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Compile Data Set for Download or QSAR

Found 67 hits of ic50 data for polymerid = 49000717   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GPR145


(Homo sapiens (Human))
BDBM50360702
PNG
(CHEMBL1934121)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC(NC(C)=O)c5ccccc45)CC3)ccc12
Show InChI InChI=1S/C30H33N3O/c1-3-33-28-11-7-5-8-23(28)25-18-22(12-13-29(25)33)20-32-16-14-30(15-17-32)19-27(31-21(2)34)24-9-4-6-10-26(24)30/h4-13,18,27H,3,14-17,19-20H2,1-2H3,(H,31,34)
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n/an/a 0.100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360704
PNG
(CHEMBL1934123)
Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc12
Show InChI InChI=1S/C28H29N3O/c1-19(32)29-27-17-28(24-8-4-2-7-22(24)27)12-14-31(15-13-28)18-20-10-11-26-23(16-20)21-6-3-5-9-25(21)30-26/h2-11,16,27,30H,12-15,17-18H2,1H3,(H,29,32)/t27-/m1/s1
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n/an/a 0.100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360683
PNG
(CHEMBL1934130)
Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4n(C(N)=O)c5ccccc5c4c3)CC2)c2ccccc12
Show InChI InChI=1S/C29H30N4O2/c1-19(34)31-25-17-29(24-8-4-2-7-22(24)25)12-14-32(15-13-29)18-20-10-11-27-23(16-20)21-6-3-5-9-26(21)33(27)28(30)35/h2-11,16,25H,12-15,17-18H2,1H3,(H2,30,35)(H,31,34)/t25-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360708
PNG
(CHEMBL1934127)
Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Cl)cc5c4c3)CC2)c2ccccc12
Show InChI InChI=1S/C28H28ClN3O/c1-18(33)30-27-16-28(24-5-3-2-4-21(24)27)10-12-32(13-11-28)17-19-6-8-25-22(14-19)23-15-20(29)7-9-26(23)31-25/h2-9,14-15,27,31H,10-13,16-17H2,1H3,(H,30,33)/t27-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172440
PNG
(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
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n/an/a 3.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360691
PNG
(CHEMBL1934109)
Show SMILES CN(C)C(=O)n1c2ccccc2c2cc(CN3CCC4(CC3)C=Cc3ccccc43)ccc12
Show InChI InChI=1S/C29H29N3O/c1-30(2)28(33)32-26-10-6-4-8-23(26)24-19-21(11-12-27(24)32)20-31-17-15-29(16-18-31)14-13-22-7-3-5-9-25(22)29/h3-14,19H,15-18,20H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360694
PNG
(CHEMBL1934112)
Show SMILES NC(=O)n1c2ccccc2c2cc(CN3CCC4(CC3)C=Cc3ccccc43)ccc12
Show InChI InChI=1S/C27H25N3O/c28-26(31)30-24-8-4-2-6-21(24)22-17-19(9-10-25(22)30)18-29-15-13-27(14-16-29)12-11-20-5-1-3-7-23(20)27/h1-12,17H,13-16,18H2,(H2,28,31)
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n/an/a 4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172432
PNG
(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30)
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n/an/a 4.5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172425
PNG
(CHEMBL197026 | N-[2-(4-Amino-piperidin-1-yl)-4-met...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(N)CC1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-12-22(31-10-8-16(28)9-11-31)30-21-7-2-17(13-20(15)21)29-23(32)14-33-18-3-5-19(6-4-18)34-24(25,26)27/h2-7,12-13,16H,8-11,14,28H2,1H3,(H,29,32)
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n/an/a 4.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172418
PNG
(CHEMBL195635 | N-[4-Methyl-2-(4-pyrrolidin-1-yl-pi...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C28H31F3N4O3/c1-19-16-26(35-14-10-21(11-15-35)34-12-2-3-13-34)33-25-9-4-20(17-24(19)25)32-27(36)18-37-22-5-7-23(8-6-22)38-28(29,30)31/h4-9,16-17,21H,2-3,10-15,18H2,1H3,(H,32,36)
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n/an/a 6.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172441
PNG
((E)-N-{2-[(2-Hydroxy-ethyl)-methyl-amino]-4-methyl...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C23H22F3N3O3/c1-15-13-21(29(2)11-12-30)28-20-9-6-17(14-19(15)20)27-22(31)10-5-16-3-7-18(8-4-16)32-23(24,25)26/h3-10,13-14,30H,11-12H2,1-2H3,(H,27,31)/b10-5+
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n/an/a 6.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172416
PNG
(CHEMBL427540 | N-[2-(2,5-Diaza-bicyclo[2.2.1]hept-...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CC2CC1CN2
Show InChI InChI=1S/C24H23F3N4O3/c1-14-8-22(31-12-16-9-17(31)11-28-16)30-21-7-2-15(10-20(14)21)29-23(32)13-33-18-3-5-19(6-4-18)34-24(25,26)27/h2-8,10,16-17,28H,9,11-13H2,1H3,(H,29,32)
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n/an/a 6.80n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172413
PNG
(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)
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n/an/a 6.80n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172427
PNG
(CHEMBL196581 | N-[2-(3-Dimethylamino-propylamino)-...)
Show SMILES CN(C)CCCNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H27F3N4O3/c1-16-13-22(28-11-4-12-31(2)3)30-21-10-5-17(14-20(16)21)29-23(32)15-33-18-6-8-19(9-7-18)34-24(25,26)27/h5-10,13-14H,4,11-12,15H2,1-3H3,(H,28,30)(H,29,32)
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n/an/a 7.10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360706
PNG
(CHEMBL1934125)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)C2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc12
Show InChI InChI=1S/C28H29N3O2/c1-18(32)29-26-21-7-2-4-8-23(21)28(27(26)33)12-14-31(15-13-28)17-19-10-11-25-22(16-19)20-6-3-5-9-24(20)30-25/h2-11,16,26-27,30,33H,12-15,17H2,1H3,(H,29,32)/t26-,27+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172442
PNG
((E)-N-[2-(2-Dimethylamino-ethylamino)-4-methyl-qui...)
Show SMILES CN(C)CCNc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O2/c1-16-14-22(28-12-13-31(2)3)30-21-10-7-18(15-20(16)21)29-23(32)11-6-17-4-8-19(9-5-17)33-24(25,26)27/h4-11,14-15H,12-13H2,1-3H3,(H,28,30)(H,29,32)/b11-6+
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n/an/a 8.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172414
PNG
(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Show SMILES CN(C)CCOc1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28)
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n/an/a 8.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360709
PNG
(CHEMBL1934128)
Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Br)cc5c4c3)CC2)c2ccccc12
Show InChI InChI=1S/C28H28BrN3O/c1-18(33)30-27-16-28(24-5-3-2-4-21(24)27)10-12-32(13-11-28)17-19-6-8-25-22(14-19)23-15-20(29)7-9-26(23)31-25/h2-9,14-15,27,31H,10-13,16-17H2,1H3,(H,30,33)/t27-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360697
PNG
(CHEMBL1934116)
Show SMILES O[C@@H]1Cc2ccccc2C11CCN(Cc2ccc3[nH]c4ccccc4c3c2)CC1
Show InChI InChI=1S/C26H26N2O/c29-25-16-19-5-1-3-7-22(19)26(25)11-13-28(14-12-26)17-18-9-10-24-21(15-18)20-6-2-4-8-23(20)27-24/h1-10,15,25,27,29H,11-14,16-17H2/t25-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172430
PNG
((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Show SMILES Cc1cc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCNCC1
Show InChI InChI=1S/C24H23F3N4O2/c1-16-14-22(31-12-10-28-11-13-31)30-21-8-5-18(15-20(16)21)29-23(32)9-4-17-2-6-19(7-3-17)33-24(25,26)27/h2-9,14-15,28H,10-13H2,1H3,(H,29,32)/b9-4+
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n/an/a>10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50301708
PNG
((Z)-1'-((6-((3,4-difluorophenyl)(ethoxyimino)methy...)
Show SMILES CCO\N=C(\c1ccc(F)c(F)c1)c1ccc(CN2CCC3(CC2)OCc2cn(C)c(=O)cc32)cn1
Show InChI InChI=1S/C27H28F2N4O3/c1-3-36-31-26(19-5-6-22(28)23(29)12-19)24-7-4-18(14-30-24)15-33-10-8-27(9-11-33)21-13-25(34)32(2)16-20(21)17-35-27/h4-7,12-14,16H,3,8-11,15,17H2,1-2H3/b31-26-
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n/an/a>10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human MCH2R


Bioorg Med Chem Lett 19: 5339-45 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.132
BindingDB Entry DOI: 10.7270/Q27P90BK
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172424
PNG
(CHEMBL198361 | N-(4-Methyl-2-morpholin-4-yl-quinol...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12)N1CCOCC1
Show InChI InChI=1S/C23H22F3N3O4/c1-15-12-21(29-8-10-31-11-9-29)28-20-7-2-16(13-19(15)20)27-22(30)14-32-17-3-5-18(6-4-17)33-23(24,25)26/h2-7,12-13H,8-11,14H2,1H3,(H,27,30)
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n/an/a>10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172438
PNG
(CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...)
Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)
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n/an/a>10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50150709
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-11-22(29-9-7-28(2)8-10-29)27-20-5-4-17(13-18(15)20)26-23(30)14-31-21-6-3-16(24)12-19(21)25/h3-6,11-13H,7-10,14H2,1-2H3,(H,26,30)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360707
PNG
(CHEMBL1934126)
Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(F)cc5c4c3)CC2)c2ccccc12
Show InChI InChI=1S/C28H28FN3O/c1-18(33)30-27-16-28(24-5-3-2-4-21(24)27)10-12-32(13-11-28)17-19-6-8-25-22(14-19)23-15-20(29)7-9-26(23)31-25/h2-9,14-15,27,31H,10-13,16-17H2,1H3,(H,30,33)/t27-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172415
PNG
(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-m...)
Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H21Cl2N3O3/c1-13-9-20(26(2)7-8-27)25-18-5-4-15(11-16(13)18)24-21(28)12-29-19-6-3-14(22)10-17(19)23/h3-6,9-11,27H,7-8,12H2,1-2H3,(H,24,28)
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n/an/a>10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172434
PNG
(Acetic acid 2-({6-[2-(3,4-dichloro-phenoxy)-acetyl...)
Show SMILES CN(CCOC(C)=O)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H23Cl2N3O4/c1-14-10-22(28(3)8-9-31-15(2)29)27-20-6-5-17(12-18(14)20)26-23(30)13-32-21-7-4-16(24)11-19(21)25/h4-7,10-12H,8-9,13H2,1-3H3,(H,26,30)
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7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360703
PNG
(CHEMBL1934122)
Show SMILES CC(=O)N[C@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc12
Show InChI InChI=1S/C28H29N3O/c1-19(32)29-27-17-28(24-8-4-2-7-22(24)27)12-14-31(15-13-28)18-20-10-11-26-23(16-20)21-6-3-5-9-25(21)30-26/h2-11,16,27,30H,12-15,17-18H2,1H3,(H,29,32)/t27-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360696
PNG
(CHEMBL1934114)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC3)C(O)Cc3ccccc43)ccc12
Show InChI InChI=1S/C28H30N2O/c1-2-30-25-10-6-4-8-22(25)23-17-20(11-12-26(23)30)19-29-15-13-28(14-16-29)24-9-5-3-7-21(24)18-27(28)31/h3-12,17,27,31H,2,13-16,18-19H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360690
PNG
(CHEMBL1934108)
Show SMILES CC(=O)n1c2ccccc2c2cc(CN3CCC4(CC3)C=Cc3ccccc43)ccc12
Show InChI InChI=1S/C28H26N2O/c1-20(31)30-26-9-5-3-7-23(26)24-18-21(10-11-27(24)30)19-29-16-14-28(15-17-29)13-12-22-6-2-4-8-25(22)28/h2-13,18H,14-17,19H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360698
PNG
(CHEMBL1934117)
Show SMILES O[C@H]1Cc2ccccc2C11CCN(Cc2ccc3[nH]c4ccccc4c3c2)CC1
Show InChI InChI=1S/C26H26N2O/c29-25-16-19-5-1-3-7-22(19)26(25)11-13-28(14-12-26)17-18-9-10-24-21(15-18)20-6-2-4-8-23(20)27-24/h1-10,15,25,27,29H,11-14,16-17H2/t25-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360689
PNG
(CHEMBL1934107)
Show SMILES C(N1CCC2(CC1)C=Cc1ccccc21)c1ccc2[nH]c3ccccc3c2c1
Show InChI InChI=1S/C26H24N2/c1-3-7-23-20(5-1)11-12-26(23)13-15-28(16-14-26)18-19-9-10-25-22(17-19)21-6-2-4-8-24(21)27-25/h1-12,17,27H,13-16,18H2
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360695
PNG
(CHEMBL1934113)
Show SMILES CCC(=O)n1c2ccccc2c2cc(CN3CCC4(CC3)C=Cc3ccccc43)ccc12
Show InChI InChI=1S/C29H28N2O/c1-2-28(32)31-26-10-6-4-8-23(26)24-19-21(11-12-27(24)31)20-30-17-15-29(16-18-30)14-13-22-7-3-5-9-25(22)29/h3-14,19H,2,15-18,20H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360700
PNG
(CHEMBL1934119)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC3)[C@H](O)[C@@H](NC(C)=O)c3ccccc43)ccc12
Show InChI InChI=1S/C30H33N3O2/c1-3-33-26-11-7-5-8-22(26)24-18-21(12-13-27(24)33)19-32-16-14-30(15-17-32)25-10-6-4-9-23(25)28(29(30)35)31-20(2)34/h4-13,18,28-29,35H,3,14-17,19H2,1-2H3,(H,31,34)/t28-,29+/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360699
PNG
(CHEMBL1934118)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC3)[C@H](O)[C@@H](O)c3ccccc43)ccc12
Show InChI InChI=1S/C28H30N2O2/c1-2-30-24-10-6-4-7-20(24)22-17-19(11-12-25(22)30)18-29-15-13-28(14-16-29)23-9-5-3-8-21(23)26(31)27(28)32/h3-12,17,26-27,31-32H,2,13-16,18H2,1H3/t26-,27+/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360693
PNG
(CHEMBL1934111)
Show SMILES CS(=O)(=O)n1c2ccccc2c2cc(CN3CCC4(CC3)C=Cc3ccccc43)ccc12
Show InChI InChI=1S/C27H26N2O2S/c1-32(30,31)29-25-9-5-3-7-22(25)23-18-20(10-11-26(23)29)19-28-16-14-27(15-17-28)13-12-21-6-2-4-8-24(21)27/h2-13,18H,14-17,19H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360711
PNG
(CHEMBL1934115)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC(O)c5ccccc45)CC3)ccc12
Show InChI InChI=1S/C28H30N2O/c1-2-30-25-10-6-4-7-21(25)23-17-20(11-12-26(23)30)19-29-15-13-28(14-16-29)18-27(31)22-8-3-5-9-24(22)28/h3-12,17,27,31H,2,13-16,18-19H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360705
PNG
(CHEMBL1934124)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC3)[C@@H](O)[C@@H](O)c3ccccc43)ccc12
Show InChI InChI=1S/C28H30N2O2/c1-2-30-24-10-6-4-7-20(24)22-17-19(11-12-25(22)30)18-29-15-13-28(14-16-29)23-9-5-3-8-21(23)26(31)27(28)32/h3-12,17,26-27,31-32H,2,13-16,18H2,1H3/t26-,27-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360701
PNG
(CHEMBL1934120)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC3)C(Cc3ccccc43)NC(C)=O)ccc12
Show InChI InChI=1S/C30H33N3O/c1-3-33-27-11-7-5-9-24(27)25-18-22(12-13-28(25)33)20-32-16-14-30(15-17-32)26-10-6-4-8-23(26)19-29(30)31-21(2)34/h4-13,18,29H,3,14-17,19-20H2,1-2H3,(H,31,34)
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n/an/a 250n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360692
PNG
(CHEMBL1934110)
Show SMILES COC(=O)n1c2ccccc2c2cc(CN3CCC4(CC3)C=Cc3ccccc43)ccc12
Show InChI InChI=1S/C28H26N2O2/c1-32-27(31)30-25-9-5-3-7-22(25)23-18-20(10-11-26(23)30)19-29-16-14-28(15-17-29)13-12-21-6-2-4-8-24(21)28/h2-13,18H,14-17,19H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360710
PNG
(CHEMBL1934129)
Show SMILES CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(cc5c4c3)C(F)(F)F)CC2)c2ccccc12
Show InChI InChI=1S/C29H28F3N3O/c1-18(36)33-27-16-28(24-5-3-2-4-21(24)27)10-12-35(13-11-28)17-19-6-8-25-22(14-19)23-15-20(29(30,31)32)7-9-26(23)34-25/h2-9,14-15,27,34H,10-13,16-17H2,1H3,(H,33,36)/t27-/m1/s1
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n/an/a 678n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50193608
PNG
((E)-N-(4-(cyclobutylamino)-2-propylquinolin-6-yl)-...)
Show SMILES CCCc1cc(NC2CCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H26F3N3O/c1-2-4-20-16-24(30-19-5-3-6-19)22-15-21(12-13-23(22)31-20)32-25(33)14-9-17-7-10-18(11-8-17)26(27,28)29/h7-16,19H,2-6H2,1H3,(H,30,31)(H,32,33)/b14-9+
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n/an/a 960n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R2


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50360684
PNG
(CHEMBL1934102)
Show SMILES CCn1c2ccccc2c2cc(CN3CCC4(CC3)C=Cc3ccccc43)ccc12
Show InChI InChI=1S/C28H28N2/c1-2-30-26-10-6-4-8-23(26)24-19-21(11-12-27(24)30)20-29-17-15-28(16-18-29)14-13-22-7-3-5-9-25(22)28/h3-14,19H,2,15-18,20H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior ...


Bioorg Med Chem Lett 22: 363-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.125
BindingDB Entry DOI: 10.7270/Q2VD6ZW1
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50258478
PNG
(2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[fur...)
Show SMILES FCCN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1
Show InChI InChI=1S/C27H29F4N5O2/c28-7-14-35(26(37)25(36-11-1-8-33-36)19-3-4-22(29)23(30)15-19)10-2-9-34-12-5-27(6-13-34)21-17-32-24(31)16-20(21)18-38-27/h1,3-4,8,11,15-17,25H,2,5-7,9-10,12-14,18H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to MCHR2 (unknown origin)


Bioorg Med Chem Lett 19: 3072-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50153204
PNG
(CHEMBL186894 | N-[2-(4-Benzyl-piperazin-1-yl)-ethy...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc(cc1)C(=O)NCCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C33H35N5O3/c39-32(34-19-20-37-21-23-38(24-22-37)25-26-7-3-1-4-8-26)27-11-13-28(14-12-27)35-33(40)36-29-15-17-31(18-16-29)41-30-9-5-2-6-10-30/h1-18H,19-25H2,(H,34,39)(H2,35,36,40)
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n/an/a 2.88E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]-MCH as radioligand


Bioorg Med Chem Lett 14: 5075-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.077
BindingDB Entry DOI: 10.7270/Q2CF9PKT
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50296043
PNG
(CHEMBL540930 | N-((5-chloro-6-oxo-1,6-dihydropyrid...)
Show SMILES Fc1ccc(cc1)C(NC(=O)CC1CCN(Cc2ccn(c2)-c2ccc(cc2)C(F)(F)F)CC1)c1c[nH]c(=O)c(Cl)c1
Show InChI InChI=1S/C31H29ClF4N4O2/c32-27-16-23(17-37-30(27)42)29(22-1-5-25(33)6-2-22)38-28(41)15-20-9-12-39(13-10-20)18-21-11-14-40(19-21)26-7-3-24(4-8-26)31(34,35)36/h1-8,11,14,16-17,19-20,29H,9-10,12-13,15,18H2,(H,37,42)(H,38,41)
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n/an/a 4.60E+3n/an/an/an/an/an/a



AstraZeneca R&D M£lndal

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCHR2 expressed in CHO cells


Bioorg Med Chem Lett 19: 4268-73 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.067
BindingDB Entry DOI: 10.7270/Q2RX9C4H
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50153210
PNG
(CHEMBL184292 | N-(1-Ethyl-pyrrolidin-2-ylmethyl)-4...)
Show SMILES CCN1CCCC1CNC(=O)c1ccc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C27H30N4O3/c1-2-31-18-6-7-23(31)19-28-26(32)20-10-12-21(13-11-20)29-27(33)30-22-14-16-25(17-15-22)34-24-8-4-3-5-9-24/h3-5,8-17,23H,2,6-7,18-19H2,1H3,(H,28,32)(H2,29,30,33)
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n/an/a 6.31E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]-MCH as radioligand


Bioorg Med Chem Lett 14: 5075-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.077
BindingDB Entry DOI: 10.7270/Q2CF9PKT
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50153220
PNG
(2-Methoxy-4-[3-(3-phenylamino-phenyl)-ureido]-N-(3...)
Show SMILES COc1cc(NC(=O)Nc2cccc(Nc3ccccc3)c2)ccc1C(=O)NCCCN1CCCCC1
Show InChI InChI=1S/C29H35N5O3/c1-37-27-21-25(14-15-26(27)28(35)30-16-9-19-34-17-6-3-7-18-34)33-29(36)32-24-13-8-12-23(20-24)31-22-10-4-2-5-11-22/h2,4-5,8,10-15,20-21,31H,3,6-7,9,16-19H2,1H3,(H,30,35)(H2,32,33,36)
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n/an/a 1.00E+4n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]-MCH as radioligand


Bioorg Med Chem Lett 14: 5075-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.077
BindingDB Entry DOI: 10.7270/Q2CF9PKT
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50153206
PNG
(2-Methoxy-4-[3-(4-phenoxy-phenyl)-ureido]-N-(3-pip...)
Show SMILES COc1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)ccc1C(=O)NCCCN1CCCCC1
Show InChI InChI=1S/C29H34N4O4/c1-36-27-21-23(13-16-26(27)28(34)30-17-8-20-33-18-6-3-7-19-33)32-29(35)31-22-11-14-25(15-12-22)37-24-9-4-2-5-10-24/h2,4-5,9-16,21H,3,6-8,17-20H2,1H3,(H,30,34)(H2,31,32,35)
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n/an/a 1.00E+4n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]-MCH as radioligand


Bioorg Med Chem Lett 14: 5075-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.077
BindingDB Entry DOI: 10.7270/Q2CF9PKT
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50201273
PNG
(CHEMBL214585 | N-(1-(6,7-dihydro-5H-indeno[5,6-d][...)
Show SMILES Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(CC1)C1CCc2cc3OCOc3cc12
Show InChI InChI=1S/C25H23FN2O5/c26-15-2-4-21-18(10-15)20(29)12-24(33-21)25(30)27-16-5-7-28(8-6-16)19-3-1-14-9-22-23(11-17(14)19)32-13-31-22/h2,4,9-12,16,19H,1,3,5-8,13H2,(H,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Affinity for MCH-R2


Bioorg Med Chem Lett 17: 884-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.061
BindingDB Entry DOI: 10.7270/Q2J38S6V
More data for this
Ligand-Target Pair
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