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Found 166 of ic50 for UniProtKB: P28565
LigandPNGBDBM50280830(3-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  0.5nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280826(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280822(4-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50047098(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.20nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280819(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.5nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280831(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.80nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280817(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  2.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016966(1,1-Dioxo-2-[4-(4-thieno[3,2-c]pyridin-4-yl-pipera...)
Affinity DataIC50:  2.30nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280828(3-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  2.60nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50227493(CHEMBL288111)
Affinity DataIC50:  3nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  3nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039564(CHEMBL83597 | [3-((R)-1-Methyl-pyrrolidin-2-ylmeth...)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280824(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  3.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016967(3-{4-[4-(2-Methyl-thieno[3,2-c]pyridin-4-yl)-piper...)
Affinity DataIC50:  3.60nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280823(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  3.70nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016957(3-[4-(4-Thieno[2,3-c]pyridin-7-yl-piperazin-1-yl)-...)
Affinity DataIC50:  3.70nMAssay Description:In vitro evaluation for arachidonic acid induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50016956(1-{4-[4-(2-Bromo-thieno[3,2-c]pyridin-4-yl)-pipera...)
Affinity DataIC50:  3.70nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50016958(1-(4-Fluoro-phenyl)-4-(4-thieno[3,2-c]pyridin-4-yl...)
Affinity DataIC50:  3.80nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280832(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  3.80nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280827(1'-{2-[4-(5-fluoro-1H-3-indolylmethyl)hexahydro-1-...)
Affinity DataIC50:  4nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50227485(CHEMBL291097)
Affinity DataIC50:  5nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50016963(2-[4-(4-Thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-...)
Affinity DataIC50:  5.30nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280829(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  5.40nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016960(4,4-Dimethyl-1-[4-(4-thieno[3,2-c]pyridin-4-yl-pip...)
Affinity DataIC50:  5.70nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280825(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  5.90nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280815(CHEMBL56377 | N-{2-[4-(5-Fluoro-1H-indol-3-ylmethy...)
Affinity DataIC50:  6nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039566((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227483(CHEMBL36379)
Affinity DataIC50:  8nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50016964(3-[4-(4-Thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-...)
Affinity DataIC50:  8.10nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50016959(4-Methyl-1-[4-(4-thieno[3,2-c]pyridin-4-yl-piperaz...)
Affinity DataIC50:  8.80nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039565(CHEMBL314213 | [3-(2-Dimethylamino-ethyl)-1H-indol...)
Affinity DataIC50:  10nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280818(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  12nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50007692(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  13nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor was measured using radioligand ([3H]5-HT) binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280821(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  14nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016479((7-Methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]qui...)
Affinity DataIC50:  15nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50039567(CHEMBL84942 | [3-(1-Methyl-pyrrolidin-3-yl)-1H-ind...)
Affinity DataIC50:  15nMAssay Description:Binding affinity of the compound was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataIC50:  15nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50227484(CHEMBL37867)
Affinity DataIC50:  17nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227496(CHEMBL39604)
Affinity DataIC50:  20nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227482(CHEMBL285723)
Affinity DataIC50:  20nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227486(CHEMBL289517)
Affinity DataIC50:  20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
LigandPNGBDBM50227497(CHEMBL291044)
Affinity DataIC50:  20nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280820(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  23nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016973(3-{4-[4-(2-Bromo-thieno[3,2-c]pyridin-4-yl)-pipera...)
Affinity DataIC50:  25nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227490(CHEMBL288480)
Affinity DataIC50:  26nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT as a radioligand from rat frontal cortex homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280816(CHEMBL293729 | N-{2-[4-(5-Fluoro-1H-indol-3-ylmeth...)
Affinity DataIC50:  30nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50016961(4-[4-(4-Furo[3,2-c]pyridin-4-yl-piperazin-1-yl)-bu...)
Affinity DataIC50:  34nMAssay Description:Ability to bind at 5-hydroxytryptamine 1 receptor of rat hippocampus by displacing [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227629(CHEMBL433084)
Affinity DataIC50:  36nMAssay Description:Ability to inhibit binding of titreated serotonin to the 5-hydroxytryptamine 1 receptor in rat brain frontal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227520(CHEMBL285284)
Affinity DataIC50:  40nMAssay Description:Tested for its binding affinity towards 5-hydroxytryptamine 1 receptor in rat cortical membrane homogenates using radioligand ([3H]5-HT) binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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