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Found 311 of kon for UniProtKB: P08246
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291924((4S,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-3-met...)
Affinity DataKoff:  1s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291939((4S,7S)-7-Chloro-2-(2,2-dimethyl-propionyl)-3-meth...)
Affinity DataKoff:  1s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291916((S)-7-Chloro-2-(2,2-dimethyl-propionyl)-3-(1-methy...)
Affinity DataKoff:  1.20s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291921((S)-3-Acetoxymethyl-7-chloro-5,5,8-trioxo-5lambda*...)
Affinity DataKoff:  1.30s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291928((4S,7S)-2-Benzoyl-7-chloro-3-methyl-4-(1-methyl-1H...)
Affinity DataKoff:  1.30s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291948(Acetic acid (S)-2-benzoyl-7-chloro-5,5,8-trioxo-5l...)
Affinity DataKoff:  1.5s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291927((S)-7-Chloro-2-(2,2-dimethyl-propionyl)-3-methoxym...)
Affinity DataKoff:  1.5s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291918(2alpha-(benzoyloxy)3-[(benzoyloxy)methyl]-4-(tert-...)
Affinity DataKoff:  1.60s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280672((6R,7S)-2-Benzoyl-7-methoxy-3-(1-methyl-1H-tetrazo...)
Affinity DataKoff:  1.80s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280676((6R,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-3-(1-...)
Affinity DataKoff:  1.90s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50015925((S)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanyl...)
Affinity DataKoff:  2s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291942(Benzoic acid (4S,7S)-2-(2,2-dimethyl-propionyl)-7-...)
Affinity DataKoff: >2s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291950(Acetic acid (4S,7S)-2-(2,2-dimethyl-propionyl)-7-m...)
Affinity DataKoff:  2s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291931((4S,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-4-(5-...)
Affinity DataKoff:  2.10s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291920(Acetic acid (S)-7-chloro-5,5,8-trioxo-2-(3-oxo-but...)
Affinity DataKoff:  2.10s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291914((S)-7-Chloro-2-(2,2-dimethyl-propionyl)-3-methyl-5...)
Affinity DataKoff:  2.10s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291949((4S,7S)-2-Benzoyl-7-methoxy-4-(1-methyl-1H-tetrazo...)
Affinity DataKoff:  2.20s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291943(Acetic acid (S)-7-chloro-2-(2,2-dimethyl-propionyl...)
Affinity DataKoff:  2.30s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291919((4S,7S)-2-Benzoyl-7-methoxy-3-methyl-4-(1-methyl-1...)
Affinity DataKoff:  2.30s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291923((4S,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-4-(1-...)
Affinity DataKoff:  2.60s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291929((4S,7S)-2-Benzoyl-7-methoxy-4-(5-methyl-2,5-dihydr...)
Affinity DataKoff:  3.90s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291944((S)-2-(2,2-Dimethyl-propionyl)-3-(6-hydroxy-2-meth...)
Affinity DataKoff:  4.5s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291937(Acetic acid (S)-7-chloro-5,5,8-trioxo-2-phenylacet...)
Affinity DataKoff:  4.90s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291936((4S,7S)-2-(2,2-Dimethyl-propionyl)-4-(6-hydroxy-2-...)
Affinity DataKoff:  5.30s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50212647(CHEMBL75236)
Affinity DataKoff:  5.60s-1Assay Description:Compound was evaluated for the inhibitory activity against Human leukocyte elastase; time-dependent inhibition was not observedMore data for this Ligand-Target Pair
In DepthDetails
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291946(Acetic acid (4S,7S)-7-chloro-2-(2,2-dimethyl-propi...)
Affinity DataKoff:  5.70s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291935(4-(6-Hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]tri...)
Affinity DataKoff:  7s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291926(Acetic acid (S)-7-chloro-5,5,8-trioxo-2-propionyl-...)
Affinity DataKoff:  7.30s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291945((S)-2-Benzoyl-7-chloro-3-methyl-5,5-dioxo-5lambda*...)
Affinity DataKoff:  8s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50003159(3-(6-Hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]tri...)
Affinity DataKoff:  9.20s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50291754(2-Amino-5-ethyl-benzo[d][1,3]oxazin-4-one | CHEMBL...)
Affinity DataKi:  5.01E+3nM Kon:  0.0000776M-1s-1 Koff:  15.1s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50406212(CHEMBL357238)
Affinity DataKi:  1.26E+3nM Kon:  0.0000200M-1s-1 Koff:  15.8s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50406303(CHEMBL145690)
Affinity DataKi:  398nM Kon:  0.0000240M-1s-1 Koff:  66.1s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50406244(CHEMBL444082)
Affinity DataKi:  251nM Kon:  0.0000182M-1s-1 Koff:  75.9s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50286678((2S,2aR)-7-tert-Butyl-2-methoxy-3,3-dioxo-2,2a,3,4...)
Affinity DataKoff:  80s-1Assay Description:Inhibitory activity against human leukocyte elastase (HLE) expressed as second order inhibition rate constantMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280682((6R,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-3-met...)
Affinity DataKoff:  90s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280682((6R,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-3-met...)
Affinity DataKoff:  90s-1Assay Description:Inhibition of human leukocyte elastase II (HLE-II) as second order rate constantMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280682((6R,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-3-met...)
Affinity DataKoff:  90s-1Assay Description:Inhibitory activity against human leukocyte elastase (HLE) expressed as second order inhibition rate constantMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280682((6R,7S)-2-(2,2-Dimethyl-propionyl)-7-methoxy-3-met...)
Affinity DataKoff:  90s-1Assay Description:Inhibitory activity against human leukocyte elastase (HLE) expressed as second order inhibition rate constantMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50406196(CHEMBL335798)
Affinity DataKi:  398nM Kon:  0.0000389M-1s-1 Koff:  97.7s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50406254(CHEMBL344969)
Affinity DataKi:  1.26E+3nM Kon:  0.000129M-1s-1 Koff:  102s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50406210(CHEMBL443745)
Affinity DataKi:  631nM Kon:  0.0000741M-1s-1 Koff:  112s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50281004(CHEMBL419820 | [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-...)
Affinity DataKi:  3.20E+3nM Koff:  130s-1Assay Description:Rate constant for the compound was determined (k2/ki) against human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280675((6R,7S)-2-Benzoyl-7-methoxy-3-methyl-5,5-dioxo-5la...)
Affinity DataKoff:  130s-1Assay Description:Inhibitory activity against human leukocyte elastase (HLE) expressed as second order inhibition rate constantMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280675((6R,7S)-2-Benzoyl-7-methoxy-3-methyl-5,5-dioxo-5la...)
Affinity DataKoff:  130s-1Assay Description:Inhibitory activity against human leukocyte elastase (HLE) expressed as second order inhibition rate constantMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280675((6R,7S)-2-Benzoyl-7-methoxy-3-methyl-5,5-dioxo-5la...)
Affinity DataKoff:  130s-1Assay Description:Inhibition of human leukocyte elastase II (HLE-II) as second order rate constantMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50280675((6R,7S)-2-Benzoyl-7-methoxy-3-methyl-5,5-dioxo-5la...)
Affinity DataKoff:  130s-1Assay Description:Tested for the rate constant against Human Leukocyte Elastase (HLE) inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50281004(CHEMBL419820 | [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-...)
Affinity DataKoff:  130s-1Assay Description:Rate constant for the compound was determined (k2/ki) against human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50406306(CHEMBL145107)
Affinity DataKi:  100nM Kon:  0.0000138M-1s-1 Koff:  132s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Pharmacia-Farmitalia Carlo Erba

Curated by ChEMBL
LigandPNGBDBM50281009(CHEMBL74813 | [(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-o...)
Affinity DataKoff:  150s-1Assay Description:Rate constant for the compound was determined (k2/ki) against human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
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