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Compile Data Set for Download or QSAR

Found 419 hits of ic50 for UniProtKB: A0A024R4P3   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520819
PNG
(CHEMBL4440913)
Show SMILES CCCCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520815
PNG
(CHEMBL4574711)
Show SMILES CCCCC[C@@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27+/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520818
PNG
(CHEMBL4462922)
Show SMILES CCCCC[C@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520822
PNG
(CHEMBL4436717)
Show SMILES CCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520818
PNG
(CHEMBL4462922)
Show SMILES CCCCC[C@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520818
PNG
(CHEMBL4462922)
Show SMILES CCCCC[C@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27-/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520824
PNG
(CHEMBL4536276)
Show SMILES CCCCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520815
PNG
(CHEMBL4574711)
Show SMILES CCCCC[C@@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27+/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520816
PNG
(CHEBI:6498 | LIPOXIN A4)
Show SMILES CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520816
PNG
(CHEBI:6498 | LIPOXIN A4)
Show SMILES CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520819
PNG
(CHEMBL4440913)
Show SMILES CCCCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18-/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520823
PNG
(CHEMBL4434857)
Show SMILES CCCCC[C@H](O)c1nc(oc1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C)-c1ccccc1
Show InChI InChI=1S/C26H37NO6/c1-4-5-7-13-22(30)25-23(33-26(27-25)19-11-8-6-9-12-19)17-16-21(29)20(28)14-10-15-24(31)32-18(2)3/h6,8-9,11-12,16-18,20-22,28-30H,4-5,7,10,13-15H2,1-3H3/b17-16+/t20-,21+,22-/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520819
PNG
(CHEMBL4440913)
Show SMILES CCCCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520823
PNG
(CHEMBL4434857)
Show SMILES CCCCC[C@H](O)c1nc(oc1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C)-c1ccccc1
Show InChI InChI=1S/C26H37NO6/c1-4-5-7-13-22(30)25-23(33-26(27-25)19-11-8-6-9-12-19)17-16-21(29)20(28)14-10-15-24(31)32-18(2)3/h6,8-9,11-12,16-18,20-22,28-30H,4-5,7,10,13-15H2,1-3H3/b17-16+/t20-,21+,22-/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520819
PNG
(CHEMBL4440913)
Show SMILES CCCCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18-/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520820
PNG
(CHEMBL4551559)
Show SMILES CCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16+/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520822
PNG
(CHEMBL4436717)
Show SMILES CCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16-/m0/s1
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n/an/a 3.60n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520820
PNG
(CHEMBL4551559)
Show SMILES CCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16+/m0/s1
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University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520825
PNG
(CHEMBL4534051)
Show SMILES COC(=O)CCC[C@H](O)[C@H](O)\C=C\c1nc(C)n(C)c1[C@@H](C)O
Show InChI InChI=1S/C16H26N2O5/c1-10(19)16-12(17-11(2)18(16)3)8-9-14(21)13(20)6-5-7-15(22)23-4/h8-10,13-14,19-21H,5-7H2,1-4H3/b9-8+/t10-,13+,14-/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520818
PNG
(CHEMBL4462922)
Show SMILES CCCCC[C@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520820
PNG
(CHEMBL4551559)
Show SMILES CCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16+/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520824
PNG
(CHEMBL4536276)
Show SMILES CCCCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18+/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520820
PNG
(CHEMBL4551559)
Show SMILES CCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16+/m0/s1
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n/an/a 4.80n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520823
PNG
(CHEMBL4434857)
Show SMILES CCCCC[C@H](O)c1nc(oc1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C)-c1ccccc1
Show InChI InChI=1S/C26H37NO6/c1-4-5-7-13-22(30)25-23(33-26(27-25)19-11-8-6-9-12-19)17-16-21(29)20(28)14-10-15-24(31)32-18(2)3/h6,8-9,11-12,16-18,20-22,28-30H,4-5,7,10,13-15H2,1-3H3/b17-16+/t20-,21+,22-/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520824
PNG
(CHEMBL4536276)
Show SMILES CCCCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18+/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520824
PNG
(CHEMBL4536276)
Show SMILES CCCCC[C@@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18+/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520822
PNG
(CHEMBL4436717)
Show SMILES CCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520817
PNG
(CHEMBL4582724)
Show SMILES CCCCC[C@@H](O)c1nc(oc1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C)-c1ccccc1
Show InChI InChI=1S/C26H37NO6/c1-4-5-7-13-22(30)25-23(33-26(27-25)19-11-8-6-9-12-19)17-16-21(29)20(28)14-10-15-24(31)32-18(2)3/h6,8-9,11-12,16-18,20-22,28-30H,4-5,7,10,13-15H2,1-3H3/b17-16+/t20-,21+,22+/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520823
PNG
(CHEMBL4434857)
Show SMILES CCCCC[C@H](O)c1nc(oc1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C)-c1ccccc1
Show InChI InChI=1S/C26H37NO6/c1-4-5-7-13-22(30)25-23(33-26(27-25)19-11-8-6-9-12-19)17-16-21(29)20(28)14-10-15-24(31)32-18(2)3/h6,8-9,11-12,16-18,20-22,28-30H,4-5,7,10,13-15H2,1-3H3/b17-16+/t20-,21+,22-/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520817
PNG
(CHEMBL4582724)
Show SMILES CCCCC[C@@H](O)c1nc(oc1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C)-c1ccccc1
Show InChI InChI=1S/C26H37NO6/c1-4-5-7-13-22(30)25-23(33-26(27-25)19-11-8-6-9-12-19)17-16-21(29)20(28)14-10-15-24(31)32-18(2)3/h6,8-9,11-12,16-18,20-22,28-30H,4-5,7,10,13-15H2,1-3H3/b17-16+/t20-,21+,22+/m0/s1
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n/an/a 6.80n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520815
PNG
(CHEMBL4574711)
Show SMILES CCCCC[C@@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27+/m0/s1
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n/an/a 7.10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520816
PNG
(CHEBI:6498 | LIPOXIN A4)
Show SMILES CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
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n/an/a 7.70n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520815
PNG
(CHEMBL4574711)
Show SMILES CCCCC[C@@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50238903
PNG
(CHEMBL4077102)
Show SMILES CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)c3ccc(cc3oc2c1)=[N+](CC)CC
Show InChI InChI=1S/C124H163F6N21O14/c1-5-144(6-2)97-55-57-101-109(77-97)165-110-78-98(145(7-3)8-4)56-58-102(110)117(101)99-23-9-10-24-100(99)118(158)143-108(30-16-22-70-136)124(164)151(84-90-41-53-96(130)54-42-90)76-64-116(157)142-107(29-15-21-69-135)123(163)150(83-89-39-51-95(129)52-40-89)75-63-115(156)141-106(28-14-20-68-134)122(162)149(82-88-37-49-94(128)50-38-88)74-62-114(155)140-105(27-13-19-67-133)121(161)148(81-87-35-47-93(127)48-36-87)73-61-113(154)139-104(26-12-18-66-132)120(160)147(80-86-33-45-92(126)46-34-86)72-60-112(153)138-103(25-11-17-65-131)119(159)146(71-59-111(137)152)79-85-31-43-91(125)44-32-85/h9-10,23-24,31-58,77-78,103-108H,5-8,11-22,25-30,59-76,79-84,131-136H2,1-4H3,(H7-,137,138,139,140,141,142,143,152,153,154,155,156,157,158)/p+1/t103-,104-,105-,106-,107-,108-/m0/s1
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PubMed
n/an/a 10n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production p...


J Med Chem 60: 6991-6997 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00489
BindingDB Entry DOI: 10.7270/Q2V40XFR
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520816
PNG
(CHEBI:6498 | LIPOXIN A4)
Show SMILES CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520818
PNG
(CHEMBL4462922)
Show SMILES CCCCC[C@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50238899
PNG
(CHEMBL4066521)
Show SMILES CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(cc3oc2c1)=[N+](CC)CC
Show InChI InChI=1S/C92H123N15O10/c1-5-102(6-2)71-45-47-75-81(61-71)117-82-62-72(103(7-3)8-4)46-48-76(82)87(75)73-39-21-22-40-74(73)88(112)101-80(44-26-30-56-96)92(116)107(66-70-37-19-12-20-38-70)60-52-86(111)100-79(43-25-29-55-95)91(115)106(65-69-35-17-11-18-36-69)59-51-85(110)99-78(42-24-28-54-94)90(114)105(64-68-33-15-10-16-34-68)58-50-84(109)98-77(41-23-27-53-93)89(113)104(57-49-83(97)108)63-67-31-13-9-14-32-67/h9-22,31-40,45-48,61-62,77-80H,5-8,23-30,41-44,49-60,63-66,93-96H2,1-4H3,(H5-,97,98,99,100,101,108,109,110,111,112)/p+1/t77-,78-,79-,80-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Opioid receptor mu 1 affinity against the receptor site model site 1 (mu1) by using the curve-fitting program LIGAND


J Med Chem 60: 6991-6997 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00489
BindingDB Entry DOI: 10.7270/Q2V40XFR
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50238906
PNG
(CHEMBL4081147)
Show SMILES CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(cc3oc2c1)=[N+](CC)CC
Show InChI InChI=1S/C124H169N21O14/c1-5-138(6-2)97-61-63-101-109(83-97)159-110-84-98(139(7-3)8-4)62-64-102(110)117(101)99-53-27-28-54-100(99)118(152)137-108(60-34-40-76-130)124(158)145(90-96-51-25-14-26-52-96)82-70-116(151)136-107(59-33-39-75-129)123(157)144(89-95-49-23-13-24-50-95)81-69-115(150)135-106(58-32-38-74-128)122(156)143(88-94-47-21-12-22-48-94)80-68-114(149)134-105(57-31-37-73-127)121(155)142(87-93-45-19-11-20-46-93)79-67-113(148)133-104(56-30-36-72-126)120(154)141(86-92-43-17-10-18-44-92)78-66-112(147)132-103(55-29-35-71-125)119(153)140(77-65-111(131)146)85-91-41-15-9-16-42-91/h9-28,41-54,61-64,83-84,103-108H,5-8,29-40,55-60,65-82,85-90,125-130H2,1-4H3,(H7-,131,132,133,134,135,136,137,146,147,148,149,150,151,152)/p+1/t103-,104-,105-,106-,107-,108-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production p...


J Med Chem 60: 6991-6997 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00489
BindingDB Entry DOI: 10.7270/Q2V40XFR
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50238900
PNG
(CHEMBL4090485)
Show SMILES CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(cc3oc2c1)=[N+](CC)CC
Show InChI InChI=1S/C108H146N18O12/c1-5-120(6-2)84-53-55-88-95(72-84)138-96-73-85(121(7-3)8-4)54-56-89(96)102(88)86-46-24-25-47-87(86)103(132)119-94(52-30-35-66-113)108(137)126(78-83-44-22-13-23-45-83)71-61-101(131)118-93(51-29-34-65-112)107(136)125(77-82-42-20-12-21-43-82)70-60-100(130)117-92(50-28-33-64-111)106(135)124(76-81-40-18-11-19-41-81)69-59-99(129)116-91(49-27-32-63-110)105(134)123(75-80-38-16-10-17-39-80)68-58-98(128)115-90(48-26-31-62-109)104(133)122(67-57-97(114)127)74-79-36-14-9-15-37-79/h9-25,36-47,53-56,72-73,90-94H,5-8,26-35,48-52,57-71,74-78,109-113H2,1-4H3,(H6-,114,115,116,117,118,119,127,128,129,130,131,132)/p+1/t90-,91-,92-,93-,94-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGAND


J Med Chem 60: 6991-6997 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00489
BindingDB Entry DOI: 10.7270/Q2V40XFR
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520815
PNG
(CHEMBL4574711)
Show SMILES CCCCC[C@@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27+/m0/s1
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n/an/a 19n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520816
PNG
(CHEBI:6498 | LIPOXIN A4)
Show SMILES CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50238909
PNG
(CHEMBL4062611)
Show SMILES CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)c3ccc(cc3oc2c1)=[N+](CC)CC
Show InChI InChI=1S/C130H181N21O14/c1-11-144(12-2)103-61-63-107-115(83-103)165-116-84-104(145(13-3)14-4)62-64-108(116)123(107)105-29-15-16-30-106(105)124(158)143-114(36-22-28-76-136)130(164)151(90-102-59-47-96(10)48-60-102)82-70-122(157)142-113(35-21-27-75-135)129(163)150(89-101-57-45-95(9)46-58-101)81-69-121(156)141-112(34-20-26-74-134)128(162)149(88-100-55-43-94(8)44-56-100)80-68-120(155)140-111(33-19-25-73-133)127(161)148(87-99-53-41-93(7)42-54-99)79-67-119(154)139-110(32-18-24-72-132)126(160)147(86-98-51-39-92(6)40-52-98)78-66-118(153)138-109(31-17-23-71-131)125(159)146(77-65-117(137)152)85-97-49-37-91(5)38-50-97/h15-16,29-30,37-64,83-84,109-114H,11-14,17-28,31-36,65-82,85-90,131-136H2,1-10H3,(H7-,137,138,139,140,141,142,143,152,153,154,155,156,157,158)/p+1/t109-,110-,111-,112-,113-,114-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production p...


J Med Chem 60: 6991-6997 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00489
BindingDB Entry DOI: 10.7270/Q2V40XFR
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520819
PNG
(CHEMBL4440913)
Show SMILES CCCCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C20H34N2O5/c1-5-6-7-9-18(25)20-15(21-14(2)22(20)3)12-13-17(24)16(23)10-8-11-19(26)27-4/h12-13,16-18,23-25H,5-11H2,1-4H3/b13-12+/t16-,17+,18-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520816
PNG
(CHEBI:6498 | LIPOXIN A4)
Show SMILES CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520815
PNG
(CHEMBL4574711)
Show SMILES CCCCC[C@@H](O)c1nc(-c2ccccc2)n(c1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)-c1ccccc1
Show InChI InChI=1S/C30H38N2O5/c1-3-4-7-17-27(35)29-24(20-21-26(34)25(33)18-12-19-28(36)37-2)32(23-15-10-6-11-16-23)30(31-29)22-13-8-5-9-14-22/h5-6,8-11,13-16,20-21,25-27,33-35H,3-4,7,12,17-19H2,1-2H3/b21-20+/t25-,26+,27+/m0/s1
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n/an/a 26n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50238907
PNG
(CHEMBL4082093)
Show SMILES CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(cc3oc2c1)=[N+](CC)CC
Show InChI InChI=1S/C76H100N12O8/c1-5-84(6-2)58-37-39-62-67(50-58)96-68-51-59(85(7-3)8-4)38-40-63(68)72(62)60-32-18-19-33-61(60)73(92)83-66(36-22-25-46-79)76(95)88(54-57-30-16-11-17-31-57)49-43-71(91)82-65(35-21-24-45-78)75(94)87(53-56-28-14-10-15-29-56)48-42-70(90)81-64(34-20-23-44-77)74(93)86(47-41-69(80)89)52-55-26-12-9-13-27-55/h9-19,26-33,37-40,50-51,64-66H,5-8,20-25,34-36,41-49,52-54,77-79H2,1-4H3,(H4-,80,81,82,83,89,90,91,92)/p+1/t64-,65-,66-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production p...


J Med Chem 60: 6991-6997 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00489
BindingDB Entry DOI: 10.7270/Q2V40XFR
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520821
PNG
(CHEMBL4460558)
Show SMILES COC(=O)CCC[C@H](O)[C@H](O)\C=C\c1nc(C)n(C)c1[C@H](C)O
Show InChI InChI=1S/C16H26N2O5/c1-10(19)16-12(17-11(2)18(16)3)8-9-14(21)13(20)6-5-7-15(22)23-4/h8-10,13-14,19-21H,5-7H2,1-4H3/b9-8+/t10-,13-,14+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520825
PNG
(CHEMBL4534051)
Show SMILES COC(=O)CCC[C@H](O)[C@H](O)\C=C\c1nc(C)n(C)c1[C@@H](C)O
Show InChI InChI=1S/C16H26N2O5/c1-10(19)16-12(17-11(2)18(16)3)8-9-14(21)13(20)6-5-7-15(22)23-4/h8-10,13-14,19-21H,5-7H2,1-4H3/b9-8+/t10-,13+,14-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520823
PNG
(CHEMBL4434857)
Show SMILES CCCCC[C@H](O)c1nc(oc1\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C)-c1ccccc1
Show InChI InChI=1S/C26H37NO6/c1-4-5-7-13-22(30)25-23(33-26(27-25)19-11-8-6-9-12-19)17-16-21(29)20(28)14-10-15-24(31)32-18(2)3/h6,8-9,11-12,16-18,20-22,28-30H,4-5,7,10,13-15H2,1-3H3/b17-16+/t20-,21+,22-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50520822
PNG
(CHEMBL4436717)
Show SMILES CCC[C@H](O)c1c(\C=C\[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C
Show InChI InChI=1S/C18H30N2O5/c1-5-7-16(23)18-13(19-12(2)20(18)3)10-11-15(22)14(21)8-6-9-17(24)25-4/h10-11,14-16,21-23H,5-9H2,1-4H3/b11-10+/t14-,15+,16-/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...


Eur J Med Chem 162: 80-108 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.049
More data for this
Ligand-Target Pair
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