB Entry DOI: 10.7270/Q2PK0JVH
More data for this
Ligand-Target Pair