BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 220 hits of ic50 for UniProtKB: Q2NNR5   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50023198
PNG
(8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...)
Show SMILES O=C(Nc1cccc2c1oc(cc2=O)-c1nnn[nH]1)c1ccc(OCCCCc2ccccc2)cc1
Show InChI InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 0.0440n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting meth...


J Med Chem 60: 5235-5266 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01287
BindingDB Entry DOI: 10.7270/Q2T43WDQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286261
PNG
((S)-2-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vi...)
Show SMILES CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)C(O)=O
Show InChI InChI=1S/C34H36ClNO3S/c1-4-24(33(37)38)22-40-32(19-15-25-9-5-6-11-30(25)34(2,3)39)27-10-7-8-23(20-27)12-17-29-18-14-26-13-16-28(35)21-31(26)36-29/h5-14,16-18,20-21,24,32,39H,4,15,19,22H2,1-3H3,(H,37,38)/b17-12+/t24-,32-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280701
PNG
(CHEMBL275357 | Sodium; (R)-3-{(R)-1-[3-(7-chloro-q...)
Show SMILES C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1S/C32H34ClNO4S/c1-21(31(35)36)20-39-30(16-13-22-7-4-5-10-28(22)32(2,3)37)24-8-6-9-27(17-24)38-19-26-15-12-23-11-14-25(33)18-29(23)34-26/h4-12,14-15,17-18,21,30,37H,13,16,19-20H2,1-3H3,(H,35,36)/p-1/t21-,30+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50001273
PNG
(3-((2-Carbamoyl-ethylsulfanyl)-{3-[2-(7-chloro-qui...)
Show SMILES NC(=O)CCSC(SCCC(O)=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C24H23ClN2O3S2/c25-19-7-5-17-6-9-20(27-21(17)15-19)8-4-16-2-1-3-18(14-16)24(31-12-10-22(26)28)32-13-11-23(29)30/h1-9,14-15,24H,10-13H2,(H2,26,28)(H,29,30)/b8-4+
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes


J Med Chem 35: 3832-44 (1992)


Article DOI: 10.1021/jm00099a011
BindingDB Entry DOI: 10.7270/Q2TQ625N
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280701
PNG
(CHEMBL275357 | Sodium; (R)-3-{(R)-1-[3-(7-chloro-q...)
Show SMILES C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1S/C32H34ClNO4S/c1-21(31(35)36)20-39-30(16-13-22-7-4-5-10-28(22)32(2,3)37)24-8-6-9-27(17-24)38-19-26-15-12-23-11-14-25(33)18-29(23)34-26/h4-12,14-15,17-18,21,30,37H,13,16,19-20H2,1-3H3,(H,35,36)/p-1/t21-,30+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286257
PNG
((2R,3R)-3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl...)
Show SMILES C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(O)=O
Show InChI InChI=1S/C34H36ClNO3S/c1-22(33(37)38)23(2)40-32(19-15-25-9-5-6-11-30(25)34(3,4)39)27-10-7-8-24(20-27)12-17-29-18-14-26-13-16-28(35)21-31(26)36-29/h5-14,16-18,20-23,32,39H,15,19H2,1-4H3,(H,37,38)/b17-12+/t22-,23+,32+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286260
PNG
(4-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]...)
Show SMILES CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)CC(O)=O
Show InChI InChI=1S/C35H38ClNO3S/c1-34(2,22-33(38)39)23-41-32(19-15-25-9-5-6-11-30(25)35(3,4)40)27-10-7-8-24(20-27)12-17-29-18-14-26-13-16-28(36)21-31(26)37-29/h5-14,16-18,20-21,32,40H,15,19,22-23H2,1-4H3,(H,38,39)/b17-12+/t32-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286253
PNG
((S)-3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vi...)
Show SMILES C[C@@H](CC(O)=O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1S/C33H34ClNO3S/c1-22(19-32(36)37)39-31(18-14-24-8-4-5-10-29(24)33(2,3)38)26-9-6-7-23(20-26)11-16-28-17-13-25-12-15-27(34)21-30(25)35-28/h4-13,15-17,20-22,31,38H,14,18-19H2,1-3H3,(H,36,37)/b16-11+/t22-,31+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.330n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280712
PNG
(CHEMBL14819 | Sodium; 3-{1-[3-(7-chloro-quinolin-2...)
Show SMILES [O-]C(=O)CCSC(CCc1ccccc1-c1nnc[nH]1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C30H27ClN4O3S/c31-23-11-8-21-9-12-24(34-27(21)17-23)18-38-25-6-3-5-22(16-25)28(39-15-14-29(36)37)13-10-20-4-1-2-7-26(20)30-32-19-33-35-30/h1-9,11-12,16-17,19,28H,10,13-15,18H2,(H,36,37)(H,32,33,35)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.360n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280694
PNG
(CHEMBL15292 | Sodium; 3-[1-[3-(7-chloro-quinolin-2...)
Show SMILES NS(=O)(=O)c1ccccc1CCC(SCCC([O-])=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C28H27ClN2O5S2/c29-22-11-8-19-9-12-23(31-25(19)17-22)18-36-24-6-3-5-21(16-24)26(37-15-14-28(32)33)13-10-20-4-1-2-7-27(20)38(30,34)35/h1-9,11-12,16-17,26H,10,13-15,18H2,(H,32,33)(H2,30,34,35)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280713
PNG
(CHEMBL15232 | Sodium; 2-{1-[3-(7-chloro-quinolin-2...)
Show SMILES CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1/C32H32ClN5O3S/c1-3-21(32(39)40)20-42-30(16-13-22-7-4-5-10-28(22)31-35-36-37-38(31)2)24-8-6-9-27(17-24)41-19-26-15-12-23-11-14-25(33)18-29(23)34-26/h4-12,14-15,17-18,21,30H,3,13,16,19-20H2,1-2H3,(H,39,40)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280693
PNG
(CHEMBL15370 | Sodium; 3-[1-[3-(7-chloro-quinolin-2...)
Show SMILES CC(CSC(CCc1ccccc1[N+]([O-])=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1/C29H27ClN2O5S/c1-19(29(33)34)18-38-28(14-11-21-5-2-3-8-27(21)32(35)36)22-6-4-7-25(15-22)37-17-24-13-10-20-9-12-23(30)16-26(20)31-24/h2-10,12-13,15-16,19,28H,11,14,17-18H2,1H3,(H,33,34)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071633
PNG
(CHEMBL83166 | [3-[2-Methoxy-4-(toluene-2-sulfonyla...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C35H38N4O8S/c1-23-7-3-6-10-32(23)48(43,44)37-33(40)25-12-11-24(31(20-25)45-2)19-26-22-39(35(42)38-15-17-46-18-16-38)30-14-13-27(21-29(26)30)36-34(41)47-28-8-4-5-9-28/h3,6-7,10-14,20-22,28H,4-5,8-9,15-19H2,1-2H3,(H,36,41)(H,37,40)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071631
PNG
(CHEMBL79952 | [3-[2-Methoxy-4-(toluene-2-sulfonyla...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C38H38N4O7S/c1-25-11-7-10-16-35(25)50(46,47)40-36(43)27-18-17-26(34(22-27)48-3)21-28-24-42(38(45)41(2)30-12-5-4-6-13-30)33-20-19-29(23-32(28)33)39-37(44)49-31-14-8-9-15-31/h4-7,10-13,16-20,22-24,31H,8-9,14-15,21H2,1-3H3,(H,39,44)(H,40,43)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071637
PNG
(CHEMBL79366 | {1-Dimethylcarbamoyl-3-[2-methoxy-4-...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C33H36N4O7S/c1-21-9-5-8-12-30(21)45(41,42)35-31(38)23-14-13-22(29(18-23)43-4)17-24-20-37(33(40)36(2)3)28-16-15-25(19-27(24)28)34-32(39)44-26-10-6-7-11-26/h5,8-9,12-16,18-20,26H,6-7,10-11,17H2,1-4H3,(H,34,39)(H,35,38)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286262
PNG
(4-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]...)
Show SMILES CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)CC(O)=O
Show InChI InChI=1S/C34H36ClNO3S/c1-23(19-33(37)38)22-40-32(18-14-25-8-4-5-10-30(25)34(2,3)39)27-9-6-7-24(20-27)11-16-29-17-13-26-12-15-28(35)21-31(26)36-29/h4-13,15-17,20-21,23,32,39H,14,18-19,22H2,1-3H3,(H,37,38)/b16-11+/t23?,32-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.430n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286255
PNG
(3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]...)
Show SMILES CC(S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)C(C)C(O)=O
Show InChI InChI=1S/C34H36ClNO3S/c1-22(33(37)38)23(2)40-32(19-15-25-9-5-6-11-30(25)34(3,4)39)27-10-7-8-24(20-27)12-17-29-18-14-26-13-16-28(35)21-31(26)36-29/h5-14,16-18,20-23,32,39H,15,19H2,1-4H3,(H,37,38)/b17-12+/t22?,23?,32-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50009073
PNG
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Show SMILES COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
n/an/a 0.440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280687
PNG
(CHEMBL280310 | Sodium; 2-[1-[3-(7-chloro-quinolin-...)
Show SMILES CCNC(=O)c1ccccc1CCC(SCC(CC)C([O-])=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C33H35ClN2O4S/c1-3-22(33(38)39)21-41-31(17-14-23-8-5-6-11-29(23)32(37)35-4-2)25-9-7-10-28(18-25)40-20-27-16-13-24-12-15-26(34)19-30(24)36-27/h5-13,15-16,18-19,22,31H,3-4,14,17,20-21H2,1-2H3,(H,35,37)(H,38,39)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.450n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280686
PNG
(CHEMBL15120 | Sodium; 2-{3-(2-carbamoyl-phenyl)-1-...)
Show SMILES CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1/C31H31ClN2O4S/c1-2-20(31(36)37)19-39-29(15-12-21-6-3-4-9-27(21)30(33)35)23-7-5-8-26(16-23)38-18-25-14-11-22-10-13-24(32)17-28(22)34-25/h3-11,13-14,16-17,20,29H,2,12,15,18-19H2,1H3,(H2,33,35)(H,36,37)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.470n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280693
PNG
(CHEMBL15370 | Sodium; 3-[1-[3-(7-chloro-quinolin-2...)
Show SMILES CC(CSC(CCc1ccccc1[N+]([O-])=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1/C29H27ClN2O5S/c1-19(29(33)34)18-38-28(14-11-21-5-2-3-8-27(21)32(35)36)22-6-4-7-25(15-22)37-17-24-13-10-20-9-12-23(30)16-26(20)31-24/h2-10,12-13,15-16,19,28H,11,14,17-18H2,1H3,(H,33,34)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.490n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50281859
PNG
(CHEMBL14268 | Sodium; (S)-6-{3-[(E)-2-(7-chloro-qu...)
Show SMILES CC(CC[C@H](SCCCC(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)CC([O-])=O
Show InChI InChI=1S/C30H36ClNO3S/c1-21(18-29(33)34)8-15-28(36-17-5-16-30(2,3)35)24-7-4-6-22(19-24)9-13-26-14-11-23-10-12-25(31)20-27(23)32-26/h4,6-7,9-14,19-21,28,35H,5,8,15-18H2,1-3H3,(H,33,34)/p-1/b13-9+/t21?,28-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding to guinea-pig lung membrane


Bioorg Med Chem Lett 3: 1125-1130 (1993)


Article DOI: 10.1016/S0960-894X(00)80300-5
BindingDB Entry DOI: 10.7270/Q2VM4C6B
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071638
PNG
(CHEMBL311868 | {1-Carbamoyl-3-[2-methoxy-4-(toluen...)
Show SMILES COc1cc(ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H32N4O7S/c1-19-7-3-6-10-28(19)43(39,40)34-29(36)21-12-11-20(27(16-21)41-2)15-22-18-35(30(32)37)26-14-13-23(17-25(22)26)33-31(38)42-24-8-4-5-9-24/h3,6-7,10-14,16-18,24H,4-5,8-9,15H2,1-2H3,(H2,32,37)(H,33,38)(H,34,36)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071639
PNG
(CHEMBL79741 | [3-[2-Methoxy-4-(toluene-2-sulfonyla...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C40H42N4O7S/c1-27-11-6-9-17-37(27)52(48,49)43-38(45)30-19-18-29(36(24-30)50-2)23-31-26-44(39(46)41-22-10-14-28-12-4-3-5-13-28)35-21-20-32(25-34(31)35)42-40(47)51-33-15-7-8-16-33/h3-6,9,11-13,17-21,24-26,33H,7-8,10,14-16,22-23H2,1-2H3,(H,41,46)(H,42,47)(H,43,45)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50052024
PNG
(CHEMBL787 | montelukast)
Show SMILES CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Displacement of [3H]LTD4 from LTD4 receptor in guinea pig lung membrane


J Med Chem 59: 8712-8756 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00472
BindingDB Entry DOI: 10.7270/Q29G5PR8
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50284902
PNG
((1-{(R)-1-{3-[(E)-2-(4-Cyclobutyl-thiazol-2-yl)-vi...)
Show SMILES CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2nc(cs2)C2CCC2)c1
Show InChI InChI=1S/C33H39NO3S2/c1-32(2,37)27-12-4-3-8-24(27)14-15-29(39-22-33(17-18-33)20-31(35)36)26-11-5-7-23(19-26)13-16-30-34-28(21-38-30)25-9-6-10-25/h3-5,7-8,11-13,16,19,21,25,29,37H,6,9-10,14-15,17-18,20,22H2,1-2H3,(H,35,36)/b16-13+/t29-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]LTD4 binding on guinea-pig lung membranes


Bioorg Med Chem Lett 5: 1615-1620 (1995)


Article DOI: 10.1016/0960-894X(95)00265-U
BindingDB Entry DOI: 10.7270/Q2NV9J6V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280695
PNG
(CHEMBL279630 | Sodium; 2-[1-{3-[2-(7-chloro-quinol...)
Show SMILES CCOC(=O)Nc1ccccc1CCC(SCC(CC)C([O-])=O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C34H37ClN2O4S/c1-3-24(33(38)39)22-42-32(19-15-25-9-5-6-11-30(25)37-34(40)41-4-2)27-10-7-8-23(20-27)12-17-29-18-14-26-13-16-28(35)21-31(26)36-29/h5-11,13-14,16,18,20-21,24,32H,3-4,12,15,17,19,22H2,1-2H3,(H,37,40)(H,38,39)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071632
PNG
(CHEMBL310446 | {1-Diethylcarbamoyl-3-[2-methoxy-4-...)
Show SMILES CCN(CC)C(=O)n1cc(Cc2ccc(cc2OC)C(=O)NS(=O)(=O)c2ccccc2C)c2cc(NC(=O)OC3CCCC3)ccc12
Show InChI InChI=1S/C35H40N4O7S/c1-5-38(6-2)35(42)39-22-26(29-21-27(17-18-30(29)39)36-34(41)46-28-12-8-9-13-28)19-24-15-16-25(20-31(24)45-4)33(40)37-47(43,44)32-14-10-7-11-23(32)3/h7,10-11,14-18,20-22,28H,5-6,8-9,12-13,19H2,1-4H3,(H,36,41)(H,37,40)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280696
PNG
(CHEMBL274913 | Sodium; (S)-3-{(S)-1-[3-(7-chloro-q...)
Show SMILES C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1S/C32H34ClNO4S/c1-21(31(35)36)20-39-30(16-13-22-7-4-5-10-28(22)32(2,3)37)24-8-6-9-27(17-24)38-19-26-15-12-23-11-14-25(33)18-29(23)34-26/h4-12,14-15,17-18,21,30,37H,13,16,19-20H2,1-3H3,(H,35,36)/p-1/t21-,30+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50052024
PNG
(CHEMBL787 | montelukast)
Show SMILES CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071636
PNG
(CHEMBL79479 | {1-(2-Dimethylamino-ethylcarbamoyl)-...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C35H41N5O7S/c1-23-9-5-8-12-32(23)48(44,45)38-33(41)25-14-13-24(31(20-25)46-4)19-26-22-40(34(42)36-17-18-39(2)3)30-16-15-27(21-29(26)30)37-35(43)47-28-10-6-7-11-28/h5,8-9,12-16,20-22,28H,6-7,10-11,17-19H2,1-4H3,(H,36,42)(H,37,43)(H,38,41)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280699
PNG
(3-[1-[3-(7-Chloro-quinolin-2-ylmethoxy)-phenyl]-3-...)
Show SMILES CC(CSC(CCc1ccccc1C(=O)N(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(O)=O
Show InChI InChI=1/C32H33ClN2O4S/c1-21(32(37)38)20-40-30(16-13-22-7-4-5-10-28(22)31(36)35(2)3)24-8-6-9-27(17-24)39-19-26-15-12-23-11-14-25(33)18-29(23)34-26/h4-12,14-15,17-18,21,30H,13,16,19-20H2,1-3H3,(H,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280698
PNG
(CHEMBL274049 | Sodium; 3-[1-[3-(7-chloro-quinolin-...)
Show SMILES CS(=O)(=O)Nc1ccccc1CCC(SCCC([O-])=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C29H29ClN2O5S2/c1-39(35,36)32-26-8-3-2-5-20(26)11-14-28(38-16-15-29(33)34)22-6-4-7-25(17-22)37-19-24-13-10-21-9-12-23(30)18-27(21)31-24/h2-10,12-13,17-18,28,32H,11,14-16,19H2,1H3,(H,33,34)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.560n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286254
PNG
(3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]...)
Show SMILES CCC(CC(O)=O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1S/C34H36ClNO3S/c1-4-29(22-33(37)38)40-32(19-15-24-9-5-6-11-30(24)34(2,3)39)26-10-7-8-23(20-26)12-17-28-18-14-25-13-16-27(35)21-31(25)36-28/h5-14,16-18,20-21,29,32,39H,4,15,19,22H2,1-3H3,(H,37,38)/b17-12+/t29?,32-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.580n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50284902
PNG
((1-{(R)-1-{3-[(E)-2-(4-Cyclobutyl-thiazol-2-yl)-vi...)
Show SMILES CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2nc(cs2)C2CCC2)c1
Show InChI InChI=1S/C33H39NO3S2/c1-32(2,37)27-12-4-3-8-24(27)14-15-29(39-22-33(17-18-33)20-31(35)36)26-11-5-7-23(19-26)13-16-30-34-28(21-38-30)25-9-6-10-25/h3-5,7-8,11-13,16,19,21,25,29,37H,6,9-10,14-15,17-18,20,22H2,1-2H3,(H,35,36)/b16-13+/t29-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding on guinea-pig lung membranes


Bioorg Med Chem Lett 5: 1615-1620 (1995)


Article DOI: 10.1016/0960-894X(95)00265-U
BindingDB Entry DOI: 10.7270/Q2NV9J6V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280695
PNG
(CHEMBL279630 | Sodium; 2-[1-{3-[2-(7-chloro-quinol...)
Show SMILES CCOC(=O)Nc1ccccc1CCC(SCC(CC)C([O-])=O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C34H37ClN2O4S/c1-3-24(33(38)39)22-42-32(19-15-25-9-5-6-11-30(25)37-34(40)41-4-2)27-10-7-8-23(20-27)12-17-29-18-14-26-13-16-28(35)21-31(26)36-29/h5-11,13-14,16,18,20-21,24,32H,3-4,12,15,17,19,22H2,1-2H3,(H,37,40)(H,38,39)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280689
PNG
(CHEMBL278411 | Sodium; 3-{1-[3-(7-chloro-quinolin-...)
Show SMILES [O-]C(=O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C34H35ClN2O4S/c35-27-14-11-25-12-15-28(36-31(25)22-27)23-41-29-9-6-8-26(21-29)32(42-20-17-33(38)39)16-13-24-7-2-3-10-30(24)34(40)37-18-4-1-5-19-37/h2-3,6-12,14-15,21-22,32H,1,4-5,13,16-20,23H2,(H,38,39)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286256
PNG
((R)-3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vi...)
Show SMILES C[C@H](CC(O)=O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1S/C33H34ClNO3S/c1-22(19-32(36)37)39-31(18-14-24-8-4-5-10-29(24)33(2,3)38)26-9-6-7-23(20-26)11-16-28-17-13-25-12-15-27(34)21-30(25)35-28/h4-13,15-17,20-22,31,38H,14,18-19H2,1-3H3,(H,36,37)/b16-11+/t22-,31-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50281863
PNG
(CHEMBL14451 | Sodium; (S)-6-{3-[2-(7-chloro-quinol...)
Show SMILES CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC([O-])=O
Show InChI InChI=1S/C35H40ClNO3S/c1-34(2,22-33(38)39)19-18-32(41-23-27-9-5-6-11-30(27)35(3,4)40)26-10-7-8-24(20-26)12-16-29-17-14-25-13-15-28(36)21-31(25)37-29/h5-11,13-15,17,20-21,32,40H,12,16,18-19,22-23H2,1-4H3,(H,38,39)/p-1/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding to guinea-pig lung membrane


Bioorg Med Chem Lett 3: 1125-1130 (1993)


Article DOI: 10.1016/S0960-894X(00)80300-5
BindingDB Entry DOI: 10.7270/Q2VM4C6B
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50281858
PNG
(CHEMBL273343 | Sodium; (S)-6-{3-[(E)-2-(7-chloro-q...)
Show SMILES CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)CC([O-])=O
Show InChI InChI=1S/C35H38ClNO3S/c1-34(2,22-33(38)39)19-18-32(41-23-27-9-5-6-11-30(27)35(3,4)40)26-10-7-8-24(20-26)12-16-29-17-14-25-13-15-28(36)21-31(25)37-29/h5-17,20-21,32,40H,18-19,22-23H2,1-4H3,(H,38,39)/p-1/b16-12+/t32-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding to guinea-pig lung membrane


Bioorg Med Chem Lett 3: 1125-1130 (1993)


Article DOI: 10.1016/S0960-894X(00)80300-5
BindingDB Entry DOI: 10.7270/Q2VM4C6B
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280698
PNG
(CHEMBL274049 | Sodium; 3-[1-[3-(7-chloro-quinolin-...)
Show SMILES CS(=O)(=O)Nc1ccccc1CCC(SCCC([O-])=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C29H29ClN2O5S2/c1-39(35,36)32-26-8-3-2-5-20(26)11-14-28(38-16-15-29(33)34)22-6-4-7-25(17-22)37-19-24-13-10-21-9-12-23(30)18-27(21)31-24/h2-10,12-13,17-18,28,32H,11,14-16,19H2,1H3,(H,33,34)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280709
PNG
(CHEMBL15344 | Sodium; 2-[1-[3-(7-chloro-quinolin-2...)
Show SMILES CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1/C31H32ClNO5S2/c1-3-21(31(34)35)20-39-29(16-13-23-7-4-5-10-30(23)40(2,36)37)24-8-6-9-27(17-24)38-19-26-15-12-22-11-14-25(32)18-28(22)33-26/h4-12,14-15,17-18,21,29H,3,13,16,19-20H2,1-2H3,(H,34,35)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Leukotriene D4 induced contraction of guinea-pig trachea was determined


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50280694
PNG
(CHEMBL15292 | Sodium; 3-[1-[3-(7-chloro-quinolin-2...)
Show SMILES NS(=O)(=O)c1ccccc1CCC(SCCC([O-])=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1/C28H27ClN2O5S2/c29-22-11-8-19-9-12-23(31-25(19)17-22)18-36-24-6-3-5-21(16-24)26(37-15-14-28(32)33)13-10-20-4-1-2-7-27(20)38(30,34)35/h1-9,11-12,16-17,26H,10,13-15,18H2,(H,32,33)(H2,30,34,35)/p-1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against [3H]-Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2


Bioorg Med Chem Lett 2: 1141-1146 (1992)


Article DOI: 10.1016/S0960-894X(00)80635-6
BindingDB Entry DOI: 10.7270/Q2D21XJR
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286259
PNG
(3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]...)
Show SMILES CC(C)(CC(O)=O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1S/C34H36ClNO3S/c1-33(2,22-32(37)38)40-31(19-15-24-9-5-6-11-29(24)34(3,4)39)26-10-7-8-23(20-26)12-17-28-18-14-25-13-16-27(35)21-30(25)36-28/h5-14,16-18,20-21,31,39H,15,19,22H2,1-4H3,(H,37,38)/b17-12+/t31-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.680n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50284899
PNG
(CHEMBL287722 | {1-[(R)-3-[2-(1-Hydroxy-1-methyl-et...)
Show SMILES CC(CC(F)(F)F)c1csc(\C=C\c2cccc(c2)[C@@H](CCc2ccccc2C(C)(C)O)SCC2(CC(O)=O)CC2)n1
Show InChI InChI=1S/C33H38F3NO3S2/c1-22(18-33(34,35)36)27-20-41-29(37-27)14-11-23-7-6-9-25(17-23)28(42-21-32(15-16-32)19-30(38)39)13-12-24-8-4-5-10-26(24)31(2,3)40/h4-11,14,17,20,22,28,40H,12-13,15-16,18-19,21H2,1-3H3,(H,38,39)/b14-11+/t22?,28-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding on guinea-pig lung membranes


Bioorg Med Chem Lett 5: 1615-1620 (1995)


Article DOI: 10.1016/0960-894X(95)00265-U
BindingDB Entry DOI: 10.7270/Q2NV9J6V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50013919
PNG
(3-[{3-[2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(...)
Show SMILES CN(C)C(=O)CCS[C@@H](SCCC(O)=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+/t26-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.770n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung membrane


J Med Chem 33: 2841-5 (1990)


Article DOI: 10.1021/jm00172a025
BindingDB Entry DOI: 10.7270/Q25M64QQ
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50286253
PNG
((S)-3-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vi...)
Show SMILES C[C@@H](CC(O)=O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Show InChI InChI=1S/C33H34ClNO3S/c1-22(19-32(36)37)39-31(18-14-24-8-4-5-10-29(24)33(2,3)38)26-9-6-7-23(20-26)11-16-28-17-13-25-12-15-27(34)21-30(25)35-28/h4-13,15-17,20-22,31,38H,14,18-19H2,1-3H3,(H,36,37)/b16-11+/t22-,31+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.790n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes(different expt)


Bioorg Med Chem Lett 5: 283-288 (1995)


Article DOI: 10.1016/0960-894X(95)00023-M
BindingDB Entry DOI: 10.7270/Q2KD1XW7
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50281856
PNG
(CHEMBL275823 | Sodium; (2R,6R)-6-{3-[(E)-2-(7-chlo...)
Show SMILES C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1)C([O-])=O
Show InChI InChI=1S/C29H34ClNO3S/c1-20(28(32)33)6-4-9-27(35-17-16-29(2,3)34)23-8-5-7-21(18-23)10-14-25-15-12-22-11-13-24(30)19-26(22)31-25/h5,7-8,10-15,18-20,27,34H,4,6,9,16-17H2,1-3H3,(H,32,33)/p-1/b14-10+/t20-,27-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding to guinea-pig lung membrane


Bioorg Med Chem Lett 3: 1125-1130 (1993)


Article DOI: 10.1016/S0960-894X(00)80300-5
BindingDB Entry DOI: 10.7270/Q2VM4C6B
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50284905
PNG
((1-{(R)-1-{3-[(E)-2-(5,6-Difluoro-benzothiazol-2-y...)
Show SMILES CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2nc3cc(F)c(F)cc3s2)c1
Show InChI InChI=1S/C33H33F2NO3S2/c1-32(2,39)24-9-4-3-7-22(24)11-12-28(40-20-33(14-15-33)19-31(37)38)23-8-5-6-21(16-23)10-13-30-36-27-17-25(34)26(35)18-29(27)41-30/h3-10,13,16-18,28,39H,11-12,14-15,19-20H2,1-2H3,(H,37,38)/b13-10+/t28-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding on guinea-pig lung membranes


Bioorg Med Chem Lett 5: 1615-1620 (1995)


Article DOI: 10.1016/0960-894X(95)00265-U
BindingDB Entry DOI: 10.7270/Q2NV9J6V
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50284895
PNG
((1-{(R)-1-{3-[(E)-2-(4-Cyclopentyl-thiazol-2-yl)-v...)
Show SMILES CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2nc(cs2)C2CCCC2)c1
Show InChI InChI=1S/C34H41NO3S2/c1-33(2,38)28-13-6-5-9-25(28)15-16-30(40-23-34(18-19-34)21-32(36)37)27-12-7-8-24(20-27)14-17-31-35-29(22-39-31)26-10-3-4-11-26/h5-9,12-14,17,20,22,26,30,38H,3-4,10-11,15-16,18-19,21,23H2,1-2H3,(H,36,37)/b17-14+/t30-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTD4 binding on guinea-pig lung membranes


Bioorg Med Chem Lett 5: 1615-1620 (1995)


Article DOI: 10.1016/0960-894X(95)00265-U
BindingDB Entry DOI: 10.7270/Q2NV9J6V
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 220 total )  |  Next  |  Last  >>
Jump to: