Found 519 hits of ki for UniProtKB: A0A024QYW7 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM106896
(US8592455, 96)Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F Show InChI InChI=1S/C23H22F3N5O2/c1-12-10-31(11-16(27)22(12)32)19-7-8-28-9-18(19)30-23(33)17-6-5-15(26)21(29-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,22,32H,10-11,27H2,1H3,(H,30,33)/t12-,16+,22+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) |
ACS Med Chem Lett 4: 1193-7 (2013)
Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM106803
(US8592455, 3)Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F Show InChI InChI=1S/C23H23F3N6O2/c1-11-9-32(10-16(28)22(11)33)18-5-6-29-8-17(18)30-23(34)21-15(27)7-14(26)20(31-21)19-12(24)3-2-4-13(19)25/h2-8,11,16,22,33H,9-10,27-28H2,1H3,(H,30,34)/t11-,16+,22+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) |
ACS Med Chem Lett 4: 1193-7 (2013)
Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50445124
(CHEMBL3103868)Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F Show InChI InChI=1S/C22H22F2N6O/c23-14-4-1-5-15(24)20(14)17-7-6-16(26)21(28-17)22(31)29-18-11-27-9-8-19(18)30-10-2-3-13(25)12-30/h1,4-9,11,13H,2-3,10,12,25-26H2,(H,29,31)/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by AlphaScreen assay |
ACS Med Chem Lett 4: 1193-7 (2013)
Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50445133
(CHEMBL3103869)Show SMILES N[C@@H]1CN(CC[C@H]1O)c1ccncc1NC(=O)c1nc(ccc1N)-c1c(F)cccc1F Show InChI InChI=1S/C22H22F2N6O2/c23-12-2-1-3-13(24)20(12)16-5-4-14(25)21(28-16)22(32)29-17-10-27-8-6-18(17)30-9-7-19(31)15(26)11-30/h1-6,8,10,15,19,31H,7,9,11,25-26H2,(H,29,32)/t15-,19-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.00600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) |
ACS Med Chem Lett 4: 1193-7 (2013)
Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM106870
(US8592455, 70)Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F Show InChI InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
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antibodypedia
GoogleScholar
| Purchase
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay |
J Med Chem 58: 8373-86 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01275
BindingDB Entry DOI: 10.7270/Q2H41VGN |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50434655
(CHEMBL2387464)Show SMILES F[C@H]1CNCC[C@@H]1CNc1ccn2ncc(C(=O)Nc3c[nH]c4ncc(cc34)-c3ccccc3F)c2n1 Show InChI InChI=1S/C26H24F2N8O/c27-20-4-2-1-3-17(20)16-9-18-22(14-32-24(18)31-11-16)34-26(37)19-12-33-36-8-6-23(35-25(19)36)30-10-15-5-7-29-13-21(15)28/h1-4,6,8-9,11-12,14-15,21,29H,5,7,10,13H2,(H,30,35)(H,31,32)(H,34,37)/t15-,21+/m1/s1 | PDB
MMDB
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UniProtKB/SwissProt
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GoogleScholar
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 0.0320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP |
Bioorg Med Chem Lett 23: 3149-53 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.020
BindingDB Entry DOI: 10.7270/Q2PC33S9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50434654
(CHEMBL2387465)Show SMILES F[C@H]1CNCC[C@@H]1CNc1ccn2ncc(C(=O)Nc3c[nH]c4ncc(cc34)-c3c(F)cccc3F)c2n1 Show InChI InChI=1S/C26H23F3N8O/c27-18-2-1-3-19(28)23(18)15-8-16-21(13-33-24(16)32-10-15)35-26(38)17-11-34-37-7-5-22(36-25(17)37)31-9-14-4-6-30-12-20(14)29/h1-3,5,7-8,10-11,13-14,20,30H,4,6,9,12H2,(H,31,36)(H,32,33)(H,35,38)/t14-,20+/m1/s1 | PDB
MMDB
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UniProtKB/SwissProt
UniProtKB/TrEMBL
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antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP |
Bioorg Med Chem Lett 23: 3149-53 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.020
BindingDB Entry DOI: 10.7270/Q2PC33S9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50505052
(CHEMBL3623150)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)CC(F)(F)C1 Show InChI InChI=1S/C20H21F4N7OS/c1-30-19(31-6-5-10(25)7-20(23,24)9-31)13(8-27-30)28-17(32)15-16(26)33-18(29-15)14-11(21)3-2-4-12(14)22/h2-4,8,10H,5-7,9,25-26H2,1H3,(H,28,32)/t10-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50505059
(CHEMBL4459538)Show SMILES CO[C@H]1C[C@H](N)CCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C Show InChI InChI=1S/C21H25F2N7O2S/c1-29-21(30-7-6-11(24)8-12(10-30)32-2)15(9-26-29)27-19(31)17-18(25)33-20(28-17)16-13(22)4-3-5-14(16)23/h3-5,9,11-12H,6-8,10,24-25H2,1-2H3,(H,27,31)/t11-,12+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131224
(CHEMBL3634783 | US9260425, 505)Show SMILES Cc1cncc(n1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C20H20N8/c1-13-10-22-11-18(24-13)16-9-14-17(12-23-16)26-27-20(14)15-3-2-4-19(25-15)28-7-5-21-6-8-28/h2-4,9-12,21H,5-8H2,1H3,(H,26,27) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50505050
(CHEMBL4439756)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC(N)CC(F)C1 Show InChI InChI=1S/C20H22F3N7OS/c1-29-20(30-6-5-11(24)7-10(21)9-30)14(8-26-29)27-18(31)16-17(25)32-19(28-16)15-12(22)3-2-4-13(15)23/h2-4,8,10-11H,5-7,9,24-25H2,1H3,(H,27,31) | PDB
MMDB
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UniProtKB/SwissProt
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antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50505057
(CHEMBL3676285)Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F Show InChI InChI=1S/C20H20F2N6OS/c21-12-4-1-5-13(22)16(12)20-27-17(18(24)30-20)19(29)26-14-9-25-7-6-15(14)28-8-2-3-11(23)10-28/h1,4-7,9,11H,2-3,8,10,23-24H2,(H,26,29)/t11-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50434666
(CHEMBL2387471)Show SMILES Fc1cccc(F)c1-c1cnc2[nH]cc(NC(=O)c3cnn4ccc(NCC5CCNCC5)nc34)c2c1 Show InChI InChI=1S/C26H24F2N8O/c27-19-2-1-3-20(28)23(19)16-10-17-21(14-32-24(17)31-12-16)34-26(37)18-13-33-36-9-6-22(35-25(18)36)30-11-15-4-7-29-8-5-15/h1-3,6,9-10,12-15,29H,4-5,7-8,11H2,(H,30,35)(H,31,32)(H,34,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0760 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP |
Bioorg Med Chem Lett 23: 3149-53 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.020
BindingDB Entry DOI: 10.7270/Q2PC33S9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248950
(US9434725, 181)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C24H26N8/c1-15-10-26-13-21(29-15)20-9-22-17(11-27-20)12-28-32(22)23-7-6-19(16-4-5-16)24(30-23)31-8-2-3-18(25)14-31/h6-7,9-13,16,18H,2-5,8,14,25H2,1H3/t18-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| US Patent
| 0.0770 | -13.8 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131278
(CHEMBL3634760 | US9260425, 433)Show SMILES Cc1ccc(nc1N1CCC[C@H](N)C1)-c1n[nH]c2cnc(cc12)-c1cnn(C)c1 Show InChI InChI=1S/C21H24N8/c1-13-5-6-17(25-21(13)29-7-3-4-15(22)12-29)20-16-8-18(14-9-24-28(2)11-14)23-10-19(16)26-27-20/h5-6,8-11,15H,3-4,7,12,22H2,1-2H3,(H,26,27)/t15-/m0/s1 | PDB
MMDB
KEGG
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GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50434656
(CHEMBL2387463)Show SMILES Fc1ccccc1-c1cnc2[nH]cc(NC(=O)c3cnn4ccc(NCC5CCNCC5)nc34)c2c1 Show InChI InChI=1S/C26H25FN8O/c27-21-4-2-1-3-18(21)17-11-19-22(15-31-24(19)30-13-17)33-26(36)20-14-32-35-10-7-23(34-25(20)35)29-12-16-5-8-28-9-6-16/h1-4,7,10-11,13-16,28H,5-6,8-9,12H2,(H,29,34)(H,30,31)(H,33,36) | PDB
MMDB
KEGG
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GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0940 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP |
Bioorg Med Chem Lett 23: 3149-53 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.020
BindingDB Entry DOI: 10.7270/Q2PC33S9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50505051
(CHEMBL4437940)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC[C@H](N)CC1 Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)/t11-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM110706
(US8614206, 139)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)[C@H](F)CC1 Show InChI InChI=1S/C20H22F3N7OS/c1-29-20(30-7-5-10(21)13(24)6-8-30)14(9-26-29)27-18(31)16-17(25)32-19(28-16)15-11(22)3-2-4-12(15)23/h2-4,9-10,13H,5-8,24-25H2,1H3,(H,27,31)/t10-,13-/m1/s1 | PDB
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| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248940
(US9434725, 171 | US9434725, 182 | US9434725, 183)Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3 | PDB
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| US Patent
| 0.109 | -13.6 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248955
(US9434725, 186)Show SMILES COc1ccc(nc1N1CCC[C@H](N)C1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C22H24N8O/c1-14-9-24-12-18(27-14)17-8-19-15(10-25-17)11-26-30(19)21-6-5-20(31-2)22(28-21)29-7-3-4-16(23)13-29/h5-6,8-12,16H,3-4,7,13,23H2,1-2H3/t16-/m0/s1 | PDB
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| 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as... |
J Med Chem 60: 4458-4473 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00418
BindingDB Entry DOI: 10.7270/Q2H997PN |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM206757
(US9260425, 522)Show SMILES Cc1cncc(n1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCCNCC1 Show InChI InChI=1S/C21H22N8/c1-14-11-23-12-19(25-14)17-10-15-18(13-24-17)27-28-21(15)16-4-2-5-20(26-16)29-8-3-6-22-7-9-29/h2,4-5,10-13,22H,3,6-9H2,1H3,(H,27,28) | PDB
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Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as... |
J Med Chem 60: 4458-4473 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00418
BindingDB Entry DOI: 10.7270/Q2H997PN |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248989
(US9434725, 220)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(c(n1)N1CCC[C@H](N)C1)C(F)(F)F Show InChI InChI=1S/C22H21F3N8/c1-13-8-27-11-18(30-13)17-7-19-14(9-28-17)10-29-33(19)20-5-4-16(22(23,24)25)21(31-20)32-6-2-3-15(26)12-32/h4-5,7-11,15H,2-3,6,12,26H2,1H3/t15-/m0/s1 | PDB
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| US Patent
| 0.115 | -13.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131227
(CHEMBL3634771 | US9260425, 473)Show SMILES N#CCn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C20H19N9/c21-4-7-29-13-14(11-24-29)17-10-15-18(12-23-17)26-27-20(15)16-2-1-3-19(25-16)28-8-5-22-6-9-28/h1-3,10-13,22H,5-9H2,(H,26,27) | PDB
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| Article
PubMed
| 0.127 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248955
(US9434725, 186)Show SMILES COc1ccc(nc1N1CCC[C@H](N)C1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C22H24N8O/c1-14-9-24-12-18(27-14)17-8-19-15(10-25-17)11-26-30(19)21-6-5-20(31-2)22(28-21)29-7-3-4-16(23)13-29/h5-6,8-12,16H,3-4,7,13,23H2,1-2H3/t16-/m0/s1 | PDB
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| US Patent
| 0.134 | -13.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248974
(US9434725, 205)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C)c(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C22H24N8/c1-14-5-6-21(28-22(14)29-7-3-4-17(23)13-29)30-20-8-18(25-10-16(20)11-26-30)19-12-24-9-15(2)27-19/h5-6,8-12,17H,3-4,7,13,23H2,1-2H3/t17-/m0/s1 | PDB
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| US Patent
| 0.142 | -13.4 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131225
(CHEMBL3634769 | US9260425, 515)Show SMILES CCn1cncc(-c2cc3c(n[nH]c3cn2)-c2cccc(n2)N2CCNCC2)c1=O Show InChI InChI=1S/C21H22N8O/c1-2-28-13-23-11-15(21(28)30)17-10-14-18(12-24-17)26-27-20(14)16-4-3-5-19(25-16)29-8-6-22-7-9-29/h3-5,10-13,22H,2,6-9H2,1H3,(H,26,27) | PDB
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| 0.145 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50387298
(CHEMBL2048872)Show SMILES N[C@@H]1CCCN(C1)c1c(C=C2SC(O)=NC2=O)cccc1-c1ccccc1 Show InChI InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/t16-/m1/s1 | PDB
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| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay |
J Med Chem 58: 8373-86 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01275
BindingDB Entry DOI: 10.7270/Q2H41VGN |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50387298
(CHEMBL2048872)Show SMILES N[C@@H]1CCCN(C1)c1c(C=C2SC(O)=NC2=O)cccc1-c1ccccc1 Show InChI InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/t16-/m1/s1 | PDB
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| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) |
ACS Med Chem Lett 4: 1193-7 (2013)
Article DOI: 10.1021/ml400307j
BindingDB Entry DOI: 10.7270/Q23X8840 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM119398
(US8669361, 140 | US9573943, Example 140)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1 Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)/t11-/m1/s1 | PDB
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| US Patent
| 0.167 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US8669361 (2014)
BindingDB Entry DOI: 10.7270/Q2P26WSV |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM119398
(US8669361, 140 | US9573943, Example 140)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1 Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)/t11-/m1/s1 | PDB
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| 0.167 | -13.3 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Genentech Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9573943 (2017)
BindingDB Entry DOI: 10.7270/Q2CF9S5P |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131261
(CHEMBL3634767)Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCCNCC1 Show InChI InChI=1S/C20H22N8/c1-27-13-14(11-23-27)17-10-15-18(12-22-17)25-26-20(15)16-4-2-5-19(24-16)28-8-3-6-21-7-9-28/h2,4-5,10-13,21H,3,6-9H2,1H3,(H,25,26) | PDB
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| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50434663
(CHEMBL2387474)Show SMILES Fc1cccc(F)c1-c1cnc2[nH]cc(NC(=O)c3cnn4ccc(CCC5CCNCC5)nc34)c2c1 Show InChI InChI=1S/C27H25F2N7O/c28-21-2-1-3-22(29)24(21)17-12-19-23(15-32-25(19)31-13-17)35-27(37)20-14-33-36-11-8-18(34-26(20)36)5-4-16-6-9-30-10-7-16/h1-3,8,11-16,30H,4-7,9-10H2,(H,31,32)(H,35,37) | PDB
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| Article
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| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP |
Bioorg Med Chem Lett 23: 3149-53 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.020
BindingDB Entry DOI: 10.7270/Q2PC33S9 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248908
(US9434725, 139)Show SMILES CCc1cncc(c1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C26H29N7/c1-2-17-10-19(13-28-12-17)23-11-24-20(14-29-23)15-30-33(24)25-8-7-22(18-5-6-18)26(31-25)32-9-3-4-21(27)16-32/h7-8,10-15,18,21H,2-6,9,16,27H2,1H3/t21-/m0/s1 | PDB
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| US Patent
| 0.187 | -13.3 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131266
(CHEMBL3634758 | US9260425, 173)Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C20H22N8/c1-27-11-13(9-23-27)17-8-15-18(10-22-17)25-26-20(15)16-5-2-6-19(24-16)28-7-3-4-14(21)12-28/h2,5-6,8-11,14H,3-4,7,12,21H2,1H3,(H,25,26)/t14-/m0/s1 | PDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as... |
J Med Chem 60: 4458-4473 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00418
BindingDB Entry DOI: 10.7270/Q2H997PN |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM206420
(US9260425, 161)Show SMILES N[C@H]1CCCN(C1)c1cccc(n1)-c1n[nH]c2cnc(cc12)-c1cccnc1 | PDB
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Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as... |
J Med Chem 60: 4458-4473 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00418
BindingDB Entry DOI: 10.7270/Q2H997PN |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50005209
(CHEMBL3103867)Show SMILES N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F Show InChI InChI=1S/C22H23FN6O/c23-16-6-2-1-5-15(16)18-8-7-17(25)21(27-18)22(30)28-19-12-26-10-9-20(19)29-11-3-4-14(24)13-29/h1-2,5-10,12,14H,3-4,11,13,24-25H2,(H,28,30)/t14-/m0/s1 | PDB
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PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM110756
(US8614206, 289)Show SMILES CO[C@@H]1CCN(CC[C@H]1N)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C Show InChI InChI=1S/C21H25F2N7O2S/c1-29-21(30-8-6-13(24)15(32-2)7-9-30)14(10-26-29)27-19(31)17-18(25)33-20(28-17)16-11(22)4-3-5-12(16)23/h3-5,10,13,15H,6-9,24-25H2,1-2H3,(H,27,31)/t13-,15-/m1/s1 | PDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50505061
(CHEMBL4453890)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)[C@@H](O)CC1 Show InChI InChI=1S/C20H23F2N7O2S/c1-28-20(29-7-5-12(23)14(30)6-8-29)13(9-25-28)26-18(31)16-17(24)32-19(27-16)15-10(21)3-2-4-11(15)22/h2-4,9,12,14,30H,5-8,23-24H2,1H3,(H,26,31)/t12-,14+/m1/s1 | PDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248940
(US9434725, 171 | US9434725, 182 | US9434725, 183)Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1 Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3 | PDB
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UniChem
| US Patent
| 0.204 | -13.2 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM249069
(US9434725, 300)Show SMILES OCC#Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C22H20N8O/c31-10-2-3-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-5-1-4-21(28-22)29-8-6-23-7-9-29/h1,4-5,11-15,23,31H,6-10H2 | PDB
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| US Patent
| 0.228 | -13.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50266631
(CHEMBL4076913)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)[C@H]1CNCCC1(F)F Show InChI InChI=1S/C21H19F2N7/c1-13-8-25-12-18(28-13)17-7-19-14(9-26-17)10-27-30(19)20-4-2-3-16(29-20)15-11-24-6-5-21(15,22)23/h2-4,7-10,12,15,24H,5-6,11H2,1H3/t15-/m1/s1 | PDB
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| Article
PubMed
| 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as... |
J Med Chem 60: 4458-4473 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00418
BindingDB Entry DOI: 10.7270/Q2H997PN |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248996
(US9434725, 227)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C(F)F)c(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C22H22F2N8/c1-13-8-26-11-18(29-13)17-7-19-14(9-27-17)10-28-32(19)20-5-4-16(21(23)24)22(30-20)31-6-2-3-15(25)12-31/h4-5,7-11,15,21H,2-3,6,12,25H2,1H3/t15-/m0/s1 | PDB
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| US Patent
| 0.233 | -13.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM249028
(US9434725, 259 | US9434725, 271 | US9434725, 272)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)C1CNCCC1(F)F Show InChI InChI=1S/C21H19F2N7/c1-13-8-25-12-18(28-13)17-7-19-14(9-26-17)10-27-30(19)20-4-2-3-16(29-20)15-11-24-6-5-21(15,22)23/h2-4,7-10,12,15,24H,5-6,11H2,1H3 | PDB
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| US Patent
| 0.234 | -13.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM249028
(US9434725, 259 | US9434725, 271 | US9434725, 272)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)C1CNCCC1(F)F Show InChI InChI=1S/C21H19F2N7/c1-13-8-25-12-18(28-13)17-7-19-14(9-26-17)10-27-30(19)20-4-2-3-16(29-20)15-11-24-6-5-21(15,22)23/h2-4,7-10,12,15,24H,5-6,11H2,1H3 | PDB
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| US Patent
| 0.242 | -13.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131228
(CHEMBL3634772 | US9260425, 497)Show SMILES C(C1CC1)n1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C22H24N8/c1-2-18(26-21(3-1)29-8-6-23-7-9-29)22-17-10-19(24-12-20(17)27-28-22)16-11-25-30(14-16)13-15-4-5-15/h1-3,10-12,14-15,23H,4-9,13H2,(H,27,28) | PDB
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| Article
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| 0.253 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM249007
(US9434725, 238)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cnc(C2CC2)c(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C23H25N9/c1-14-8-25-11-19(29-14)18-7-20-16(9-26-18)10-28-32(20)21-12-27-22(15-4-5-15)23(30-21)31-6-2-3-17(24)13-31/h7-12,15,17H,2-6,13,24H2,1H3/t17-/m0/s1 | PDB
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| US Patent
| 0.257 | -13.1 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131266
(CHEMBL3634758 | US9260425, 173)Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C20H22N8/c1-27-11-13(9-23-27)17-8-15-18(10-22-17)25-26-20(15)16-5-2-6-19(24-16)28-7-3-4-14(21)12-28/h2,5-6,8-11,14H,3-4,7,12,21H2,1H3,(H,25,26)/t14-/m0/s1 | PDB
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| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM248970
(US9434725, 201)Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C#N)c(n1)N1CCC[C@H](N)C1 Show InChI InChI=1S/C22H21N9/c1-14-9-25-12-19(28-14)18-7-20-16(10-26-18)11-27-31(20)21-5-4-15(8-23)22(29-21)30-6-2-3-17(24)13-30/h4-5,7,9-12,17H,2-3,6,13,24H2,1H3/t17-/m0/s1 | PDB
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| US Patent
| 0.286 | -13.0 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
F. Hoffmann-La Roche Inc
US Patent
| Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a... |
US Patent US9434725 (2016)
BindingDB Entry DOI: 10.7270/Q2CF9P1N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50505058
(CHEMBL4450356)Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)C(F)(F)CC1 Show InChI InChI=1S/C20H21F4N7OS/c1-30-19(31-7-5-13(25)20(23,24)6-8-31)12(9-27-30)28-17(32)15-16(26)33-18(29-15)14-10(21)3-2-4-11(14)22/h2-4,9,13H,5-8,25-26H2,1H3,(H,28,32)/t13-/m1/s1 | PDB
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| Article
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay |
J Med Chem 62: 2140-2153 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01857 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50131378
(CHEMBL3634782 | US9260425, 384)Show SMILES Cc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C21H21N7/c1-14-9-15(12-23-11-14)18-10-16-19(13-24-18)26-27-21(16)17-3-2-4-20(25-17)28-7-5-22-6-8-28/h2-4,9-13,22H,5-8H2,1H3,(H,26,27) | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of Pim2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins |
Bioorg Med Chem Lett 25: 5258-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.052
BindingDB Entry DOI: 10.7270/Q2TT4SR7 |
More data for this
Ligand-Target Pair | |
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