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Compile Data Set for Download or QSAR

Found 40 hits of ic50 for UniProtKB: P00730   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50365328
PNG
(CHEMBL1955927)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@H](Cc2ccccc2)NC1=O)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1/C31H41N5O6/c1-3-20(2)26-29(39)33-24(18-21-12-6-4-7-13-21)27(37)32-17-11-10-16-23(28(38)36-26)34-31(42)35-25(30(40)41)19-22-14-8-5-9-15-22/h4-9,12-15,20,23-26H,3,10-11,16-19H2,1-2H3,(H,32,37)(H,33,39)(H,36,38)(H,40,41)(H2,34,35,42)/t20-,23+,24-,25-,26-/s2
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n/an/a 250n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas carboxypeptidase A using N-(4-methoxyphenylazoformyl)-phenylalanine as substrate after 5 mins by colorimetry


J Med Chem 55: 735-42 (2012)


Article DOI: 10.1021/jm201238p
BindingDB Entry DOI: 10.7270/Q24F1R7Z
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283501
PNG
(CHEMBL4167456)
Show SMILES CC(C)C[C@@H]([C@@H]1CS1)C(O)=O
Show InChI InChI=1S/C8H14O2S/c1-5(2)3-6(8(9)10)7-4-11-7/h5-7H,3-4H2,1-2H3,(H,9,10)/t6-,7-/m0/s1
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n/an/a 260n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283541
PNG
(CHEMBL4176703)
Show SMILES OC(=O)[C@@H](Cc1ccc(F)cc1)[C@H]1CS1
Show InChI InChI=1S/C11H11FO2S/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10+/m0/s1
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n/an/a 470n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283502
PNG
(CHEMBL4168849)
Show SMILES OC(=O)[C@@H](Cc1ccc(F)cc1)[C@@H]1CO1
Show InChI InChI=1S/C11H11FO3/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10-/m0/s1
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n/an/a 510n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283507
PNG
(CHEMBL4163047)
Show SMILES CC(C)C[C@@H]([C@H]1CO1)C(O)=O
Show InChI InChI=1S/C8H14O3/c1-5(2)3-6(8(9)10)7-4-11-7/h5-7H,3-4H2,1-2H3,(H,9,10)/t6-,7+/m0/s1
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n/an/a 570n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283495
PNG
(CHEMBL4172319)
Show SMILES CCC[C@@H]([C@@H]1CS1)C(O)=O
Show InChI InChI=1S/C7H12O2S/c1-2-3-5(7(8)9)6-4-10-6/h5-6H,2-4H2,1H3,(H,8,9)/t5-,6-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50277985
PNG
(CHEMBL4166112)
Show SMILES CC[C@@H](C)[C@H](NC(=O)N[C@@H]1CCCCNC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC1=O)[C@H](C)CC)C(O)=O
Show InChI InChI=1S/C29H45N5O7/c1-5-17(3)23-27(38)31-22(15-12-19-10-13-20(35)14-11-19)25(36)30-16-8-7-9-21(26(37)33-23)32-29(41)34-24(28(39)40)18(4)6-2/h10-11,13-14,17-18,21-24,35H,5-9,12,15-16H2,1-4H3,(H,30,36)(H,31,38)(H,33,37)(H,39,40)(H2,32,34,41)/t17-,18-,21-,22+,23+,24+/m1/s1
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n/an/a 750n/an/an/an/an/an/a



University of S£o Paulo

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas carboxypeptidase A using N-4-(methoxyphenylazoformyl)-Phe-OH as substrate measured after 5 mins by colorimetric method


J Nat Prod 80: 2492-2501 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283499
PNG
(CHEMBL4173339)
Show SMILES OC(=O)[C@@H](Cc1ccc(I)cc1)[C@H]1CS1
Show InChI InChI=1S/C11H11IO2S/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10+/m0/s1
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n/an/a 960n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283496
PNG
(CHEMBL4169911)
Show SMILES OC(=O)[C@@H](CC1CCC1)[C@H]1CS1
Show InChI InChI=1S/C9H14O2S/c10-9(11)7(8-5-12-8)4-6-2-1-3-6/h6-8H,1-5H2,(H,10,11)/t7-,8+/m0/s1
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n/an/a 970n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283497
PNG
(CHEMBL4165424)
Show SMILES OC(=O)[C@@H](Cc1ccc(I)cc1)[C@@H]1CO1
Show InChI InChI=1S/C11H11IO3/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10-/m0/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283505
PNG
(CHEMBL4159372)
Show SMILES CCC[C@@H]([C@@H]1CO1)C(O)=O
Show InChI InChI=1S/C7H12O3/c1-2-3-5(7(8)9)6-4-10-6/h5-6H,2-4H2,1H3,(H,8,9)/t5-,6-/m0/s1
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n/an/a 1.13E+3n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283508
PNG
(CHEMBL4161983)
Show SMILES OC(=O)[C@@H](CC1CCC1)[C@@H]1CO1
Show InChI InChI=1S/C9H14O3/c10-9(11)7(8-5-12-8)4-6-2-1-3-6/h6-8H,1-5H2,(H,10,11)/t7-,8-/m0/s1
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n/an/a 1.13E+3n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283500
PNG
(CHEMBL4166484)
Show SMILES OC(=O)[C@@H](CC1CC1)[C@H]1CS1
Show InChI InChI=1S/C8H12O2S/c9-8(10)6(7-4-11-7)3-5-1-2-5/h5-7H,1-4H2,(H,9,10)/t6-,7+/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50277995
PNG
(CHEMBL4159803)
Show SMILES CC[C@@H](C)[C@H](NC(=O)N[C@@H]1CCCCNC(=O)[C@H](CCc2ccc(O)cc2)NC(=O)[C@@H](NC1=O)C(C)C)C(O)=O
Show InChI InChI=1S/C28H43N5O7/c1-5-17(4)23(27(38)39)33-28(40)31-20-8-6-7-15-29-24(35)21(14-11-18-9-12-19(34)13-10-18)30-26(37)22(16(2)3)32-25(20)36/h9-10,12-13,16-17,20-23,34H,5-8,11,14-15H2,1-4H3,(H,29,35)(H,30,37)(H,32,36)(H,38,39)(H2,31,33,40)/t17-,20-,21+,22+,23+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of S£o Paulo

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas carboxypeptidase A using N-4-(methoxyphenylazoformyl)-Phe-OH as substrate measured after 5 mins by colorimetric method


J Nat Prod 80: 2492-2501 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21478
PNG
((2S)-2-{[(1S)-2-(1-benzyl-1H-imidazol-5-yl)-1-carb...)
Show SMILES CC[C@H](N[C@@H](Cc1cncn1Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1/C17H21N3O4/c1-2-14(16(21)22)19-15(17(23)24)8-13-9-18-11-20(13)10-12-6-4-3-5-7-12/h3-7,9,11,14-15,19H,2,8,10H2,1H3,(H,21,22)(H,23,24)/t14-,15-/s2
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n/an/a 2.80E+3n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50365329
PNG
(CHEMBL1955931)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](CCCCN)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C31H44N6O6/c1-3-20(2)26(29(40)34-24(27(33)38)18-21-12-6-4-7-13-21)37-28(39)23(16-10-11-17-32)35-31(43)36-25(30(41)42)19-22-14-8-5-9-15-22/h4-9,12-15,20,23-26H,3,10-11,16-19,32H2,1-2H3,(H2,33,38)(H,34,40)(H,37,39)(H,41,42)(H2,35,36,43)/t20-,23+,24-,25-,26-/s2
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n/an/a 4.50E+3n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Inhibition of bovine pancreas carboxypeptidase A using N-(4-methoxyphenylazoformyl)-phenylalanine as substrate after 5 mins by colorimetry


J Med Chem 55: 735-42 (2012)


Article DOI: 10.1021/jm201238p
BindingDB Entry DOI: 10.7270/Q24F1R7Z
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283494
PNG
(CHEMBL4175727)
Show SMILES OC(=O)[C@@H](CCc1ccccc1)[C@@H]1CO1
Show InChI InChI=1S/C12H14O3/c13-12(14)10(11-8-15-11)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8H2,(H,13,14)/t10-,11-/m0/s1
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n/an/a 8.25E+3n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21488
PNG
((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dimethylphenyl)...)
Show SMILES CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(C)cc(C)c1)C(O)=O)C(O)=O
Show InChI InChI=1/C21H29N3O4/c1-13(2)5-18(20(25)26)23-19(21(27)28)9-17-10-22-12-24(17)11-16-7-14(3)6-15(4)8-16/h6-8,10,12-13,18-19,23H,5,9,11H2,1-4H3,(H,25,26)(H,27,28)/t18-,19-/s2
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n/an/a>1.00E+4n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21487
PNG
((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,4-dimethylphenyl)...)
Show SMILES CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1ccc(C)c(C)c1)C(O)=O)C(O)=O
Show InChI InChI=1/C21H29N3O4/c1-13(2)7-18(20(25)26)23-19(21(27)28)9-17-10-22-12-24(17)11-16-6-5-14(3)15(4)8-16/h5-6,8,10,12-13,18-19,23H,7,9,11H2,1-4H3,(H,25,26)(H,27,28)/t18-,19-/s2
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n/an/a>1.00E+4n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21486
PNG
((2S)-2-{[(1S)-1-carboxy-2-{1-[(3-methylphenyl)meth...)
Show SMILES CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cccc(C)c1)C(O)=O)C(O)=O
Show InChI InChI=1/C20H27N3O4/c1-13(2)7-17(19(24)25)22-18(20(26)27)9-16-10-21-12-23(16)11-15-6-4-5-14(3)8-15/h4-6,8,10,12-13,17-18,22H,7,9,11H2,1-3H3,(H,24,25)(H,26,27)/t17-,18-/s2
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n/an/a>1.00E+4n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21484
PNG
((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-methylphenyl)meth...)
Show SMILES CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1ccc(C)cc1)C(O)=O)C(O)=O
Show InChI InChI=1/C20H27N3O4/c1-13(2)8-17(19(24)25)22-18(20(26)27)9-16-10-21-12-23(16)11-15-6-4-14(3)5-7-15/h4-7,10,12-13,17-18,22H,8-9,11H2,1-3H3,(H,24,25)(H,26,27)/t17-,18-/s2
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n/an/a>1.00E+4n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21482
PNG
((2S)-2-{[(1S)-1-carboxy-2-{1-[(4-chlorophenyl)meth...)
Show SMILES CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1/C19H24ClN3O4/c1-12(2)7-16(18(24)25)22-17(19(26)27)8-15-9-21-11-23(15)10-13-3-5-14(20)6-4-13/h3-6,9,11-12,16-17,22H,7-8,10H2,1-2H3,(H,24,25)(H,26,27)/t16-,17-/s2
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n/an/a>1.00E+4n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283506
PNG
(CHEMBL4177108)
Show SMILES OC(=O)[C@@H](CC1CC1)[C@@H]1CO1
Show InChI InChI=1S/C8H12O3/c9-8(10)6(7-4-11-7)3-5-1-2-5/h5-7H,1-4H2,(H,9,10)/t6-,7-/m0/s1
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n/an/a 1.12E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21491
PNG
((2S)-2-{[(1S)-1-carboxy-2-[1-(2-cyclohexylpropan-2...)
Show SMILES CC(C)C[C@H](N[C@@H](Cc1cncn1C(C)(C)C1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C21H35N3O4/c1-14(2)10-17(19(25)26)23-18(20(27)28)11-16-12-22-13-24(16)21(3,4)15-8-6-5-7-9-15/h12-15,17-18,23H,5-11H2,1-4H3,(H,25,26)(H,27,28)/t17-,18-/s2
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n/an/a 1.20E+4n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283501
PNG
(CHEMBL4167456)
Show SMILES CC(C)C[C@@H]([C@@H]1CS1)C(O)=O
Show InChI InChI=1S/C8H14O2S/c1-5(2)3-6(8(9)10)7-4-11-7/h5-7H,3-4H2,1-2H3,(H,9,10)/t6-,7-/m0/s1
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n/an/a 1.41E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283538
PNG
(CHEMBL4165531)
Show SMILES OC(=O)[C@@H](CCc1ccccc1)[C@@H]1CS1
Show InChI InChI=1S/C12H14O2S/c13-12(14)10(11-8-15-11)7-6-9-4-2-1-3-5-9/h1-5,10-11H,6-8H2,(H,13,14)/t10-,11-/m0/s1
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n/an/a 1.64E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283541
PNG
(CHEMBL4176703)
Show SMILES OC(=O)[C@@H](Cc1ccc(F)cc1)[C@H]1CS1
Show InChI InChI=1S/C11H11FO2S/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10+/m0/s1
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n/an/a 1.87E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283502
PNG
(CHEMBL4168849)
Show SMILES OC(=O)[C@@H](Cc1ccc(F)cc1)[C@@H]1CO1
Show InChI InChI=1S/C11H11FO3/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10-/m0/s1
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n/an/a 2.19E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM21489
PNG
((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichlorophenyl)...)
Show SMILES CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1/C19H23Cl2N3O4/c1-11(2)3-16(18(25)26)23-17(19(27)28)7-15-8-22-10-24(15)9-12-4-13(20)6-14(21)5-12/h4-6,8,10-11,16-17,23H,3,7,9H2,1-2H3,(H,25,26)(H,27,28)/t16-,17-/s2
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n/an/a 2.70E+4n/an/an/an/a7.522



Millennium Pharmaceuticals



Assay Description
Assay for the inhibition of carboxypeptidase A (CPDA) was conducted in 96-well microplates format. Activity was monitored by measuring decrease in ab...


J Am Chem Soc 124: 11852-3 (2002)


Article DOI: 10.1021/ja0277226
BindingDB Entry DOI: 10.7270/Q2KP80FN
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50289561
PNG
(4-tert-Butyl-benzoic acid [1-(2-hydroxy-naphthalen...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)N\N=C\c1c(O)ccc2ccccc12
Show InChI InChI=1S/C22H22N2O2/c1-22(2,3)17-11-8-16(9-12-17)21(26)24-23-14-19-18-7-5-4-6-15(18)10-13-20(19)25/h4-14,25H,1-3H3,(H,24,26)/b23-14+
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n/an/a 2.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required to inhibit carboxypeptidase A (CPA, bovine, Type I) was evaluated


Bioorg Med Chem Lett 7: 1557-1562 (1997)


Article DOI: 10.1016/S0960-894X(97)00267-9
BindingDB Entry DOI: 10.7270/Q2CN73W4
More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283495
PNG
(CHEMBL4172319)
Show SMILES CCC[C@@H]([C@@H]1CS1)C(O)=O
Show InChI InChI=1S/C7H12O2S/c1-2-3-5(7(8)9)6-4-10-6/h5-6H,2-4H2,1H3,(H,8,9)/t5-,6-/m0/s1
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n/an/a 3.19E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283504
PNG
(CHEMBL4159548)
Show SMILES CC(C)C[C@@H]([C@H]1CS1)C(O)=O
Show InChI InChI=1S/C8H14O2S/c1-5(2)3-6(8(9)10)7-4-11-7/h5-7H,3-4H2,1-2H3,(H,9,10)/t6-,7+/m0/s1
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n/an/a 3.19E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283503
PNG
(CHEMBL4173750)
Show SMILES CC(C)C[C@@H]([C@@H]1CO1)C(O)=O
Show InChI InChI=1S/C8H14O3/c1-5(2)3-6(8(9)10)7-4-11-7/h5-7H,3-4H2,1-2H3,(H,9,10)/t6-,7-/m0/s1
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n/an/a 3.31E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283499
PNG
(CHEMBL4173339)
Show SMILES OC(=O)[C@@H](Cc1ccc(I)cc1)[C@H]1CS1
Show InChI InChI=1S/C11H11IO2S/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10+/m0/s1
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n/an/a 4.63E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283497
PNG
(CHEMBL4165424)
Show SMILES OC(=O)[C@@H](Cc1ccc(I)cc1)[C@@H]1CO1
Show InChI InChI=1S/C11H11IO3/c12-8-3-1-7(2-4-8)5-9(11(13)14)10-6-15-10/h1-4,9-10H,5-6H2,(H,13,14)/t9-,10-/m0/s1
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n/an/a 4.83E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283508
PNG
(CHEMBL4161983)
Show SMILES OC(=O)[C@@H](CC1CCC1)[C@@H]1CO1
Show InChI InChI=1S/C9H14O3/c10-9(11)7(8-5-12-8)4-6-2-1-3-6/h6-8H,1-5H2,(H,10,11)/t7-,8-/m0/s1
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n/an/a 5.79E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283496
PNG
(CHEMBL4169911)
Show SMILES OC(=O)[C@@H](CC1CCC1)[C@H]1CS1
Show InChI InChI=1S/C9H14O2S/c10-9(11)7(8-5-12-8)4-6-2-1-3-6/h6-8H,1-5H2,(H,10,11)/t7-,8+/m0/s1
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n/an/a 6.00E+4n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283505
PNG
(CHEMBL4159372)
Show SMILES CCC[C@@H]([C@@H]1CO1)C(O)=O
Show InChI InChI=1S/C7H12O3/c1-2-3-5(7(8)9)6-4-10-6/h5-6H,2-4H2,1H3,(H,8,9)/t5-,6-/m0/s1
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n/an/a 1.15E+5n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283500
PNG
(CHEMBL4166484)
Show SMILES OC(=O)[C@@H](CC1CC1)[C@H]1CS1
Show InChI InChI=1S/C8H12O2S/c9-8(10)6(7-4-11-7)3-5-1-2-5/h5-7H,1-4H2,(H,9,10)/t6-,7+/m0/s1
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n/an/a 1.74E+5n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 3 hrs followed by susbtrate addition ...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair
Carboxypeptidase A1


(Bos taurus (bovine))
BDBM50283506
PNG
(CHEMBL4177108)
Show SMILES OC(=O)[C@@H](CC1CC1)[C@@H]1CO1
Show InChI InChI=1S/C8H12O3/c9-8(10)6(7-4-11-7)3-5-1-2-5/h5-7H,1-4H2,(H,9,10)/t6-,7-/m0/s1
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n/an/a 2.76E+5n/an/an/an/an/an/a



University of Notre Dame

Curated by ChEMBL


Assay Description
Inhibition of bovine carboxypeptidase A using N-(4-methoxyphenylazoformyl)-Phe-OH as substrate preincubated for 2 mins followed by susbtrate addition...


ACS Med Chem Lett 8: 1122-1127 (2017)

More data for this
Ligand-Target Pair