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Compile Data Set for Download or QSAR

Found 264 hits of kd data for polymerid = 2294,49000667,50001382,5875   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HRH3


(GUINEA PIG)
BDBM50175833
PNG
(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Show SMILES Clc1ccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C18H23ClN4O/c19-15-1-3-16(4-2-15)22-18(24)7-10-23-8-5-14(6-9-23)11-17-12-20-13-21-17/h1-4,12-14H,5-11H2,(H,20,21)(H,22,24)
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n/an/an/a 0.0794n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50175828
PNG
(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Show SMILES Fc1cccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)c1
Show InChI InChI=1S/C18H23FN4O/c19-15-2-1-3-16(11-15)22-18(24)6-9-23-7-4-14(5-8-23)10-17-12-20-13-21-17/h1-3,11-14H,4-10H2,(H,20,21)(H,22,24)
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n/an/an/a 0.126n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50175843
PNG
(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Show SMILES Clc1cccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)c1
Show InChI InChI=1S/C18H23ClN4O/c19-15-2-1-3-16(11-15)22-18(24)6-9-23-7-4-14(5-8-23)10-17-12-20-13-21-17/h1-3,11-14H,4-10H2,(H,20,21)(H,22,24)
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n/an/an/a 0.158n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM22541
PNG
(CLOBENPROPIT | Clobenpropit | N''-[(4-chlorophenyl...)
Show SMILES NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1
Show InChI InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
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n/an/an/a 0.158n/an/an/an/an/a



De Novo Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortex


J Med Chem 44: 1666-74 (2001)


Article DOI: 10.1021/jm001109k
BindingDB Entry DOI: 10.7270/Q2WH2QP8
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325466
PNG
(1-(3-(dimethylamino)propyl)-3-(1-(1-(pyridin-4-ylm...)
Show SMILES CN(C)CCCn1c2ccccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccncc3)CC2)c1=O
Show InChI InChI=1S/C29H40N6O2/c1-31(2)16-5-17-34-26-6-3-4-7-27(26)35(29(34)37)25-12-20-33(21-13-25)28(36)24-10-18-32(19-11-24)22-23-8-14-30-15-9-23/h3-4,6-9,14-15,24-25H,5,10-13,16-22H2,1-2H3
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n/an/an/a 0.200n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50278350
PNG
(4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Show SMILES FC1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1
Show InChI InChI=1S/C20H31FN2O/c21-19-9-14-23(15-10-19)17-18-5-7-20(8-6-18)24-16-4-13-22-11-2-1-3-12-22/h5-8,19H,1-4,9-17H2
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n/an/an/a 0.340n/an/an/an/an/a



ETH Zurich (Swiss Federal Institute of Technology)

Curated by ChEMBL


Assay Description
Binding affinity to rat brain histamine H3 receptor after 1 hr by gamma counting


Bioorg Med Chem 20: 2889-96 (2012)


Article DOI: 10.1016/j.bmc.2012.03.024
BindingDB Entry DOI: 10.7270/Q2JQ1258
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325450
PNG
(1-(2-(dimethylamino)ethyl)-3-(1-(1-(pyridin-4-ylme...)
Show SMILES CN(C)CCn1c2ccccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccncc3)CC2)c1=O
Show InChI InChI=1S/C28H38N6O2/c1-30(2)19-20-33-25-5-3-4-6-26(25)34(28(33)36)24-11-17-32(18-12-24)27(35)23-9-15-31(16-10-23)21-22-7-13-29-14-8-22/h3-8,13-14,23-24H,9-12,15-21H2,1-2H3
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n/an/an/a 0.501n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325469
PNG
(1-(2-isopropoxyethyl)-3-(1-(1-(pyridin-4-ylmethyl)...)
Show SMILES CC(C)OCCn1c2ccccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccncc3)CC2)c1=O
Show InChI InChI=1S/C29H39N5O3/c1-22(2)37-20-19-33-26-5-3-4-6-27(26)34(29(33)36)25-11-17-32(18-12-25)28(35)24-9-15-31(16-10-24)21-23-7-13-30-14-8-23/h3-8,13-14,22,24-25H,9-12,15-21H2,1-2H3
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n/an/an/a 0.501n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325468
PNG
(1-(2-phenoxyethyl)-3-(1-(1-(pyridin-4-ylmethyl)pip...)
Show SMILES O=C(C1CCN(Cc2ccncc2)CC1)N1CCC(CC1)n1c2ccccc2n(CCOc2ccccc2)c1=O
Show InChI InChI=1S/C32H37N5O3/c38-31(26-12-18-34(19-13-26)24-25-10-16-33-17-11-25)35-20-14-27(15-21-35)37-30-9-5-4-8-29(30)36(32(37)39)22-23-40-28-6-2-1-3-7-28/h1-11,16-17,26-27H,12-15,18-24H2
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n/an/an/a 0.794n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325448
PNG
(1-(2-morpholinoethyl)-3-(1-(1-(pyridin-4-ylmethyl)...)
Show SMILES O=C(C1CCN(Cc2ccncc2)CC1)N1CCC(CC1)n1c2ccccc2n(CCN2CCOCC2)c1=O
Show InChI InChI=1S/C30H40N6O3/c37-29(25-7-13-33(14-8-25)23-24-5-11-31-12-6-24)34-15-9-26(10-16-34)36-28-4-2-1-3-27(28)35(30(36)38)18-17-32-19-21-39-22-20-32/h1-6,11-12,25-26H,7-10,13-23H2
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n/an/an/a 0.794n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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n/an/an/a 0.871n/an/an/an/an/a



Medical University

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in guinea pig jejunum assessed as electrically evoked contractions


Eur J Med Chem 44: 1674-81 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.019
BindingDB Entry DOI: 10.7270/Q2VM4DGB
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50118159
PNG
(CHEMBL340932 | Dicyclopropylmethyl-carbamic acid 3...)
Show SMILES O=C(NC(C1CC1)C1CC1)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H21N3O2/c18-14(17-13(10-3-4-10)11-5-6-11)19-7-1-2-12-8-15-9-16-12/h8-11,13H,1-7H2,(H,15,16)(H,17,18)
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n/an/an/a 1n/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Receptor profile was evaluated at Histamine H3 receptor of guinea pig ileum


J Med Chem 45: 4000-10 (2002)


Article DOI: 10.1021/jm020910m
BindingDB Entry DOI: 10.7270/Q24F1RG3
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50411494
PNG
(CHEMBL429458)
Show SMILES Fc1ccc(cc1)C(=O)N1CCN(C(=O)C1)c1ccc(OCCCN2CCCC2)cc1
Show InChI InChI=1S/C24H28FN3O3/c25-20-6-4-19(5-7-20)24(30)27-15-16-28(23(29)18-27)21-8-10-22(11-9-21)31-17-3-14-26-12-1-2-13-26/h4-11H,1-3,12-18H2
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n/an/an/a 1.26n/an/an/an/an/a



GlaxoSmithKline Medicines REsearch Centre

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in guinea pig ileum assessed as inhibition of (R)-methyl histamine induced longitudinal smooth muscle co...


J Med Chem 50: 6706-17 (2007)


Article DOI: 10.1021/jm0708228
BindingDB Entry DOI: 10.7270/Q2H41S9K
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325449
PNG
(1-(2-(piperidin-1-yl)ethyl)-3-(1-(1-(pyridin-4-ylm...)
Show SMILES O=C(C1CCN(Cc2ccncc2)CC1)N1CCC(CC1)n1c2ccccc2n(CCN2CCCCC2)c1=O
Show InChI InChI=1S/C31H42N6O2/c38-30(26-10-18-34(19-11-26)24-25-8-14-32-15-9-25)35-20-12-27(13-21-35)37-29-7-3-2-6-28(29)36(31(37)39)23-22-33-16-4-1-5-17-33/h2-3,6-9,14-15,26-27H,1,4-5,10-13,16-24H2
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n/an/an/a 1.26n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325465
PNG
(1-benzyl-3-(1-(1-(pyridin-4-ylmethyl)piperidine-4-...)
Show SMILES O=C(C1CCN(Cc2ccncc2)CC1)N1CCC(CC1)n1c2ccccc2n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C31H35N5O2/c37-30(26-12-18-33(19-13-26)22-25-10-16-32-17-11-25)34-20-14-27(15-21-34)36-29-9-5-4-8-28(29)35(31(36)38)23-24-6-2-1-3-7-24/h1-11,16-17,26-27H,12-15,18-23H2
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n/an/an/a 1.26n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM85830
PNG
(VUF5202)
Show SMILES Clc1ccc(CNCCCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H20ClN3/c16-14-7-5-13(6-8-14)10-17-9-3-1-2-4-15-11-18-12-19-15/h5-8,11-12,17H,1-4,9-10H2,(H,18,19)
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n/an/an/a 1.26n/an/an/an/an/a



De Novo Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortex


J Med Chem 44: 1666-74 (2001)


Article DOI: 10.1021/jm001109k
BindingDB Entry DOI: 10.7270/Q2WH2QP8
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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n/an/an/a 1.26n/an/an/an/an/a



De Novo Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortex


J Med Chem 44: 1666-74 (2001)


Article DOI: 10.1021/jm001109k
BindingDB Entry DOI: 10.7270/Q2WH2QP8
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50175851
PNG
(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-p...)
Show SMILES O=C(CCN1CCC(Cc2cnc[nH]2)CC1)Nc1ccccc1
Show InChI InChI=1S/C18H24N4O/c23-18(21-16-4-2-1-3-5-16)8-11-22-9-6-15(7-10-22)12-17-13-19-14-20-17/h1-5,13-15H,6-12H2,(H,19,20)(H,21,23)
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n/an/an/a 1.26n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50441644
PNG
(CHEMBL2437423)
Show SMILES Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccc(F)cc3n(CCCC(F)(F)F)c2=O)ccn1
Show InChI InChI=1S/C28H34F4N6O2/c29-21-2-3-23-24(17-21)37(11-1-9-28(30,31)32)27(40)38(23)22-7-14-36(15-8-22)26(39)20-5-12-35(13-6-20)18-19-4-10-34-25(33)16-19/h2-4,10,16-17,20,22H,1,5-9,11-15,18H2,(H2,33,34)
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n/an/an/a 1.30n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 23: 6001-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.012
BindingDB Entry DOI: 10.7270/Q2542Q1F
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50408180
PNG
(CHEMBL314614)
Show SMILES Clc1ccc(cc1)-c1c[nH]c(SCCc2cnc[nH]2)n1
Show InChI InChI=1S/C14H13ClN4S/c15-11-3-1-10(2-4-11)13-8-17-14(19-13)20-6-5-12-7-16-9-18-12/h1-4,7-9H,5-6H2,(H,16,18)(H,17,19)
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n/an/an/a 1.35n/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Histamine H3-antagonist potency on electrically stimulated guinea pig ileum


J Med Chem 40: 2571-8 (1997)


Article DOI: 10.1021/jm970070p
BindingDB Entry DOI: 10.7270/Q2W0974S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50293200
PNG
(4-cyclopentyl-2-((4-(piperidin-1-ylmethyl)phenoxy)...)
Show SMILES C(Oc1ccc(CN2CCCCC2)cc1)C1CN(CCO1)C1CCCC1
Show InChI InChI=1S/C22H34N2O2/c1-4-12-23(13-5-1)16-19-8-10-21(11-9-19)26-18-22-17-24(14-15-25-22)20-6-2-3-7-20/h8-11,20,22H,1-7,12-18H2
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n/an/an/a 1.55n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity rat recombinant histamine H3 receptor expressed in human SK-N-MC cells


Bioorg Med Chem Lett 18: 5796-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.09.077
BindingDB Entry DOI: 10.7270/Q2154H28
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325471
PNG
(1-(2-methoxyethyl)-3-(1-(1-(pyridin-4-ylmethyl)pip...)
Show SMILES COCCn1c2ccccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccncc3)CC2)c1=O
Show InChI InChI=1S/C27H35N5O3/c1-35-19-18-31-24-4-2-3-5-25(24)32(27(31)34)23-10-16-30(17-11-23)26(33)22-8-14-29(15-9-22)20-21-6-12-28-13-7-21/h2-7,12-13,22-23H,8-11,14-20H2,1H3
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n/an/an/a 1.58n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50177535
PNG
(CHEMBL379445 | N-(4-(3-(4-((1H-imidazol-4-yl)methy...)
Show SMILES CCN(CC)Cc1ccc(OCCCN2CCC(Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C23H36N4O/c1-3-26(4-2)18-21-6-8-23(9-7-21)28-15-5-12-27-13-10-20(11-14-27)16-22-17-24-19-25-22/h6-9,17,19-20H,3-5,10-16,18H2,1-2H3,(H,24,25)
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n/an/an/a 1.58n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against histamine H3 receptor in guinea pig ileum


Bioorg Med Chem Lett 16: 989-94 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.087
BindingDB Entry DOI: 10.7270/Q2SJ1K5X
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50175830
PNG
(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Show SMILES COc1ccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C19H26N4O2/c1-25-18-4-2-16(3-5-18)22-19(24)8-11-23-9-6-15(7-10-23)12-17-13-20-14-21-17/h2-5,13-15H,6-12H2,1H3,(H,20,21)(H,22,24)
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n/an/an/a 1.58n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50175831
PNG
(CHEMBL373263 | methyl 4-(3-(4-((1H-imidazol-4-yl)m...)
Show SMILES COC(=O)c1ccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C20H26N4O3/c1-27-20(26)16-2-4-17(5-3-16)23-19(25)8-11-24-9-6-15(7-10-24)12-18-13-21-14-22-18/h2-5,13-15H,6-12H2,1H3,(H,21,22)(H,23,25)
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n/an/an/a 1.58n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50293199
PNG
(4-cyclopentyl-2-((4-(pyrrolidin-1-ylmethyl)phenoxy...)
Show SMILES C(Oc1ccc(CN2CCCC2)cc1)C1CN(CCO1)C1CCCC1
Show InChI InChI=1S/C21H32N2O2/c1-2-6-19(5-1)23-13-14-24-21(16-23)17-25-20-9-7-18(8-10-20)15-22-11-3-4-12-22/h7-10,19,21H,1-6,11-17H2
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n/an/an/a 1.58n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity rat recombinant histamine H3 receptor expressed in human SK-N-MC cells


Bioorg Med Chem Lett 18: 5796-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.09.077
BindingDB Entry DOI: 10.7270/Q2154H28
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50175857
PNG
(4-((1H-imidazol-4-yl)methyl)-1-(4-(4-chlorophenyl)...)
Show SMILES Clc1ccc(CCCCN2CCC(Cc3cnc[nH]3)CC2)cc1
Show InChI InChI=1S/C19H26ClN3/c20-18-6-4-16(5-7-18)3-1-2-10-23-11-8-17(9-12-23)13-19-14-21-15-22-19/h4-7,14-15,17H,1-3,8-13H2,(H,21,22)
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n/an/an/a 1.58n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50346208
PNG
((1-isopropylpiperidin-4-yl)(4-(piperidin-1-ylmethy...)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(CN2CCCCC2)cc1
Show InChI InChI=1S/C20H31N3O/c1-17(2)22-12-14-23(15-13-22)20(24)19-8-6-18(7-9-19)16-21-10-4-3-5-11-21/h6-9,17H,3-5,10-16H2,1-2H3
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n/an/an/a 1.82n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in rat cortical hemispheres assessed as inhibition of forskolin stimulated cAMP accumulation after 6 hrs


Eur J Med Chem 44: 4413-25 (2009)


Article DOI: 10.1016/j.ejmech.2009.06.007
BindingDB Entry DOI: 10.7270/Q28S4Q7C
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50441641
PNG
(CHEMBL2437426)
Show SMILES Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccc(F)cc3n(CC3CC3)c2=O)ccn1
Show InChI InChI=1S/C28H35FN6O2/c29-22-3-4-24-25(16-22)34(18-19-1-2-19)28(37)35(24)23-8-13-33(14-9-23)27(36)21-6-11-32(12-7-21)17-20-5-10-31-26(30)15-20/h3-5,10,15-16,19,21,23H,1-2,6-9,11-14,17-18H2,(H2,30,31)
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n/an/an/a 2n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 23: 6001-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.012
BindingDB Entry DOI: 10.7270/Q2542Q1F
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50441646
PNG
(CHEMBL2437421)
Show SMILES Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccccc3n(CCN3CCOCC3)c2=O)ccn1
Show InChI InChI=1S/C30H41N7O3/c31-28-21-23(5-10-32-28)22-34-11-6-24(7-12-34)29(38)35-13-8-25(9-14-35)37-27-4-2-1-3-26(27)36(30(37)39)16-15-33-17-19-40-20-18-33/h1-5,10,21,24-25H,6-9,11-20,22H2,(H2,31,32)
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n/an/an/a 2n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 23: 6001-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.012
BindingDB Entry DOI: 10.7270/Q2542Q1F
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50441642
PNG
(CHEMBL2437425)
Show SMILES Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccc(F)cc3n(CC(F)(F)F)c2=O)ccn1
Show InChI InChI=1S/C26H30F4N6O2/c27-19-1-2-21-22(14-19)35(16-26(28,29)30)25(38)36(21)20-6-11-34(12-7-20)24(37)18-4-9-33(10-5-18)15-17-3-8-32-23(31)13-17/h1-3,8,13-14,18,20H,4-7,9-12,15-16H2,(H2,31,32)
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n/an/an/a 2n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 23: 6001-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.012
BindingDB Entry DOI: 10.7270/Q2542Q1F
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325470
PNG
(1-(2-ethoxyethyl)-3-(1-(1-(pyridin-4-ylmethyl)pipe...)
Show SMILES CCOCCn1c2ccccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccncc3)CC2)c1=O
Show InChI InChI=1S/C28H37N5O3/c1-2-36-20-19-32-25-5-3-4-6-26(25)33(28(32)35)24-11-17-31(18-12-24)27(34)23-9-15-30(16-10-23)21-22-7-13-29-14-8-22/h3-8,13-14,23-24H,2,9-12,15-21H2,1H3
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n/an/an/a 2n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50441637
PNG
(CHEMBL2437430)
Show SMILES Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccc(F)cc3n(-c3cc(F)cc(F)c3)c2=O)ccn1
Show InChI InChI=1S/C30H31F3N6O2/c31-21-1-2-26-27(17-21)39(25-15-22(32)14-23(33)16-25)30(41)38(26)24-6-11-37(12-7-24)29(40)20-4-9-36(10-5-20)18-19-3-8-35-28(34)13-19/h1-3,8,13-17,20,24H,4-7,9-12,18H2,(H2,34,35)
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n/an/an/a 2n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 23: 6001-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.012
BindingDB Entry DOI: 10.7270/Q2542Q1F
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50411492
PNG
(CHEMBL394144)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)N1CCN(CC1=O)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C25H30FN3O3/c1-19-4-2-13-27(19)14-3-17-32-23-11-9-22(10-12-23)29-16-15-28(18-24(29)30)25(31)20-5-7-21(26)8-6-20/h5-12,19H,2-4,13-18H2,1H3/t19-/m1/s1
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n/an/an/a 2n/an/an/an/an/a



GlaxoSmithKline Medicines REsearch Centre

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in guinea pig ileum assessed as inhibition of (R)-methyl histamine induced longitudinal smooth muscle co...


J Med Chem 50: 6706-17 (2007)


Article DOI: 10.1021/jm0708228
BindingDB Entry DOI: 10.7270/Q2H41S9K
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50293202
PNG
((S)-4-cyclopentyl-2-((4-(morpholinomethyl)phenoxy)...)
Show SMILES C(Oc1ccc(CN2CCOCC2)cc1)[C@@H]1CN(CCO1)C1CCCC1
Show InChI InChI=1S/C21H32N2O3/c1-2-4-19(3-1)23-11-14-25-21(16-23)17-26-20-7-5-18(6-8-20)15-22-9-12-24-13-10-22/h5-8,19,21H,1-4,9-17H2/t21-/m0/s1
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n/an/an/a 2.14n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity rat recombinant histamine H3 receptor expressed in human SK-N-MC cells


Bioorg Med Chem Lett 18: 5796-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.09.077
BindingDB Entry DOI: 10.7270/Q2154H28
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50317706
PNG
(1-((2R,4S)-2-(4-cyclobutyl-1,4-diazepane-1-carbony...)
Show SMILES CC(=O)N1C[C@H](C[C@@H]1C(=O)N1CCCN(CC1)C1CCC1)Oc1ccc(F)cc1
Show InChI InChI=1S/C22H30FN3O3/c1-16(27)26-15-20(29-19-8-6-17(23)7-9-19)14-21(26)22(28)25-11-3-10-24(12-13-25)18-4-2-5-18/h6-9,18,20-21H,2-5,10-15H2,1H3/t20-,21+/m0/s1
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n/an/an/a 2.29n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at rat H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after 6 hrs


Bioorg Med Chem Lett 20: 2755-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.071
BindingDB Entry DOI: 10.7270/Q2Z60P7S
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50441643
PNG
(CHEMBL2437424)
Show SMILES CC(C)Cn1c2cc(F)ccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccnc(N)c3)CC2)c1=O
Show InChI InChI=1S/C28H37FN6O2/c1-19(2)17-34-25-16-22(29)3-4-24(25)35(28(34)37)23-8-13-33(14-9-23)27(36)21-6-11-32(12-7-21)18-20-5-10-31-26(30)15-20/h3-5,10,15-16,19,21,23H,6-9,11-14,17-18H2,1-2H3,(H2,30,31)
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n/an/an/a 2.5n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 23: 6001-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.012
BindingDB Entry DOI: 10.7270/Q2542Q1F
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50175827
PNG
(4-((1H-imidazol-4-yl)methyl)-1-heptylpiperidine | ...)
Show SMILES CCCCCCCN1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C16H29N3/c1-2-3-4-5-6-9-19-10-7-15(8-11-19)12-16-13-17-14-18-16/h13-15H,2-12H2,1H3,(H,17,18)
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n/an/an/a 2.51n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileum


Bioorg Med Chem Lett 16: 395-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.076
BindingDB Entry DOI: 10.7270/Q29S1QK1
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50177536
PNG
(1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...)
Show SMILES C(COc1ccc(CN2CCCCC2)cc1)CN1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C24H36N4O/c1-2-11-28(12-3-1)19-22-5-7-24(8-6-22)29-16-4-13-27-14-9-21(10-15-27)17-23-18-25-20-26-23/h5-8,18,20-21H,1-4,9-17,19H2,(H,25,26)
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n/an/an/a 2.51n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against histamine H3 receptor in guinea pig ileum


Bioorg Med Chem Lett 16: 989-94 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.087
BindingDB Entry DOI: 10.7270/Q2SJ1K5X
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50317702
PNG
(((2R,4S)-4-(3-chlorophenoxy)pyrrolidin-2-yl)(4-cyc...)
Show SMILES Clc1cccc(O[C@@H]2CN[C@H](C2)C(=O)N2CCCN(CC2)C2CCC2)c1
Show InChI InChI=1S/C20H28ClN3O2/c21-15-4-1-7-17(12-15)26-18-13-19(22-14-18)20(25)24-9-3-8-23(10-11-24)16-5-2-6-16/h1,4,7,12,16,18-19,22H,2-3,5-6,8-11,13-14H2/t18-,19+/m0/s1
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n/an/an/a 2.57n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at rat H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after 6 hrs


Bioorg Med Chem Lett 20: 2755-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.071
BindingDB Entry DOI: 10.7270/Q2Z60P7S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)
BDBM50246289
PNG
(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Show SMILES Cn1c(nc2ccccc2c1=O)-c1ccc(OCCCN2CCCC2)cc1
Show InChI InChI=1S/C22H25N3O2/c1-24-21(23-20-8-3-2-7-19(20)22(24)26)17-9-11-18(12-10-17)27-16-6-15-25-13-4-5-14-25/h2-3,7-12H,4-6,13-16H2,1H3
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n/an/an/a 2.60n/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to mouse histamine H3 receptor overexpressed in HEK293 cells


Bioorg Med Chem Lett 19: 4075-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.025
BindingDB Entry DOI: 10.7270/Q2GQ6XSZ
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50317705
PNG
(4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Show SMILES O=C([C@H]1C[C@@H](CN1)Oc1ccc(cc1)C#N)N1CCCN(CC1)C1CCCC1
Show InChI InChI=1S/C22H30N4O2/c23-15-17-6-8-19(9-7-17)28-20-14-21(24-16-20)22(27)26-11-3-10-25(12-13-26)18-4-1-2-5-18/h6-9,18,20-21,24H,1-5,10-14,16H2/t20-,21+/m0/s1
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n/an/an/a 3.09n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at rat H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after 6 hrs


Bioorg Med Chem Lett 20: 2755-60 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.071
BindingDB Entry DOI: 10.7270/Q2Z60P7S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Mus musculus)
BDBM50246289
PNG
(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Show SMILES Cn1c(nc2ccccc2c1=O)-c1ccc(OCCCN2CCCC2)cc1
Show InChI InChI=1S/C22H25N3O2/c1-24-21(23-20-8-3-2-7-19(20)22(24)26)17-9-11-18(12-10-17)27-16-6-15-25-13-4-5-14-25/h2-3,7-12H,4-6,13-16H2,1H3
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n/an/an/a 3.10n/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to histamine H3 receptor in wild type mouse brain membrane


Bioorg Med Chem Lett 19: 4075-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.025
BindingDB Entry DOI: 10.7270/Q2GQ6XSZ
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50110291
PNG
((7-Chloro-quinolin-4-yl)-[4-(3-piperidin-1-yl-prop...)
Show SMILES Clc1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1
Show InChI InChI=1S/C23H26ClN3O/c24-18-5-10-21-22(11-12-25-23(21)17-18)26-19-6-8-20(9-7-19)28-16-4-15-27-13-2-1-3-14-27/h5-12,17H,1-4,13-16H2,(H,25,26)
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n/an/an/a 3.16n/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activity at Histamine H3 receptor using functional H3 receptor assay on guinea pig ileum


J Med Chem 45: 1128-41 (2002)


Article DOI: 10.1021/jm0110845
BindingDB Entry DOI: 10.7270/Q2H70F4V
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50110288
PNG
(CHEMBL15153 | N-(4-(3-(piperidin-1-yl)propoxy)phen...)
Show SMILES C(COc1ccc(Nc2ccnc3ccccc23)cc1)CN1CCCCC1
Show InChI InChI=1S/C23H27N3O/c1-4-15-26(16-5-1)17-6-18-27-20-11-9-19(10-12-20)25-23-13-14-24-22-8-3-2-7-21(22)23/h2-3,7-14H,1,4-6,15-18H2,(H,24,25)
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n/an/an/a 3.16n/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Activity at Histamine H3 receptor using functional H3 receptor assay on guinea pig ileum


J Med Chem 45: 1128-41 (2002)


Article DOI: 10.1021/jm0110845
BindingDB Entry DOI: 10.7270/Q2H70F4V
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50325467
PNG
(1-(3-ethoxypropyl)-3-(1-(1-(pyridin-4-ylmethyl)pip...)
Show SMILES CCOCCCn1c2ccccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccncc3)CC2)c1=O
Show InChI InChI=1S/C29H39N5O3/c1-2-37-21-5-16-33-26-6-3-4-7-27(26)34(29(33)36)25-12-19-32(20-13-25)28(35)24-10-17-31(18-11-24)22-23-8-14-30-15-9-23/h3-4,6-9,14-15,24-25H,2,5,10-13,16-22H2,1H3
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n/an/an/a 3.16n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in electrically-stimulated guinea pig ileum


Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50177531
PNG
(1-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...)
Show SMILES C(COc1ccc(CCN2CCCCC2)cc1)CN1CCC(Cc2cnc[nH]2)CC1
Show InChI InChI=1S/C25H38N4O/c1-2-12-28(13-3-1)15-9-22-5-7-25(8-6-22)30-18-4-14-29-16-10-23(11-17-29)19-24-20-26-21-27-24/h5-8,20-21,23H,1-4,9-19H2,(H,26,27)
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n/an/an/a 3.16n/an/an/an/an/a



The Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against histamine H3 receptor in guinea pig ileum


Bioorg Med Chem Lett 16: 989-94 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.087
BindingDB Entry DOI: 10.7270/Q2SJ1K5X
More data for this
Ligand-Target Pair
HRH3


(GUINEA PIG)
BDBM50408184
PNG
(CHEMBL87911)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1c[nH]c(SCCc2cnc[nH]2)n1
Show InChI InChI=1S/C14H13N5O2S/c20-19(21)12-3-1-2-10(6-12)13-8-16-14(18-13)22-5-4-11-7-15-9-17-11/h1-3,6-9H,4-5H2,(H,15,17)(H,16,18)
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n/an/an/a 3.47n/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Histamine H3-antagonist potency on electrically stimulated guinea pig ileum


J Med Chem 40: 2571-8 (1997)


Article DOI: 10.1021/jm970070p
BindingDB Entry DOI: 10.7270/Q2W0974S
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50321467
PNG
((4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenox...)
Show SMILES Fc1ccc(Oc2ccc(cn2)C(=O)N2CCCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C21H24FN3O2/c22-17-6-8-19(9-7-17)27-20-10-5-16(15-23-20)21(26)25-12-2-11-24(13-14-25)18-3-1-4-18/h5-10,15,18H,1-4,11-14H2
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n/an/an/a 3.55n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at rat histamine H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after...


Bioorg Med Chem Lett 20: 4210-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.041
BindingDB Entry DOI: 10.7270/Q29G5NS9
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50321472
PNG
((4-cyclobutyl-1,4-diazepan-1-yl)(6-phenoxypyridin-...)
Show SMILES O=C(N1CCCN(CC1)C1CCC1)c1ccc(Oc2ccccc2)nc1
Show InChI InChI=1S/C21H25N3O2/c25-21(24-13-5-12-23(14-15-24)18-6-4-7-18)17-10-11-20(22-16-17)26-19-8-2-1-3-9-19/h1-3,8-11,16,18H,4-7,12-15H2
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n/an/an/a 3.72n/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at rat histamine H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after...


Bioorg Med Chem Lett 20: 4210-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.041
BindingDB Entry DOI: 10.7270/Q29G5NS9
More data for this
Ligand-Target Pair
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