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Compile Data Set for Download or QSAR

Found 865 hits of ec50 for UniProtKB: A0A024R4P3   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450307
PNG
(US10676431, Example 70)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H21ClF4N3O3P/c1-37(2,36)23-15(4-3-5-16(23)27)14-7-9-20(22(30)21(14)29)33-11-10-19(24(33)34)32-25(35)31-18-8-6-13(26)12-17(18)28/h3-9,12,19H,10-11H2,1-2H3,(H2,31,32,35)/t19-/m1/s1
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n/an/an/an/a 0.0770n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454204
PNG
(US10717708, Example 188)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O
Show InChI InChI=1S/C25H24ClFN4O4S/c1-36(34,35)30-21-6-3-2-5-19(21)16-8-11-18(12-9-16)31-14-4-7-23(24(31)32)29-25(33)28-22-13-10-17(26)15-20(22)27/h2-3,5-6,8-13,15,23,30H,4,7,14H2,1H3,(H2,28,29,33)/t23-/m1/s1
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n/an/an/an/a 0.130n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454192
PNG
(US10717708, Example 86)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C25H25ClN4O4S/c1-35(33,34)29-22-6-3-2-5-21(22)17-8-14-20(15-9-17)30-16-4-7-23(24(30)31)28-25(32)27-19-12-10-18(26)11-13-19/h2-3,5-6,8-15,23,29H,4,7,16H2,1H3,(H2,27,28,32)/t23-/m1/s1
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n/an/an/an/a 0.140n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450267
PNG
(US10676431, Example 30)
Show SMILES COC[C@@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1ccccc1P(C)(C)=O
Show InChI InChI=1S/C27H26ClF3N3O4P/c1-38-14-16-13-21(33-27(36)32-20-10-8-15(28)12-19(20)29)26(35)34(16)22-11-9-18(24(30)25(22)31)17-6-4-5-7-23(17)39(2,3)37/h4-12,16,21H,13-14H2,1-3H3,(H2,32,33,36)/t16-,21+/m0/s1
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n/an/an/an/a 0.220n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450349
PNG
(US10676431, Example 112)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2[C@H](CO)C[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H24ClF3N3O4P/c1-38(2,37)22-6-4-3-5-16(22)17-8-10-21(24(30)23(17)29)33-15(13-34)12-20(25(33)35)32-26(36)31-19-9-7-14(27)11-18(19)28/h3-11,15,20,34H,12-13H2,1-2H3,(H2,31,32,36)/t15-,20+/m0/s1
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n/an/an/an/a 0.270n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM350655
PNG
(US10208071, Compound 117 | US10434112, Compound 11...)
Show SMILES CCC[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCP(=O)(OCC)OCC
Show InChI InChI=1S/C17H27BrN3O5P/c1-4-7-15(16(22)19-12-27(24,25-5-2)26-6-3)21-17(23)20-14-10-8-13(18)9-11-14/h8-11,15H,4-7,12H2,1-3H3,(H,19,22)(H2,20,21,23)/t15-/m0/s1
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n/an/an/an/a 0.270n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...


US Patent US10434112 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G16
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454206
PNG
(US10717708, Example 199)
Show SMILES COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2NS(C)(=O)=O)cc1
Show InChI InChI=1S/C26H28N4O5S/c1-35-21-15-11-19(12-16-21)27-26(32)28-24-8-5-17-30(25(24)31)20-13-9-18(10-14-20)22-6-3-4-7-23(22)29-36(2,33)34/h3-4,6-7,9-16,24,29H,5,8,17H2,1-2H3,(H2,27,28,32)/t24-/m1/s1
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n/an/an/an/a 0.280n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450358
PNG
(US10676431, Example 121 | US10676431, Example 122)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O
Show InChI InChI=1S/C25H23ClF3N4O3P/c1-13-11-19(32-25(35)31-18-8-6-14(26)12-17(18)27)24(34)33(13)20-9-7-15(21(28)22(20)29)16-5-4-10-30-23(16)37(2,3)36/h4-10,12-13,19H,11H2,1-3H3,(H2,31,32,35)/t13?,19-/m1/s1
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n/an/an/an/a 0.300n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454187
PNG
(US10717708, Example 66)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C26H25F3N4O4S/c1-38(36,37)32-22-6-3-2-5-21(22)17-8-14-20(15-9-17)33-16-4-7-23(24(33)34)31-25(35)30-19-12-10-18(11-13-19)26(27,28)29/h2-3,5-6,8-15,23,32H,4,7,16H2,1H3,(H2,30,31,35)/t23-/m1/s1
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n/an/an/an/a 0.320n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454196
PNG
(US10717708, Example 145)
Show SMILES CN(c1ncccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(cc2)C(F)(F)F)C1=O)S(C)(=O)=O
Show InChI InChI=1S/C26H26F3N5O4S/c1-33(39(2,37)38)23-21(5-3-15-30-23)17-7-13-20(14-8-17)34-16-4-6-22(24(34)35)32-25(36)31-19-11-9-18(10-12-19)26(27,28)29/h3,5,7-15,22H,4,6,16H2,1-2H3,(H2,31,32,36)/t22-/m1/s1
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n/an/an/an/a 0.360n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450350
PNG
(US10676431, Example 113)
Show SMILES CC1(C)CN(C(=O)[C@@H]1NC(=O)Nc1ccc(Cl)cc1F)c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O
Show InChI InChI=1S/C26H25ClF3N4O3P/c1-26(2)13-34(24(35)22(26)33-25(36)32-18-9-7-14(27)12-17(18)28)19-10-8-15(20(29)21(19)30)16-6-5-11-31-23(16)38(3,4)37/h5-12,22H,13H2,1-4H3,(H2,32,33,36)/t22-/m0/s1
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n/an/an/an/a 0.390n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450320
PNG
(US10676431, Example 83)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1C(F)(F)F
Show InChI InChI=1S/C26H22ClF5N3O3P/c1-39(2,38)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)26(30,31)32)35-12-11-19(24(35)36)34-25(37)33-18-9-7-14(27)13-17(18)28/h3-10,13,19H,11-12H2,1-2H3,(H2,33,34,37)/t19-/m1/s1
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n/an/an/an/a 0.410n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450236
PNG
(US10676431, Example 1)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1F
Show InChI InChI=1S/C24H21ClF2N4O4S/c1-36(34,35)30-18-5-3-2-4-16(18)17-10-11-20(22(27)21(17)26)31-13-12-19(23(31)32)29-24(33)28-15-8-6-14(25)7-9-15/h2-11,19,30H,12-13H2,1H3,(H2,28,29,33)/t19-/m1/s1
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n/an/an/an/a 0.430n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450346
PNG
(US10676431, Example 109)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1ccccc1P(C)(C)=O
Show InChI InChI=1S/C26H24ClF3N3O3P/c1-14-12-20(32-26(35)31-19-10-8-15(27)13-18(19)28)25(34)33(14)21-11-9-17(23(29)24(21)30)16-6-4-5-7-22(16)37(2,3)36/h4-11,13-14,20H,12H2,1-3H3,(H2,31,32,35)/t14?,20-/m1/s1
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n/an/an/an/a 0.440n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454202
PNG
(US10717708, Example 183)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C28H31ClN4O4S/c1-28(2,3)32-38(36,37)25-9-5-4-7-23(25)19-10-16-22(17-11-19)33-18-6-8-24(26(33)34)31-27(35)30-21-14-12-20(29)13-15-21/h4-5,7,9-17,24,32H,6,8,18H2,1-3H3,(H2,30,31,35)/t24-/m1/s1
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n/an/an/an/a 0.460n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450369
PNG
(US10676431, Example 132)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC3(CC3)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C27H24ClF3N3O3P/c1-38(2,37)21-6-4-3-5-16(21)17-8-10-20(23(31)22(17)30)34-14-27(11-12-27)24(25(34)35)33-26(36)32-19-9-7-15(28)13-18(19)29/h3-10,13,24H,11-12,14H2,1-2H3,(H2,32,33,36)/t24-/m0/s1
PDB

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n/an/an/an/a 0.480n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM350650
PNG
(US10208071, Compound 112 | US10434112, Compound 11...)
Show SMILES CCOP(=O)(CNC(=O)[C@H](CC(C)C)NC(=O)Nc1ccc(Br)cc1)OCC
Show InChI InChI=1S/C18H29BrN3O5P/c1-5-26-28(25,27-6-2)12-20-17(23)16(11-13(3)4)22-18(24)21-15-9-7-14(19)8-10-15/h7-10,13,16H,5-6,11-12H2,1-4H3,(H,20,23)(H2,21,22,24)/t16-/m0/s1
PDB

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n/an/an/an/a 0.480n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...


US Patent US10434112 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G16
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450264
PNG
(US10676431, Example 27)
Show SMILES CC(C)c1cc(ccc1N1CC[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C1=O)-c1ccccc1NS(C)(=O)=O
Show InChI InChI=1S/C27H28ClFN4O4S/c1-16(2)20-14-17(19-6-4-5-7-22(19)32-38(3,36)37)8-11-25(20)33-13-12-24(26(33)34)31-27(35)30-23-10-9-18(28)15-21(23)29/h4-11,14-16,24,32H,12-13H2,1-3H3,(H2,30,31,35)/t24-/m1/s1
PDB

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n/an/an/an/a 0.5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450318
PNG
(US10676431, Example 81)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1Cl
Show InChI InChI=1S/C25H22Cl2F2N3O3P/c1-36(2,35)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)27)32-12-11-19(24(32)33)31-25(34)30-18-9-7-14(26)13-17(18)28/h3-10,13,19H,11-12H2,1-2H3,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 0.520n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450262
PNG
(US10676431, Example 25)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H22ClF3N3O3P/c1-36(2,35)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)28)32-12-11-19(24(32)33)31-25(34)30-18-9-7-14(26)13-17(18)27/h3-10,13,19H,11-12H2,1-2H3,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 0.530n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450305
PNG
(US10676431, Example 68)
Show SMILES CCP(=O)(CC)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C28H26F6N3O3P/c1-3-41(40,4-2)23-8-6-5-7-17(23)18-10-12-22(25(31)24(18)30)37-14-13-21(26(37)38)36-27(39)35-20-11-9-16(15-19(20)29)28(32,33)34/h5-12,15,21H,3-4,13-14H2,1-2H3,(H2,35,36,39)/t21-/m1/s1
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n/an/an/an/a 0.530n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450263
PNG
(US10676431, Example 26)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(c1)C1CC1
Show InChI InChI=1S/C27H26ClFN4O4S/c1-38(36,37)32-22-5-3-2-4-19(22)17-8-11-25(20(14-17)16-6-7-16)33-13-12-24(26(33)34)31-27(35)30-23-10-9-18(28)15-21(23)29/h2-5,8-11,14-16,24,32H,6-7,12-13H2,1H3,(H2,30,31,35)/t24-/m1/s1
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n/an/an/an/a 0.550n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450340
PNG
(US10676431, Example 103)
Show SMILES CC1(C)CN(C(=O)[C@@H]1NC(=O)Nc1ccc(Cl)cc1F)c1ccc(c(F)c1F)-c1ccccc1P(C)(C)=O
Show InChI InChI=1S/C27H26ClF3N3O3P/c1-27(2)14-34(25(35)24(27)33-26(36)32-19-11-9-15(28)13-18(19)29)20-12-10-17(22(30)23(20)31)16-7-5-6-8-21(16)38(3,4)37/h5-13,24H,14H2,1-4H3,(H2,32,33,36)/t24-/m0/s1
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n/an/an/an/a 0.570n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450276
PNG
(US10676431, Example 39)
Show SMILES CS(=O)(=O)c1ccccc1-c1ccc(N2[C@H](CO)C[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H21F6N3O5S/c1-41(39,40)21-5-3-2-4-15(21)16-7-9-20(23(29)22(16)28)35-14(12-36)11-19(24(35)37)34-25(38)33-18-8-6-13(10-17(18)27)26(30,31)32/h2-10,14,19,36H,11-12H2,1H3,(H2,33,34,38)/t14-,19+/m0/s1
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n/an/an/an/a 0.580n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM350553
PNG
(3-[(4- iodophenyl)carbamoyl] spiro[bicyclo[2.2.1]h...)
Show SMILES OC(=O)C1C2CCC(C1C(=O)Nc1ccc(I)cc1)C21CC1
Show InChI InChI=1S/C17H18INO3/c18-9-1-3-10(4-2-9)19-15(20)13-11-5-6-12(14(13)16(21)22)17(11)7-8-17/h1-4,11-14H,5-8H2,(H,19,20)(H,21,22)
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n/an/an/an/a 0.600n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...


US Patent US10434112 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G16
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450309
PNG
(US10676431, Example 72)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H21F7N3O3P/c1-40(2,39)23-15(4-3-5-16(23)27)14-7-9-20(22(30)21(14)29)36-11-10-19(24(36)37)35-25(38)34-18-8-6-13(12-17(18)28)26(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H2,34,35,38)/t19-/m1/s1
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n/an/an/an/a 0.610n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450322
PNG
(US10676431, Example 85)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1Cl
Show InChI InChI=1S/C25H21Cl2F3N3O3P/c1-37(2,36)23-15(4-3-5-16(23)28)14-7-9-20(22(30)21(14)27)33-11-10-19(24(33)34)32-25(35)31-18-8-6-13(26)12-17(18)29/h3-9,12,19H,10-11H2,1-2H3,(H2,31,32,35)/t19-/m1/s1
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n/an/an/an/a 0.620n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450338
PNG
(US10676431, Example 101)
Show SMILES CCOP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H24ClF3N3O4P/c1-3-37-38(2,36)22-7-5-4-6-16(22)17-9-11-21(24(30)23(17)29)33-13-12-20(25(33)34)32-26(35)31-19-10-8-15(27)14-18(19)28/h4-11,14,20H,3,12-13H2,1-2H3,(H2,31,32,35)/t20-,38?/m1/s1
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n/an/an/an/a 0.660n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454189
PNG
(US10717708, Example 77)
Show SMILES OCc1ccccc1-c1ccc(cc1)N1CCC[C@@H](NC(=O)Nc2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C25H24ClN3O3/c26-19-9-11-20(12-10-19)27-25(32)28-23-6-3-15-29(24(23)31)21-13-7-17(8-14-21)22-5-2-1-4-18(22)16-30/h1-2,4-5,7-14,23,30H,3,6,15-16H2,(H2,27,28,32)/t23-/m1/s1
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n/an/an/an/a 0.680n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450240
PNG
(US10676431, Example 5)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C24H20ClF3N4O4S/c1-37(35,36)31-17-5-3-2-4-14(17)15-7-9-20(22(28)21(15)27)32-11-10-19(23(32)33)30-24(34)29-18-8-6-13(25)12-16(18)26/h2-9,12,19,31H,10-11H2,1H3,(H2,29,30,34)/t19-/m1/s1
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n/an/an/an/a 0.680n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454205
PNG
(US10717708, Example 197)
Show SMILES COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2NS(C)(=O)=O)c(F)c1
Show InChI InChI=1S/C26H27FN4O5S/c1-36-19-13-14-23(21(27)16-19)28-26(33)29-24-8-5-15-31(25(24)32)18-11-9-17(10-12-18)20-6-3-4-7-22(20)30-37(2,34)35/h3-4,6-7,9-14,16,24,30H,5,8,15H2,1-2H3,(H2,28,29,33)/t24-/m1/s1
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n/an/an/an/a 0.760n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450357
PNG
(US10676431, Example 120 | US10676431, Example 128)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(cc2F)C(F)(F)F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O
Show InChI InChI=1S/C26H23F6N4O3P/c1-13-11-19(35-25(38)34-18-8-6-14(12-17(18)27)26(30,31)32)24(37)36(13)20-9-7-15(21(28)22(20)29)16-5-4-10-33-23(16)40(2,3)39/h4-10,12-13,19H,11H2,1-3H3,(H2,34,35,38)/t13?,19-/m1/s1
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n/an/an/an/a 0.780n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450361
PNG
(US10676431, Example 124)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC(CO)[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C27H24F6N3O4P/c1-41(2,40)21-6-4-3-5-16(21)17-8-10-20(23(30)22(17)29)36-12-14(13-37)24(25(36)38)35-26(39)34-19-9-7-15(11-18(19)28)27(31,32)33/h3-11,14,24,37H,12-13H2,1-2H3,(H2,34,35,39)/t14?,24-/m1/s1
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n/an/an/an/a 0.790n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450336
PNG
(US10676431, Example 99)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(Cl)c1F
Show InChI InChI=1S/C25H22Cl2F2N3O3P/c1-36(2,35)21-6-4-3-5-15(21)16-8-10-20(22(27)23(16)29)32-12-11-19(24(32)33)31-25(34)30-18-9-7-14(26)13-17(18)28/h3-10,13,19H,11-12H2,1-2H3,(H2,30,31,34)/t19-/m1/s1
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n/an/an/an/a 0.790n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450358
PNG
(US10676431, Example 121 | US10676431, Example 122)
Show SMILES CC1C[C@@H](NC(=O)Nc2ccc(Cl)cc2F)C(=O)N1c1ccc(c(F)c1F)-c1cccnc1P(C)(C)=O
Show InChI InChI=1S/C25H23ClF3N4O3P/c1-13-11-19(32-25(35)31-18-8-6-14(26)12-17(18)27)24(34)33(13)20-9-7-15(21(28)22(20)29)16-5-4-10-30-23(16)37(2,3)36/h4-10,12-13,19H,11H2,1-3H3,(H2,31,32,35)/t13?,19-/m1/s1
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n/an/an/an/a 0.810n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454188
PNG
(US10717708, Example 76)
Show SMILES Clc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2C#N)cc1
Show InChI InChI=1S/C25H21ClN4O2/c26-19-9-11-20(12-10-19)28-25(32)29-23-6-3-15-30(24(23)31)21-13-7-17(8-14-21)22-5-2-1-4-18(22)16-27/h1-2,4-5,7-14,23H,3,6,15H2,(H2,28,29,32)/t23-/m1/s1
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n/an/an/an/a 0.810n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450323
PNG
(US10676431, Example 86)
Show SMILES CP(C)(=O)c1c(F)cccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1Cl
Show InChI InChI=1S/C26H21ClF6N3O3P/c1-40(2,39)23-15(4-3-5-16(23)28)14-7-9-20(22(30)21(14)27)36-11-10-19(24(36)37)35-25(38)34-18-8-6-13(12-17(18)29)26(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H2,34,35,38)/t19-/m1/s1
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n/an/an/an/a 0.850n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450351
PNG
(US10676431, Example 114)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2[C@H](CO)C[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C27H24F6N3O4P/c1-41(2,40)22-6-4-3-5-16(22)17-8-10-21(24(30)23(17)29)36-15(13-37)12-20(25(36)38)35-26(39)34-19-9-7-14(11-18(19)28)27(31,32)33/h3-11,15,20,37H,12-13H2,1-2H3,(H2,34,35,39)/t15-,20+/m0/s1
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n/an/an/an/a 0.860n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450310
PNG
(US10676431, Example 73)
Show SMILES CP(C)(=O)c1ncccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C25H21F6N4O3P/c1-39(2,38)22-15(4-3-10-32-22)14-6-8-19(21(28)20(14)27)35-11-9-18(23(35)36)34-24(37)33-17-7-5-13(12-16(17)26)25(29,30)31/h3-8,10,12,18H,9,11H2,1-2H3,(H2,33,34,37)/t18-/m1/s1
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n/an/an/an/a 0.890n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM454190
PNG
(US10717708, Example 78)
Show SMILES NC(=O)c1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1
Show InChI InChI=1S/C25H22ClFN4O3/c26-16-8-10-17(11-9-16)29-25(34)30-21-6-3-13-31(24(21)33)22-12-7-15(14-20(22)27)18-4-1-2-5-19(18)23(28)32/h1-2,4-5,7-12,14,21H,3,6,13H2,(H2,28,32)(H2,29,30,34)/t21-/m1/s1
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n/an/an/an/a 0.890n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
FPR2 and FPR1 Cyclic Adenosine Monophosphate (cAMP) Assays. A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (...


US Patent US10717708 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450269
PNG
(US10676431, Example 32)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1
Show InChI InChI=1S/C24H21ClF2N4O4S/c1-36(34,35)30-19-5-3-2-4-16(19)14-6-9-22(18(27)12-14)31-11-10-21(23(31)32)29-24(33)28-20-8-7-15(25)13-17(20)26/h2-9,12-13,21,30H,10-11H2,1H3,(H2,28,29,33)/t21-/m1/s1
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n/an/an/an/a 0.910n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450239
PNG
(US10676431, Example 4)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3c(F)cc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C24H19ClF4N4O4S/c1-38(36,37)32-17-5-3-2-4-13(17)14-6-7-19(21(29)20(14)28)33-9-8-18(23(33)34)30-24(35)31-22-15(26)10-12(25)11-16(22)27/h2-7,10-11,18,32H,8-9H2,1H3,(H2,30,31,35)/t18-/m1/s1
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n/an/an/an/a 0.930n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM350643
PNG
(US10208071, Compound 105 | US10434112, Compound 10...)
Show SMILES CCOP(O)(=O)CNC(=O)[C@H](CC(C)C)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C16H25BrN3O5P/c1-4-25-26(23,24)10-18-15(21)14(9-11(2)3)20-16(22)19-13-7-5-12(17)6-8-13/h5-8,11,14H,4,9-10H2,1-3H3,(H,18,21)(H,23,24)(H2,19,20,22)/t14-/m0/s1
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n/an/an/an/a 0.950n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...


US Patent US10434112 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G16
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450294
PNG
(US10676431, Example 57)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(cc3F)C(F)(F)F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H22F6N3O3P/c1-39(2,38)21-6-4-3-5-15(21)16-8-10-20(23(29)22(16)28)35-12-11-19(24(35)36)34-25(37)33-18-9-7-14(13-17(18)27)26(30,31)32/h3-10,13,19H,11-12H2,1-2H3,(H2,33,34,37)/t19-/m1/s1
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n/an/an/an/a 0.950n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM350647
PNG
(1-(4-bromophenyl)-3-{4-[2-(2- hydroxyphenyl)ethyl]...)
Show SMILES CC1(CCc2ccccc2O)NC(=O)N(NC(=O)Nc2ccc(Br)cc2)C1=O
Show InChI InChI=1S/C19H19BrN4O4/c1-19(11-10-12-4-2-3-5-15(12)25)16(26)24(18(28)22-19)23-17(27)21-14-8-6-13(20)7-9-14/h2-9,25H,10-11H2,1H3,(H,22,28)(H2,21,23,27)
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n/an/an/an/a 0.970n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-Gα16 cells stably expressing the human FPR2 receptor was utilized. Cells were plated into 384-well poly-D-lysine coated plates at a density ...


US Patent US10434112 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G16
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM450362
PNG
(US10676431, Example 125 | US10676431, Example 126 ...)
Show SMILES CP(C)(=O)c1ccccc1-c1ccc(N2CC(CO)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F
Show InChI InChI=1S/C26H24ClF3N3O4P/c1-38(2,37)21-6-4-3-5-16(21)17-8-10-20(23(30)22(17)29)33-12-14(13-34)24(25(33)35)32-26(36)31-19-9-7-15(27)11-18(19)28/h3-11,14,24,34H,12-13H2,1-2H3,(H2,31,32,36)/t14?,24-/m1/s1
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n/an/an/an/a 0.990n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
A mixture of forskolin (5 μM final for FPR2 or 10 μM final for FPR1) and IBMX (200 μM final) were added to 384-well Proxiplates (Perki...


US Patent US10676431 (2020)

More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377288
PNG
(US10265310, Example 39 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@H]2CCN(C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)C(=O)C2CC2)c(F)c1
Show InChI InChI=1S/C23H24ClF2N3O3/c1-32-16-10-18(25)21(19(26)11-16)17-8-9-29(22(30)13-2-3-13)12-20(17)28-23(31)27-15-6-4-14(24)5-7-15/h4-7,10-11,13,17,20H,2-3,8-9,12H2,1H3,(H2,27,28,31)/t17-,20-/m0/s1
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TB4
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377290
PNG
(US10265310, Example 42 | trans-ent1-1-(4-chlorophe...)
Show SMILES COc1ccc([C@H]2CC(=O)NC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H19ClFN3O3/c1-27-13-6-7-14(16(21)8-13)15-9-18(25)22-10-17(15)24-19(26)23-12-4-2-11(20)3-5-12/h2-8,15,17H,9-10H2,1H3,(H,22,25)(H2,23,24,26)/t15-,17+/m1/s1
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TB4
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377292
PNG
(US10265310, Example 45 | ent1-1-(4-chlorophenyl)-3...)
Show SMILES COc1ccc([C@H]2CCNC[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H21ClFN3O2/c1-26-14-6-7-15(17(21)10-14)16-8-9-22-11-18(16)24-19(25)23-13-4-2-12(20)3-5-13/h2-7,10,16,18,22H,8-9,11H2,1H3,(H2,23,24,25)/t16-,18+/m1/s1
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TB4
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM377297
PNG
(US10265310, Example 50 | trans-ent2-1-(4-chlorophe...)
Show SMILES COc1cc(F)c([C@@H]2CC(=O)NC[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C19H18ClF2N3O3/c1-28-12-6-14(21)18(15(22)7-12)13-8-17(26)23-9-16(13)25-19(27)24-11-4-2-10(20)3-5-11/h2-7,13,16H,8-9H2,1H3,(H,23,26)(H2,24,25,27)/t13-,16-/m1/s1
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n/an/an/an/a<1n/an/an/an/a



GRÜNENTHAL GMBH

US Patent


Assay Description
Cryo-vial containing 6106 cells (hFPR1-Gα15-CHO or hFPR2-Aq-CHO) was thawed in a 37 C. water bath. Cells were suspended in 10 ml of respective...


US Patent US10265310 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TB4
More data for this
Ligand-Target Pair
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