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Compile Data Set for Download or QSAR

Found 19 hits of ec50 data for polymerid = 3629   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50470944
PNG
(CHEMBL336161)
Show SMILES CS(=O)(=O)Nc1c(O)ccc2[C@@H](CCCc12)C1=NCCN1
Show InChI InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)/t11-/m1/s1
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n/an/an/an/a 186n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen


J Med Chem 39: 4116-9 (1996)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50474630
PNG
(CHEMBL108804)
Show SMILES CS(=O)(=O)Nc1c(O)ccc2C(CCCc12)c1c[nH]cn1
Show InChI InChI=1/C14H17N3O3S/c1-21(19,20)17-14-11-4-2-3-10(12-7-15-8-16-12)9(11)5-6-13(14)18/h5-8,10,17-18H,2-4H2,1H3,(H,15,16)
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n/an/an/an/a 229n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50118703
PNG
(CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...)
Show SMILES CS(=O)(=O)Nc1c(O)ccc2C(CCCc12)C1=NCCN1
Show InChI InChI=1/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)
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n/an/an/an/a 316n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50118703
PNG
(CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...)
Show SMILES CS(=O)(=O)Nc1c(O)ccc2C(CCCc12)C1=NCCN1
Show InChI InChI=1/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)
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n/an/an/an/a 316n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen


J Med Chem 39: 4116-9 (1996)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50118703
PNG
(CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...)
Show SMILES CS(=O)(=O)Nc1c(O)ccc2C(CCCc12)C1=NCCN1
Show InChI InChI=1/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)
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n/an/an/an/a 320n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Eeffective concentration of the compound was determined in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentrat...


J Med Chem 45: 4395-7 (2002)


Article DOI: 10.1021/jm025550h
BindingDB Entry DOI: 10.7270/Q20001FV
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM30712
PNG
(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)
Show SMILES Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C
Show InChI InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
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n/an/an/an/a 339n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen


J Med Chem 39: 4116-9 (1996)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50118705
PNG
(ABT-866 | CHEMBL326702 | Ethanesulfonic acid [3-(1...)
Show SMILES CCS(=O)(=O)Nc1cccc(Cc2cnc[nH]2)c1
Show InChI InChI=1S/C12H15N3O2S/c1-2-18(16,17)15-11-5-3-4-10(6-11)7-12-8-13-9-14-12/h3-6,8-9,15H,2,7H2,1H3,(H,13,14)
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n/an/an/an/a 692n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50474654
PNG
(CHEMBL323402)
Show SMILES Nc1cccc2C(CCCc12)c1c[nH]cn1
Show InChI InChI=1/C13H15N3/c14-12-6-2-3-9-10(12)4-1-5-11(9)13-7-15-8-16-13/h2-3,6-8,11H,1,4-5,14H2,(H,15,16)
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n/an/an/an/a 977n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50487266
PNG
(CHEMBL2261355)
Show SMILES CCS(=O)(=O)Nc1cccc2[C@@H](CCCc12)c1c[nH]cn1
Show InChI InChI=1S/C15H19N3O2S/c1-2-21(19,20)18-14-8-4-5-11-12(14)6-3-7-13(11)15-9-16-10-17-15/h4-5,8-10,13,18H,2-3,6-7H2,1H3,(H,16,17)/t13-/m1/s1
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n/an/an/an/a 3.80E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50474671
PNG
(CHEMBL111554)
Show SMILES CS(=O)(=O)Nc1cccc2C(CCCc12)c1c[nH]cn1
Show InChI InChI=1/C14H17N3O2S/c1-20(18,19)17-13-7-3-4-10-11(13)5-2-6-12(10)14-8-15-9-16-14/h3-4,7-9,12,17H,2,5-6H2,1H3,(H,15,16)
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n/an/an/an/a 5.13E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1
Show InChI InChI=1/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/s2
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n/an/an/an/a 1.02E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen


J Med Chem 39: 4116-9 (1996)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50067212
PNG
(CHEBI:8093 | Cyclomydril | Duo-Medihaler | PHENYLE...)
Show SMILES CNC[C@H](O)c1cccc(O)c1
Show InChI InChI=1/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/s2
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n/an/an/an/a 1.10E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen


J Med Chem 39: 4116-9 (1996)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50474650
PNG
(CHEMBL111537)
Show SMILES CC(C)S(=O)(=O)Nc1cccc2C(CCCc12)c1c[nH]cn1
Show InChI InChI=1/C16H21N3O2S/c1-11(2)22(20,21)19-15-8-4-5-12-13(15)6-3-7-14(12)16-9-17-10-18-16/h4-5,8-11,14,19H,3,6-7H2,1-2H3,(H,17,18)
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n/an/an/an/a 1.41E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50474648
PNG
(CHEMBL109848)
Show SMILES CC(=O)Nc1cccc2C(CCCc12)c1c[nH]cn1
Show InChI InChI=1/C15H17N3O/c1-10(19)18-14-7-3-4-11-12(14)5-2-6-13(11)15-8-16-9-17-15/h3-4,7-9,13H,2,5-6H2,1H3,(H,16,17)(H,18,19)
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n/an/an/an/a 1.45E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50118702
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-ethanol | CHEMBL1...)
Show SMILES COc1ccc(OC)c(c1)C(O)CN
Show InChI InChI=1/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3
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n/an/an/an/a 8.50E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Eeffective concentration of the compound was determined in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentrat...


J Med Chem 45: 4395-7 (2002)


Article DOI: 10.1021/jm025550h
BindingDB Entry DOI: 10.7270/Q20001FV
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50118702
PNG
(2-Amino-1-(2,5-dimethoxy-phenyl)-ethanol | CHEMBL1...)
Show SMILES COc1ccc(OC)c(c1)C(O)CN
Show InChI InChI=1/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3
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n/an/an/an/a 8.51E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50470943
PNG
(CHEMBL133451)
Show SMILES CS(=O)(=O)Nc1c(O)ccc2[C@H](CCCc12)C1=NCCN1
Show InChI InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)/t11-/m0/s1
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n/an/an/an/a<1.00E+5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen


J Med Chem 39: 4116-9 (1996)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50022722
PNG
((+)2-Amino-1-phenyl-propan-1-ol | (1R, 2R)-2-Amino...)
Show SMILES CC(N)C(O)c1ccccc1
Show InChI InChI=1/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3
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n/an/an/an/a 2.80E+5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Eeffective concentration of the compound was determined in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentrat...


J Med Chem 45: 4395-7 (2002)


Article DOI: 10.1021/jm025550h
BindingDB Entry DOI: 10.7270/Q20001FV
More data for this
Ligand-Target Pair
Alpha adrenergic receptor 1A and 1B


(Rattus norvegicus (rat))
BDBM50022722
PNG
((+)2-Amino-1-phenyl-propan-1-ol | (1R, 2R)-2-Amino...)
Show SMILES CC(N)C(O)c1ccccc1
Show InChI InChI=1/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3
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n/an/an/an/a 2.82E+5n/an/an/an/a


TBA

Assay Description
Agonist activity at alpha1B adrenoreceptor in Rattus norvegicus (rat) spleen


Citation and Details
More data for this
Ligand-Target Pair