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Compile Data Set for Download or QSAR

Found 11 hits of ec50 data for polymerid = 3627,6564,7880   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 10n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor


J Med Chem 37: 2509-12 (1994)


Article DOI: 10.1021/jm00042a003
BindingDB Entry DOI: 10.7270/Q2S181JQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039564
PNG
(CHEMBL83597 | [3-((R)-1-Methyl-pyrrolidin-2-ylmeth...)
Show SMILES CN1CCC[C@@H]1Cc1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12
Show InChI InChI=1S/C19H21N5O2/c1-23-9-3-4-15(23)10-13-12-21-17-7-6-14(11-16(13)17)22-19-18(24(25)26)5-2-8-20-19/h2,5-8,11-12,15,21H,3-4,9-10H2,1H3,(H,20,22)/t15-/m1/s1
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n/an/an/an/a 47n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor


J Med Chem 37: 2509-12 (1994)


Article DOI: 10.1021/jm00042a003
BindingDB Entry DOI: 10.7270/Q2S181JQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50036286
PNG
((R)-(-)-10-methyl-11-hydroxyaporphine | (R)-6,10-d...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(C)c(O)c-31
Show InChI InChI=1S/C18H19NO/c1-11-6-7-13-10-15-16-12(8-9-19(15)2)4-3-5-14(16)17(13)18(11)20/h3-7,15,20H,8-10H2,1-2H3/t15-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptami...


J Med Chem 38: 647-58 (1995)


Article DOI: 10.1021/jm00004a011
BindingDB Entry DOI: 10.7270/Q2HX1BQH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039565
PNG
(CHEMBL314213 | [3-(2-Dimethylamino-ethyl)-1H-indol...)
Show SMILES CN(C)CCc1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12
Show InChI InChI=1S/C17H19N5O2/c1-21(2)9-7-12-11-19-15-6-5-13(10-14(12)15)20-17-16(22(23)24)4-3-8-18-17/h3-6,8,10-11,19H,7,9H2,1-2H3,(H,18,20)
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n/an/an/an/a 170n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor


J Med Chem 37: 2509-12 (1994)


Article DOI: 10.1021/jm00042a003
BindingDB Entry DOI: 10.7270/Q2S181JQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039566
PNG
((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...)
Show SMILES [O-][N+](=O)c1cccnc1Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1
Show InChI InChI=1S/C18H19N5O2/c24-23(25)17-4-2-8-20-18(17)22-14-5-6-16-15(10-14)12(11-21-16)9-13-3-1-7-19-13/h2,4-6,8,10-11,13,19,21H,1,3,7,9H2,(H,20,22)/t13-/m1/s1
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n/an/an/an/a 220n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor


J Med Chem 37: 2509-12 (1994)


Article DOI: 10.1021/jm00042a003
BindingDB Entry DOI: 10.7270/Q2S181JQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50262582
PNG
(2-[[3-[4-(Pyridin-2-yl)-1-piperazinyl]propyl]thio]...)
Show SMILES C(CSc1nc2ccccc2s1)CN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C19H22N4S2/c1-2-7-17-16(6-1)21-19(25-17)24-15-5-10-22-11-13-23(14-12-22)18-8-3-4-9-20-18/h1-4,6-9H,5,10-15H2
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n/an/an/an/a 323n/an/an/an/a



Università di Catania

Curated by ChEMBL


Assay Description
Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding


J Med Chem 51: 4529-38 (2008)


Article DOI: 10.1021/jm800176x
BindingDB Entry DOI: 10.7270/Q2Q81CWG
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 323n/an/an/an/a



Università di Catania

Curated by ChEMBL


Assay Description
Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding


J Med Chem 51: 4529-38 (2008)


Article DOI: 10.1021/jm800176x
BindingDB Entry DOI: 10.7270/Q2Q81CWG
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50039567
PNG
(CHEMBL84942 | [3-(1-Methyl-pyrrolidin-3-yl)-1H-ind...)
Show SMILES CN1CCC(C1)c1c[nH]c2ccc(Nc3ncccc3[N+]([O-])=O)cc12
Show InChI InChI=1S/C18H19N5O2/c1-22-8-6-12(11-22)15-10-20-16-5-4-13(9-14(15)16)21-18-17(23(24)25)3-2-7-19-18/h2-5,7,9-10,12,20H,6,8,11H2,1H3,(H,19,21)
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n/an/an/an/a 885n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor


J Med Chem 37: 2509-12 (1994)


Article DOI: 10.1021/jm00042a003
BindingDB Entry DOI: 10.7270/Q2S181JQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50262833
PNG
(3-amino-6-ethyl-2-(3-(4-(pyrimidin-2-yl)piperazin-...)
Show SMILES CCC1SC2N=C(SCCCN3CCN(CC3)c3ncccn3)N(N)C(=O)C2=C1
Show InChI InChI=1S/C19H27N7OS2/c1-2-14-13-15-16(29-14)23-19(26(20)17(15)27)28-12-4-7-24-8-10-25(11-9-24)18-21-5-3-6-22-18/h3,5-6,13-14,16H,2,4,7-12,20H2,1H3
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n/an/an/an/a 1.21E+3n/an/an/an/a



Università di Catania

Curated by ChEMBL


Assay Description
Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding


J Med Chem 51: 4529-38 (2008)


Article DOI: 10.1021/jm800176x
BindingDB Entry DOI: 10.7270/Q2Q81CWG
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50005835
PNG
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor


J Med Chem 37: 2509-12 (1994)


Article DOI: 10.1021/jm00042a003
BindingDB Entry DOI: 10.7270/Q2S181JQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016013
PNG
((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31
Show InChI InChI=1S/C17H17NO/c1-18-9-8-11-4-2-6-13-16(11)14(18)10-12-5-3-7-15(19)17(12)13/h2-7,14,19H,8-10H2,1H3/t14-/m1/s1
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n/an/an/an/a 5.20E+3n/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptami...


J Med Chem 38: 647-58 (1995)


Article DOI: 10.1021/jm00004a011
BindingDB Entry DOI: 10.7270/Q2HX1BQH
More data for this
Ligand-Target Pair