Compile Data Set for Download or QSAR
maximum 50k data
Found 2503 of ic50 data for polymerid = 49000502,49000504
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141472((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-2-isopropylamin...)
Affinity DataIC50:  0.0110nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141458((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-hydroxy...)
Affinity DataIC50:  0.0110nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141472((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-2-isopropylamin...)
Affinity DataIC50:  0.0110nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141458((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-hydroxy...)
Affinity DataIC50:  0.0110nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141475((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-hydroxy...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143796(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143792(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141465((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(3-hydroxy...)
Affinity DataIC50:  0.0220nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155246(CHEMBL3775234)
Affinity DataIC50:  0.0230nMAssay Description:Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155246(CHEMBL3775234)
Affinity DataIC50:  0.0230nMAssay Description:Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.0230nMAssay Description:Displacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141468((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-dimethy...)
Affinity DataIC50:  0.0240nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141468((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-dimethy...)
Affinity DataIC50:  0.0240nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532607(CHEMBL4538570)
Affinity DataIC50:  0.0260nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532607(CHEMBL4538570)
Affinity DataIC50:  0.0260nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141471((5S,6R,7R)-7-{2-[(Acetyl-methyl-amino)-methyl]-4-m...)
Affinity DataIC50:  0.0270nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143802(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143797(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143786(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141463((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-hydroxy...)
Affinity DataIC50:  0.0310nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50070888(CHEMBL298725 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  0.0320nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  0.0340nMAssay Description:Ability of the compound to displace endothelin ([125I]-ET-1) from human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  0.0340nMAssay Description:Binding ability determined by the displacement of [125I]-ET-1 from the human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369954(CHEMBL1627023)
Affinity DataIC50:  0.0340nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104995(CHEMBL369489 | sodium salt of N-{6-[2-(5-Bromo-pyr...)
Affinity DataIC50:  0.0390nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105033(CHEMBL112531 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0390nMAssay Description:Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143778(2-{[3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-t...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143783(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098777(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50:  0.0400nMAssay Description:Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098777(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibitory concentration was determined against selective Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50:  0.0440nMAssay Description:Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  0.0470nMAssay Description:Inhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141470((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-(2,4-dimethox...)
Affinity DataIC50:  0.0470nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141461((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2,3-dihyd...)
Affinity DataIC50:  0.0480nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141461((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2,3-dihyd...)
Affinity DataIC50:  0.0480nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143773(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143789(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146613(5-{5-[(Z)-3-Benzo[1,3]dioxol-5-yl-3-carboxy-2-(4-m...)
Affinity DataIC50:  0.0500nMAssay Description:Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077930(5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061078((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50:  0.0550nMAssay Description:Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  0.0550nMAssay Description:Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141467((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-hydroxy...)
Affinity DataIC50:  0.0570nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141467((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(2-hydroxy...)
Affinity DataIC50:  0.0570nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141460((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(3-hydroxy...)
Affinity DataIC50:  0.0590nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141460((5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-7-[2-(3-hydroxy...)
Affinity DataIC50:  0.0590nMAssay Description:Inhibitory activity against [125I]-ET-1 binding to human endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143785(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143801(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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