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Compile Data Set for Download or QSAR

Found 99 hits of ec50 for UniProtKB: P47871   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))
BDBM50324724
PNG
((2S,5S,8S,11S,14S,20S,23S,25S)-2-((S)-1-((S)-1-((2...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C155H224N42O50S/c1-73(2)54-98(135(227)179-97(49-53-248-11)134(226)187-105(62-116(159)209)145(237)197-125(79(10)203)153(246)247)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(225)95(43-47-115(158)208)180-149(241)122(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-120(214)215)188-132(224)94(42-46-114(157)207)173-126(218)76(7)171-128(220)91(31-22-51-166-154(160)161)174-129(221)92(32-23-52-167-155(162)163)175-131(223)96-44-48-117(210)165-50-21-20-30-90(130(222)183-100(58-82-33-37-86(204)38-34-82)137(229)181-99(55-74(3)4)136(228)189-106(63-119(212)213)140(232)178-96)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-121(216)217)190-148(240)112(71-200)193-151(243)124(78(9)202)196-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(77(8)201)194-118(211)68-169-127(219)93(41-45-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-164-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,170)(H,165,210)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,223)(H,176,239)(H,177,238)(H,178,232)(H,179,227)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,225)(H,187,226)(H,188,224)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,211)(H,195,235)(H,196,236)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,160,161,166)(H4,162,163,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0460n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324714
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C155H227N41O50S/c1-74(2)55-99(137(228)178-98(50-54-247-11)136(227)186-106(63-117(161)208)147(238)195-124(78(8)200)127(162)218)181-141(232)105(61-85-67-167-90-30-19-18-29-89(85)90)185-135(226)96(44-48-116(160)207)179-151(242)123(76(5)6)194-145(236)103(57-81-25-14-12-15-26-81)184-143(234)108(65-121(214)215)187-131(222)91(31-20-22-51-156)172-128(219)77(7)170-130(221)93(33-24-53-166-155(163)164)173-133(224)95(43-47-115(159)206)176-134(225)97(45-49-119(210)211)177-142(233)107(64-120(212)213)188-138(229)100(56-75(3)4)180-139(230)101(59-83-34-38-87(203)39-35-83)182-132(223)92(32-21-23-52-157)174-149(240)112(71-198)191-140(231)102(60-84-36-40-88(204)41-37-84)183-144(235)109(66-122(216)217)189-150(241)113(72-199)192-153(244)126(80(10)202)196-146(237)104(58-82-27-16-13-17-28-82)190-152(243)125(79(9)201)193-118(209)69-168-129(220)94(42-46-114(158)205)175-148(239)111(70-197)171-110(154(245)246)62-86-68-165-73-169-86/h12-19,25-30,34-41,67-68,73-80,91-113,123-126,167,171,197-204H,20-24,31-33,42-66,69-72,156-157H2,1-11H3,(H2,158,205)(H2,159,206)(H2,160,207)(H2,161,208)(H2,162,218)(H,165,169)(H,168,220)(H,170,221)(H,172,219)(H,173,224)(H,174,240)(H,175,239)(H,176,225)(H,177,233)(H,178,228)(H,179,242)(H,180,230)(H,181,232)(H,182,223)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,222)(H,188,229)(H,189,241)(H,190,243)(H,191,231)(H,192,244)(H,193,209)(H,194,236)(H,195,238)(H,196,237)(H,210,211)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,163,164,166)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,123-,124-,125-,126-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0480n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324702
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C155H227N43O50S/c1-73(2)54-98(136(230)180-97(49-53-249-11)135(229)188-105(62-116(160)210)146(240)197-123(77(8)202)126(161)220)183-140(234)104(60-84-66-169-89-29-19-18-28-88(84)89)187-134(228)95(43-47-115(159)209)181-150(244)122(75(5)6)196-144(238)102(56-80-24-14-12-15-25-80)186-142(236)107(64-120(216)217)189-133(227)94(42-46-114(158)208)174-127(221)76(7)172-129(223)91(31-22-51-167-154(162)163)175-130(224)92(32-23-52-168-155(164)165)176-132(226)96(44-48-118(212)213)179-141(235)106(63-119(214)215)190-137(231)99(55-74(3)4)182-138(232)100(58-82-33-37-86(205)38-34-82)184-131(225)90(30-20-21-50-156)177-148(242)111(70-200)193-139(233)101(59-83-35-39-87(206)40-36-83)185-143(237)108(65-121(218)219)191-149(243)112(71-201)194-152(246)125(79(10)204)198-145(239)103(57-81-26-16-13-17-27-81)192-151(245)124(78(9)203)195-117(211)68-170-128(222)93(41-45-113(157)207)178-147(241)110(69-199)173-109(153(247)248)61-85-67-166-72-171-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,169,173,199-206H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,220)(H,166,171)(H,170,222)(H,172,223)(H,174,221)(H,175,224)(H,176,226)(H,177,242)(H,178,241)(H,179,235)(H,180,230)(H,181,244)(H,182,232)(H,183,234)(H,184,225)(H,185,237)(H,186,236)(H,187,228)(H,188,229)(H,189,227)(H,190,231)(H,191,243)(H,192,245)(H,193,233)(H,194,246)(H,195,211)(H,196,238)(H,197,240)(H,198,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,162,163,167)(H4,164,165,168)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0490n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324703
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C155H226N42O51S/c1-73(2)54-98(135(228)179-97(49-53-249-11)134(227)187-105(62-116(160)209)145(238)197-125(79(10)203)153(247)248)182-139(232)104(60-84-66-168-89-29-19-18-28-88(84)89)186-133(226)95(43-47-115(159)208)180-149(242)122(75(5)6)195-143(236)102(56-80-24-14-12-15-25-80)185-141(234)107(64-120(215)216)188-132(225)94(42-46-114(158)207)173-126(219)76(7)171-128(221)91(31-22-51-166-154(161)162)174-129(222)92(32-23-52-167-155(163)164)175-131(224)96(44-48-118(211)212)178-140(233)106(63-119(213)214)189-136(229)99(55-74(3)4)181-137(230)100(58-82-33-37-86(204)38-34-82)183-130(223)90(30-20-21-50-156)176-147(240)111(70-199)192-138(231)101(59-83-35-39-87(205)40-36-83)184-142(235)108(65-121(217)218)190-148(241)112(71-200)193-151(244)124(78(9)202)196-144(237)103(57-81-26-16-13-17-27-81)191-150(243)123(77(8)201)194-117(210)68-169-127(220)93(41-45-113(157)206)177-146(239)110(69-198)172-109(152(245)246)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,168,172,198-205H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,209)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,224)(H,176,240)(H,177,239)(H,178,233)(H,179,228)(H,180,242)(H,181,230)(H,182,232)(H,183,223)(H,184,235)(H,185,234)(H,186,226)(H,187,227)(H,188,225)(H,189,229)(H,190,241)(H,191,243)(H,192,231)(H,193,244)(H,194,210)(H,195,236)(H,196,237)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,245,246)(H,247,248)(H4,161,162,166)(H4,163,164,167)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0530n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324706
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C156H229N43O50S/c1-74(2)54-99(138(232)181-98(49-53-250-11)136(230)189-106(63-117(161)211)147(241)198-125(78(8)203)128(162)222)184-142(236)105(60-85-67-170-91-29-19-18-28-90(85)91)188-135(229)97(44-47-116(160)210)182-151(245)124(76(5)6)197-145(239)103(56-81-24-14-12-15-25-81)187-143(237)108(65-122(218)219)190-134(228)96(43-46-115(159)209)177-129(223)77(7)173-131(225)94(32-23-52-169-156(165)166)178-132(226)92(31-22-51-168-155(163)164)176-118(212)62-86(37-48-120(214)215)174-137(231)107(64-121(216)217)191-139(233)100(55-75(3)4)183-140(234)101(58-83-33-38-88(206)39-34-83)185-133(227)93(30-20-21-50-157)179-149(243)112(71-201)194-141(235)102(59-84-35-40-89(207)41-36-84)186-144(238)109(66-123(220)221)192-150(244)113(72-202)195-153(247)127(80(10)205)199-146(240)104(57-82-26-16-13-17-27-82)193-152(246)126(79(9)204)196-119(213)69-171-130(224)95(42-45-114(158)208)180-148(242)111(70-200)175-110(154(248)249)61-87-68-167-73-172-87/h12-19,24-29,33-36,38-41,67-68,73-80,86,92-113,124-127,170,175,200-207H,20-23,30-32,37,42-66,69-72,157H2,1-11H3,(H2,158,208)(H2,159,209)(H2,160,210)(H2,161,211)(H2,162,222)(H,167,172)(H,171,224)(H,173,225)(H,174,231)(H,176,212)(H,177,223)(H,178,226)(H,179,243)(H,180,242)(H,181,232)(H,182,245)(H,183,234)(H,184,236)(H,185,227)(H,186,238)(H,187,237)(H,188,229)(H,189,230)(H,190,228)(H,191,233)(H,192,244)(H,193,246)(H,194,235)(H,195,247)(H,196,213)(H,197,239)(H,198,241)(H,199,240)(H,214,215)(H,216,217)(H,218,219)(H,220,221)(H,248,249)(H4,163,164,168)(H4,165,166,169)/t77-,78+,79+,80+,86-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0540n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324729
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,44S)...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C153H220N36O48S/c1-15-76(6)122(149(231)166-80(10)129(211)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(223)176-101(56-74(2)3)137(219)173-100(52-55-238-14)136(218)180-108(64-116(157)199)146(228)189-125(83(13)194)153(236)237)187-144(226)105(58-84-28-18-16-19-29-84)178-135(217)99(47-51-119(202)203)171-132(214)94-35-25-27-54-159-117(200)50-46-98(134(216)170-97(45-49-115(156)198)131(213)165-78(8)127(209)164-79(9)128(210)168-94)172-142(224)109(65-120(204)205)181-138(220)102(57-75(4)5)175-139(221)103(60-86-36-40-90(195)41-37-86)177-133(215)95(34-24-26-53-154)169-147(229)112(71-190)184-140(222)104(61-87-38-42-91(196)43-39-87)179-143(225)110(66-121(206)207)182-148(230)113(72-191)185-151(233)124(82(12)193)188-145(227)106(59-85-30-20-17-21-31-85)183-150(232)123(81(11)192)186-118(201)70-162-130(212)96(44-48-114(155)197)167-126(208)77(7)67-160-111(152(234)235)63-89-69-158-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154H2,1-14H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,163)(H,159,200)(H,162,212)(H,164,209)(H,165,213)(H,166,231)(H,167,208)(H,168,210)(H,169,229)(H,170,216)(H,171,214)(H,172,224)(H,173,219)(H,174,211)(H,175,221)(H,176,223)(H,177,215)(H,178,217)(H,179,225)(H,180,218)(H,181,220)(H,182,230)(H,183,232)(H,184,222)(H,185,233)(H,186,201)(H,187,226)(H,188,227)(H,189,228)(H,202,203)(H,204,205)(H,206,207)(H,234,235)(H,236,237)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0550n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324725
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,41S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C156H228N42O49S/c1-75(2)56-100(136(227)180-99(50-55-248-11)135(226)188-107(64-117(160)209)146(237)198-126(81(10)204)154(246)247)183-140(231)106(62-86-68-169-91-31-19-18-30-90(86)91)187-134(225)97(45-48-116(159)208)181-150(241)123(77(5)6)196-144(235)104(58-82-26-14-12-15-27-82)186-142(233)109(66-121(214)215)189-131(222)92-33-21-23-52-166-118(210)49-46-98(133(224)176-95(35-25-54-168-156(163)164)130(221)175-94(34-24-53-167-155(161)162)129(220)172-78(7)127(218)174-92)179-141(232)108(65-120(212)213)190-137(228)101(57-76(3)4)182-138(229)102(60-84-36-40-88(205)41-37-84)184-132(223)93(32-20-22-51-157)177-148(239)113(72-200)193-139(230)103(61-85-38-42-89(206)43-39-85)185-143(234)110(67-122(216)217)191-149(240)114(73-201)194-152(243)125(80(9)203)197-145(236)105(59-83-28-16-13-17-29-83)192-151(242)124(79(8)202)195-119(211)70-170-128(219)96(44-47-115(158)207)178-147(238)112(71-199)173-111(153(244)245)63-87-69-165-74-171-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,169,173,199-206H,20-25,32-35,44-67,70-73,157H2,1-11H3,(H2,158,207)(H2,159,208)(H2,160,209)(H,165,171)(H,166,210)(H,170,219)(H,172,220)(H,174,218)(H,175,221)(H,176,224)(H,177,239)(H,178,238)(H,179,232)(H,180,227)(H,181,241)(H,182,229)(H,183,231)(H,184,223)(H,185,234)(H,186,233)(H,187,225)(H,188,226)(H,189,222)(H,190,228)(H,191,240)(H,192,242)(H,193,230)(H,194,243)(H,195,211)(H,196,235)(H,197,236)(H,198,237)(H,212,213)(H,214,215)(H,216,217)(H,244,245)(H,246,247)(H4,161,162,167)(H4,163,164,168)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0580n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266693
PNG
(CHEBI:5391 | GLUCAGON | Glucagen Hypokit | Glucago...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.0600n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 5 hrs by luciferase reporter gene assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324716
PNG
((2S,4S,7S,13S,16S,19S,22S,25S,28S,31S,34S,37S,40S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C157H233N43O49S/c1-76(2)58-102(139(232)183-101(52-57-250-11)138(231)191-109(66-118(162)211)148(241)199-125(80(8)204)128(163)221)186-143(236)108(64-87-69-171-92-31-19-18-30-91(87)92)190-136(229)98(45-49-117(161)210)184-152(245)124(78(5)6)198-146(239)106(60-83-26-14-12-15-27-83)188-137(230)100(47-51-121(215)216)181-132(225)93(32-20-22-53-158)176-129(222)79(7)174-131(224)95(34-24-55-169-156(164)165)177-133(226)96(35-25-56-170-157(166)167)178-135(228)99(46-50-120(213)214)182-144(237)110(67-122(217)218)192-140(233)103(59-77(3)4)185-141(234)104(62-85-36-40-89(207)41-37-85)187-134(227)94(33-21-23-54-159)179-150(243)114(73-202)195-142(235)105(63-86-38-42-90(208)43-39-86)189-145(238)111(68-123(219)220)193-151(244)115(74-203)196-154(247)127(82(10)206)200-147(240)107(61-84-28-16-13-17-29-84)194-153(246)126(81(9)205)197-119(212)71-172-130(223)97(44-48-116(160)209)180-149(242)113(72-201)175-112(155(248)249)65-88-70-168-75-173-88/h12-19,26-31,36-43,69-70,75-82,93-115,124-127,171,175,201-208H,20-25,32-35,44-68,71-74,158-159H2,1-11H3,(H2,160,209)(H2,161,210)(H2,162,211)(H2,163,221)(H,168,173)(H,172,223)(H,174,224)(H,176,222)(H,177,226)(H,178,228)(H,179,243)(H,180,242)(H,181,225)(H,182,237)(H,183,232)(H,184,245)(H,185,234)(H,186,236)(H,187,227)(H,188,230)(H,189,238)(H,190,229)(H,191,231)(H,192,233)(H,193,244)(H,194,246)(H,195,235)(H,196,247)(H,197,212)(H,198,239)(H,199,241)(H,200,240)(H,213,214)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,164,165,169)(H4,166,167,170)/t79-,80+,81+,82+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,124-,125-,126-,127-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0680n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324713
PNG
(CHEMBL1222087 | HSQGTFTSDYSKYLDEQAAKEFIAWLMNT)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C152H220N36O50S/c1-14-75(6)121(148(232)164-78(9)127(211)173-105(61-86-66-159-91-32-22-21-31-90(86)91)139(223)175-99(55-73(2)3)135(219)172-98(51-54-239-13)134(218)179-106(63-115(157)199)144(228)188-124(81(12)194)152(237)238)186-142(226)103(57-82-27-17-15-18-28-82)177-133(217)97(46-50-118(203)204)170-130(214)92(33-23-25-52-153)166-126(210)77(8)162-125(209)76(7)163-129(213)95(44-48-114(156)198)169-132(216)96(45-49-117(201)202)171-140(224)107(64-119(205)206)180-136(220)100(56-74(4)5)174-137(221)101(59-84-35-39-88(195)40-36-84)176-131(215)93(34-24-26-53-154)167-146(230)111(70-190)183-138(222)102(60-85-37-41-89(196)42-38-85)178-141(225)108(65-120(207)208)181-147(231)112(71-191)184-150(234)123(80(11)193)187-143(227)104(58-83-29-19-16-20-30-83)182-149(233)122(79(10)192)185-116(200)68-160-128(212)94(43-47-113(155)197)168-145(229)110(69-189)165-109(151(235)236)62-87-67-158-72-161-87/h15-22,27-32,35-42,66-67,72-81,92-112,121-124,159,165,189-196H,14,23-26,33-34,43-65,68-71,153-154H2,1-13H3,(H2,155,197)(H2,156,198)(H2,157,199)(H,158,161)(H,160,212)(H,162,209)(H,163,213)(H,164,232)(H,166,210)(H,167,230)(H,168,229)(H,169,216)(H,170,214)(H,171,224)(H,172,219)(H,173,211)(H,174,221)(H,175,223)(H,176,215)(H,177,217)(H,178,225)(H,179,218)(H,180,220)(H,181,231)(H,182,233)(H,183,222)(H,184,234)(H,185,200)(H,186,226)(H,187,227)(H,188,228)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t75-,76-,77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0680n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324708
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C154H225N43O50S/c1-72(2)52-96(134(228)178-95(47-51-248-11)133(227)186-103(60-115(159)209)145(239)196-122(76(8)201)125(160)219)181-138(232)102(58-83-65-168-88-29-19-18-28-87(83)88)185-132(226)94(43-46-114(158)208)179-149(243)121(74(5)6)195-143(237)100(54-79-24-14-12-15-25-79)184-140(234)105(62-118(213)214)187-131(225)93(42-45-113(157)207)173-126(220)75(7)171-128(222)90(31-22-49-166-153(161)162)174-129(223)91(32-23-50-167-154(163)164)175-139(233)104(61-117(211)212)189-142(236)106(63-119(215)216)188-135(229)97(53-73(3)4)180-136(230)98(56-81-33-37-85(204)38-34-81)182-130(224)89(30-20-21-48-155)176-147(241)110(69-199)192-137(231)99(57-82-35-39-86(205)40-36-82)183-141(235)107(64-120(217)218)190-148(242)111(70-200)193-151(245)124(78(10)203)197-144(238)101(55-80-26-16-13-17-27-80)191-150(244)123(77(9)202)194-116(210)67-169-127(221)92(41-44-112(156)206)177-146(240)109(68-198)172-108(152(246)247)59-84-66-165-71-170-84/h12-19,24-29,33-40,65-66,71-78,89-111,121-124,168,172,198-205H,20-23,30-32,41-64,67-70,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,219)(H,165,170)(H,169,221)(H,171,222)(H,173,220)(H,174,223)(H,175,233)(H,176,241)(H,177,240)(H,178,228)(H,179,243)(H,180,230)(H,181,232)(H,182,224)(H,183,235)(H,184,234)(H,185,226)(H,186,227)(H,187,225)(H,188,229)(H,189,236)(H,190,242)(H,191,244)(H,192,231)(H,193,245)(H,194,210)(H,195,237)(H,196,239)(H,197,238)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,246,247)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0680n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0710n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324705
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C155H228N44O49S/c1-73(2)54-98(136(230)181-97(49-53-249-11)135(229)189-105(62-117(161)212)146(240)198-123(77(8)203)126(162)220)184-140(234)104(60-84-66-170-89-29-19-18-28-88(84)89)188-134(228)96(44-48-116(160)211)182-150(244)122(75(5)6)197-144(238)102(56-80-24-14-12-15-25-80)187-142(236)107(64-120(216)217)190-133(227)94(42-46-114(158)209)175-127(221)76(7)173-129(223)91(31-22-51-168-154(163)164)176-130(224)92(32-23-52-169-155(165)166)177-132(226)95(43-47-115(159)210)180-141(235)106(63-119(214)215)191-137(231)99(55-74(3)4)183-138(232)100(58-82-33-37-86(206)38-34-82)185-131(225)90(30-20-21-50-156)178-148(242)111(70-201)194-139(233)101(59-83-35-39-87(207)40-36-83)186-143(237)108(65-121(218)219)192-149(243)112(71-202)195-152(246)125(79(10)205)199-145(239)103(57-81-26-16-13-17-27-81)193-151(245)124(78(9)204)196-118(213)68-171-128(222)93(41-45-113(157)208)179-147(241)110(69-200)174-109(153(247)248)61-85-67-167-72-172-85/h12-19,24-29,33-40,66-67,72-79,90-112,122-125,170,174,200-207H,20-23,30-32,41-65,68-71,156H2,1-11H3,(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,211)(H2,161,212)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,226)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,225)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,227)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,213)(H,197,238)(H,198,240)(H,199,239)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0710n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324717
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C161H240N44O51S/c1-13-79(6)126(155(251)187-100(47-50-119(165)216)139(235)193-109(64-89-70-175-94-33-21-20-32-93(89)94)145(241)189-103(58-77(2)3)141(237)186-102(52-57-257-12)140(236)194-110(66-120(166)217)151(247)205-130(84(11)212)158(254)203-127(81(8)209)131(167)227)202-149(245)107(60-85-28-16-14-17-29-85)192-147(243)112(68-124(223)224)195-136(232)95(34-22-24-53-162)180-132(228)80(7)178-134(230)97(36-26-55-173-160(168)169)181-135(231)98(37-27-56-174-161(170)171)182-138(234)101(48-51-122(219)220)185-146(242)111(67-123(221)222)196-142(238)104(59-78(4)5)188-143(239)105(62-87-38-42-91(213)43-39-87)190-137(233)96(35-23-25-54-163)183-153(249)116(74-207)199-144(240)106(63-88-40-44-92(214)45-41-88)191-148(244)113(69-125(225)226)197-154(250)117(75-208)200-157(253)129(83(10)211)204-150(246)108(61-86-30-18-15-19-31-86)198-156(252)128(82(9)210)201-121(218)72-176-133(229)99(46-49-118(164)215)184-152(248)115(73-206)179-114(159(255)256)65-90-71-172-76-177-90/h14-21,28-33,38-45,70-71,76-84,95-117,126-130,175,179,206-214H,13,22-27,34-37,46-69,72-75,162-163H2,1-12H3,(H2,164,215)(H2,165,216)(H2,166,217)(H2,167,227)(H,172,177)(H,176,229)(H,178,230)(H,180,228)(H,181,231)(H,182,234)(H,183,249)(H,184,248)(H,185,242)(H,186,237)(H,187,251)(H,188,239)(H,189,241)(H,190,233)(H,191,244)(H,192,243)(H,193,235)(H,194,236)(H,195,232)(H,196,238)(H,197,250)(H,198,252)(H,199,240)(H,200,253)(H,201,218)(H,202,245)(H,203,254)(H,204,246)(H,205,247)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,255,256)(H4,168,169,173)(H4,170,171,174)/t79-,80-,81+,82+,83+,84+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,126-,127-,128-,129-,130-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0730n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324727
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C
Show InChI InChI=1/C155H227N41O49S/c1-75(2)56-100-135(225)178-99(50-55-246-11)133(223)173-93(134(224)196-125(81(10)203)153(244)245)33-21-23-52-164-117(208)49-46-98(132(222)185-106(139(229)181-100)62-86-67-167-91-31-19-18-30-90(86)91)179-149(239)122(77(5)6)194-143(233)104(58-82-26-14-12-15-27-82)184-140(230)107(64-119(210)211)186-131(221)97(45-48-116(158)207)172-126(216)78(7)170-128(218)94(34-24-53-165-154(159)160)174-129(219)95(35-25-54-166-155(161)162)176-147(237)113(72-199)191-142(232)109(66-121(214)215)187-136(226)101(57-76(3)4)180-137(227)102(60-84-36-40-88(204)41-37-84)182-130(220)92(32-20-22-51-156)175-146(236)112(71-198)190-138(228)103(61-85-38-42-89(205)43-39-85)183-141(231)108(65-120(212)213)188-148(238)114(73-200)192-151(241)124(80(9)202)195-144(234)105(59-83-28-16-13-17-29-83)189-150(240)123(79(8)201)193-118(209)69-168-127(217)96(44-47-115(157)206)177-145(235)111(70-197)171-110(152(242)243)63-87-68-163-74-169-87/h12-19,26-31,36-43,67-68,74-81,92-114,122-125,167,171,197-205H,20-25,32-35,44-66,69-73,156H2,1-11H3,(H2,157,206)(H2,158,207)(H,163,169)(H,164,208)(H,168,217)(H,170,218)(H,172,216)(H,173,223)(H,174,219)(H,175,236)(H,176,237)(H,177,235)(H,178,225)(H,179,239)(H,180,227)(H,181,229)(H,182,220)(H,183,231)(H,184,230)(H,185,222)(H,186,221)(H,187,226)(H,188,238)(H,189,240)(H,190,228)(H,191,232)(H,192,241)(H,193,209)(H,194,233)(H,195,234)(H,196,224)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H,244,245)(H4,159,160,165)(H4,161,162,166)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0760n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324711
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C156H231N43O49S/c1-75(2)56-100(137(230)181-99(50-55-249-11)136(229)189-107(64-117(161)210)147(240)198-124(79(8)203)127(162)220)184-141(234)106(62-86-68-170-91-31-19-18-30-90(86)91)188-135(228)97(45-48-116(160)209)182-151(244)123(77(5)6)197-145(238)104(58-82-26-14-12-15-27-82)187-143(236)109(66-121(216)217)190-132(225)92(32-20-22-51-157)175-128(221)78(7)173-130(223)94(34-24-53-168-155(163)164)176-131(224)95(35-25-54-169-156(165)166)177-134(227)98(46-49-119(212)213)180-142(235)108(65-120(214)215)191-138(231)101(57-76(3)4)183-139(232)102(60-84-36-40-88(206)41-37-84)185-133(226)93(33-21-23-52-158)178-149(242)113(72-201)194-140(233)103(61-85-38-42-89(207)43-39-85)186-144(237)110(67-122(218)219)192-150(243)114(73-202)195-153(246)126(81(10)205)199-146(239)105(59-83-28-16-13-17-29-83)193-152(245)125(80(9)204)196-118(211)70-171-129(222)96(44-47-115(159)208)179-148(241)112(71-200)174-111(154(247)248)63-87-69-167-74-172-87/h12-19,26-31,36-43,68-69,74-81,92-114,123-126,170,174,200-207H,20-25,32-35,44-67,70-73,157-158H2,1-11H3,(H2,159,208)(H2,160,209)(H2,161,210)(H2,162,220)(H,167,172)(H,171,222)(H,173,223)(H,175,221)(H,176,224)(H,177,227)(H,178,242)(H,179,241)(H,180,235)(H,181,230)(H,182,244)(H,183,232)(H,184,234)(H,185,226)(H,186,237)(H,187,236)(H,188,228)(H,189,229)(H,190,225)(H,191,231)(H,192,243)(H,193,245)(H,194,233)(H,195,246)(H,196,211)(H,197,238)(H,198,240)(H,199,239)(H,212,213)(H,214,215)(H,216,217)(H,218,219)(H,247,248)(H4,163,164,168)(H4,165,166,169)/t78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0770n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324726
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,38S,41S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc2cnc[nH]2)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C154H225N41O49S/c1-74(2)54-98(133(223)176-97(48-53-245-11)132(222)184-105(62-115(157)206)143(233)195-124(80(10)202)152(243)244)179-137(227)104(60-85-66-166-90-31-19-18-30-89(85)90)183-131(221)96-45-47-116(207)163-50-23-21-33-91(129(219)185-106(63-118(209)210)138(228)182-102(56-81-26-14-12-15-27-81)141(231)193-121(76(5)6)148(238)177-96)171-125(215)77(7)169-127(217)93(34-24-51-164-153(158)159)172-128(218)94(35-25-52-165-154(160)161)174-146(236)112(71-198)190-140(230)108(65-120(213)214)186-134(224)99(55-75(3)4)178-135(225)100(58-83-36-40-87(203)41-37-83)180-130(220)92(32-20-22-49-155)173-145(235)111(70-197)189-136(226)101(59-84-38-42-88(204)43-39-84)181-139(229)107(64-119(211)212)187-147(237)113(72-199)191-150(240)123(79(9)201)194-142(232)103(57-82-28-16-13-17-29-82)188-149(239)122(78(8)200)192-117(208)68-167-126(216)95(44-46-114(156)205)175-144(234)110(69-196)170-109(151(241)242)61-86-67-162-73-168-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,166,170,196-204H,20-25,32-35,44-65,68-72,155H2,1-11H3,(H2,156,205)(H2,157,206)(H,162,168)(H,163,207)(H,167,216)(H,169,217)(H,171,215)(H,172,218)(H,173,235)(H,174,236)(H,175,234)(H,176,223)(H,177,238)(H,178,225)(H,179,227)(H,180,220)(H,181,229)(H,182,228)(H,183,221)(H,184,222)(H,185,219)(H,186,224)(H,187,237)(H,188,239)(H,189,226)(H,190,230)(H,191,240)(H,192,208)(H,193,231)(H,194,232)(H,195,233)(H,209,210)(H,211,212)(H,213,214)(H,241,242)(H,243,244)(H4,158,159,164)(H4,160,161,165)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0780n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324718
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C154H228N42O48S/c1-74(2)55-99(135(226)179-98(49-54-245-12)134(225)186-106(63-115(158)206)145(236)195-122(79(9)200)125(159)216)182-139(230)105(61-86-67-167-91-32-20-19-31-90(86)91)180-127(218)78(8)171-149(240)121(76(5)6)194-143(234)103(57-82-27-15-13-16-28-82)185-141(232)108(65-119(212)213)187-131(222)92(33-21-23-50-155)173-126(217)77(7)170-129(220)94(35-25-52-165-153(160)161)174-130(221)95(36-26-53-166-154(162)163)175-133(224)97(46-48-117(208)209)178-140(231)107(64-118(210)211)188-136(227)100(56-75(3)4)181-137(228)101(59-84-37-41-88(203)42-38-84)183-132(223)93(34-22-24-51-156)176-147(238)112(71-198)191-138(229)102(60-85-39-43-89(204)44-40-85)184-142(233)109(66-120(214)215)189-148(239)113(72-199)192-151(242)124(81(11)202)196-144(235)104(58-83-29-17-14-18-30-83)190-150(241)123(80(10)201)193-116(207)69-168-128(219)96(45-47-114(157)205)177-146(237)111(70-197)172-110(152(243)244)62-87-68-164-73-169-87/h13-20,27-32,37-44,67-68,73-81,92-113,121-124,167,172,197-204H,21-26,33-36,45-66,69-72,155-156H2,1-12H3,(H2,157,205)(H2,158,206)(H2,159,216)(H,164,169)(H,168,219)(H,170,220)(H,171,240)(H,173,217)(H,174,221)(H,175,224)(H,176,238)(H,177,237)(H,178,231)(H,179,226)(H,180,218)(H,181,228)(H,182,230)(H,183,223)(H,184,233)(H,185,232)(H,186,225)(H,187,222)(H,188,227)(H,189,239)(H,190,241)(H,191,229)(H,192,242)(H,193,207)(H,194,234)(H,195,236)(H,196,235)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H,243,244)(H4,160,161,165)(H4,162,163,166)/t77-,78-,79+,80+,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0800n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324715
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C153H224N40O49S/c1-73(2)54-98(135(224)175-97(49-53-243-12)134(223)183-105(62-115(158)204)145(234)192-122(78(9)197)125(159)214)178-139(228)104(60-85-66-164-90-31-20-19-30-89(85)90)182-133(222)95(44-47-114(157)203)176-149(238)121(75(5)6)191-143(232)102(56-81-26-15-13-16-27-81)181-141(230)107(64-119(210)211)184-130(219)91(32-21-23-50-154)170-127(216)77(8)167-126(215)76(7)168-129(218)93(34-25-52-163-153(160)161)171-132(221)96(45-48-117(206)207)174-140(229)106(63-118(208)209)185-136(225)99(55-74(3)4)177-137(226)100(58-83-35-39-87(200)40-36-83)179-131(220)92(33-22-24-51-155)172-147(236)111(70-195)188-138(227)101(59-84-37-41-88(201)42-38-84)180-142(231)108(65-120(212)213)186-148(237)112(71-196)189-151(240)124(80(11)199)193-144(233)103(57-82-28-17-14-18-29-82)187-150(239)123(79(10)198)190-116(205)68-165-128(217)94(43-46-113(156)202)173-146(235)110(69-194)169-109(152(241)242)61-86-67-162-72-166-86/h13-20,26-31,35-42,66-67,72-80,91-112,121-124,164,169,194-201H,21-25,32-34,43-65,68-71,154-155H2,1-12H3,(H2,156,202)(H2,157,203)(H2,158,204)(H2,159,214)(H,162,166)(H,165,217)(H,167,215)(H,168,218)(H,170,216)(H,171,221)(H,172,236)(H,173,235)(H,174,229)(H,175,224)(H,176,238)(H,177,226)(H,178,228)(H,179,220)(H,180,231)(H,181,230)(H,182,222)(H,183,223)(H,184,219)(H,185,225)(H,186,237)(H,187,239)(H,188,227)(H,189,240)(H,190,205)(H,191,232)(H,192,234)(H,193,233)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,160,161,163)/t76-,77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0870n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324707
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCS(O)(=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C154H227N43O51S2/c1-73(2)54-98(135(227)178-96(47-52-249-11)133(225)187-105(62-116(159)209)145(237)196-122(77(8)201)125(160)217)182-139(231)104(60-84-66-168-89-29-19-18-28-88(84)89)186-132(224)95(43-46-115(158)208)180-149(241)121(75(5)6)195-143(235)102(56-80-24-14-12-15-25-80)185-141(233)107(64-119(213)214)188-131(223)94(42-45-114(157)207)173-126(218)76(7)171-128(220)91(31-22-50-166-153(161)162)174-129(221)92(32-23-51-167-154(163)164)175-134(226)97(48-53-250(246,247)248)179-140(232)106(63-118(211)212)189-136(228)99(55-74(3)4)181-137(229)100(58-82-33-37-86(204)38-34-82)183-130(222)90(30-20-21-49-155)176-147(239)111(70-199)192-138(230)101(59-83-35-39-87(205)40-36-83)184-142(234)108(65-120(215)216)190-148(240)112(71-200)193-151(243)124(79(10)203)197-144(236)103(57-81-26-16-13-17-27-81)191-150(242)123(78(9)202)194-117(210)68-169-127(219)93(41-44-113(156)206)177-146(238)110(69-198)172-109(152(244)245)61-85-67-165-72-170-85/h12-19,24-29,33-40,66-67,72-79,90-112,121-124,168,172,198-205H,20-23,30-32,41-65,68-71,155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,226)(H,176,239)(H,177,238)(H,178,227)(H,179,232)(H,180,241)(H,181,229)(H,182,231)(H,183,222)(H,184,234)(H,185,233)(H,186,224)(H,187,225)(H,188,223)(H,189,228)(H,190,240)(H,191,242)(H,192,230)(H,193,243)(H,194,210)(H,195,235)(H,196,237)(H,197,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)(H,246,247,248)/t76-,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324704
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C156H227N45O48S/c1-74(2)52-99(136(230)182-98(47-51-250-11)135(229)191-107(61-118(161)213)147(241)200-124(78(8)205)127(162)221)185-140(234)105(58-85-65-171-91-29-19-18-28-90(85)91)189-134(228)97(43-46-117(160)212)183-151(245)123(76(5)6)199-145(239)103(54-81-24-14-12-15-25-81)188-142(236)108(62-120(215)216)192-133(227)96(42-45-116(159)211)177-128(222)77(7)175-130(224)93(31-22-49-169-155(163)164)178-131(225)94(32-23-50-170-156(165)166)179-141(235)106(59-86-66-167-72-173-86)190-144(238)109(63-121(217)218)193-137(231)100(53-75(3)4)184-138(232)101(56-83-33-37-88(208)38-34-83)186-132(226)92(30-20-21-48-157)180-149(243)113(70-203)196-139(233)102(57-84-35-39-89(209)40-36-84)187-143(237)110(64-122(219)220)194-150(244)114(71-204)197-153(247)126(80(10)207)201-146(240)104(55-82-26-16-13-17-27-82)195-152(246)125(79(9)206)198-119(214)68-172-129(223)95(41-44-115(158)210)181-148(242)112(69-202)176-111(154(248)249)60-87-67-168-73-174-87/h12-19,24-29,33-40,65-67,72-80,92-114,123-126,171,176,202-209H,20-23,30-32,41-64,68-71,157H2,1-11H3,(H2,158,210)(H2,159,211)(H2,160,212)(H2,161,213)(H2,162,221)(H,167,173)(H,168,174)(H,172,223)(H,175,224)(H,177,222)(H,178,225)(H,179,235)(H,180,243)(H,181,242)(H,182,230)(H,183,245)(H,184,232)(H,185,234)(H,186,226)(H,187,237)(H,188,236)(H,189,228)(H,190,238)(H,191,229)(H,192,227)(H,193,231)(H,194,244)(H,195,246)(H,196,233)(H,197,247)(H,198,214)(H,199,239)(H,200,241)(H,201,240)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,163,164,169)(H4,165,166,170)/t77-,78+,79+,80+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,123-,124-,125-,126-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.100n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324723
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C154H229N43O48S/c1-74(2)54-98(134(226)178-97(48-53-246-11)133(225)186-105(62-116(159)209)144(236)196-122(78(8)202)125(160)217)181-138(230)104(60-85-66-168-90-31-19-18-30-89(85)90)185-132(224)96(45-47-115(158)208)179-149(241)121(76(5)6)195-142(234)102(56-81-26-14-12-15-27-81)184-139(231)106(63-118(211)212)187-130(222)91(32-20-22-49-155)173-126(218)77(7)171-128(220)93(34-24-51-166-153(161)162)174-129(221)94(35-25-52-167-154(163)164)176-147(239)112(71-200)192-141(233)108(65-120(215)216)188-135(227)99(55-75(3)4)180-136(228)100(58-83-36-40-87(205)41-37-83)182-131(223)92(33-21-23-50-156)175-146(238)111(70-199)191-137(229)101(59-84-38-42-88(206)43-39-84)183-140(232)107(64-119(213)214)189-148(240)113(72-201)193-151(243)124(80(10)204)197-143(235)103(57-82-28-16-13-17-29-82)190-150(242)123(79(9)203)194-117(210)68-169-127(219)95(44-46-114(157)207)177-145(237)110(69-198)172-109(152(244)245)61-86-67-165-73-170-86/h12-19,26-31,36-43,66-67,73-80,91-113,121-124,168,172,198-206H,20-25,32-35,44-65,68-72,155-156H2,1-11H3,(H2,157,207)(H2,158,208)(H2,159,209)(H2,160,217)(H,165,170)(H,169,219)(H,171,220)(H,173,218)(H,174,221)(H,175,238)(H,176,239)(H,177,237)(H,178,226)(H,179,241)(H,180,228)(H,181,230)(H,182,223)(H,183,232)(H,184,231)(H,185,224)(H,186,225)(H,187,222)(H,188,227)(H,189,240)(H,190,242)(H,191,229)(H,192,233)(H,193,243)(H,194,210)(H,195,234)(H,196,236)(H,197,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,161,162,166)(H4,163,164,167)/t77-,78+,79+,80+,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.120n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266695
PNG
(CHEMBL4098991)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1/C189H280N54O61S/c1-90(2)65-116(163(280)216-115(56-64-305-12)162(279)224-123(73-141(195)259)173(290)238-149(95(9)251)181(298)207-81-144(262)240-60-25-38-134(240)179(296)234-132(87-249)178(295)231-128(83-245)156(273)206-79-142(260)209-94(8)185(302)242-62-27-40-136(242)187(304)243-63-28-41-137(243)186(303)241-61-26-39-135(241)180(297)229-127(82-244)152(196)269)219-167(284)122(71-102-77-204-108-34-20-19-33-106(102)108)223-161(278)114(52-55-140(194)258)217-182(299)148(92(5)6)237-171(288)120(67-98-29-15-13-16-30-98)222-168(285)124(74-145(263)264)225-160(277)113(51-54-139(193)257)211-153(270)93(7)210-157(274)110(36-23-58-202-188(197)198)212-158(275)111(37-24-59-203-189(199)200)214-176(293)131(86-248)233-170(287)126(76-147(267)268)226-164(281)117(66-91(3)4)218-165(282)118(69-100-42-46-104(254)47-43-100)220-159(276)109(35-21-22-57-190)213-175(292)130(85-247)232-166(283)119(70-101-44-48-105(255)49-45-101)221-169(286)125(75-146(265)266)227-177(294)133(88-250)235-184(301)151(97(11)253)239-172(289)121(68-99-31-17-14-18-32-99)228-183(300)150(96(10)252)236-143(261)80-205-155(272)112(50-53-138(192)256)215-174(291)129(84-246)230-154(271)107(191)72-103-78-201-89-208-103/h13-20,29-34,42-49,77-78,89-97,107,109-137,148-151,204,244-255H,21-28,35-41,50-76,79-88,190-191H2,1-12H3,(H2,192,256)(H2,193,257)(H2,194,258)(H2,195,259)(H2,196,269)(H,201,208)(H,205,272)(H,206,273)(H,207,298)(H,209,260)(H,210,274)(H,211,270)(H,212,275)(H,213,292)(H,214,293)(H,215,291)(H,216,280)(H,217,299)(H,218,282)(H,219,284)(H,220,276)(H,221,286)(H,222,285)(H,223,278)(H,224,279)(H,225,277)(H,226,281)(H,227,294)(H,228,300)(H,229,297)(H,230,271)(H,231,295)(H,232,283)(H,233,287)(H,234,296)(H,235,301)(H,236,261)(H,237,288)(H,238,290)(H,239,289)(H,263,264)(H,265,266)(H,267,268)(H4,197,198,202)(H4,199,200,203)/t93-,94-,95+,96+,97+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,148-,149-,150-,151-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.120n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 5 hrs by luciferase reporter gene assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324709
PNG
((2S,5S,8S,11S,14S,20S,23S,26S,29S,32S,35S,38S,41S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C152H223N43O48S/c1-72(2)52-96(134(226)177-95(47-51-244-11)133(225)185-103(60-114(157)207)143(235)194-121(76(8)199)124(158)216)180-138(230)102(58-83-64-166-88-29-19-18-28-87(83)88)184-132(224)94(43-46-113(156)206)178-147(239)120(74(5)6)193-141(233)100(54-79-24-14-12-15-25-79)183-139(231)105(62-118(212)213)187-131(223)93(42-45-112(155)205)173-125(217)75(7)170-128(220)91(32-23-50-165-152(161)162)174-129(221)89(31-22-49-164-151(159)160)172-115(208)66-168-127(219)104(61-117(210)211)186-135(227)97(53-73(3)4)179-136(228)98(56-81-33-37-85(202)38-34-81)181-130(222)90(30-20-21-48-153)175-145(237)109(69-197)190-137(229)99(57-82-35-39-86(203)40-36-82)182-140(232)106(63-119(214)215)188-146(238)110(70-198)191-149(241)123(78(10)201)195-142(234)101(55-80-26-16-13-17-27-80)189-148(240)122(77(9)200)192-116(209)67-167-126(218)92(41-44-111(154)204)176-144(236)108(68-196)171-107(150(242)243)59-84-65-163-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-110,120-123,166,171,196-203H,20-23,30-32,41-63,66-70,153H2,1-11H3,(H2,154,204)(H2,155,205)(H2,156,206)(H2,157,207)(H2,158,216)(H,163,169)(H,167,218)(H,168,219)(H,170,220)(H,172,208)(H,173,217)(H,174,221)(H,175,237)(H,176,236)(H,177,226)(H,178,239)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,227)(H,187,223)(H,188,238)(H,189,240)(H,190,229)(H,191,241)(H,192,209)(H,193,233)(H,194,235)(H,195,234)(H,210,211)(H,212,213)(H,214,215)(H,242,243)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,120-,121-,122-,123-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.130n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324710
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C154H227N43O49S/c1-72(2)53-97(134(227)177-96(48-52-247-12)133(226)186-104(61-115(159)210)143(236)195-121(76(8)201)125(160)218)181-138(231)103(59-84-65-168-89-30-20-19-29-88(84)89)185-132(225)95(44-47-114(158)209)179-148(241)120(74(5)6)194-141(234)101(55-80-25-15-13-16-26-80)184-139(232)105(62-117(212)213)187-131(224)94(43-46-113(157)208)173-126(219)75(7)171-128(221)91(32-23-50-166-153(161)162)174-129(222)92(33-24-51-167-154(163)164)178-150(243)123(78(10)203)197-144(237)107(64-119(216)217)188-135(228)98(54-73(3)4)180-136(229)99(57-82-34-38-86(205)39-35-82)182-130(223)90(31-21-22-49-155)175-146(239)110(69-199)191-137(230)100(58-83-36-40-87(206)41-37-83)183-140(233)106(63-118(214)215)189-147(240)111(70-200)192-151(244)124(79(11)204)196-142(235)102(56-81-27-17-14-18-28-81)190-149(242)122(77(9)202)193-116(211)67-169-127(220)93(42-45-112(156)207)176-145(238)109(68-198)172-108(152(245)246)60-85-66-165-71-170-85/h13-20,25-30,34-41,65-66,71-79,90-111,120-124,168,172,198-206H,21-24,31-33,42-64,67-70,155H2,1-12H3,(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,210)(H2,160,218)(H,165,170)(H,169,220)(H,171,221)(H,173,219)(H,174,222)(H,175,239)(H,176,238)(H,177,227)(H,178,243)(H,179,241)(H,180,229)(H,181,231)(H,182,223)(H,183,233)(H,184,232)(H,185,225)(H,186,226)(H,187,224)(H,188,228)(H,189,240)(H,190,242)(H,191,230)(H,192,244)(H,193,211)(H,194,234)(H,195,236)(H,196,235)(H,197,237)(H,212,213)(H,214,215)(H,216,217)(H,245,246)(H4,161,162,166)(H4,163,164,167)/t75-,76+,77+,78+,79+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.130n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324732
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C153H225N43O49S/c1-72(2)52-96(133(226)177-95(47-51-246-11)132(225)185-103(60-115(158)209)143(236)195-121(76(8)201)124(159)217)180-137(230)102(58-83-64-167-88-29-19-18-28-87(83)88)184-131(224)94(43-46-114(157)208)178-148(241)120(74(5)6)194-141(234)100(54-79-24-14-12-15-25-79)183-138(231)104(61-117(211)212)186-130(223)93(42-45-113(156)207)172-125(218)75(7)170-127(220)90(31-22-49-165-152(160)161)173-128(221)91(32-23-50-166-153(162)163)175-146(239)110(69-199)191-140(233)106(63-119(215)216)187-134(227)97(53-73(3)4)179-135(228)98(56-81-33-37-85(204)38-34-81)181-129(222)89(30-20-21-48-154)174-145(238)109(68-198)190-136(229)99(57-82-35-39-86(205)40-36-82)182-139(232)105(62-118(213)214)188-147(240)111(70-200)192-150(243)123(78(10)203)196-142(235)101(55-80-26-16-13-17-27-80)189-149(242)122(77(9)202)193-116(210)66-168-126(219)92(41-44-112(155)206)176-144(237)108(67-197)171-107(151(244)245)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,89-111,120-123,167,171,197-205H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,206)(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,217)(H,164,169)(H,168,219)(H,170,220)(H,172,218)(H,173,221)(H,174,238)(H,175,239)(H,176,237)(H,177,226)(H,178,241)(H,179,228)(H,180,230)(H,181,222)(H,182,232)(H,183,231)(H,184,224)(H,185,225)(H,186,223)(H,187,227)(H,188,240)(H,189,242)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,236)(H,196,235)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.150n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266693
PNG
(CHEBI:5391 | GLUCAGON | Glucagen Hypokit | Glucago...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.400n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50277056
PNG
(CHEMBL4163714)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C152H226N44O46S2/c1-72(2)52-97(133(225)176-96(47-51-244-11)132(224)184-104(60-115(158)209)142(234)195-120(76(8)201)123(159)215)179-137(229)103(58-83-63-167-89-29-19-18-28-87(83)89)183-131(223)95(43-46-114(157)208)177-148(240)119(74(5)6)194-140(232)101(54-79-24-14-12-15-25-79)182-138(230)105(61-117(211)212)185-130(222)94(42-45-113(156)207)171-124(216)75(7)170-127(219)91(31-22-49-165-151(160)161)172-128(220)92(32-23-50-166-152(162)163)174-145(237)109(68-199)190-147(239)111(70-243)192-134(226)98(53-73(3)4)178-135(227)99(56-81-33-37-85(204)38-34-81)180-129(221)90(30-20-21-48-153)173-144(236)108(67-198)189-136(228)100(57-82-35-39-86(205)40-36-82)181-139(231)106(62-118(213)214)186-146(238)110(69-200)191-150(242)122(78(10)203)196-141(233)102(55-80-26-16-13-17-27-80)187-149(241)121(77(9)202)193-116(210)65-168-126(218)93(41-44-112(155)206)175-143(235)107(66-197)188-125(217)88(154)59-84-64-164-71-169-84/h12-19,24-29,33-40,63-64,71-78,88,90-111,119-122,167,197-205,243H,20-23,30-32,41-62,65-70,153-154H2,1-11H3,(H2,155,206)(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,215)(H,164,169)(H,168,218)(H,170,219)(H,171,216)(H,172,220)(H,173,236)(H,174,237)(H,175,235)(H,176,225)(H,177,240)(H,178,227)(H,179,229)(H,180,221)(H,181,231)(H,182,230)(H,183,223)(H,184,224)(H,185,222)(H,186,238)(H,187,241)(H,188,217)(H,189,228)(H,190,239)(H,191,242)(H,192,226)(H,193,210)(H,194,232)(H,195,234)(H,196,233)(H,211,212)(H,213,214)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,119-,120-,121-,122-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.460n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324712
PNG
(CHEMBL1222086 | HSQGTFTSDYSKYLDEQAAKEFIAWLVKG)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(O)=O
Show InChI InChI=1/C152H222N36O48/c1-14-78(8)123(149(232)165-81(11)128(211)174-107(63-88-67-159-93-34-22-21-33-92(88)93)139(222)176-102(58-76(4)5)142(225)186-122(77(6)7)148(231)173-94(35-23-26-54-153)129(212)161-70-121(207)208)187-143(226)105(59-84-29-17-15-18-30-84)178-135(218)100(49-53-118(201)202)171-132(215)95(36-24-27-55-154)167-127(210)80(10)163-126(209)79(9)164-131(214)98(47-51-115(157)197)170-134(217)99(48-52-117(199)200)172-140(223)108(65-119(203)204)180-136(219)101(57-75(2)3)175-137(220)103(61-86-38-42-90(194)43-39-86)177-133(216)96(37-25-28-56-155)168-146(229)112(72-190)183-138(221)104(62-87-40-44-91(195)45-41-87)179-141(224)109(66-120(205)206)181-147(230)113(73-191)184-151(234)125(83(13)193)188-144(227)106(60-85-31-19-16-20-32-85)182-150(233)124(82(12)192)185-116(198)69-160-130(213)97(46-50-114(156)196)169-145(228)111(71-189)166-110(152(235)236)64-89-68-158-74-162-89/h15-22,29-34,38-45,67-68,74-83,94-113,122-125,159,166,189-195H,14,23-28,35-37,46-66,69-73,153-155H2,1-13H3,(H2,156,196)(H2,157,197)(H,158,162)(H,160,213)(H,161,212)(H,163,209)(H,164,214)(H,165,232)(H,167,210)(H,168,229)(H,169,228)(H,170,217)(H,171,215)(H,172,223)(H,173,231)(H,174,211)(H,175,220)(H,176,222)(H,177,216)(H,178,218)(H,179,224)(H,180,219)(H,181,230)(H,182,233)(H,183,221)(H,184,234)(H,185,198)(H,186,225)(H,187,226)(H,188,227)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)/t78-,79-,80-,81-,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.470n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266693
PNG
(CHEBI:5391 | GLUCAGON | Glucagen Hypokit | Glucago...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.5n/an/an/an/a



Sanofi-Aventis Deutschland GmbH , R&D , Industriepark Höchst , D-65926 Frankfurt am Main , Germany.

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 61: 5580-5593 (2018)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50324728
PNG
((2S,8S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)CN[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C153H222N36O49S/c1-15-76(6)122(149(232)166-80(10)129(212)174-107(62-88-68-161-93-33-23-22-32-92(88)93)141(224)176-101(56-74(2)3)137(220)173-100(52-55-239-14)136(219)180-108(64-116(158)199)146(229)189-125(83(13)194)153(237)238)187-144(227)105(58-84-28-18-16-19-29-84)178-135(218)99(47-51-119(203)204)171-132(215)94(34-24-26-53-154)168-128(211)79(9)164-127(210)78(8)165-131(214)97(45-49-115(157)198)170-134(217)98(46-50-118(201)202)172-142(225)109(65-120(205)206)181-138(221)102(57-75(4)5)175-139(222)103(60-86-36-40-90(195)41-37-86)177-133(216)95(35-25-27-54-155)169-147(230)112(71-190)184-140(223)104(61-87-38-42-91(196)43-39-87)179-143(226)110(66-121(207)208)182-148(231)113(72-191)185-151(234)124(82(12)193)188-145(228)106(59-85-30-20-17-21-31-85)183-150(233)123(81(11)192)186-117(200)70-162-130(213)96(44-48-114(156)197)167-126(209)77(7)67-160-111(152(235)236)63-89-69-159-73-163-89/h16-23,28-33,36-43,68-69,73-83,94-113,122-125,160-161,190-196H,15,24-27,34-35,44-67,70-72,154-155H2,1-14H3,(H2,156,197)(H2,157,198)(H2,158,199)(H,159,163)(H,162,213)(H,164,210)(H,165,214)(H,166,232)(H,167,209)(H,168,211)(H,169,230)(H,170,217)(H,171,215)(H,172,225)(H,173,220)(H,174,212)(H,175,222)(H,176,224)(H,177,216)(H,178,218)(H,179,226)(H,180,219)(H,181,221)(H,182,231)(H,183,233)(H,184,223)(H,185,234)(H,186,200)(H,187,227)(H,188,228)(H,189,229)(H,201,202)(H,203,204)(H,205,206)(H,207,208)(H,235,236)(H,237,238)/t76-,77?,78-,79-,80-,81+,82+,83+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.590n/an/an/an/a



Indiana University

Curated by ChEMBL


Assay Description
Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assay


Nat Chem Biol 5: 749-57 (2009)


Article DOI: 10.1038/nchembio.209
BindingDB Entry DOI: 10.7270/Q2WW7JNF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266691
PNG
(CHEMBL4086979)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O
Show InChI InChI=1/C203H319N57O64/c1-12-14-15-16-17-18-19-20-21-22-23-24-31-61-154(275)228-128(201(323)324)65-70-153(274)217-74-39-36-54-121(230-177(299)126(64-69-151(209)272)236-173(295)119(52-34-37-72-204)233-189(311)141(100-264)250-181(303)130(82-106(5)6)239-183(305)136(89-161(284)285)245-191(313)144(103-267)253-197(319)165(111(11)269)256-187(309)132(84-113-48-29-26-30-49-113)246-196(318)164(110(10)268)254-157(278)95-223-169(291)124(62-67-149(207)270)235-188(310)140(99-263)248-168(290)117(206)86-115-92-216-104-225-115)176(298)243-137(90-162(286)287)185(307)251-142(101-265)190(312)234-123(56-41-76-219-203(214)215)174(296)231-122(55-40-75-218-202(212)213)172(294)227-108(8)167(289)229-125(63-68-150(208)271)178(300)244-135(88-160(282)283)184(306)240-131(83-112-46-27-25-28-47-112)186(308)255-163(107(7)13-2)195(317)237-127(66-71-159(280)281)179(301)241-133(85-114-91-220-118-51-33-32-50-116(114)118)182(304)238-129(81-105(3)4)180(302)232-120(53-35-38-73-205)175(297)242-134(87-152(210)273)170(292)222-93-155(276)221-96-158(279)257-77-42-57-145(257)193(315)252-143(102-266)192(314)249-139(98-262)171(293)224-94-156(277)226-109(9)198(320)259-79-44-59-147(259)200(322)260-80-45-60-148(260)199(321)258-78-43-58-146(258)194(316)247-138(97-261)166(211)288/h25-30,32-33,46-51,91-92,104-111,117,119-148,163-165,220,261-269H,12-24,31,34-45,52-90,93-103,204-206H2,1-11H3,(H2,207,270)(H2,208,271)(H2,209,272)(H2,210,273)(H2,211,288)(H,216,225)(H,217,274)(H,221,276)(H,222,292)(H,223,291)(H,224,293)(H,226,277)(H,227,294)(H,228,275)(H,229,289)(H,230,299)(H,231,296)(H,232,302)(H,233,311)(H,234,312)(H,235,310)(H,236,295)(H,237,317)(H,238,304)(H,239,305)(H,240,306)(H,241,301)(H,242,297)(H,243,298)(H,244,300)(H,245,313)(H,246,318)(H,247,316)(H,248,290)(H,249,314)(H,250,303)(H,251,307)(H,252,315)(H,253,319)(H,254,278)(H,255,308)(H,256,309)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,323,324)(H4,212,213,218)(H4,214,215,219)/t107-,108-,109-,110+,111+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,163-,164-,165-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.700n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50275564
PNG
(CHEMBL4128125)
Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1/C204H320N56O65/c1-12-14-15-16-17-18-19-20-21-22-23-24-25-32-62-155(275)228-129(201(322)323)66-71-154(274)217-75-40-37-55-122(230-177(298)127(65-70-152(210)272)236-173(294)120(53-35-38-73-205)233-189(310)141(100-263)249-181(302)131(83-107(5)6)239-183(304)137(90-162(284)285)245-191(312)144(103-266)252-197(318)166(112(11)269)256-187(308)133(85-114-49-30-27-31-50-114)246-196(317)165(111(10)268)254-158(278)96-223-169(290)125(63-68-150(208)270)235-188(309)140(99-262)247-168(289)118(207)87-116-93-216-105-225-116)176(297)243-138(91-163(286)287)185(306)250-142(101-264)190(311)234-124(57-42-77-219-204(214)215)174(295)231-123(56-41-76-218-203(212)213)172(293)227-109(8)167(288)229-126(64-69-151(209)271)178(299)244-136(89-161(282)283)184(305)240-132(84-113-47-28-26-29-48-113)186(307)255-164(108(7)13-2)195(316)237-128(67-72-160(280)281)179(300)241-134(86-115-92-220-119-52-34-33-51-117(115)119)182(303)238-130(82-106(3)4)180(301)232-121(54-36-39-74-206)175(296)242-135(88-153(211)273)170(291)222-94-156(276)221-97-159(279)257-78-43-58-146(257)193(314)251-143(102-265)192(313)248-139(98-261)171(292)224-95-157(277)226-110(9)198(319)259-80-45-60-148(259)200(321)260-81-46-61-149(260)199(320)258-79-44-59-147(258)194(315)253-145(104-267)202(324)325/h26-31,33-34,47-52,92-93,105-112,118,120-149,164-166,220,261-269H,12-25,32,35-46,53-91,94-104,205-207H2,1-11H3,(H2,208,270)(H2,209,271)(H2,210,272)(H2,211,273)(H,216,225)(H,217,274)(H,221,276)(H,222,291)(H,223,290)(H,224,292)(H,226,277)(H,227,293)(H,228,275)(H,229,288)(H,230,298)(H,231,295)(H,232,301)(H,233,310)(H,234,311)(H,235,309)(H,236,294)(H,237,316)(H,238,303)(H,239,304)(H,240,305)(H,241,300)(H,242,296)(H,243,297)(H,244,299)(H,245,312)(H,246,317)(H,247,289)(H,248,313)(H,249,302)(H,250,306)(H,251,314)(H,252,318)(H,253,315)(H,254,278)(H,255,307)(H,256,308)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,322,323)(H,324,325)(H4,212,213,218)(H4,214,215,219)/t108-,109-,110-,111+,112+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,164-,165-,166-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.700n/an/an/an/a



Sanofi-Aventis Deutschland GmbH , R&D , Industriepark Höchst , D-65926 Frankfurt am Main , Germany.

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 61: 5580-5593 (2018)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50277078
PNG
(CHEMBL4170727)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C151H222N44O48S2/c1-71(2)50-95(132(226)176-94(45-49-245-9)131(225)183-102(58-114(157)208)142(236)194-119(74(6)200)122(158)216)178-137(231)101(56-81-62-166-87-27-17-16-26-85(81)87)182-130(224)93(41-44-113(156)207)175-147(241)110(69-244)192-136(230)97(52-77-22-12-10-13-23-77)180-138(232)103(59-116(210)211)184-129(223)92(40-43-112(155)206)170-123(217)73(5)169-126(220)89(29-20-47-164-150(159)160)171-127(221)90(30-21-48-165-151(161)162)173-145(239)108(67-198)190-140(234)105(61-118(214)215)185-133(227)96(51-72(3)4)177-134(228)98(54-79-31-35-83(203)36-32-79)179-128(222)88(28-18-19-46-152)172-144(238)107(66-197)189-135(229)99(55-80-33-37-84(204)38-34-80)181-139(233)104(60-117(212)213)186-146(240)109(68-199)191-149(243)121(76(8)202)195-141(235)100(53-78-24-14-11-15-25-78)187-148(242)120(75(7)201)193-115(209)64-167-125(219)91(39-42-111(154)205)174-143(237)106(65-196)188-124(218)86(153)57-82-63-163-70-168-82/h10-17,22-27,31-38,62-63,70-76,86,88-110,119-121,166,196-204,244H,18-21,28-30,39-61,64-69,152-153H2,1-9H3,(H2,154,205)(H2,155,206)(H2,156,207)(H2,157,208)(H2,158,216)(H,163,168)(H,167,219)(H,169,220)(H,170,217)(H,171,221)(H,172,238)(H,173,239)(H,174,237)(H,175,241)(H,176,226)(H,177,228)(H,178,231)(H,179,222)(H,180,232)(H,181,233)(H,182,224)(H,183,225)(H,184,223)(H,185,227)(H,186,240)(H,187,242)(H,188,218)(H,189,229)(H,190,234)(H,191,243)(H,192,230)(H,193,209)(H,194,236)(H,195,235)(H,210,211)(H,212,213)(H,214,215)(H4,159,160,164)(H4,161,162,165)/t73-,74+,75+,76+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-,120-,121-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.75n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50277057
PNG
(CHEMBL4174154)
Show SMILES CCCCCCN1C(=O)CC(SC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C1=O
Show InChI InChI=1/C163H241N45O49S2/c1-13-14-15-26-56-208-125(222)70-119(161(208)257)259-77-118(157(253)185-99(37-28-55-177-163(173)174)138(234)183-98(36-27-54-176-162(171)172)137(233)181-82(8)134(230)182-101(47-50-121(167)218)140(236)196-112(67-126(223)224)148(244)193-108(60-86-29-18-16-19-30-86)151(247)205-129(81(6)7)158(254)188-102(48-51-122(168)219)141(237)194-110(64-90-71-178-96-34-23-22-33-94(90)96)147(243)190-104(58-79(2)3)143(239)187-103(52-57-258-12)142(238)195-111(66-123(169)220)153(249)206-130(83(9)212)133(170)229)203-150(246)114(69-128(227)228)197-144(240)105(59-80(4)5)189-145(241)106(62-88-38-42-92(215)43-39-88)191-139(235)97(35-24-25-53-164)184-155(251)116(75-210)201-146(242)107(63-89-40-44-93(216)45-41-89)192-149(245)113(68-127(225)226)198-156(252)117(76-211)202-160(256)132(85(11)214)207-152(248)109(61-87-31-20-17-21-32-87)199-159(255)131(84(10)213)204-124(221)73-179-136(232)100(46-49-120(166)217)186-154(250)115(74-209)200-135(231)95(165)65-91-72-175-78-180-91/h16-23,29-34,38-45,71-72,78-85,95,97-119,129-132,178,209-216H,13-15,24-28,35-37,46-70,73-77,164-165H2,1-12H3,(H2,166,217)(H2,167,218)(H2,168,219)(H2,169,220)(H2,170,229)(H,175,180)(H,179,232)(H,181,233)(H,182,230)(H,183,234)(H,184,251)(H,185,253)(H,186,250)(H,187,239)(H,188,254)(H,189,241)(H,190,243)(H,191,235)(H,192,245)(H,193,244)(H,194,237)(H,195,238)(H,196,236)(H,197,240)(H,198,252)(H,199,255)(H,200,231)(H,201,242)(H,202,256)(H,203,246)(H,204,221)(H,205,247)(H,206,249)(H,207,248)(H,223,224)(H,225,226)(H,227,228)(H4,171,172,176)(H4,173,174,177)/t82-,83+,84+,85+,95-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119?,129-,130-,131-,132-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.860n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50277074
PNG
(CHEMBL4166241)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C151H223N43O47S2/c1-71(2)50-95(131(223)174-94(45-49-243-11)130(222)181-102(58-113(156)206)141(233)193-119(75(8)199)122(157)214)176-135(227)101(56-82-62-165-88-29-19-18-28-86(82)88)180-146(238)110(69-242)190-147(239)118(73(5)6)192-139(231)99(52-78-24-14-12-15-25-78)179-136(228)103(59-115(208)209)182-129(221)93(42-44-112(155)205)169-123(215)74(7)168-126(218)90(31-22-47-163-150(158)159)170-127(219)91(32-23-48-164-151(160)161)172-144(236)108(67-197)188-138(230)105(61-117(212)213)183-132(224)96(51-72(3)4)175-133(225)97(54-80-33-37-84(202)38-34-80)177-128(220)89(30-20-21-46-152)171-143(235)107(66-196)187-134(226)98(55-81-35-39-85(203)40-36-81)178-137(229)104(60-116(210)211)184-145(237)109(68-198)189-149(241)121(77(10)201)194-140(232)100(53-79-26-16-13-17-27-79)185-148(240)120(76(9)200)191-114(207)64-166-125(217)92(41-43-111(154)204)173-142(234)106(65-195)186-124(216)87(153)57-83-63-162-70-167-83/h12-19,24-29,33-40,62-63,70-77,87,89-110,118-121,165,195-203,242H,20-23,30-32,41-61,64-69,152-153H2,1-11H3,(H2,154,204)(H2,155,205)(H2,156,206)(H2,157,214)(H,162,167)(H,166,217)(H,168,218)(H,169,215)(H,170,219)(H,171,235)(H,172,236)(H,173,234)(H,174,223)(H,175,225)(H,176,227)(H,177,220)(H,178,229)(H,179,228)(H,180,238)(H,181,222)(H,182,221)(H,183,224)(H,184,237)(H,185,240)(H,186,216)(H,187,226)(H,188,230)(H,189,241)(H,190,239)(H,191,207)(H,192,231)(H,193,233)(H,194,232)(H,208,209)(H,210,211)(H,212,213)(H4,158,159,163)(H4,160,161,164)/t74-,75+,76+,77+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,118-,119-,120-,121-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.900n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266693
PNG
(CHEBI:5391 | GLUCAGON | Glucagen Hypokit | Glucago...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 0.970n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50275578
PNG
(CHEMBL4128112)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(N)=O
Show InChI InChI=1S/C143H223N37O44S2/c1-15-74(10)115(140(221)163-89(42-46-112(191)192)126(207)169-95(58-80-61-150-83-32-20-19-31-81(80)83)132(213)167-90(53-70(2)3)128(209)156-76(12)118(199)155-75(11)117(198)152-62-108(186)151-64-110(188)177-49-25-35-102(177)138(219)173-99(67-183)136(217)171-97(65-181)121(202)153-63-109(187)154-78(14)141(222)179-51-27-37-104(179)143(224)180-52-28-38-105(180)142(223)178-50-26-36-103(178)139(220)174-100(68-225)116(149)197)176-134(215)94(57-79-29-17-16-18-30-79)168-129(210)92(55-72(6)7)165-123(204)84(33-21-23-47-144)158-119(200)77(13)157-137(218)101(69-226)175-127(208)87(40-44-107(148)185)161-124(205)88(41-45-111(189)190)162-133(214)96(60-114(195)196)170-130(211)93(56-73(8)9)166-125(206)86(39-43-106(147)184)160-122(203)85(34-22-24-48-145)159-135(216)98(66-182)172-131(212)91(54-71(4)5)164-120(201)82(146)59-113(193)194/h16-20,29-32,61,70-78,82,84-105,115,150,181-183,225-226H,15,21-28,33-60,62-69,144-146H2,1-14H3,(H2,147,184)(H2,148,185)(H2,149,197)(H,151,186)(H,152,198)(H,153,202)(H,154,187)(H,155,199)(H,156,209)(H,157,218)(H,158,200)(H,159,216)(H,160,203)(H,161,205)(H,162,214)(H,163,221)(H,164,201)(H,165,204)(H,166,206)(H,167,213)(H,168,210)(H,169,207)(H,170,211)(H,171,217)(H,172,212)(H,173,219)(H,174,220)(H,175,208)(H,176,215)(H,189,190)(H,191,192)(H,193,194)(H,195,196)/t74-,75-,76-,77-,78-,82-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,115-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH , R&D , Industriepark Höchst , D-65926 Frankfurt am Main , Germany.

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 61: 5580-5593 (2018)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50241203
PNG
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH , R&D , Industriepark Höchst , D-65926 Frankfurt am Main , Germany.

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 61: 5580-5593 (2018)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50152769
PNG
(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50275566
PNG
(CHEMBL4128276)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1/C149H225N39O46/c1-17-76(10)119(145(230)166-80(14)125(210)174-104(60-86-63-158-91-36-25-24-35-89(86)91)135(220)176-100(56-73(4)5)136(221)185-117(74(6)7)143(228)173-92(37-26-28-52-150)127(212)159-66-111(197)168-98(148(233)234)39-30-54-157-149(154)155)187-137(222)102(57-83-31-20-18-21-32-83)177-132(217)97(47-51-115(203)204)172-131(216)93(38-27-29-53-151)169-123(208)78(12)163-122(207)77(11)165-130(215)96(44-48-109(153)195)167-110(196)65-160-129(214)95(46-50-114(201)202)171-133(218)99(55-72(2)3)175-134(219)101(59-85-40-42-88(194)43-41-85)178-140(225)106(68-189)181-142(227)108(70-191)182-144(229)118(75(8)9)186-139(224)105(62-116(205)206)179-141(226)107(69-190)183-147(232)121(82(16)193)188-138(223)103(58-84-33-22-19-23-34-84)180-146(231)120(81(15)192)184-112(198)67-161-128(213)94(45-49-113(199)200)170-124(209)79(13)164-126(211)90(152)61-87-64-156-71-162-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,158,189-194H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,195)(H,156,162)(H,159,212)(H,160,214)(H,161,213)(H,163,207)(H,164,211)(H,165,215)(H,166,230)(H,167,196)(H,168,197)(H,169,208)(H,170,209)(H,171,218)(H,172,216)(H,173,228)(H,174,210)(H,175,219)(H,176,220)(H,177,217)(H,178,225)(H,179,226)(H,180,231)(H,181,227)(H,182,229)(H,183,232)(H,184,198)(H,185,221)(H,186,224)(H,187,222)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H,233,234)(H4,154,155,157)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH , R&D , Industriepark Höchst , D-65926 Frankfurt am Main , Germany.

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 61: 5580-5593 (2018)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50275565
PNG
(CHEMBL4125912)
Show SMILES CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O
Show InChI InChI=1/C173H267N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-31-38-54-130(225)196-117(171(266)267)60-65-129(224)181-69-42-41-51-112(154(249)200-116(63-68-136(233)234)155(250)205-121(74-101-45-34-32-35-46-101)160(255)215-141(94(11)19-2)168(263)193-98(15)147(242)202-123(77-104-80-184-109-50-40-39-49-107(104)109)158(253)204-119(73-91(5)6)159(254)213-139(92(7)8)166(261)201-111(53-44-71-183-173(178)179)150(245)185-82-131(226)194-110(52-43-70-182-172(176)177)149(244)188-85-138(237)238)197-145(240)96(13)190-144(239)95(12)192-153(248)115(59-64-128(175)223)195-132(227)83-186-152(247)114(62-67-135(231)232)199-156(251)118(72-90(3)4)203-157(252)120(76-103-55-57-106(222)58-56-103)206-163(258)125(86-217)209-165(260)127(88-219)210-167(262)140(93(9)10)214-162(257)124(79-137(235)236)207-164(259)126(87-218)211-170(265)143(100(17)221)216-161(256)122(75-102-47-36-33-37-48-102)208-169(264)142(99(16)220)212-133(228)84-187-151(246)113(61-66-134(229)230)198-146(241)97(14)191-148(243)108(174)78-105-81-180-89-189-105/h32-37,39-40,45-50,55-58,80-81,89-100,108,110-127,139-143,184,217-222H,18-31,38,41-44,51-54,59-79,82-88,174H2,1-17H3,(H2,175,223)(H,180,189)(H,181,224)(H,185,245)(H,186,247)(H,187,246)(H,188,244)(H,190,239)(H,191,243)(H,192,248)(H,193,263)(H,194,226)(H,195,227)(H,196,225)(H,197,240)(H,198,241)(H,199,251)(H,200,249)(H,201,261)(H,202,242)(H,203,252)(H,204,253)(H,205,250)(H,206,258)(H,207,259)(H,208,264)(H,209,260)(H,210,262)(H,211,265)(H,212,228)(H,213,254)(H,214,257)(H,215,255)(H,216,256)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H,266,267)(H4,176,177,182)(H4,178,179,183)/t94-,95-,96-,97-,98-,99+,100+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,139-,140-,141-,142-,143-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH , R&D , Industriepark Höchst , D-65926 Frankfurt am Main , Germany.

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 61: 5580-5593 (2018)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266672
PNG
(CHEMBL4100420)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1/C194H305N57O60S2/c1-18-98(10)152(185(305)231-121(56-62-149(272)273)169(289)236-129(80-106-85-212-110-42-26-25-41-108(106)110)175(295)233-124(75-94(2)3)172(292)228-123(64-74-313-17)171(291)238-131(83-141(200)260)180(300)248-154(102(14)256)187(307)230-113(44-28-30-66-196)163(283)221-114(46-32-68-210-193(204)205)164(284)237-130(82-140(199)259)176(296)220-111(45-31-67-209-192(202)203)159(279)214-87-142(261)217-100(12)189(309)250-71-35-49-137(250)191(311)251-72-36-50-138(251)190(310)249-70-34-48-136(249)183(303)241-133(90-252)156(201)276)246-178(298)127(78-104-37-21-19-22-38-104)235-173(293)125(76-95(4)5)232-165(285)115(47-33-69-211-194(206)207)229-184(304)151(97(8)9)245-157(277)99(11)218-161(281)118(53-59-146(266)267)224-167(287)119(54-60-147(268)269)225-168(288)120(55-61-148(270)271)226-170(290)122(63-73-312-16)227-166(286)117(51-57-139(198)258)223-162(282)112(43-27-29-65-195)222-181(301)134(91-253)242-174(294)126(77-96(6)7)234-177(297)132(84-150(274)275)239-182(302)135(92-254)243-188(308)155(103(15)257)247-179(299)128(79-105-39-23-20-24-40-105)240-186(306)153(101(13)255)244-144(263)89-215-160(280)116(52-58-145(264)265)219-143(262)88-213-158(278)109(197)81-107-86-208-93-216-107/h19-26,37-42,85-86,93-103,109,111-138,151-155,212,252-257H,18,27-36,43-84,87-92,195-197H2,1-17H3,(H2,198,258)(H2,199,259)(H2,200,260)(H2,201,276)(H,208,216)(H,213,278)(H,214,279)(H,215,280)(H,217,261)(H,218,281)(H,219,262)(H,220,296)(H,221,283)(H,222,301)(H,223,282)(H,224,287)(H,225,288)(H,226,290)(H,227,286)(H,228,292)(H,229,304)(H,230,307)(H,231,305)(H,232,285)(H,233,295)(H,234,297)(H,235,293)(H,236,289)(H,237,284)(H,238,291)(H,239,302)(H,240,306)(H,241,303)(H,242,294)(H,243,308)(H,244,263)(H,245,277)(H,246,298)(H,247,299)(H,248,300)(H,264,265)(H,266,267)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H4,202,203,209)(H4,204,205,210)(H4,206,207,211)/t98-,99-,100-,101+,102+,103+,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,151-,152-,153-,154-,155-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266690
PNG
(CHEMBL439305)
Show SMILES CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O)C(O)=O
Show InChI InChI=1S/C172H265N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-53-129(224)195-116(170(265)266)59-64-128(223)180-68-41-40-50-111(153(248)199-115(62-67-135(232)233)154(249)204-120(73-100-44-33-31-34-45-100)159(254)214-140(93(11)19-2)167(262)192-97(15)146(241)201-122(76-103-79-183-108-49-39-38-48-106(103)108)157(252)203-118(72-90(5)6)158(253)212-138(91(7)8)165(260)200-110(52-43-70-182-172(177)178)149(244)184-81-130(225)193-109(51-42-69-181-171(175)176)148(243)187-84-137(236)237)196-144(239)95(13)189-143(238)94(12)191-152(247)114(58-63-127(174)222)194-131(226)82-185-151(246)113(61-66-134(230)231)198-155(250)117(71-89(3)4)202-156(251)119(75-102-54-56-105(221)57-55-102)205-162(257)124(85-216)208-164(259)126(87-218)209-166(261)139(92(9)10)213-161(256)123(78-136(234)235)206-163(258)125(86-217)210-169(264)142(99(17)220)215-160(255)121(74-101-46-35-32-36-47-101)207-168(263)141(98(16)219)211-132(227)83-186-150(245)112(60-65-133(228)229)197-145(240)96(14)190-147(242)107(173)77-104-80-179-88-188-104/h31-36,38-39,44-49,54-57,79-80,88-99,107,109-126,138-142,183,216-221H,18-30,37,40-43,50-53,58-78,81-87,173H2,1-17H3,(H2,174,222)(H,179,188)(H,180,223)(H,184,244)(H,185,246)(H,186,245)(H,187,243)(H,189,238)(H,190,242)(H,191,247)(H,192,262)(H,193,225)(H,194,226)(H,195,224)(H,196,239)(H,197,240)(H,198,250)(H,199,248)(H,200,260)(H,201,241)(H,202,251)(H,203,252)(H,204,249)(H,205,257)(H,206,258)(H,207,263)(H,208,259)(H,209,261)(H,210,264)(H,211,227)(H,212,253)(H,213,256)(H,214,254)(H,215,255)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,265,266)(H4,175,176,181)(H4,177,178,182)/t93-,94-,95-,96-,97-,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116?,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-,142-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266671
PNG
(CHEMBL4101203)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1/C179H274N54O60S/c1-86(2)62-109(158(274)206-101(37-21-23-54-181)153(269)216-114(68-130(185)244)148(264)197-74-131(245)195-78-135(249)230-57-26-40-124(230)170(286)225-122(83-238)169(285)222-119(80-235)149(265)199-75-132(246)201-90(8)175(291)232-59-28-42-126(232)177(293)233-60-29-43-127(233)176(292)231-58-27-41-125(231)171(287)221-118(79-234)144(186)260)212-160(276)113(66-95-72-194-99-35-19-18-34-97(95)99)215-156(272)107(47-51-137(252)253)211-172(288)141(88(5)6)228-164(280)111(64-93-30-14-12-15-31-93)214-162(278)115(69-138(254)255)217-155(271)105(44-48-128(183)242)204-145(261)89(7)202-150(266)102(38-24-55-192-178(187)188)205-152(268)103(39-25-56-193-179(189)190)208-167(283)121(82-237)224-163(279)117(71-140(258)259)218-157(273)108(52-61-294-11)210-154(270)106(45-49-129(184)243)209-151(267)100(36-20-22-53-180)207-166(282)120(81-236)223-159(275)110(63-87(3)4)213-161(277)116(70-139(256)257)219-168(284)123(84-239)226-174(290)143(92(10)241)229-165(281)112(65-94-32-16-13-17-33-94)220-173(289)142(91(9)240)227-134(248)77-198-147(263)104(46-50-136(250)251)203-133(247)76-196-146(262)98(182)67-96-73-191-85-200-96/h12-19,30-35,72-73,85-92,98,100-127,141-143,194,234-241H,20-29,36-71,74-84,180-182H2,1-11H3,(H2,183,242)(H2,184,243)(H2,185,244)(H2,186,260)(H,191,200)(H,195,245)(H,196,262)(H,197,264)(H,198,263)(H,199,265)(H,201,246)(H,202,266)(H,203,247)(H,204,261)(H,205,268)(H,206,274)(H,207,282)(H,208,283)(H,209,267)(H,210,270)(H,211,288)(H,212,276)(H,213,277)(H,214,278)(H,215,272)(H,216,269)(H,217,271)(H,218,273)(H,219,284)(H,220,289)(H,221,287)(H,222,285)(H,223,275)(H,224,279)(H,225,286)(H,226,290)(H,227,248)(H,228,280)(H,229,281)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H4,187,188,192)(H4,189,190,193)/t89-,90-,91+,92+,98-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,141-,142-,143-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50241203
PNG
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/an/an/a>1n/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay


J Med Chem 60: 4293-4303 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50266668
PNG
(CHEMBL4098545)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1/C192H295N61O60S/c1-15-92(8)149(184(308)220-94(10)188(312)313)251-177(301)128(76-142(201)268)240-171(295)127(75-141(200)267)238-161(285)114(43-31-64-215-192(209)210)224-170(294)126(74-140(199)266)237-160(284)113(42-30-63-214-191(207)208)223-157(281)110(39-25-27-60-194)229-186(310)151(96(12)259)253-178(302)129(77-143(202)269)239-164(288)118(58-65-314-14)228-165(289)119(66-89(2)3)232-169(293)125(72-102-81-216-108-37-23-22-36-106(102)108)236-163(287)117(54-57-139(198)265)230-183(307)148(91(6)7)250-175(299)123(68-98-32-18-16-19-33-98)235-172(296)130(78-145(271)272)241-162(286)116(53-56-138(197)264)221-153(277)93(9)219-156(280)111(40-28-61-212-189(203)204)222-158(282)112(41-29-62-213-190(205)206)226-181(305)135(86-256)247-174(298)132(80-147(275)276)242-166(290)120(67-90(4)5)231-167(291)121(70-100-44-48-104(261)49-45-100)233-159(283)109(38-24-26-59-193)225-180(304)134(85-255)246-168(292)122(71-101-46-50-105(262)51-47-101)234-173(297)131(79-146(273)274)243-182(306)136(87-257)248-187(311)152(97(13)260)252-176(300)124(69-99-34-20-17-21-35-99)244-185(309)150(95(11)258)249-144(270)83-217-155(279)115(52-55-137(196)263)227-179(303)133(84-254)245-154(278)107(195)73-103-82-211-88-218-103/h16-23,32-37,44-51,81-82,88-97,107,109-136,148-152,216,254-262H,15,24-31,38-43,52-80,83-87,193-195H2,1-14H3,(H2,196,263)(H2,197,264)(H2,198,265)(H2,199,266)(H2,200,267)(H2,201,268)(H2,202,269)(H,211,218)(H,217,279)(H,219,280)(H,220,308)(H,221,277)(H,222,282)(H,223,281)(H,224,294)(H,225,304)(H,226,305)(H,227,303)(H,228,289)(H,229,310)(H,230,307)(H,231,291)(H,232,293)(H,233,283)(H,234,297)(H,235,296)(H,236,287)(H,237,284)(H,238,285)(H,239,288)(H,240,295)(H,241,286)(H,242,290)(H,243,306)(H,244,309)(H,245,278)(H,246,292)(H,247,298)(H,248,311)(H,249,270)(H,250,299)(H,251,301)(H,252,300)(H,253,302)(H,271,272)(H,273,274)(H,275,276)(H,312,313)(H4,203,204,212)(H4,205,206,213)(H4,207,208,214)(H4,209,210,215)/t92-,93-,94-,95+,96+,97+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,148-,149-,150-,151-,152-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 1.20n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50277060
PNG
(CHEMBL4167331)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C152H226N44O46S2/c1-72(2)52-97(133(225)176-96(47-51-244-11)132(224)184-104(60-115(158)209)142(234)195-120(76(8)201)123(159)215)179-137(229)103(58-83-63-167-89-29-19-18-28-87(83)89)183-130(222)95(43-46-114(157)208)177-148(240)119(74(5)6)194-140(232)101(54-79-24-14-12-15-25-79)182-147(239)111(70-243)192-131(223)94(42-45-113(156)207)171-124(216)75(7)170-127(219)91(31-22-49-165-151(160)161)172-128(220)92(32-23-50-166-152(162)163)174-145(237)109(68-199)190-139(231)106(62-118(213)214)185-134(226)98(53-73(3)4)178-135(227)99(56-81-33-37-85(204)38-34-81)180-129(221)90(30-20-21-48-153)173-144(236)108(67-198)189-136(228)100(57-82-35-39-86(205)40-36-82)181-138(230)105(61-117(211)212)186-146(238)110(69-200)191-150(242)122(78(10)203)196-141(233)102(55-80-26-16-13-17-27-80)187-149(241)121(77(9)202)193-116(210)65-168-126(218)93(41-44-112(155)206)175-143(235)107(66-197)188-125(217)88(154)59-84-64-164-71-169-84/h12-19,24-29,33-40,63-64,71-78,88,90-111,119-122,167,197-205,243H,20-23,30-32,41-62,65-70,153-154H2,1-11H3,(H2,155,206)(H2,156,207)(H2,157,208)(H2,158,209)(H2,159,215)(H,164,169)(H,168,218)(H,170,219)(H,171,216)(H,172,220)(H,173,236)(H,174,237)(H,175,235)(H,176,225)(H,177,240)(H,178,227)(H,179,229)(H,180,221)(H,181,230)(H,182,239)(H,183,222)(H,184,224)(H,185,226)(H,186,238)(H,187,241)(H,188,217)(H,189,228)(H,190,231)(H,191,242)(H,192,223)(H,193,210)(H,194,232)(H,195,234)(H,196,233)(H,211,212)(H,213,214)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,119-,120-,121-,122-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 1.30n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50277081
PNG
(CHEMBL4162383)
Show SMILES CCCCCCN1C(=O)CC(SC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)C1=O
Show InChI InChI=1/C160H234N42O50S2/c1-13-14-15-26-53-202-123(217)67-117(159(202)252)254-75-116(155(248)178-96(35-27-52-171-160(168)169)135(228)175-80(8)132(225)176-98(45-48-119(164)213)137(230)189-109(64-124(218)219)145(238)186-105(57-84-28-18-16-19-29-84)148(241)199-127(79(6)7)156(249)181-99(46-49-120(165)214)138(231)187-107(61-88-68-172-94-33-23-22-32-92(88)94)144(237)183-101(55-77(2)3)140(233)180-100(50-54-253-12)139(232)188-108(63-121(166)215)150(243)200-128(81(9)207)131(167)224)197-154(247)114(73-205)195-147(240)111(66-126(222)223)190-141(234)102(56-78(4)5)182-142(235)103(59-86-36-40-90(210)41-37-86)184-136(229)95(34-24-25-51-161)177-152(245)113(72-204)194-143(236)104(60-87-38-42-91(211)43-39-87)185-146(239)110(65-125(220)221)191-153(246)115(74-206)196-158(251)130(83(11)209)201-149(242)106(58-85-30-20-17-21-31-85)192-157(250)129(82(10)208)198-122(216)70-173-134(227)97(44-47-118(163)212)179-151(244)112(71-203)193-133(226)93(162)62-89-69-170-76-174-89/h16-23,28-33,36-43,68-69,76-83,93,95-117,127-130,172,203-211H,13-15,24-27,34-35,44-67,70-75,161-162H2,1-12H3,(H2,163,212)(H2,164,213)(H2,165,214)(H2,166,215)(H2,167,224)(H,170,174)(H,173,227)(H,175,228)(H,176,225)(H,177,245)(H,178,248)(H,179,244)(H,180,233)(H,181,249)(H,182,235)(H,183,237)(H,184,229)(H,185,239)(H,186,238)(H,187,231)(H,188,232)(H,189,230)(H,190,234)(H,191,246)(H,192,250)(H,193,226)(H,194,236)(H,195,240)(H,196,251)(H,197,247)(H,198,216)(H,199,241)(H,200,243)(H,201,242)(H,218,219)(H,220,221)(H,222,223)(H4,168,169,171)/t80-,81+,82+,83+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117?,127-,128-,129-,130-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 1.30n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50277068
PNG
(CHEMBL4167169)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1/C150H219N41O48S2/c1-70(2)49-94(131(221)170-93(45-48-241-11)130(220)178-101(57-113(156)204)141(231)190-119(74(8)196)122(157)212)173-135(225)100(55-81-61-162-87-28-19-18-27-85(81)87)177-129(219)92(41-44-112(155)203)171-147(237)118(72(5)6)189-139(229)98(51-77-23-14-12-15-24-77)176-136(226)102(58-115(206)207)179-128(218)91(40-43-111(154)202)166-123(213)73(7)165-126(216)89(30-22-47-161-150(158)159)168-146(236)109(68-240)187-145(235)107(66-194)185-138(228)104(60-117(210)211)180-132(222)95(50-71(3)4)172-133(223)96(53-79-31-35-83(199)36-32-79)174-127(217)88(29-20-21-46-151)167-143(233)106(65-193)184-134(224)97(54-80-33-37-84(200)38-34-80)175-137(227)103(59-116(208)209)181-144(234)108(67-195)186-149(239)121(76(10)198)191-140(230)99(52-78-25-16-13-17-26-78)182-148(238)120(75(9)197)188-114(205)63-163-125(215)90(39-42-110(153)201)169-142(232)105(64-192)183-124(214)86(152)56-82-62-160-69-164-82/h12-19,23-28,31-38,61-62,69-76,86,88-109,118-121,162,192-200,240H,20-22,29-30,39-60,63-68,151-152H2,1-11H3,(H2,153,201)(H2,154,202)(H2,155,203)(H2,156,204)(H2,157,212)(H,160,164)(H,163,215)(H,165,216)(H,166,213)(H,167,233)(H,168,236)(H,169,232)(H,170,221)(H,171,237)(H,172,223)(H,173,225)(H,174,217)(H,175,227)(H,176,226)(H,177,219)(H,178,220)(H,179,218)(H,180,222)(H,181,234)(H,182,238)(H,183,214)(H,184,224)(H,185,228)(H,186,239)(H,187,235)(H,188,205)(H,189,229)(H,190,231)(H,191,230)(H,206,207)(H,208,209)(H,210,211)(H4,158,159,161)/t73-,74+,75+,76+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-/s2
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 1.40n/an/an/an/a



Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Structural Biology Center, Wenzhou Medical University, Wenzhou 325027,

Curated by ChEMBL


Assay Description
Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay


Eur J Med Chem 138: 1158-1169 (2017)

More data for this
Ligand-Target Pair
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