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Compile Data Set for Download or QSAR

Found 3405 hits of ic50 for UniProtKB: A0A024QYW7   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238725
PNG
(US9394297, 406)
Show SMILES CC(C)n1c(NC(C)(C)C)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1
Show InChI InChI=1S/C22H27N5O2/c1-11(2)27-20(29)14-9-7-8-13(18(14)25-21(27)26-22(4,5)6)16-10-15-17(24-16)12(3)23-19(15)28/h7-12,24H,1-6H3,(H,23,28)(H,25,26)/t12-/m1/s1
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US Patent
n/an/a 0.0120n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238724
PNG
(US9394297, 405)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O
Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1
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n/an/a 0.0120n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238817
PNG
(US9394297, 504)
Show SMILES Cn1c(NC(C)(C)C)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](CCN)c2[nH]1
Show InChI InChI=1S/C21H26N6O2/c1-21(2,3)26-20-25-16-11(6-5-7-12(16)19(29)27(20)4)15-10-13-17(23-15)14(8-9-22)24-18(13)28/h5-7,10,14,23H,8-9,22H2,1-4H3,(H,24,28)(H,25,26)/t14-/m1/s1
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n/an/a 0.0200n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238714
PNG
(US9394297, 378)
Show SMILES Cc1nc2ccc(F)c(-c3cc4C(=O)NC5(CC5)c4[nH]3)c2nc1NC1(C)CC1
Show InChI InChI=1S/C21H20FN5O/c1-10-18(26-20(2)5-6-20)25-16-13(23-10)4-3-12(22)15(16)14-9-11-17(24-14)21(7-8-21)27-19(11)28/h3-4,9,24H,5-8H2,1-2H3,(H,25,26)(H,27,28)
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n/an/a 0.0354n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238796
PNG
(US9394297, 483)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2nc(C)c(N[C@H]3CCC[C@@H](N)C3)nc12
Show InChI InChI=1S/C22H26N6O/c1-11-19-16(22(29)25-11)10-18(27-19)15-7-4-8-17-20(15)28-21(12(2)24-17)26-14-6-3-5-13(23)9-14/h4,7-8,10-11,13-14,27H,3,5-6,9,23H2,1-2H3,(H,25,29)(H,26,28)/t11-,13-,14+/m1/s1
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n/an/a 0.0358n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238826
PNG
(US9394297, 513)
Show SMILES CCn1c(NC2(C)CC2)nc2c(-c3cc4C(=O)N[C@H](C)c4[nH]3)c(F)ccc2c1=O
Show InChI InChI=1S/C21H22FN5O2/c1-4-27-19(29)11-5-6-13(22)15(17(11)25-20(27)26-21(3)7-8-21)14-9-12-16(24-14)10(2)23-18(12)28/h5-6,9-10,24H,4,7-8H2,1-3H3,(H,23,28)(H,25,26)/t10-/m1/s1
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n/an/a 0.0378n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238624
PNG
(US9394297, 284)
Show SMILES CC(C)(C)Nc1nc2c(cccc2[nH]c1=O)-c1cc2c(CCNC2=O)[nH]1
Show InChI InChI=1S/C19H21N5O2/c1-19(2,3)24-16-18(26)22-13-6-4-5-10(15(13)23-16)14-9-11-12(21-14)7-8-20-17(11)25/h4-6,9,21H,7-8H2,1-3H3,(H,20,25)(H,22,26)(H,23,24)
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n/an/a 0.0378n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238715
PNG
(US9394297, 379)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2nc(C)c(NC3(C)CC3)nc12
Show InChI InChI=1S/C20H20FN5O/c1-9-16-11(19(27)23-9)8-14(24-16)15-12(21)4-5-13-17(15)25-18(10(2)22-13)26-20(3)6-7-20/h4-5,8-9,24H,6-7H2,1-3H3,(H,23,27)(H,25,26)/t9-/m1/s1
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n/an/a 0.0484n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50174162
PNG
(CHEMBL3808669)
Show SMILES Cc1nc2cccc3-c4cc5c([nH]4)[C@H](CNC5=O)CCCCNc1nc23
Show InChI InChI=1S/C20H21N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h4,6-7,9,12,24H,2-3,5,8,10H2,1H3,(H,21,25)(H,22,26)/t12-/m0/s1
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n/an/a 0.0500n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...


ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517428
PNG
(CHEMBL4568404)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(c2=O)C1(C)CC1
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n/an/a 0.0500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50174153
PNG
(CHEMBL3808887)
Show SMILES C[C@H]1Nc2nc3c(cccc3nc2C)-c2cc3c([nH]2)[C@H](CNC3=O)C\C=C\1
Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3+/t11-,13+/m1/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...


ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238808
PNG
(US9394297, 495)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2CN(C3CC3)C(NC3(C)CC3)=Nc12
Show InChI InChI=1S/C22H24FN5O/c1-11-18-14(20(29)24-11)9-16(25-18)17-15(23)6-3-12-10-28(13-4-5-13)21(26-19(12)17)27-22(2)7-8-22/h3,6,9,11,13,25H,4-5,7-8,10H2,1-2H3,(H,24,29)(H,26,27)/t11-/m1/s1
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n/an/a 0.0600n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238707
PNG
(US9394297, 371)
Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C
Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26)
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n/an/a 0.0667n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50174168
PNG
(CHEMBL3810121)
Show SMILES Cc1nc2cccc3-c4cc5c([nH]4)[C@H](CNC5=O)C\C=C/CNc1nc23
Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2-/t12-/m0/s1
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n/an/a 0.0700n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...


ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238825
PNG
(US9394297, 512)
Show SMILES CCn1c(NC(C)(C)C)nc2c(-c3cc4C(=O)N[C@H](C)c4[nH]3)c(F)ccc2c1=O
Show InChI InChI=1S/C21H24FN5O2/c1-6-27-19(29)11-7-8-13(22)15(17(11)25-20(27)26-21(3,4)5)14-9-12-16(24-14)10(2)23-18(12)28/h7-10,24H,6H2,1-5H3,(H,23,28)(H,25,26)/t10-/m1/s1
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n/an/a 0.0741n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238788
PNG
(US9394297, 475)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(C1CC1)c2=O
Show InChI InChI=1S/C22H25N5O2/c1-11-17-15(19(28)23-11)10-16(24-17)13-6-5-7-14-18(13)25-21(26-22(2,3)4)27(20(14)29)12-8-9-12/h5-7,10-12,24H,8-9H2,1-4H3,(H,23,28)(H,25,26)/t11-/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238794
PNG
(US9394297, 481)
Show SMILES CCn1c(NC(C)(C)C)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1
Show InChI InChI=1S/C21H25N5O2/c1-6-26-19(28)13-9-7-8-12(17(13)24-20(26)25-21(3,4)5)15-10-14-16(23-15)11(2)22-18(14)27/h7-11,23H,6H2,1-5H3,(H,22,27)(H,24,25)/t11-/m1/s1
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n/an/a 0.0770n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238695
PNG
(US9394297, 358)
Show SMILES Cc1nc2cccc(-c3[nH]c4CNC(=O)c4c3Cl)c2nc1NC1(C)CC1
Show InChI InChI=1S/C19H18ClN5O/c1-9-17(25-19(2)6-7-19)24-15-10(4-3-5-11(15)22-9)16-14(20)13-12(23-16)8-21-18(13)26/h3-5,23H,6-8H2,1-2H3,(H,21,26)(H,24,25)
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n/an/a 0.0783n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517435
PNG
(CHEMBL4441708)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(CC1CC1)c2=O
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TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM192558
PNG
(US9187486, 20)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F2N7O/c1-13-11-31(12-17(26)22(13)33)20-7-8-27-10-19(20)29-23-28-9-14-5-6-18(30-32(14)23)21-15(24)3-2-4-16(21)25/h2-10,13,17,22,33H,11-12,26H2,1H3,(H,28,29)/t13-,17+,22+/m0/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50174149
PNG
(CHEMBL3808662)
Show SMILES Cc1nc2cccc3-c4cc5c([nH]4)[C@H](CNC5=O)C\C=C(C)\CNc1nc23
Show InChI InChI=1S/C21H21N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-6,8,13,25H,7,9-10H2,1-2H3,(H,22,26)(H,23,27)/b11-6+/t13-/m0/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo...


ACS Med Chem Lett 7: 408-12 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50200531
PNG
(CHEMBL3950251)
Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1S/C22H22F2N8O/c23-13-2-1-3-14(24)20(13)17-5-4-12-8-28-22(32(12)30-17)29-18-9-27-7-6-19(18)31-10-15(25)21(33)16(26)11-31/h1-9,15-16,21,33H,10-11,25-26H2,(H,28,29)/t15-,16+,21+
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay


Bioorg Med Chem Lett 26: 5580-5590 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238805
PNG
(US9394297, 492)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C1CC1)c2=O
Show InChI InChI=1S/C22H23N5O2/c1-11-17-15(19(28)23-11)10-16(24-17)13-4-3-5-14-18(13)25-21(26-22(2)8-9-22)27(20(14)29)12-6-7-12/h3-5,10-12,24H,6-9H2,1-2H3,(H,23,28)(H,25,26)/t11-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM192574
PNG
(US9187486, 37 | US9187486, 39 | US9187486, 60)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay


Bioorg Med Chem Lett 26: 5580-5590 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238637
PNG
(US9394297, 297)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2nc(C)c(NC(C)(C)C)nc12
Show InChI InChI=1S/C20H22FN5O/c1-9-16-11(19(27)23-9)8-14(24-16)15-12(21)6-7-13-17(15)25-18(10(2)22-13)26-20(3,4)5/h6-9,24H,1-5H3,(H,23,27)(H,25,26)/t9-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...


J Med Chem 59: 6407-30 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00610
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238724
PNG
(US9394297, 405)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O
Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...


J Med Chem 59: 6407-30 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00610
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238707
PNG
(US9394297, 371)
Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C
Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...


J Med Chem 59: 6407-30 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00610
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238811
PNG
(US9394297, 498)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC1(C)CCC1)n(C1CC1)c2=O
Show InChI InChI=1S/C23H24FN5O2/c1-11-18-14(20(30)25-11)10-16(26-18)17-15(24)7-6-13-19(17)27-22(28-23(2)8-3-9-23)29(21(13)31)12-4-5-12/h6-7,10-12,26H,3-5,8-9H2,1-2H3,(H,25,30)(H,27,28)/t11-/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238819
PNG
(US9394297, 506)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(N[C@H]1CCC[C@@H](N)C1)n(C)c2=O
Show InChI InChI=1S/C22H26N6O2/c1-11-18-16(20(29)24-11)10-17(26-18)14-7-4-8-15-19(14)27-22(28(2)21(15)30)25-13-6-3-5-12(23)9-13/h4,7-8,10-13,26H,3,5-6,9,23H2,1-2H3,(H,24,29)(H,25,27)/t11-,12-,13+/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238823
PNG
(US9394297, 510)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC1(C)CC1)n(C)c2=O
Show InChI InChI=1S/C20H20FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)5-4-10-16(14)24-19(26(3)18(10)28)25-20(2)6-7-20/h4-5,8-9,23H,6-7H2,1-3H3,(H,22,27)(H,24,25)/t9-/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238510
PNG
(US9394297, 140 | US9394297, 141)
Show SMILES Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1N[C@@H]1CCC[C@H](N)C1
Show InChI InChI=1S/C22H26N6O/c1-12-21(26-14-5-2-4-13(23)10-14)28-20-15(6-3-7-18(20)25-12)19-11-16-17(27-19)8-9-24-22(16)29/h3,6-7,11,13-14,27H,2,4-5,8-10,23H2,1H3,(H,24,29)(H,26,28)/t13-,14+/m0/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238573
PNG
(US9394297, 220)
Show SMILES CCN(c1cnc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2n1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-5-26(21(2,3)4)18-12-23-16-8-6-7-13(19(16)25-18)17-11-14-15(24-17)9-10-22-20(14)27/h6-8,11-12,24H,5,9-10H2,1-4H3,(H,22,27)
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238805
PNG
(US9394297, 492)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C1CC1)c2=O
Show InChI InChI=1S/C22H23N5O2/c1-11-17-15(19(28)23-11)10-16(24-17)13-4-3-5-14-18(13)25-21(26-22(2)8-9-22)27(20(14)29)12-6-7-12/h3-5,10-12,24H,6-9H2,1-2H3,(H,23,28)(H,25,26)/t11-/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM192575
PNG
(US9187486, 38)
Show SMILES C[C@H]1C[C@@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m0/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM192629
PNG
(US9187486, 46)
Show SMILES C[C@H]1C[C@@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccc1F
Show InChI InChI=1S/C23H24FN7/c1-15-10-16(25)14-30(13-15)22-8-9-26-12-21(22)28-23-27-11-17-6-7-20(29-31(17)23)18-4-2-3-5-19(18)24/h2-9,11-12,15-16H,10,13-14,25H2,1H3,(H,27,28)/t15-,16+/m0/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM192599
PNG
(US9187486, 72)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1cc(ccc1F)C(=O)NC1CC1
Show InChI InChI=1S/C27H29FN8O/c1-16-10-18(29)15-35(14-16)25-8-9-30-13-24(25)33-27-31-12-20-5-7-23(34-36(20)27)21-11-17(2-6-22(21)28)26(37)32-19-3-4-19/h2,5-9,11-13,16,18-19H,3-4,10,14-15,29H2,1H3,(H,31,33)(H,32,37)/t16-,18+/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9187486 (2015)


BindingDB Entry DOI: 10.7270/Q24748NM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238637
PNG
(US9394297, 297)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2nc(C)c(NC(C)(C)C)nc12
Show InChI InChI=1S/C20H22FN5O/c1-9-16-11(19(27)23-9)8-14(24-16)15-12(21)6-7-13-17(15)25-18(10(2)22-13)26-20(3,4)5/h6-9,24H,1-5H3,(H,23,27)(H,25,26)/t9-/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517431
PNG
(CHEMBL4471849)
Show SMILES CC(c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238813
PNG
(US9394297, 500)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(CCCO)c2=O
Show InChI InChI=1S/C22H27N5O3/c1-12-17-15(19(29)23-12)11-16(24-17)13-7-5-8-14-18(13)25-21(26-22(2,3)4)27(20(14)30)9-6-10-28/h5,7-8,11-12,24,28H,6,9-10H2,1-4H3,(H,23,29)(H,25,26)/t12-/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517429
PNG
(CHEMBL4436404)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1CC1)c2=O
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n/an/a 0.120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238788
PNG
(US9394297, 475)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(C1CC1)c2=O
Show InChI InChI=1S/C22H25N5O2/c1-11-17-15(19(28)23-11)10-16(24-17)13-6-5-7-14-18(13)25-21(26-22(2,3)4)27(20(14)29)12-8-9-12/h5-7,10-12,24H,8-9H2,1-4H3,(H,23,28)(H,25,26)/t11-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238725
PNG
(US9394297, 406)
Show SMILES CC(C)n1c(NC(C)(C)C)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1
Show InChI InChI=1S/C22H27N5O2/c1-11(2)27-20(29)14-9-7-8-13(18(14)25-21(27)26-22(4,5)6)16-10-15-17(24-16)12(3)23-19(15)28/h7-12,24H,1-6H3,(H,23,28)(H,25,26)/t12-/m1/s1
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n/an/a 0.130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238778
PNG
(US9394297, 465)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CCC1)n(C)c2=O
Show InChI InChI=1S/C21H23N5O2/c1-11-16-14(18(27)22-11)10-15(23-16)12-6-4-7-13-17(12)24-20(26(3)19(13)28)25-21(2)8-5-9-21/h4,6-7,10-11,23H,5,8-9H2,1-3H3,(H,22,27)(H,24,25)/t11-/m1/s1
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n/an/a 0.130n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517421
PNG
(CHEMBL4461181)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(C[C@H]1CCCO1)c2=O
PDB
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n/an/a 0.130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238712
PNG
(US9394297, 376)
Show SMILES Cc1nc2ccc(F)c(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC1(C)CCC1
Show InChI InChI=1S/C21H22FN5O/c1-11-19(27-21(2)7-3-8-21)26-18-15(24-11)5-4-13(22)17(18)16-10-12-14(25-16)6-9-23-20(12)28/h4-5,10,25H,3,6-9H2,1-2H3,(H,23,28)(H,26,27)
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517433
PNG
(CHEMBL4450494)
Show SMILES C[C@@H](c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1
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n/an/a 0.150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238810
PNG
(US9394297, 497)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2nc(C)c(N[C@H]3CCC[C@H](C3)NC(=O)[C@H](N)CO)nc12
Show InChI InChI=1S/C25H31N7O3/c1-12-21-17(24(34)28-12)10-20(31-21)16-7-4-8-19-22(16)32-23(13(2)27-19)29-14-5-3-6-15(9-14)30-25(35)18(26)11-33/h4,7-8,10,12,14-15,18,31,33H,3,5-6,9,11,26H2,1-2H3,(H,28,34)(H,29,32)(H,30,35)/t12-,14+,15-,18-/m1/s1
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Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517424
PNG
(CHEMBL4456165)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(c2=O)C1(C)CC1
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n/an/a 0.160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517414
PNG
(CHEMBL4563904)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(Cc1cn(C)cn1)c2=O
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n/an/a 0.160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM50517420
PNG
(CHEMBL4513589)
Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1(N)CC1)c2=O
PDB
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n/an/a 0.160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ...


J Med Chem 62: 1523-1540 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01733
More data for this
Ligand-Target Pair
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