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Compile Data Set for Download or QSAR

Found 135 hits of ic50 for UniProtKB: P00491   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046227
PNG
(2-Amino-6-thiophen-2-ylmethyl-3,7-dihydro-pyrrolo[...)
Show SMILES Nc1nc2cc(Cc3cccs3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H10N4OS/c12-11-14-8-5-6(4-7-2-1-3-17-7)13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16)
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n/an/a 0.0300n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046231
PNG
(2-Amino-6-furan-2-ylmethyl-3,7-dihydro-pyrrolo[3,2...)
Show SMILES Nc1nc2cc(Cc3ccco3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H10N4O2/c12-11-14-8-5-6(4-7-2-1-3-17-7)13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16)
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n/an/a 0.0570n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046249
PNG
(2-Amino-6-thiophen-3-ylmethyl-3,7-dihydro-pyrrolo[...)
Show SMILES Nc1nc2cc(Cc3ccsc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H10N4OS/c12-11-14-8-4-7(3-6-1-2-17-5-6)13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16)
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n/an/a 0.0670n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046224
PNG
(2-Amino-8-[(thiophen-3-ylmethyl)-amino]-1,9-dihydr...)
Show SMILES Nc1nc2nc(NCc3ccsc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)16-9)13-10(15-7)12-3-5-1-2-18-4-5/h1-2,4H,3H2,(H5,11,12,13,14,15,16,17)
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n/an/a 0.0850n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046252
PNG
(2-Amino-6-benzyl-3,7-dihydro-pyrrolo[3,2-d]pyrimid...)
Show SMILES Nc1nc2cc(Cc3ccccc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H12N4O/c14-13-16-10-7-9(15-11(10)12(18)17-13)6-8-4-2-1-3-5-8/h1-5,7,15H,6H2,(H3,14,16,17,18)
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n/an/a 0.0850n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046246
PNG
(2-Amino-8-[(thiophen-2-ylmethyl)-amino]-1,9-dihydr...)
Show SMILES Nc1nc2nc(NCc3cccs3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)16-9)13-10(15-7)12-4-5-2-1-3-18-5/h1-3H,4H2,(H5,11,12,13,14,15,16,17)
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n/an/a 0.160n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046241
PNG
(2-Amino-8-[(furan-2-ylmethyl)-amino]-1,9-dihydro-p...)
Show SMILES Nc1nc2nc(NCc3ccco3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C10H10N6O2/c11-9-14-7-6(8(17)16-9)13-10(15-7)12-4-5-2-1-3-18-5/h1-3H,4H2,(H5,11,12,13,14,15,16,17)
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n/an/a 0.25n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046251
PNG
(2-Amino-8-benzylamino-1,9-dihydro-purin-6-one | CH...)
Show SMILES Nc1nc2nc(NCc3ccccc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C12H12N6O/c13-11-16-9-8(10(19)18-11)15-12(17-9)14-6-7-4-2-1-3-5-7/h1-5H,6H2,(H5,13,14,15,16,17,18,19)
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n/an/a 0.470n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046221
PNG
(2-Amino-6-[(thiophen-3-ylmethyl)-amino]-3,7-dihydr...)
Show SMILES Nc1nc2cc(NCc3ccsc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H11N5OS/c12-11-14-7-3-8(15-9(7)10(17)16-11)13-4-6-1-2-18-5-6/h1-3,5,13,15H,4H2,(H3,12,14,16,17)
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n/an/a 0.630n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046216
PNG
(2-Amino-6-[(furan-2-ylmethyl)-amino]-3,7-dihydro-p...)
Show SMILES Nc1nc2cc(NCc3ccco3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H11N5O2/c12-11-14-7-4-8(15-9(7)10(17)16-11)13-5-6-2-1-3-18-6/h1-4,13,15H,5H2,(H3,12,14,16,17)
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n/an/a 0.75n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046223
PNG
(2-Amino-6-benzylamino-3,7-dihydro-pyrrolo[3,2-d]py...)
Show SMILES Nc1nc2cc(NCc3ccccc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O/c14-13-16-9-6-10(17-11(9)12(19)18-13)15-7-8-4-2-1-3-5-8/h1-6,15,17H,7H2,(H3,14,16,18,19)
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n/an/a 0.850n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046243
PNG
(2-Amino-6-[(thiophen-2-ylmethyl)-amino]-3,7-dihydr...)
Show SMILES Nc1nc2cc(NCc3cccs3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H11N5OS/c12-11-14-7-4-8(15-9(7)10(17)16-11)13-5-6-2-1-3-18-6/h1-4,13,15H,5H2,(H3,12,14,16,17)
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n/an/a 1n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50195589
PNG
(2-amino-1,5-dihydro-7-[[(2S,4R)-2-(hydroxymethyl)-...)
Show SMILES Nc1nc2c(CN3C[C@H](O)C[C@H]3CO)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C12H17N5O3/c13-12-15-9-6(2-14-10(9)11(20)16-12)3-17-4-8(19)1-7(17)5-18/h2,7-8,14,18-19H,1,3-5H2,(H3,13,15,16,20)/t7-,8+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of human PNP activity


J Med Chem 49: 6037-45 (2006)


Article DOI: 10.1021/jm060547+
BindingDB Entry DOI: 10.7270/Q2NV9K11
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50195587
PNG
(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Show SMILES OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O
Show InChI InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1
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n/an/a 3.5n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of human PNP activity


J Med Chem 49: 6037-45 (2006)


Article DOI: 10.1021/jm060547+
BindingDB Entry DOI: 10.7270/Q2NV9K11
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50195593
PNG
(2-amino-1,5-dihydro-7-[[(2S)-2-(hydroxymethyl)-1-p...)
Show SMILES Nc1nc2c(CN3CCC[C@H]3CO)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C12H17N5O2/c13-12-15-9-7(4-14-10(9)11(19)16-12)5-17-3-1-2-8(17)6-18/h4,8,14,18H,1-3,5-6H2,(H3,13,15,16,19)/t8-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of human PNP activity


J Med Chem 49: 6037-45 (2006)


Article DOI: 10.1021/jm060547+
BindingDB Entry DOI: 10.7270/Q2NV9K11
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046248
PNG
(2-Amino-8-[(3-methyl-thiophen-2-ylmethyl)-amino]-1...)
Show SMILES Cc1ccsc1CNc1nc2nc(N)[nH]c(=O)c2[nH]1
Show InChI InChI=1S/C11H12N6OS/c1-5-2-3-19-6(5)4-13-11-14-7-8(16-11)15-10(12)17-9(7)18/h2-3H,4H2,1H3,(H5,12,13,14,15,16,17,18)
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n/an/a 4.05n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046218
PNG
(2-Amino-6-[(3-methyl-thiophen-2-ylmethyl)-amino]-3...)
Show SMILES Cc1ccsc1CNc1cc2nc(N)[nH]c(=O)c2[nH]1
Show InChI InChI=1S/C12H13N5OS/c1-6-2-3-19-8(6)5-14-9-4-7-10(16-9)11(18)17-12(13)15-7/h2-4,14,16H,5H2,1H3,(H3,13,15,17,18)
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n/an/a 4.05n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50195597
PNG
(2-amino-1,5-dihydro-7-[[N,N-bis-[2-(hydroxy)ethyl]...)
Show SMILES Nc1nc2c(CN(CCO)CCO)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H17N5O3/c12-11-14-8-7(5-13-9(8)10(19)15-11)6-16(1-3-17)2-4-18/h5,13,17-18H,1-4,6H2,(H3,12,14,15,19)
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n/an/a 5n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of human PNP activity


J Med Chem 49: 6037-45 (2006)


Article DOI: 10.1021/jm060547+
BindingDB Entry DOI: 10.7270/Q2NV9K11
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50078452
PNG
((S)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]...)
Show SMILES Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H](CC(O)=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50308521
PNG
(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Show SMILES CCOP(=O)(OCC)C(F)(F)CCCCCc1c[nH]c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C16H25F2N4O4P/c1-3-25-27(24,26-4-2)16(17,18)9-7-5-6-8-11-10-20-13-12(11)21-15(19)22-14(13)23/h10,20H,3-9H2,1-2H3,(H3,19,21,22,23)
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n/an/a 9.5n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...


Bioorg Med Chem 18: 2275-84 (2010)


Article DOI: 10.1016/j.bmc.2010.01.062
BindingDB Entry DOI: 10.7270/Q2N58MG0
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50214708
PNG
(6-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyri...)
Show SMILES Nc1nc2c(CCCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C12H17F2N4O4P/c13-12(14,23(20,21)22)5-3-1-2-4-7-6-16-9-8(7)17-11(15)18-10(9)19/h6,16H,1-5H2,(H2,20,21,22)(H3,15,17,18,19)
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n/an/a 9.5n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PNP in presence of 1 mM phosphate


Bioorg Med Chem Lett 17: 4173-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.054
BindingDB Entry DOI: 10.7270/Q29P31CS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50382672
PNG
(CHEMBL2024005)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1CN(C[C@@H]1O)C(=O)P(O)(O)=O
Show InChI InChI=1S/C10H13N6O6P/c11-9-13-7-6(8(18)14-9)12-3-16(7)4-1-15(2-5(4)17)10(19)23(20,21)22/h3-5,17H,1-2H2,(H2,20,21,22)(H3,11,13,14,18)/t4-,5+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PNP using MSEG as substrate preincubated with inhibitor within 10 to 20 mins measured after 5 mins by HPLC analysis


J Med Chem 55: 1612-21 (2012)


Article DOI: 10.1021/jm201409u
BindingDB Entry DOI: 10.7270/Q2VX0HJ2
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046236
PNG
(2-Amino-8-thiophen-2-ylmethyl-1,9-dihydro-purin-6-...)
Show SMILES Nc1nc2nc(Cc3cccs3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C10H9N5OS/c11-10-14-8-7(9(16)15-10)12-6(13-8)4-5-2-1-3-17-5/h1-3H,4H2,(H4,11,12,13,14,15,16)
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n/an/a 11n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046254
PNG
(2-Amino-8-thiophen-3-ylmethyl-1,9-dihydro-purin-6-...)
Show SMILES Nc1nc2nc(Cc3ccsc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C10H9N5OS/c11-10-14-8-7(9(16)15-10)12-6(13-8)3-5-1-2-17-4-5/h1-2,4H,3H2,(H4,11,12,13,14,15,16)
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n/an/a 11n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50039549
PNG
(3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyri...)
Show SMILES Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC#N)c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClN5O/c16-9-3-1-2-8(6-9)10(4-5-17)11-7-19-13-12(11)20-15(18)21-14(13)22/h1-3,6-7,10,19H,4H2,(H3,18,20,21,22)
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n/an/a 11n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042799
PNG
(3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyri...)
Show SMILES Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC(O)=O)c1ccccc1
Show InChI InChI=1S/C15H14N4O3/c16-15-18-12-10(7-17-13(12)14(22)19-15)9(6-11(20)21)8-4-2-1-3-5-8/h1-5,7,9,17H,6H2,(H,20,21)(H3,16,18,19,22)
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n/an/a 13n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046230
PNG
(2-Amino-8-furan-2-ylmethyl-1,9-dihydro-purin-6-one...)
Show SMILES Nc1nc2nc(Cc3ccco3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C10H9N5O2/c11-10-14-8-7(9(16)15-10)12-6(13-8)4-5-2-1-3-17-5/h1-3H,4H2,(H4,11,12,13,14,15,16)
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n/an/a 17.9n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042804
PNG
(2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,...)
Show SMILES Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19)
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n/an/a 20n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50195591
PNG
(2-amino-1,5-dihydro-7-[[[2-(hydroxy)ethyl]amino]me...)
Show SMILES Nc1nc2c(CNCCO)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C9H13N5O2/c10-9-13-6-5(3-11-1-2-15)4-12-7(6)8(16)14-9/h4,11-12,15H,1-3H2,(H3,10,13,14,16)
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n/an/a 20n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of human PNP activity


J Med Chem 49: 6037-45 (2006)


Article DOI: 10.1021/jm060547+
BindingDB Entry DOI: 10.7270/Q2NV9K11
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50214705
PNG
(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Show SMILES Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18)
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n/an/a 20.2n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PNP in presence of 1 mM phosphate


Bioorg Med Chem Lett 17: 4173-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.054
BindingDB Entry DOI: 10.7270/Q29P31CS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50214705
PNG
(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Show SMILES Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18)
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n/an/a 20.2n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...


Bioorg Med Chem 18: 2275-84 (2010)


Article DOI: 10.1016/j.bmc.2010.01.062
BindingDB Entry DOI: 10.7270/Q2N58MG0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50214707
PNG
(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Show SMILES Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18)
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n/an/a 20.4n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PNP in presence of 1 mM phosphate


Bioorg Med Chem Lett 17: 4173-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.054
BindingDB Entry DOI: 10.7270/Q29P31CS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50214707
PNG
(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Show SMILES Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18)
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n/an/a 20.4n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...


Bioorg Med Chem 18: 2275-84 (2010)


Article DOI: 10.1016/j.bmc.2010.01.062
BindingDB Entry DOI: 10.7270/Q2N58MG0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046255
PNG
(2-Amino-8-(pyridin-3-ylamino)-1,9-dihydro-purin-6-...)
Show SMILES Nc1nc2nc(Nc3cccnc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C10H9N7O/c11-9-15-7-6(8(18)17-9)14-10(16-7)13-5-2-1-3-12-4-5/h1-4H,(H5,11,13,14,15,16,17,18)
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n/an/a 21.9n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50308522
PNG
(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Show SMILES CCOP(=O)(OCC)C(F)(F)CCCCCCc1c[nH]c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C17H27F2N4O4P/c1-3-26-28(25,27-4-2)17(18,19)10-8-6-5-7-9-12-11-21-14-13(12)22-16(20)23-15(14)24/h11,21H,3-10H2,1-2H3,(H3,20,22,23,24)
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n/an/a 22n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...


Bioorg Med Chem 18: 2275-84 (2010)


Article DOI: 10.1016/j.bmc.2010.01.062
BindingDB Entry DOI: 10.7270/Q2N58MG0
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50078454
PNG
(2-Amino-7-pyridin-2-ylmethyl-3,5-dihydro-pyrrolo[3...)
Show SMILES Nc1nc2c(Cc3ccccn3)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C12H11N5O/c13-12-16-9-7(5-8-3-1-2-4-14-8)6-15-10(9)11(18)17-12/h1-4,6,15H,5H2,(H3,13,16,17,18)
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n/an/a 23n/an/an/an/an/an/a



Universidade Federal da Bahia

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem 18: 1421-7 (2010)


Article DOI: 10.1016/j.bmc.2010.01.022
BindingDB Entry DOI: 10.7270/Q2571C49
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042803
PNG
(3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyri...)
Show SMILES Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC#N)c1ccccc1
Show InChI InChI=1S/C15H13N5O/c16-7-6-10(9-4-2-1-3-5-9)11-8-18-13-12(11)19-15(17)20-14(13)21/h1-5,8,10,18H,6H2,(H3,17,19,20,21)
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n/an/a 23n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042807
PNG
(2-Amino-7-[1-(3-chloro-phenyl)-3-hydroxy-propyl]-3...)
Show SMILES Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CCO)c1cccc(Cl)c1
Show InChI InChI=1S/C15H15ClN4O2/c16-9-3-1-2-8(6-9)10(4-5-21)11-7-18-13-12(11)19-15(17)20-14(13)22/h1-3,6-7,10,18,21H,4-5H2,(H3,17,19,20,22)
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n/an/a 25n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046217
PNG
(2-Amino-8-benzyl-1,9-dihydro-purin-6-one | CHEMBL1...)
Show SMILES Nc1nc2nc(Cc3ccccc3)[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C12H11N5O/c13-12-16-10-9(11(18)17-12)14-8(15-10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,13,14,15,16,17,18)
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n/an/a 29.6n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50078452
PNG
((S)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]...)
Show SMILES Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H](CC(O)=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 50 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50081803
PNG
(CHEMBL94840 | {1,1-Difluoro-2-[(3R,4R)-4-(6-oxo-1,...)
Show SMILES OP(O)(=O)C(F)(F)C[C@H]1COC[C@H]1Cn1cnc2c1nc[nH]c2=O
Show InChI InChI=1S/C12H15F2N4O5P/c13-12(14,24(20,21)22)1-7-3-23-4-8(7)2-18-6-17-9-10(18)15-5-16-11(9)19/h5-8H,1-4H2,(H,15,16,19)(H2,20,21,22)/t7-,8+/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Tokyo University of Pharmacy & Life Science

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas sp


Bioorg Med Chem Lett 9: 2833-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00495-3
BindingDB Entry DOI: 10.7270/Q2JQ107B
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042363
PNG
(CHEMBL333946 | {2-[2-(2-Amino-6-oxo-1,6-dihydro-pu...)
Show SMILES Nc1nc2n(Cc3ccccc3CCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C14H16N5O4P/c15-14-17-12-11(13(20)18-14)16-8-19(12)7-10-4-2-1-3-9(10)5-6-24(21,22)23/h1-4,8H,5-7H2,(H2,21,22,23)(H3,15,17,18,20)
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n/an/a 35n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50081806
PNG
(CHEMBL94920 | {1,1-Difluoro-2-[(3R,4S)-4-(6-oxo-1,...)
Show SMILES OP(O)(=O)C(F)(F)C[C@H]1COC[C@@H]1Cn1cnc2c1nc[nH]c2=O
Show InChI InChI=1S/C12H15F2N4O5P/c13-12(14,24(20,21)22)1-7-3-23-4-8(7)2-18-6-17-9-10(18)15-5-16-11(9)19/h5-8H,1-4H2,(H,15,16,19)(H2,20,21,22)/t7-,8-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Tokyo University of Pharmacy & Life Science

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas sp


Bioorg Med Chem Lett 9: 2833-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00495-3
BindingDB Entry DOI: 10.7270/Q2JQ107B
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042800
PNG
(2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2...)
Show SMILES Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H18N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h7-8,15H,1-6H2,(H3,14,16,17,18)
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n/an/a 47n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046250
PNG
(2-Amino-6-(3-methyl-thiophen-2-ylmethyl)-3,7-dihyd...)
Show SMILES Cc1ccsc1Cc1cc2nc(N)[nH]c(=O)c2[nH]1
Show InChI InChI=1S/C12H12N4OS/c1-6-2-3-18-9(6)5-7-4-8-10(14-7)11(17)16-12(13)15-8/h2-4,14H,5H2,1H3,(H3,13,15,16,17)
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n/an/a 47.6n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046235
PNG
(2-Amino-8-(3-methyl-thiophen-2-ylmethyl)-1,9-dihyd...)
Show SMILES Cc1ccsc1Cc1nc2nc(N)[nH]c(=O)c2[nH]1
Show InChI InChI=1S/C11H11N5OS/c1-5-2-3-18-6(5)4-7-13-8-9(14-7)15-11(12)16-10(8)17/h2-3H,4H2,1H3,(H4,12,13,14,15,16,17)
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n/an/a 47.6n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042804
PNG
(2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,...)
Show SMILES Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19)
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n/an/a 50n/an/an/an/an/an/a



Universidade Federal da Bahia

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem 18: 1421-7 (2010)


Article DOI: 10.1016/j.bmc.2010.01.022
BindingDB Entry DOI: 10.7270/Q2571C49
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50039547
PNG
(2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimid...)
Show SMILES Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18)
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n/an/a 51n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4


J Med Chem 36: 3771-83 (1994)


Article DOI: 10.1021/jm00076a004
BindingDB Entry DOI: 10.7270/Q23J3DKS
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50046247
PNG
(2-Amino-8-pyridin-3-yl-1,9-dihydro-purin-6-one | C...)
Show SMILES Nc1nc2nc([nH]c2c(=O)[nH]1)-c1cccnc1
Show InChI InChI=1S/C10H8N6O/c11-10-15-8-6(9(17)16-10)13-7(14-8)5-2-1-3-12-4-5/h1-4H,(H4,11,13,14,15,16,17)
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n/an/a 57n/an/an/an/an/an/a



BioCryst Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate


J Med Chem 36: 55-69 (1993)


Article DOI: 10.1021/jm00053a008
BindingDB Entry DOI: 10.7270/Q2B27TCX
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50195595
PNG
(2-amino-1,5-dihydro-7-[[[N-[2-(hydroxy)ethyl]-N-me...)
Show SMILES CN(CCO)Cc1c[nH]c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C10H15N5O2/c1-15(2-3-16)5-6-4-12-8-7(6)13-10(11)14-9(8)17/h4,12,16H,2-3,5H2,1H3,(H3,11,13,14,17)
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n/an/a 60n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Inhibition of human PNP activity


J Med Chem 49: 6037-45 (2006)


Article DOI: 10.1021/jm060547+
BindingDB Entry DOI: 10.7270/Q2NV9K11
More data for this
Ligand-Target Pair
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