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Compile Data Set for Download or QSAR

Found 20 hits of kd data for polymerid = 3621   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50149201
PNG
(3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYD...)
Show SMILES Nc1ccc2c(c1)c(-c1ccccc1)n(CCCCCCc1cnnn1CCNc1c3CCCCc3nc3ccccc13)c1cc(=[NH2+])ccc21
Show InChI InChI=1S/C42H44N8/c43-30-19-21-33-34-22-20-31(44)27-40(34)49(42(37(33)26-30)29-12-4-3-5-13-29)24-11-2-1-6-14-32-28-46-48-50(32)25-23-45-41-35-15-7-9-17-38(35)47-39-18-10-8-16-36(39)41/h3-5,7,9,12-13,15,17,19-22,26-28,44H,1-2,6,8,10-11,14,16,18,23-25,43H2,(H,45,47)/p+1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50462576
PNG
(CHEMBL4249808)
Show SMILES Nc1ccc2c(c1)c(-c1ccccc1)[n+](CCCCCn1nncc1CCNc1c3CCCCc3nc3ccccc13)c1cc(N)ccc21
Show InChI InChI=1S/C41H42N8/c42-29-17-19-32-33-20-18-30(43)26-39(33)48(41(36(32)25-29)28-11-3-1-4-12-28)23-9-2-10-24-49-31(27-45-47-49)21-22-44-40-34-13-5-7-15-37(34)46-38-16-8-6-14-35(38)40/h1,3-5,7,11-13,15,17-20,25-27,43H,2,6,8-10,14,16,21-24,42H2,(H,44,46)/p+1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50044548
PNG
(CHEMBL3314092)
Show SMILES COc1cc2CCN(CCCCCCc3cnnn3CCNc3c4CCCCc4nc4ccccc34)[C@@H](c3ccccc3)c2cc1OC
Show InChI InChI=1S/C40H48N6O2/c1-47-37-26-30-21-24-45(40(29-14-6-5-7-15-29)34(30)27-38(37)48-2)23-13-4-3-8-16-31-28-42-44-46(31)25-22-41-39-32-17-9-11-19-35(32)43-36-20-12-10-18-33(36)39/h5-7,9,11,14-15,17,19,26-28,40H,3-4,8,10,12-13,16,18,20-25H2,1-2H3,(H,41,43)/t40-/m0/s1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50462581
PNG
(CHEMBL4246013)
Show SMILES COc1cc2CCN(CCCCCc3cnnn3CCNc3c4CCCCc4nc4ccccc34)[C@@H](c3ccccc3)c2cc1OC
Show InChI InChI=1S/C39H46N6O2/c1-46-36-25-29-20-23-44(39(28-13-5-3-6-14-28)33(29)26-37(36)47-2)22-12-4-7-15-30-27-41-43-45(30)24-21-40-38-31-16-8-10-18-34(31)42-35-19-11-9-17-32(35)38/h3,5-6,8,10,13-14,16,18,25-27,39H,4,7,9,11-12,15,17,19-24H2,1-2H3,(H,40,42)/t39-/m0/s1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50044549
PNG
(CHEMBL3314093)
Show SMILES COc1cc2CCN(CCCCCCc3cnnn3CCNc3c4CCCCc4nc4ccccc34)[C@H](c3ccccc3)c2cc1OC
Show InChI InChI=1S/C40H48N6O2/c1-47-37-26-30-21-24-45(40(29-14-6-5-7-15-29)34(30)27-38(37)48-2)23-13-4-3-8-16-31-28-42-44-46(31)25-22-41-39-32-17-9-11-19-35(32)43-36-20-12-10-18-33(36)39/h5-7,9,11,14-15,17,19,26-28,40H,3-4,8,10,12-13,16,18,20-25H2,1-2H3,(H,41,43)/t40-/m1/s1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50462580
PNG
(CHEMBL4239268)
Show SMILES Nc1ccc2c(c1)c(-c1ccccc1)[n+](CCCCCc1cnnn1CCNc1c3CCCCc3nc3ccccc13)c1cc(N)ccc21
Show InChI InChI=1S/C41H42N8/c42-29-18-20-32-33-21-19-30(43)26-39(33)48(41(36(32)25-29)28-11-3-1-4-12-28)23-10-2-5-13-31-27-45-47-49(31)24-22-44-40-34-14-6-8-16-37(34)46-38-17-9-7-15-35(38)40/h1,3-4,6,8,11-12,14,16,18-21,25-27,43H,2,5,7,9-10,13,15,17,22-24,42H2,(H,44,46)/p+1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50462578
PNG
(CHEMBL4239697)
Show SMILES Nc1ccc2c(c1)c(-c1ccccc1)[n+](CCCCCCn1nncc1CCNc1c3CCCCc3nc3ccccc13)c1cc(N)ccc21
Show InChI InChI=1S/C42H44N8/c43-30-18-20-33-34-21-19-31(44)27-40(34)49(42(37(33)26-30)29-12-4-3-5-13-29)24-10-1-2-11-25-50-32(28-46-48-50)22-23-45-41-35-14-6-8-16-38(35)47-39-17-9-7-15-36(39)41/h3-6,8,12-14,16,18-21,26-28,44H,1-2,7,9-11,15,17,22-25,43H2,(H,45,47)/p+1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50462577
PNG
(CHEMBL4243833)
Show SMILES COc1cc2CCN(CCCCCc3cnnn3CCNc3c4CCCCc4nc4ccccc34)[C@H](c3ccccc3)c2cc1OC
Show InChI InChI=1S/C39H46N6O2/c1-46-36-25-29-20-23-44(39(28-13-5-3-6-14-28)33(29)26-37(36)47-2)22-12-4-7-15-30-27-41-43-45(30)24-21-40-38-31-16-8-10-18-34(31)42-35-19-11-9-17-32(35)38/h3,5-6,8,10,13-14,16,18,25-27,39H,4,7,9,11-12,15,17,19-24H2,1-2H3,(H,40,42)/t39-/m1/s1
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n/an/an/a 0.0330n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/an/a 16n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50292572
PNG
(3,3-dimethylbutan-2-yl methylphosphonofluoridate |...)
Show SMILES CC(OP(C)(F)=O)C(C)(C)C
Show InChI InChI=1S/C7H16FO2P/c1-6(7(2,3)4)10-11(5,8)9/h6H,1-5H3
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n/an/an/a 400n/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Binding affinity against adenosine A1 receptor from rat brain membranes using [3H]cyclohexyladenosine as radioligand.


Bioorg Med Chem 25: 3053-3058 (2017)


Article DOI: 10.1016/j.bmc.2017.03.058
BindingDB Entry DOI: 10.7270/Q2H70J09
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50292572
PNG
(3,3-dimethylbutan-2-yl methylphosphonofluoridate |...)
Show SMILES CC(OP(C)(F)=O)C(C)(C)C
Show InChI InChI=1S/C7H16FO2P/c1-6(7(2,3)4)10-11(5,8)9/h6H,1-5H3
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n/an/an/a 610n/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE


J Med Chem 51: 3154-70 (2008)


Article DOI: 10.1021/jm701253t
BindingDB Entry DOI: 10.7270/Q22Z16D4
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50462582
PNG
(CHEMBL4250783)
Show SMILES CC[N+](C)(CC)CCC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccccc12
Show InChI InChI=1S/C27H33N3/c1-4-30(3,5-2)19-11-18-29-26-15-10-9-14-24(26)23-17-16-22(28)20-25(23)27(29)21-12-7-6-8-13-21/h6-10,12-17,20H,4-5,11,18-19,28H2,1-3H3/q+2
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n/an/an/a 1.10E+3n/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis


J Med Chem 61: 9395-9409 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00266
BindingDB Entry DOI: 10.7270/Q2765J0C
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50448131
PNG
(CHEMBL3122167)
Show SMILES CCNC(=O)c1ccc2nc(-c3ccc(Cl)cc3)c3CCCNc3c2c1
Show InChI InChI=1S/C21H20ClN3O/c1-2-23-21(26)14-7-10-18-17(12-14)20-16(4-3-11-24-20)19(25-18)13-5-8-15(22)9-6-13/h5-10,12,24H,2-4,11H2,1H3,(H,23,26)
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n/an/an/a 1.76E+3n/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of propidium from electric eel AChE peripheral anionic site assessed as decrease in fluorescence intensity by spectrofluorometric analys...


Eur J Med Chem 73: 141-52 (2014)


Article DOI: 10.1016/j.ejmech.2013.12.008
BindingDB Entry DOI: 10.7270/Q2CF9RKN
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50241991
PNG
(CHEMBL4085438)
Show SMILES COP(C)(=O)SCCN(C(C)C)C(C)C
Show InChI InChI=1S/C10H24NO2PS/c1-9(2)11(10(3)4)7-8-15-14(6,12)13-5/h9-10H,7-8H2,1-6H3
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n/an/an/a 2.00E+3n/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Binding affinity to Electric eel AChE


Bioorg Med Chem 25: 3053-3058 (2017)


Article DOI: 10.1016/j.bmc.2017.03.058
BindingDB Entry DOI: 10.7270/Q2H70J09
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50448130
PNG
(CHEMBL3122168)
Show SMILES CCNCc1ccc2nc(c3CCCNc3c2c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN3/c1-2-23-13-14-5-10-19-18(12-14)21-17(4-3-11-24-21)20(25-19)15-6-8-16(22)9-7-15/h5-10,12,23-24H,2-4,11,13H2,1H3
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n/an/an/a 2.18E+3n/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of propidium from electric eel AChE peripheral anionic site assessed as decrease in fluorescence intensity by spectrofluorometric analys...


Eur J Med Chem 73: 141-52 (2014)


Article DOI: 10.1016/j.ejmech.2013.12.008
BindingDB Entry DOI: 10.7270/Q2CF9RKN
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50027343
PNG
(CHEBI:75701 | ISOPROPYL METHYLPHOSPHONOFLUORIDATE)
Show SMILES CC(C)OP(C)(F)=O
Show InChI InChI=1S/C4H10FO2P/c1-4(2)7-8(3,5)6/h4H,1-3H3
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n/an/an/a 2.20E+3n/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Binding affinity to Electric eel AChE


Bioorg Med Chem 25: 3053-3058 (2017)


Article DOI: 10.1016/j.bmc.2017.03.058
BindingDB Entry DOI: 10.7270/Q2H70J09
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50448132
PNG
(CHEMBL3122150)
Show SMILES CCNCc1ccc2nc(-c3ccc(Cl)cc3)c3CCCN(Cc4ccccc4)c3c2c1
Show InChI InChI=1S/C28H28ClN3/c1-2-30-18-21-10-15-26-25(17-21)28-24(27(31-26)22-11-13-23(29)14-12-22)9-6-16-32(28)19-20-7-4-3-5-8-20/h3-5,7-8,10-15,17,30H,2,6,9,16,18-19H2,1H3
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n/an/an/a 3.20E+3n/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Displacement of propidium from electric eel AChE peripheral anionic site assessed as decrease in fluorescence intensity by spectrofluorometric analys...


Eur J Med Chem 73: 141-52 (2014)


Article DOI: 10.1016/j.ejmech.2013.12.008
BindingDB Entry DOI: 10.7270/Q2CF9RKN
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50523387
PNG
(CHEMBL4556281)
Show SMILES Cl.Cl.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCNc1c2CCCCc2nc2cc(Cl)ccc12
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n/an/an/a 4.82E+3n/an/an/an/an/a



University of Hradec Kralove

Curated by ChEMBL


Assay Description
Displacement of propidium iodide from peripheral binding site of electric eel AChE assessed as dissociation constant at 8 to 56 uM by spectrofluorome...


Eur J Med Chem 168: 491-514 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.021
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50235363
PNG
(CHEMBL4083174)
Show SMILES COc1cc(CCc2ccc(Nc3c4CCCCc4nc4cc(Cl)ccc34)cc2)cc(OC)c1
Show InChI InChI=1S/C29H29ClN2O2/c1-33-23-15-20(16-24(18-23)34-2)8-7-19-9-12-22(13-10-19)31-29-25-5-3-4-6-27(25)32-28-17-21(30)11-14-26(28)29/h9-18H,3-8H2,1-2H3,(H,31,32)
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n/an/an/a 7.31E+3n/an/an/an/an/a



University of Bologna

Curated by ChEMBL


Assay Description
Displacement of propidium iodide from electric eel AChE by spectrofluorometric method


Eur J Med Chem 127: 250-262 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.048
BindingDB Entry DOI: 10.7270/Q20P1289
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50240416
PNG
(CHEMBL23838 | O,O-diethyl O-p-nitrophenyl phosphat...)
Show SMILES CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
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n/an/an/a 1.70E+5n/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Binding affinity to Electric eel AChE using acetylthiocholine as substrate measured for 30 secs by Ellman's method


Bioorg Med Chem 25: 3053-3058 (2017)


Article DOI: 10.1016/j.bmc.2017.03.058
BindingDB Entry DOI: 10.7270/Q2H70J09
More data for this
Ligand-Target Pair