BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 644 hits of ic50 for Ionotropic glutamate receptor NMDA 1/2D
having polymerids = 49000630,49000814 and
complexids = 50000424,50004363   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212340
PNG
(CHEMBL317419)
Show SMILES Oc1c(-c2cccnc2)c(=O)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C15H9ClN2O3/c16-9-3-4-10-11(6-9)18-15(21)14(20)12(13(10)19)8-2-1-5-17-7-8/h1-7,19H,(H,18,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

n/an/a 0.190n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212337
PNG
(CHEMBL323314)
Show SMILES Oc1c(-c2ccco2)c(=O)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C14H8ClNO4/c15-7-3-4-8-9(6-7)16-14(19)13(18)11(12(8)17)10-2-1-5-20-10/h1-6,17H,(H,16,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
n/an/a 0.210n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212341
PNG
(CHEMBL105012)
Show SMILES Oc1c(-c2ccccc2)c(=O)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C16H10ClNO3/c17-10-6-7-11-12(8-10)18-16(21)15(20)13(14(11)19)9-4-2-1-3-5-9/h1-8,19H,(H,18,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

n/an/a 0.380n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212332
PNG
(CHEMBL104558)
Show SMILES Oc1ccc(cc1)-c1c(O)c2ccc(Cl)cc2[nH]c(=O)c1=O
Show InChI InChI=1S/C16H10ClNO4/c17-9-3-6-11-12(7-9)18-16(22)15(21)13(14(11)20)8-1-4-10(19)5-2-8/h1-7,19-20H,(H,18,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
n/an/a 0.570n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212339
PNG
(CHEMBL320453)
Show SMILES COc1ccc(cc1)-c1c(O)c(=O)[nH]c2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C17H12ClNO4/c1-23-11-5-2-9(3-6-11)14-15(20)12-7-4-10(18)8-13(12)19-17(22)16(14)21/h2-8,21H,1H3,(H,19,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

n/an/a 0.570n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212334
PNG
(CHEMBL106885)
Show SMILES Oc1c(-c2ccsc2)c(=O)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C14H8ClNO3S/c15-8-1-2-9-10(5-8)16-14(19)13(18)11(12(9)17)7-3-4-20-6-7/h1-6,17H,(H,16,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

n/an/a 0.590n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212335
PNG
(CHEMBL105125)
Show SMILES Oc1c(-c2cccs2)c(=O)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C14H8ClNO3S/c15-7-3-4-8-9(6-7)16-14(19)13(18)11(12(8)17)10-2-1-5-20-10/h1-6,17H,(H,16,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents

n/an/a 0.630n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212336
PNG
(CHEMBL323769)
Show SMILES COc1cccnc1-c1c(O)c(=O)[nH]c2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C16H11ClN2O4/c1-23-11-3-2-6-18-13(11)12-14(20)9-5-4-8(17)7-10(9)19-16(22)15(12)21/h2-7,21H,1H3,(H,19,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
n/an/a 0.820n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50073956
PNG
(CHEMBL85567 | {5-Aminomethyl-2-[2-((S)-9-chloro-2,...)
Show SMILES NCc1ccc(NC(=O)C[C@@H]2CCc3cc(Cl)cc4[nH]c(=O)c(=O)n2c34)c(OCC(O)=O)c1
Show InChI InChI=1S/C22H21ClN4O6/c23-13-6-12-2-3-14(27-20(12)16(7-13)26-21(31)22(27)32)8-18(28)25-15-4-1-11(9-24)5-17(15)33-10-19(29)30/h1,4-7,14H,2-3,8-10,24H2,(H,25,28)(H,26,31)(H,29,30)/t14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Sumitomo Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...


J Med Chem 46: 691-701 (2003)


Article DOI: 10.1021/jm020239l
BindingDB Entry DOI: 10.7270/Q2G44PP3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50215294
PNG
(2-(N-(6-chloro-7-methyl-2,3-dioxo-1,2,3,4-tetrahyd...)
Show SMILES Cc1cc2[nH]c(=O)c(=O)[nH]c2c(N(CC(O)=O)S(C)(=O)=O)c1Cl
Show InChI InChI=1S/C12H12ClN3O6S/c1-5-3-6-9(15-12(20)11(19)14-6)10(8(5)13)16(4-7(17)18)23(2,21)22/h3H,4H2,1-2H3,(H,14,19)(H,15,20)(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human NMDA NR1 receptor


Bioorg Med Chem Lett 17: 4599-603 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.083
BindingDB Entry DOI: 10.7270/Q2QR4WTR
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50212338
PNG
(CHEMBL104727)
Show SMILES Oc1c(-c2ccccn2)c(=O)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C15H9ClN2O3/c16-8-4-5-9-11(7-8)18-15(21)14(20)12(13(9)19)10-3-1-2-6-17-10/h1-7,19H,(H,18,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
Ability to displace [3H]glycine from strychnine-insensitive glycine receptor


Citation and Details
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50123793
PNG
(3-[(4-Aminomethyl-2-carboxymethoxy-phenylcarbamoyl...)
Show SMILES NCc1ccc(NC(=O)C[C@@H]2CCc3cc(Cl)cc4[nH]c(C(O)=O)c2c34)c(OCC(O)=O)c1
Show InChI InChI=1S/C23H22ClN3O6/c24-14-6-12-2-3-13(21-20(12)16(8-14)27-22(21)23(31)32)7-18(28)26-15-4-1-11(9-25)5-17(15)33-10-19(29)30/h1,4-6,8,13,27H,2-3,7,9-10,25H2,(H,26,28)(H,29,30)(H,31,32)/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Sumitomo Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...


J Med Chem 46: 691-701 (2003)


Article DOI: 10.1021/jm020239l
BindingDB Entry DOI: 10.7270/Q2G44PP3
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50038171
PNG
(7-Chloro-4-hydroxy-3-[3-(thiophen-3-yloxy)-phenyl]...)
Show SMILES Oc1c(-c2cccc(Oc3ccsc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C19H12ClNO3S/c20-12-4-5-15-16(9-12)21-19(23)17(18(15)22)11-2-1-3-13(8-11)24-14-6-7-25-10-14/h1-10H,(H2,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50123792
PNG
(3-[(4-Aminomethyl-2-carboxymethyl-phenylcarbamoyl)...)
Show SMILES NCc1ccc(NC(=O)C[C@@H]2CCc3cc(Cl)cc4[nH]c(C(O)=O)c2c34)c(CC(O)=O)c1
Show InChI InChI=1S/C23H22ClN3O5/c24-15-6-12-2-3-13(21-20(12)17(9-15)27-22(21)23(31)32)7-18(28)26-16-4-1-11(10-25)5-14(16)8-19(29)30/h1,4-6,9,13,27H,2-3,7-8,10,25H2,(H,26,28)(H,29,30)(H,31,32)/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Sumitomo Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...


J Med Chem 46: 691-701 (2003)


Article DOI: 10.1021/jm020239l
BindingDB Entry DOI: 10.7270/Q2G44PP3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50215284
PNG
(2-(N-(7-chloro-6-methyl-2,3-dioxo-1,2,3,4-tetrahyd...)
Show SMILES Cc1c(Cl)cc2[nH]c(=O)c(=O)[nH]c2c1N(CC(O)=O)S(C)(=O)=O
Show InChI InChI=1S/C12H12ClN3O6S/c1-5-6(13)3-7-9(15-12(20)11(19)14-7)10(5)16(4-8(17)18)23(2,21)22/h3H,4H2,1-2H3,(H,14,19)(H,15,20)(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human NMDA NR1 receptor


Bioorg Med Chem Lett 17: 4599-603 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.083
BindingDB Entry DOI: 10.7270/Q2QR4WTR
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50038168
PNG
(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Show SMILES Oc1c(-c2cccc(Oc3ccccc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace [3H]-L-689,560 from rat cortical membrane


Bioorg Med Chem Lett 5: 2089-2092 (1995)


Article DOI: 10.1016/0960-894X(95)00374-3
BindingDB Entry DOI: 10.7270/Q2HX1CMK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50215283
PNG
(2-(N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroqui...)
Show SMILES CS(=O)(=O)N(CC(O)=O)c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C11H9Cl2N3O6S/c1-23(21,22)16(3-6(17)18)9-7(13)4(12)2-5-8(9)15-11(20)10(19)14-5/h2H,3H2,1H3,(H,14,19)(H,15,20)(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human NMDA NR1 receptor


Bioorg Med Chem Lett 17: 4599-603 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.083
BindingDB Entry DOI: 10.7270/Q2QR4WTR
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50038168
PNG
(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Show SMILES Oc1c(-c2cccc(Oc3ccccc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50038168
PNG
(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Show SMILES Oc1c(-c2cccc(Oc3ccccc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Università degli Studi di Urbino

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor...


J Med Chem 41: 808-20 (1998)


Article DOI: 10.1021/jm970416w
BindingDB Entry DOI: 10.7270/Q2QZ293M
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50038168
PNG
(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Show SMILES Oc1c(-c2cccc(Oc3ccccc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membrane...


J Med Chem 40: 754-65 (1997)


Article DOI: 10.1021/jm9605492
BindingDB Entry DOI: 10.7270/Q2J67G1J
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50041466
PNG
(7-Chloro-4-hydroxy-3-[3-(4-methoxymethoxy-benzyl)-...)
Show SMILES COCOc1ccc(Cc2cccc(c2)-c2c(O)c3ccc(Cl)cc3[nH]c2=O)cc1
Show InChI InChI=1S/C24H20ClNO4/c1-29-14-30-19-8-5-15(6-9-19)11-16-3-2-4-17(12-16)22-23(27)20-10-7-18(25)13-21(20)26-24(22)28/h2-10,12-13H,11,14H2,1H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50041468
PNG
(7-Chloro-4-hydroxy-3-(3-thiophen-3-ylmethyl-phenyl...)
Show SMILES Oc1c(-c2cccc(Cc3ccsc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C20H14ClNO2S/c21-15-4-5-16-17(10-15)22-20(24)18(19(16)23)14-3-1-2-12(9-14)8-13-6-7-25-11-13/h1-7,9-11H,8H2,(H2,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50123790
PNG
(3-{[4-Aminomethyl-2-(1-carboxy-ethyl)-phenylcarbam...)
Show SMILES C[C@@H](C(O)=O)c1cc(CN)ccc1NC(=O)C[C@@H]1CCc2cc(Cl)cc3[nH]c(C(O)=O)c1c23
Show InChI InChI=1S/C24H24ClN3O5/c1-11(23(30)31)16-6-12(10-26)2-5-17(16)27-19(29)8-14-4-3-13-7-15(25)9-18-20(13)21(14)22(28-18)24(32)33/h2,5-7,9,11,14,28H,3-4,8,10,26H2,1H3,(H,27,29)(H,30,31)(H,32,33)/t11-,14+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



Sumitomo Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...


J Med Chem 46: 691-701 (2003)


Article DOI: 10.1021/jm020239l
BindingDB Entry DOI: 10.7270/Q2G44PP3
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50035373
PNG
(7-Chloro-2-(4-methoxy-phenyl)-3,5-dihydro-2H-pyraz...)
Show SMILES COc1ccc(cc1)-n1[nH]c2c(c3ccc(Cl)cc3[nH]c2=O)c1=O
Show InChI InChI=1S/C17H12ClN3O3/c1-24-11-5-3-10(4-6-11)21-17(23)14-12-7-2-9(18)8-13(12)19-16(22)15(14)20-21/h2-8,20H,1H3,(H,19,22)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.30n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-3 binding to the glycine site on the NMDA receptor in Rat cortical slices


J Med Chem 38: 2239-43 (1995)


Article DOI: 10.1021/jm00012a024
BindingDB Entry DOI: 10.7270/Q2125RQ1
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50215282
PNG
(CHEMBL429296 | N-(6-chloro-7-methyl-2,3-dioxo-1,2,...)
Show SMILES Cc1cc2[nH]c(=O)c(=O)[nH]c2c(N(CCO)S(C)(=O)=O)c1Cl
Show InChI InChI=1S/C12H14ClN3O5S/c1-6-5-7-9(15-12(19)11(18)14-7)10(8(6)13)16(3-4-17)22(2,20)21/h5,17H,3-4H2,1-2H3,(H,14,18)(H,15,19)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human NMDA NR1 receptor


Bioorg Med Chem Lett 17: 4599-603 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.083
BindingDB Entry DOI: 10.7270/Q2QR4WTR
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005075
PNG
((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50041464
PNG
(3-(3-Benzyl-phenyl)-7-chloro-4-hydroxy-1H-quinolin...)
Show SMILES Oc1c(-c2cccc(Cc3ccccc3)c2)c(=O)[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C22H16ClNO2/c23-17-9-10-18-19(13-17)24-22(26)20(21(18)25)16-8-4-7-15(12-16)11-14-5-2-1-3-6-14/h1-10,12-13H,11H2,(H2,24,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50041465
PNG
(7-Chloro-4-hydroxy-3-[3-(4-methoxy-benzyl)-phenyl]...)
Show SMILES COc1ccc(Cc2cccc(c2)-c2c(O)c3ccc(Cl)cc3[nH]c2=O)cc1
Show InChI InChI=1S/C23H18ClNO3/c1-28-18-8-5-14(6-9-18)11-15-3-2-4-16(12-15)21-22(26)19-10-7-17(24)13-20(19)25-23(21)27/h2-10,12-13H,11H2,1H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50056605
PNG
(7-Chloro-6-methyl-5-nitro-1,4-dihydro-quinoxaline-...)
Show SMILES Cc1c(Cl)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6ClN3O4/c1-3-4(10)2-5-6(7(3)13(16)17)12-9(15)8(14)11-5/h2H,1H3,(H2,11,12,14,15)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.70n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...


J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50073922
PNG
(CHEMBL86313 | {(S)-1-[(7-Bromo-2,3-dioxo-1,2,3,4-t...)
Show SMILES C[C@@H](NCc1cc(Br)cc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O
Show InChI InChI=1S/C11H13BrN3O5P/c1-5(21(18,19)20)13-4-6-2-7(12)3-8-9(6)15-11(17)10(16)14-8/h2-3,5,13H,4H2,1H3,(H,14,16)(H,15,17)(H2,18,19,20)/t5-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



University Hospital Zurich

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...


Bioorg Med Chem Lett 10: 75-8 (2000)


Article DOI: 10.1016/s0960-894x(99)00576-4
BindingDB Entry DOI: 10.7270/Q2M907WV
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005072
PNG
(5,7-Dichloro-4-(3-p-tolyl-ureido)-1,2,3,4-tetrahyd...)
Show SMILES Cc1ccc(NC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)cc1
Show InChI InChI=1S/C18H17Cl2N3O3/c1-9-2-4-11(5-3-9)21-18(26)23-14-8-15(17(24)25)22-13-7-10(19)6-12(20)16(13)14/h2-7,14-15,22H,8H2,1H3,(H,24,25)(H2,21,23,26)/t14-,15+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50091637
PNG
(5-(3-(4-benzylpiperidin-1-yl)prop-1-ynyl)-1H-benzo...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C#CCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H23N3O/c26-22-23-20-9-8-18(16-21(20)24-22)7-4-12-25-13-10-19(11-14-25)15-17-5-2-1-3-6-17/h1-3,5-6,8-9,16,19H,10-15H2,(H2,23,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.30n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes


J Med Chem 43: 3408-19 (2000)


Article DOI: 10.1021/jm000023o
BindingDB Entry DOI: 10.7270/Q2VH5N26
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50038161
PNG
(6,7-Dichloro-3-hydroxy-5-nitro-3,4-dihydro-1H-quin...)
Show SMILES [O-][N+](=O)c1c(Cl)c(Cl)cc2[n-]c(=[OH+])c(=O)[nH]c12
Show InChI InChI=1S/C8H3Cl2N3O4/c9-2-1-3-5(6(4(2)10)13(16)17)12-8(15)7(14)11-3/h1H,(H2,11,12,14,15)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...


J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005055
PNG
(7-Chloro-5-iodo-4-(3-phenyl-ureido)-1,2,3,4-tetrah...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(I)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15ClIN3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005044
PNG
((2R,4S)-5,7-Dichloro-4-(2-oxo-3-phenyl-imidazolidi...)
Show SMILES OC(=O)[C@H]1C[C@H](N2CCN(C2=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H17Cl2N3O3/c20-11-8-13(21)17-14(9-11)22-15(18(25)26)10-16(17)24-7-6-23(19(24)27)12-4-2-1-3-5-12/h1-5,8-9,15-16,22H,6-7,10H2,(H,25,26)/t15-,16+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005044
PNG
((2R,4S)-5,7-Dichloro-4-(2-oxo-3-phenyl-imidazolidi...)
Show SMILES OC(=O)[C@H]1C[C@H](N2CCN(C2=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H17Cl2N3O3/c20-11-8-13(21)17-14(9-11)22-15(18(25)26)10-16(17)24-7-6-23(19(24)27)12-4-2-1-3-5-12/h1-5,8-9,15-16,22H,6-7,10H2,(H,25,26)/t15-,16+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Università degli Studi di Urbino

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor...


J Med Chem 41: 808-20 (1998)


Article DOI: 10.1021/jm970416w
BindingDB Entry DOI: 10.7270/Q2QZ293M
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50084064
PNG
(CHEMBL167952 | {(S)-1-[(7-Chloro-2,3-dioxo-1,2,3,4...)
Show SMILES C[C@@H](NCc1cc(Cl)cc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O
Show InChI InChI=1S/C11H13ClN3O5P/c1-5(21(18,19)20)13-4-6-2-7(12)3-8-9(6)15-11(17)10(16)14-8/h2-3,5,13H,4H2,1H3,(H,14,16)(H,15,17)(H2,18,19,20)/t5-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



University Hospital Zurich

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...


Bioorg Med Chem Lett 10: 75-8 (2000)


Article DOI: 10.1016/s0960-894x(99)00576-4
BindingDB Entry DOI: 10.7270/Q2M907WV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50091635
PNG
(5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Fc1cccc(CC2CCN(CC#Cc3ccc4[nH]c(=O)[nH]c4c3)CC2)c1
Show InChI InChI=1S/C22H22FN3O/c23-19-5-1-3-18(14-19)13-17-8-11-26(12-9-17)10-2-4-16-6-7-20-21(15-16)25-22(27)24-20/h1,3,5-7,14-15,17H,8-13H2,(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes


J Med Chem 43: 3408-19 (2000)


Article DOI: 10.1021/jm000023o
BindingDB Entry DOI: 10.7270/Q2VH5N26
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50069471
PNG
(CHEMBL357190 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Show SMILES Clc1ccccc1CC(=O)NCc1cc(Br)cc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C17H13BrClN3O3/c18-11-5-10(15-13(7-11)21-16(24)17(25)22-15)8-20-14(23)6-9-3-1-2-4-12(9)19/h1-5,7H,6,8H2,(H,20,23)(H,21,24)(H,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors


Bioorg Med Chem Lett 8: 493-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00055-9
BindingDB Entry DOI: 10.7270/Q29G5NBG
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50052635
PNG
(5,6,7-Trichloro-1H-quinoline-2,3,4-trione 3-oxime ...)
Show SMILES Oc1c(N=O)c(=O)[nH]c2cc(Cl)c(Cl)c(Cl)c12
Show InChI InChI=1S/C9H3Cl3N2O3/c10-2-1-3-4(6(12)5(2)11)8(15)7(14-17)9(16)13-3/h1H,(H2,13,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes


J Med Chem 39: 3248-55 (1996)


Article DOI: 10.1021/jm960214k
BindingDB Entry DOI: 10.7270/Q2QC02KC
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005086
PNG
(5,7-Dichloro-4-(3-o-tolyl-ureido)-1,2,3,4-tetrahyd...)
Show SMILES Cc1ccccc1NC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C18H17Cl2N3O3/c1-9-4-2-3-5-12(9)22-18(26)23-14-8-15(17(24)25)21-13-7-10(19)6-11(20)16(13)14/h2-7,14-15,21H,8H2,1H3,(H,24,25)(H2,22,23,26)/t14-,15+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005075
PNG
((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50123796
PNG
(3-[(2-Carboxymethyl-phenylcarbamoyl)-methyl]-7-chl...)
Show SMILES OC(=O)Cc1ccccc1NC(=O)C[C@@H]1CCc2cc(Cl)cc3[nH]c(C(O)=O)c1c23
Show InChI InChI=1S/C22H19ClN2O5/c23-14-7-12-5-6-13(20-19(12)16(10-14)25-21(20)22(29)30)8-17(26)24-15-4-2-1-3-11(15)9-18(27)28/h1-4,7,10,13,25H,5-6,8-9H2,(H,24,26)(H,27,28)(H,29,30)/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.60n/an/an/an/an/an/a



Sumitomo Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...


J Med Chem 46: 691-701 (2003)


Article DOI: 10.1021/jm020239l
BindingDB Entry DOI: 10.7270/Q2G44PP3
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005075
PNG
((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.80n/an/an/an/an/an/a



Università degli Studi di Urbino

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor...


J Med Chem 41: 808-20 (1998)


Article DOI: 10.1021/jm970416w
BindingDB Entry DOI: 10.7270/Q2QZ293M
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50215286
PNG
(CHEMBL399275 | N-(6,7-dichloro-2,3-dioxo-1,2,3,4-t...)
Show SMILES COCCCN(c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12)S(C)(=O)=O
Show InChI InChI=1S/C13H15Cl2N3O5S/c1-23-5-3-4-18(24(2,21)22)11-9(15)7(14)6-8-10(11)17-13(20)12(19)16-8/h6H,3-5H2,1-2H3,(H,16,19)(H,17,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human NMDA NR1 receptor


Bioorg Med Chem Lett 17: 4599-603 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.083
BindingDB Entry DOI: 10.7270/Q2QR4WTR
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50073930
PNG
(CHEMBL82963 | {(S)-1-[(2,3-Dioxo-7-trifluoromethyl...)
Show SMILES C[C@@H](NCc1cc(cc2[nH]c(=O)c(=O)[nH]c12)C(F)(F)F)P(O)(O)=O
Show InChI InChI=1S/C12H13F3N3O5P/c1-5(24(21,22)23)16-4-6-2-7(12(13,14)15)3-8-9(6)18-11(20)10(19)17-8/h2-3,5,16H,4H2,1H3,(H,17,19)(H,18,20)(H2,21,22,23)/t5-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



University Hospital Zurich

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...


Bioorg Med Chem Lett 10: 75-8 (2000)


Article DOI: 10.1016/s0960-894x(99)00576-4
BindingDB Entry DOI: 10.7270/Q2M907WV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50084062
PNG
(CHEMBL354295 | {(S)-1-[(7-Iodo-2,3-dioxo-1,2,3,4-t...)
Show SMILES C[C@@H](NCc1cc(I)cc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O
Show InChI InChI=1S/C11H13IN3O5P/c1-5(21(18,19)20)13-4-6-2-7(12)3-8-9(6)15-11(17)10(16)14-8/h2-3,5,13H,4H2,1H3,(H,14,16)(H,15,17)(H2,18,19,20)/t5-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



University Hospital Zurich

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...


Bioorg Med Chem Lett 10: 75-8 (2000)


Article DOI: 10.1016/s0960-894x(99)00576-4
BindingDB Entry DOI: 10.7270/Q2M907WV
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50091636
PNG
(5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...)
Show SMILES Fc1ccc(CC2CCN(CC#Cc3ccc4[nH]c(=O)[nH]c4c3)CC2)cc1
Show InChI InChI=1S/C22H22FN3O/c23-19-6-3-17(4-7-19)14-18-9-12-26(13-10-18)11-1-2-16-5-8-20-21(15-16)25-22(27)24-20/h3-8,15,18H,9-14H2,(H2,24,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.20n/an/an/an/an/an/a



CoCensys, Inc.

Curated by ChEMBL


Assay Description
Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes


J Med Chem 43: 3408-19 (2000)


Article DOI: 10.1021/jm000023o
BindingDB Entry DOI: 10.7270/Q2VH5N26
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50056596
PNG
(7-Bromo-6-methyl-5-nitro-1,4-dihydro-quinoxaline-2...)
Show SMILES Cc1c(Br)cc2[n-]c(=[OH+])c(=O)[nH]c2c1[N+]([O-])=O
Show InChI InChI=1S/C9H6BrN3O4/c1-3-4(10)2-5-6(7(3)13(16)17)12-9(15)8(14)11-5/h2H,1H3,(H2,11,12,14,15)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 8.70n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ...


J Med Chem 40: 730-8 (1997)


Article DOI: 10.1021/jm960654b
BindingDB Entry DOI: 10.7270/Q2NZ86RJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(Homo sapiens (Human))
BDBM50000663
PNG
((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21
Show InChI InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3/t15?,16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9n/an/an/an/a6.9n/a



Medical University of Lublin

Curated by ChEMBL


Assay Description
Antagonist activity at NR1/2B receptor (unknown origin) expressed in xenopus laevis at pH 6.9 by two electrode voltage clamp method


J Med Chem 51: 3765-76 (2008)


Article DOI: 10.1021/jm7011694
BindingDB Entry DOI: 10.7270/Q21Z447W
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 644 total )  |  Next  |  Last  >>
Jump to: