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Compile Data Set for Download or QSAR

Found 458 hits of ic50 for UniProtKB: P49146   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091652
PNG
(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C190H287N53O58/c1-92(2)74-124(166(280)216-114(27-18-66-204-187(195)196)158(272)231-131(83-107-86-203-91-209-107)171(285)230-130(81-105-41-51-111(251)52-42-105)169(283)225-125(75-93(3)4)167(281)232-132(84-143(194)254)172(286)226-127(77-95(7)8)173(287)238-150(96(9)10)180(294)239-151(101(15)247)181(295)222-117(30-21-69-207-190(201)202)156(270)218-119(55-60-142(193)253)161(275)215-116(29-20-68-206-189(199)200)159(273)234-134(186(300)301)82-106-43-53-112(252)54-44-106)227-175(289)135(88-244)235-153(267)97(11)210-164(278)128(79-103-37-47-109(249)48-38-103)229-170(284)129(80-104-39-49-110(250)50-40-104)228-157(271)115(28-19-67-205-188(197)198)217-174(288)136(89-245)236-168(282)126(76-94(5)6)224-163(277)121(58-63-147(260)261)219-162(276)122(59-64-148(262)263)221-179(293)141-34-25-73-243(141)185(299)137(90-246)237-154(268)98(12)211-165(279)133(85-149(264)265)233-160(274)118(56-61-145(256)257)214-144(255)87-208-176(290)138-31-22-70-240(138)182(296)100(14)213-155(269)120(57-62-146(258)259)220-178(292)140-33-24-72-242(140)184(298)123(26-16-17-65-191)223-152(266)99(13)212-177(291)139-32-23-71-241(139)183(297)113(192)78-102-35-45-108(248)46-36-102/h35-54,86,91-101,113-141,150-151,244-252H,16-34,55-85,87-90,191-192H2,1-15H3,(H2,193,253)(H2,194,254)(H,203,209)(H,208,290)(H,210,278)(H,211,279)(H,212,291)(H,213,269)(H,214,255)(H,215,275)(H,216,280)(H,217,288)(H,218,270)(H,219,276)(H,220,292)(H,221,293)(H,222,295)(H,223,266)(H,224,277)(H,225,283)(H,226,286)(H,227,289)(H,228,271)(H,229,284)(H,230,285)(H,231,272)(H,232,281)(H,233,274)(H,234,273)(H,235,267)(H,236,282)(H,237,268)(H,238,287)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t97-,98-,99-,100-,101+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,150-,151-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0700n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50015490
PNG
(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.0900n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y2 receptor by radioligand displacement assay


Bioorg Med Chem 21: 2764-71 (2013)


Article DOI: 10.1016/j.bmc.2013.03.016
BindingDB Entry DOI: 10.7270/Q2N87C5Q
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50015490
PNG
(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.190n/an/an/an/an/an/a



Universit£ degli Studi di Siena

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y receptor type 2 by radioligand displacement assay


Eur J Med Chem 63: 85-94 (2013)


Article DOI: 10.1016/j.ejmech.2013.01.044
BindingDB Entry DOI: 10.7270/Q2JH3NKC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50435127
PNG
(CHEMBL2392022)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C125H193N41O33/c1-11-63(6)97(119(198)166-98(67(10)168)120(199)155-82(23-17-49-144-125(136)137)105(184)151-79(20-14-46-141-122(130)131)104(183)154-83(40-42-94(126)173)109(188)152-80(21-15-47-142-123(132)133)106(185)156-85(99(127)178)52-68-24-32-73(169)33-25-68)165-117(196)90(55-71-30-38-76(172)39-31-71)161-115(194)91(56-72-58-138-60-145-72)162-108(187)81(22-16-48-143-124(134)135)153-112(191)87(51-62(4)5)157-102(181)66(9)148-118(197)93(59-167)164-114(193)89(54-70-28-36-75(171)37-29-70)160-113(192)88(53-69-26-34-74(170)35-27-69)159-107(186)78(19-13-45-140-121(128)129)149-100(179)65(8)147-111(190)86(50-61(2)3)158-116(195)92(57-96(176)177)163-110(189)84(41-43-95(174)175)150-101(180)64(7)146-103(182)77-18-12-44-139-77/h24-39,58,60-67,77-93,97-98,139,167-172H,11-23,40-57,59H2,1-10H3,(H2,126,173)(H2,127,178)(H,138,145)(H,146,182)(H,147,190)(H,148,197)(H,149,179)(H,150,180)(H,151,184)(H,152,188)(H,153,191)(H,154,183)(H,155,199)(H,156,185)(H,157,181)(H,158,195)(H,159,186)(H,160,192)(H,161,194)(H,162,187)(H,163,189)(H,164,193)(H,165,196)(H,166,198)(H,174,175)(H,176,177)(H4,128,129,140)(H4,130,131,141)(H4,132,133,142)(H4,134,135,143)(H4,136,137,144)/t63-,64-,65-,66-,67+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,97-,98-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.210n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 2 in human KAN-TS cells after 2 hrs


Bioorg Med Chem Lett 23: 1834-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.025
BindingDB Entry DOI: 10.7270/Q2P55PWC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50005530
PNG
(CHEMBL267633 | D-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-G...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C190H287N55O57/c1-16-94(9)149(180(296)235-129(81-141(194)255)169(285)227-124(74-93(7)8)172(288)240-150(95(10)17-2)181(297)241-151(100(15)248)182(298)222-116(32-23-67-209-190(203)204)156(272)221-118(57-60-140(193)254)161(277)219-114(30-21-65-207-188(199)200)157(273)224-121(152(196)268)76-102-39-49-108(250)50-40-102)239-173(289)127(79-105-45-55-111(253)56-46-105)230-168(284)128(80-106-86-205-90-211-106)231-159(275)115(31-22-66-208-189(201)202)220-165(281)123(73-92(5)6)225-155(271)97(12)213-174(290)134(88-246)237-167(283)126(78-104-43-53-110(252)54-44-104)229-166(282)125(77-103-41-51-109(251)52-42-103)228-158(274)113(29-20-64-206-187(197)198)217-153(269)96(11)212-163(279)122(72-91(3)4)226-170(286)131(84-147(264)265)233-162(278)119(59-62-145(260)261)218-154(270)98(13)214-177(293)137-34-25-68-242(137)183(299)99(14)215-164(280)130(83-146(262)263)232-160(276)117(58-61-144(258)259)216-143(257)87-210-176(292)136-33-24-70-244(136)186(302)133(82-142(195)256)236-171(287)132(85-148(266)267)234-178(294)139-36-27-71-245(139)185(301)120(28-18-19-63-191)223-175(291)135(89-247)238-179(295)138-35-26-69-243(138)184(300)112(192)75-101-37-47-107(249)48-38-101/h37-56,86,90-100,112-139,149-151,246-253H,16-36,57-85,87-89,191-192H2,1-15H3,(H2,193,254)(H2,194,255)(H2,195,256)(H2,196,268)(H,205,211)(H,210,292)(H,212,279)(H,213,290)(H,214,293)(H,215,280)(H,216,257)(H,217,269)(H,218,270)(H,219,277)(H,220,281)(H,221,272)(H,222,298)(H,223,291)(H,224,273)(H,225,271)(H,226,286)(H,227,285)(H,228,274)(H,229,282)(H,230,284)(H,231,275)(H,232,276)(H,233,278)(H,234,294)(H,235,296)(H,236,287)(H,237,283)(H,238,295)(H,239,289)(H,240,288)(H,241,297)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,266,267)(H4,197,198,206)(H4,199,200,207)(H4,201,202,208)(H4,203,204,209)/t94-,95-,96-,97-,98-,99-,100+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,149-,150-,151-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.320n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091679
PNG
(CHEMBL441007 | bis(24/24'){N-alpha-Ac-[Cys24]PYY(2...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C166H264N58O44S2/c1-77(2)57-109(143(251)215-117(67-125(169)237)149(257)209-111(59-79(5)6)151(259)221-127(81(9)10)157(265)223-129(85(15)227)159(267)203-103(29-23-55-191-165(181)182)135(243)201-105(47-49-123(167)235)141(249)197-99(25-19-51-187-161(173)174)137(245)205-107(131(171)239)61-89-31-39-95(231)40-32-89)207-145(253)113(63-91-35-43-97(233)44-36-91)211-147(255)115(65-93-69-185-75-193-93)213-139(247)101(27-21-53-189-163(177)178)199-155(263)121(219-153(261)119(71-225)217-133(241)83(13)195-87(17)229)73-269-270-74-122(220-154(262)120(72-226)218-134(242)84(14)196-88(18)230)156(264)200-102(28-22-54-190-164(179)180)140(248)214-116(66-94-70-186-76-194-94)148(256)212-114(64-92-37-45-98(234)46-38-92)146(254)208-110(58-78(3)4)144(252)216-118(68-126(170)238)150(258)210-112(60-80(7)8)152(260)222-128(82(11)12)158(266)224-130(86(16)228)160(268)204-104(30-24-56-192-166(183)184)136(244)202-106(48-50-124(168)236)142(250)198-100(26-20-52-188-162(175)176)138(246)206-108(132(172)240)62-90-33-41-96(232)42-34-90/h31-46,69-70,75-86,99-122,127-130,225-228,231-234H,19-30,47-68,71-74H2,1-18H3,(H2,167,235)(H2,168,236)(H2,169,237)(H2,170,238)(H2,171,239)(H2,172,240)(H,185,193)(H,186,194)(H,195,229)(H,196,230)(H,197,249)(H,198,250)(H,199,263)(H,200,264)(H,201,243)(H,202,244)(H,203,267)(H,204,268)(H,205,245)(H,206,246)(H,207,253)(H,208,254)(H,209,257)(H,210,258)(H,211,255)(H,212,256)(H,213,247)(H,214,248)(H,215,251)(H,216,252)(H,217,241)(H,218,242)(H,219,261)(H,220,262)(H,221,259)(H,222,260)(H,223,265)(H,224,266)(H4,173,174,187)(H4,175,176,188)(H4,177,178,189)(H4,179,180,190)(H4,181,182,191)(H4,183,184,192)/t83-,84-,85+,86+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122+,127-,128-,129-,130-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.390n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50015490
PNG
(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against Y2 receptor of rabbit kidney membrane


Bioorg Med Chem Lett 3: 937-942 (1993)


Article DOI: 10.1016/S0960-894X(00)80696-4
BindingDB Entry DOI: 10.7270/Q2H9954N
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091674
PNG
(CHEMBL412698 | N-alpha-Ac-[D-Trp30]PYY(22-36)-NH2(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C91H138N30O22/c1-44(2)33-63(114-86(141)69(42-122)119-75(130)47(7)107-49(9)124)80(135)109-59(18-13-31-103-90(97)98)78(133)117-67(38-53-41-101-43-106-53)83(138)115-65(36-51-22-26-55(126)27-23-51)82(137)113-64(34-45(3)4)81(136)118-68(39-71(93)128)84(139)116-66(37-52-40-105-57-16-11-10-15-56(52)57)85(140)120-72(46(5)6)87(142)121-73(48(8)123)88(143)111-60(19-14-32-104-91(99)100)76(131)110-61(28-29-70(92)127)79(134)108-58(17-12-30-102-89(95)96)77(132)112-62(74(94)129)35-50-20-24-54(125)25-21-50/h10-11,15-16,20-27,40-41,43-48,58-69,72-73,105,122-123,125-126H,12-14,17-19,28-39,42H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,134)(H,109,135)(H,110,131)(H,111,143)(H,112,132)(H,113,137)(H,114,141)(H,115,138)(H,116,139)(H,117,133)(H,118,136)(H,119,130)(H,120,140)(H,121,142)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,72-,73-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.980n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091659
PNG
(CHEMBL384306 | N-alpha-Ac-[Trp27,CH2-NH-35-36]PYY(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C88H142N30O20/c1-43(2)31-61(112-83(136)67(41-119)116-73(126)47(9)105-49(11)121)77(130)107-57(20-15-29-100-87(94)95)76(129)114-65(36-53-39-98-42-104-53)80(133)113-64(35-51-38-102-56-19-13-12-18-55(51)56)79(132)110-62(32-44(3)4)78(131)115-66(37-69(90)124)81(134)111-63(33-45(5)6)82(135)117-70(46(7)8)84(137)118-71(48(10)120)85(138)109-58(21-16-30-101-88(96)97)75(128)108-59(26-27-68(89)123)74(127)106-52(17-14-28-99-86(92)93)40-103-60(72(91)125)34-50-22-24-54(122)25-23-50/h12-13,18-19,22-25,38-39,42-48,52,57-67,70-71,102-103,119-120,122H,14-17,20-21,26-37,40-41H2,1-11H3,(H2,89,123)(H2,90,124)(H2,91,125)(H,98,104)(H,105,121)(H,106,127)(H,107,130)(H,108,128)(H,109,138)(H,110,132)(H,111,134)(H,112,136)(H,113,133)(H,114,129)(H,115,131)(H,116,126)(H,117,135)(H,118,137)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t47-,48+,52-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,70-,71-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.05n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091662
PNG
(CHEMBL410792 | N-alpha-Ac-[Nal30]PYY(22-36)-NH2(N-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C93H139N29O22/c1-46(2)36-65(115-88(142)71(44-123)120-77(131)49(7)108-51(9)125)82(136)110-61(21-14-34-105-92(99)100)80(134)118-69(41-56-43-103-45-107-56)85(139)116-67(39-53-25-29-58(127)30-26-53)84(138)114-66(37-47(3)4)83(137)119-70(42-73(95)129)86(140)117-68(40-55-18-12-17-54-16-10-11-19-59(54)55)87(141)121-74(48(5)6)89(143)122-75(50(8)124)90(144)112-62(22-15-35-106-93(101)102)78(132)111-63(31-32-72(94)128)81(135)109-60(20-13-33-104-91(97)98)79(133)113-64(76(96)130)38-52-23-27-57(126)28-24-52/h10-12,16-19,23-30,43,45-50,60-71,74-75,123-124,126-127H,13-15,20-22,31-42,44H2,1-9H3,(H2,94,128)(H2,95,129)(H2,96,130)(H,103,107)(H,108,125)(H,109,135)(H,110,136)(H,111,132)(H,112,144)(H,113,133)(H,114,138)(H,115,142)(H,116,139)(H,117,140)(H,118,134)(H,119,137)(H,120,131)(H,121,141)(H,122,143)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)/t49-,50+,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,74-,75-/m0/s1
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Article
PubMed
n/an/a 1.09n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091676
PNG
(CHEMBL429905 | N-alpha-Ac-[Phe27,36]PYY(22-36)-NH2...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C86H139N29O20/c1-43(2)33-58(109-81(133)64(41-116)113-70(122)47(9)101-49(11)118)75(127)103-54(26-19-31-98-85(92)93)73(125)111-62(38-52-40-96-42-100-52)78(130)110-61(37-51-23-16-13-17-24-51)77(129)107-59(34-44(3)4)76(128)112-63(39-66(88)120)79(131)108-60(35-45(5)6)80(132)114-67(46(7)8)82(134)115-68(48(10)117)83(135)105-55(27-20-32-99-86(94)95)71(123)104-56(28-29-65(87)119)74(126)102-53(25-18-30-97-84(90)91)72(124)106-57(69(89)121)36-50-21-14-12-15-22-50/h12-17,21-24,40,42-48,53-64,67-68,116-117H,18-20,25-39,41H2,1-11H3,(H2,87,119)(H2,88,120)(H2,89,121)(H,96,100)(H,101,118)(H,102,126)(H,103,127)(H,104,123)(H,105,135)(H,106,124)(H,107,129)(H,108,131)(H,109,133)(H,110,130)(H,111,125)(H,112,128)(H,113,122)(H,114,132)(H,115,134)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1
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KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.16n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091668
PNG
(AcPYY(22-36) | CHEMBL269267 | N-alpha-Ac-PYY(22-36...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C86H139N29O22/c1-41(2)31-58(109-81(135)64(39-116)113-70(124)45(9)101-47(11)118)75(129)103-54(16-13-29-98-85(92)93)73(127)111-62(36-50-38-96-40-100-50)78(132)110-61(35-49-20-24-52(120)25-21-49)77(131)107-59(32-42(3)4)76(130)112-63(37-66(88)122)79(133)108-60(33-43(5)6)80(134)114-67(44(7)8)82(136)115-68(46(10)117)83(137)105-55(17-14-30-99-86(94)95)71(125)104-56(26-27-65(87)121)74(128)102-53(15-12-28-97-84(90)91)72(126)106-57(69(89)123)34-48-18-22-51(119)23-19-48/h18-25,38,40-46,53-64,67-68,116-117,119-120H,12-17,26-37,39H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,100)(H,101,118)(H,102,128)(H,103,129)(H,104,125)(H,105,137)(H,106,126)(H,107,131)(H,108,133)(H,109,135)(H,110,132)(H,111,127)(H,112,130)(H,113,124)(H,114,134)(H,115,136)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t45-,46+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1
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KEGG

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Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091672
PNG
(CHEMBL412704 | N-alpha-Ac-[CH2-NH35-36]PYY(22-36)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C86H141N29O21/c1-42(2)31-59(109-81(134)65(40-116)113-71(124)46(9)102-48(11)118)75(128)104-55(16-13-29-98-85(92)93)74(127)111-63(36-52-38-96-41-101-52)78(131)110-62(35-50-20-24-54(120)25-21-50)77(130)107-60(32-43(3)4)76(129)112-64(37-67(88)122)79(132)108-61(33-44(5)6)80(133)114-68(45(7)8)82(135)115-69(47(10)117)83(136)106-56(17-14-30-99-86(94)95)73(126)105-57(26-27-66(87)121)72(125)103-51(15-12-28-97-84(90)91)39-100-58(70(89)123)34-49-18-22-53(119)23-19-49/h18-25,38,41-47,51,55-65,68-69,100,116-117,119-120H,12-17,26-37,39-40H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,101)(H,102,118)(H,103,125)(H,104,128)(H,105,126)(H,106,136)(H,107,130)(H,108,132)(H,109,134)(H,110,131)(H,111,127)(H,112,129)(H,113,124)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,51-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1
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KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.32n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091663
PNG
(CHEMBL214707 | N-alpha-Ac-[Trp30,CH2-NH-35-36]PYY(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C91H140N30O21/c1-45(2)33-64(114-86(140)70(43-122)119-76(130)48(7)108-50(9)124)80(134)110-60(18-13-31-103-90(97)98)79(133)117-68(38-55-41-101-44-107-55)83(137)115-66(36-52-22-26-57(126)27-23-52)82(136)113-65(34-46(3)4)81(135)118-69(39-72(93)128)84(138)116-67(37-53-40-105-59-17-11-10-16-58(53)59)85(139)120-73(47(5)6)87(141)121-74(49(8)123)88(142)112-61(19-14-32-104-91(99)100)78(132)111-62(28-29-71(92)127)77(131)109-54(15-12-30-102-89(95)96)42-106-63(75(94)129)35-51-20-24-56(125)25-21-51/h10-11,16-17,20-27,40-41,44-49,54,60-70,73-74,105-106,122-123,125-126H,12-15,18-19,28-39,42-43H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,107)(H,108,124)(H,109,131)(H,110,134)(H,111,132)(H,112,142)(H,113,136)(H,114,140)(H,115,137)(H,116,138)(H,117,133)(H,118,135)(H,119,130)(H,120,139)(H,121,141)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t48-,49+,54-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-,74-/m0/s1
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KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.39n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091684
PNG
(CHEMBL412257 | N-alpha-Ac-[Nle24,28,Trp30,Nva31,CH...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C91H140N30O21/c1-7-10-20-61(113-87(141)71(46-122)120-76(130)48(4)108-50(6)124)78(132)111-63(23-15-36-103-90(97)98)81(135)118-69(41-55-44-101-47-107-55)85(139)116-67(39-52-27-31-57(126)32-28-52)83(137)112-62(21-11-8-2)80(134)119-70(42-73(93)128)86(140)117-68(40-53-43-105-59-22-13-12-19-58(53)59)84(138)110-60(17-9-3)82(136)121-74(49(5)123)88(142)115-64(24-16-37-104-91(99)100)79(133)114-65(33-34-72(92)127)77(131)109-54(18-14-35-102-89(95)96)45-106-66(75(94)129)38-51-25-29-56(125)30-26-51/h12-13,19,22,25-32,43-44,47-49,54,60-71,74,105-106,122-123,125-126H,7-11,14-18,20-21,23-24,33-42,45-46H2,1-6H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,107)(H,108,124)(H,109,131)(H,110,138)(H,111,132)(H,112,137)(H,113,141)(H,114,133)(H,115,142)(H,116,139)(H,117,140)(H,118,135)(H,119,134)(H,120,130)(H,121,136)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t48-,49+,54-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,74-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.75n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091666
PNG
(CHEMBL413612 | N-alpha-Ac-[Phe27]PYY(22-36)-NH2(N-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C86H139N29O21/c1-42(2)32-58(109-81(134)64(40-116)113-70(123)46(9)101-48(11)118)75(128)103-54(21-16-30-98-85(92)93)73(126)111-62(37-51-39-96-41-100-51)78(131)110-61(36-49-18-13-12-14-19-49)77(130)107-59(33-43(3)4)76(129)112-63(38-66(88)121)79(132)108-60(34-44(5)6)80(133)114-67(45(7)8)82(135)115-68(47(10)117)83(136)105-55(22-17-31-99-86(94)95)71(124)104-56(27-28-65(87)120)74(127)102-53(20-15-29-97-84(90)91)72(125)106-57(69(89)122)35-50-23-25-52(119)26-24-50/h12-14,18-19,23-26,39,41-47,53-64,67-68,116-117,119H,15-17,20-22,27-38,40H2,1-11H3,(H2,87,120)(H2,88,121)(H2,89,122)(H,96,100)(H,101,118)(H,102,127)(H,103,128)(H,104,124)(H,105,136)(H,106,125)(H,107,130)(H,108,132)(H,109,134)(H,110,131)(H,111,126)(H,112,129)(H,113,123)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.83n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091661
PNG
(CHEMBL410938 | N-alpha-Ac-[Trp28]PYY(22-36)-NH2(N-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C91H138N30O22/c1-44(2)33-63(114-86(141)69(42-122)119-75(130)47(7)107-49(9)124)80(135)109-59(18-13-31-103-90(97)98)78(133)117-67(38-53-41-101-43-106-53)83(138)115-65(36-51-22-26-55(126)27-23-51)81(136)116-66(37-52-40-105-57-16-11-10-15-56(52)57)82(137)118-68(39-71(93)128)84(139)113-64(34-45(3)4)85(140)120-72(46(5)6)87(142)121-73(48(8)123)88(143)111-60(19-14-32-104-91(99)100)76(131)110-61(28-29-70(92)127)79(134)108-58(17-12-30-102-89(95)96)77(132)112-62(74(94)129)35-50-20-24-54(125)25-21-50/h10-11,15-16,20-27,40-41,43-48,58-69,72-73,105,122-123,125-126H,12-14,17-19,28-39,42H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,134)(H,109,135)(H,110,131)(H,111,143)(H,112,132)(H,113,139)(H,114,141)(H,115,138)(H,116,136)(H,117,133)(H,118,137)(H,119,130)(H,120,140)(H,121,142)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,72-,73-/m0/s1
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n/an/a 2.08n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091670
PNG
(CHEMBL428320 | N-alpha-Ac-[Trp27]PYY(22-36)-NH2(N-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C88H140N30O21/c1-42(2)31-60(112-83(137)66(40-119)116-72(126)46(9)104-48(11)121)77(131)106-56(20-15-29-100-87(94)95)75(129)114-64(36-51-39-98-41-103-51)80(134)113-63(35-50-38-102-54-18-13-12-17-53(50)54)79(133)110-61(32-43(3)4)78(132)115-65(37-68(90)124)81(135)111-62(33-44(5)6)82(136)117-69(45(7)8)84(138)118-70(47(10)120)85(139)108-57(21-16-30-101-88(96)97)73(127)107-58(26-27-67(89)123)76(130)105-55(19-14-28-99-86(92)93)74(128)109-59(71(91)125)34-49-22-24-52(122)25-23-49/h12-13,17-18,22-25,38-39,41-47,55-66,69-70,102,119-120,122H,14-16,19-21,26-37,40H2,1-11H3,(H2,89,123)(H2,90,124)(H2,91,125)(H,98,103)(H,104,121)(H,105,130)(H,106,131)(H,107,127)(H,108,139)(H,109,128)(H,110,133)(H,111,135)(H,112,137)(H,113,134)(H,114,129)(H,115,132)(H,116,126)(H,117,136)(H,118,138)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t46-,47+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,69-,70-/m0/s1
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n/an/a 2.09n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091650
PNG
(Ala-Ser-Leu-Arg-His-Thi-Leu-Asn-Leu-Val-Thr-Arg-Gl...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccsc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C84H137N29O21S/c1-40(2)29-56(107-79(132)62(37-114)111-68(121)44(9)99-46(11)116)73(126)101-52(16-13-26-96-83(90)91)71(124)109-60(34-49-36-94-39-98-49)76(129)108-59(33-48-24-28-135-38-48)75(128)105-57(30-41(3)4)74(127)110-61(35-64(86)119)77(130)106-58(31-42(5)6)78(131)112-65(43(7)8)80(133)113-66(45(10)115)81(134)103-53(17-14-27-97-84(92)93)69(122)102-54(22-23-63(85)118)72(125)100-51(15-12-25-95-82(88)89)70(123)104-55(67(87)120)32-47-18-20-50(117)21-19-47/h18-21,24,28,36,38-45,51-62,65-66,114-115,117H,12-17,22-23,25-27,29-35,37H2,1-11H3,(H2,85,118)(H2,86,119)(H2,87,120)(H,94,98)(H,99,116)(H,100,125)(H,101,126)(H,102,122)(H,103,134)(H,104,123)(H,105,128)(H,106,130)(H,107,132)(H,108,129)(H,109,124)(H,110,127)(H,111,121)(H,112,131)(H,113,133)(H4,88,89,95)(H4,90,91,96)(H4,92,93,97)/t44-,45+,51-,52-,53-,54-,55-,56-,57-,58-,59+,60-,61-,62-,65-,66-/m0/s1
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n/an/a 2.63n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091658
PNG
(CHEMBL427594 | N-alpha-Ac-[Tyr22,Phe27]PYY(22-36)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C92H143N29O22/c1-46(2)35-63(115-87(141)70(44-122)119-82(136)66(107-51(10)124)40-54-24-28-57(126)29-25-54)80(134)109-59(20-15-33-104-91(98)99)78(132)117-68(41-55-43-102-45-106-55)84(138)116-67(39-52-17-12-11-13-18-52)83(137)113-64(36-47(3)4)81(135)118-69(42-72(94)128)85(139)114-65(37-48(5)6)86(140)120-73(49(7)8)88(142)121-74(50(9)123)89(143)111-60(21-16-34-105-92(100)101)76(130)110-61(30-31-71(93)127)79(133)108-58(19-14-32-103-90(96)97)77(131)112-62(75(95)129)38-53-22-26-56(125)27-23-53/h11-13,17-18,22-29,43,45-50,58-70,73-74,122-123,125-126H,14-16,19-21,30-42,44H2,1-10H3,(H2,93,127)(H2,94,128)(H2,95,129)(H,102,106)(H,107,124)(H,108,133)(H,109,134)(H,110,130)(H,111,143)(H,112,131)(H,113,137)(H,114,139)(H,115,141)(H,116,138)(H,117,132)(H,118,135)(H,119,136)(H,120,140)(H,121,142)(H4,96,97,103)(H4,98,99,104)(H4,100,101,105)/t50-,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,68+,69+,70+,73+,74+/m1/s1
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n/an/a 2.68n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50208988
PNG
(HUMAN NEUROPEPTIDE Y)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
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n/an/a 2.80n/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]peptide YY from Y2 receptor in human KAN-TS cells measured after 60 mins by scintillation counting method


Bioorg Med Chem 25: 471-482 (2017)


Article DOI: 10.1016/j.bmc.2016.11.014
BindingDB Entry DOI: 10.7270/Q2CF9S3S
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50281776
PNG
(Ac-RHYIN-(Cha)-(Cha)-TRQRY | CHEMBL268351)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C79H123N25O19/c1-5-41(2)61(101-70(116)55(35-44-22-26-49(107)27-23-44)97-69(115)56(37-48-39-88-40-92-48)98-65(111)51(93-43(4)106)19-12-32-89-77(82)83)72(118)99-57(38-60(81)110)71(117)103-63(46-15-8-6-9-16-46)75(121)104-64(47-17-10-7-11-18-47)74(120)102-62(42(3)105)73(119)96-53(21-14-34-91-79(86)87)66(112)95-54(30-31-59(80)109)68(114)94-52(20-13-33-90-78(84)85)67(113)100-58(76(122)123)36-45-24-28-50(108)29-25-45/h22-29,39-42,46-47,51-58,61-64,105,107-108H,5-21,30-38H2,1-4H3,(H2,80,109)(H2,81,110)(H,88,92)(H,93,106)(H,94,114)(H,95,112)(H,96,119)(H,97,115)(H,98,111)(H,99,118)(H,100,113)(H,101,116)(H,102,120)(H,103,117)(H,104,121)(H,122,123)(H4,82,83,89)(H4,84,85,90)(H4,86,87,91)/t41-,42+,51-,52-,53-,54-,55-,56-,57-,58-,61-,62-,63-,64-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against human neuropeptide Y2 receptor expressing LN319 cells


Bioorg Med Chem Lett 3: 937-942 (1993)


Article DOI: 10.1016/S0960-894X(00)80696-4
BindingDB Entry DOI: 10.7270/Q2H9954N
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091685
PNG
(CHEMBL411637 | N-alpha-Ac-[Trp28,30]PYY(22-36)-NH2...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C96H137N31O22/c1-47(2)35-68(119-91(147)74(45-128)125-80(136)49(5)113-51(7)130)85(141)115-64(20-13-33-108-95(102)103)83(139)123-72(40-56-44-106-46-112-56)88(144)120-69(37-53-24-28-58(132)29-25-53)86(142)121-70(38-54-42-110-61-17-10-8-15-59(54)61)87(143)124-73(41-76(98)134)89(145)122-71(39-55-43-111-62-18-11-9-16-60(55)62)90(146)126-77(48(3)4)92(148)127-78(50(6)129)93(149)117-65(21-14-34-109-96(104)105)81(137)116-66(30-31-75(97)133)84(140)114-63(19-12-32-107-94(100)101)82(138)118-67(79(99)135)36-52-22-26-57(131)27-23-52/h8-11,15-18,22-29,42-44,46-50,63-74,77-78,110-111,128-129,131-132H,12-14,19-21,30-41,45H2,1-7H3,(H2,97,133)(H2,98,134)(H2,99,135)(H,106,112)(H,113,130)(H,114,140)(H,115,141)(H,116,137)(H,117,149)(H,118,138)(H,119,147)(H,120,144)(H,121,142)(H,122,145)(H,123,139)(H,124,143)(H,125,136)(H,126,146)(H,127,148)(H4,100,101,107)(H4,102,103,108)(H4,104,105,109)/t49-,50+,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,77-,78-/m0/s1
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n/an/a 3.17n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50423655
PNG
(CHEMBL2307889)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)CC1(CC(=O)N2CCN(CC2)C2c3ccccc3NC(=O)c3ccccc23)CCCC1)C(=O)NCCn1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)/t40-,43?/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-NPY from NPYY2 receptor (unknown origin)


Bioorg Med Chem Lett 24: 430-41 (2014)


Article DOI: 10.1016/j.bmcl.2013.11.061
BindingDB Entry DOI: 10.7270/Q2H133HQ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50423655
PNG
(CHEMBL2307889)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)CC1(CC(=O)N2CCN(CC2)C2c3ccccc3NC(=O)c3ccccc23)CCCC1)C(=O)NCCn1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)/t40-,43?/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human neuropeptide Y2 receptor


Bioorg Med Chem Lett 19: 4022-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.035
BindingDB Entry DOI: 10.7270/Q2B27VBW
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091651
PNG
(CHEMBL411200 | N-alpha-Ac-[Nle24,28,Trp30,Nva31]PY...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C91H138N30O22/c1-7-10-19-59(112-87(142)70(45-122)120-75(130)47(4)107-49(6)124)76(131)109-62(23-15-36-103-90(97)98)80(135)118-68(41-53-44-101-46-106-53)85(140)116-66(39-51-27-31-55(126)32-28-51)83(138)111-60(20-11-8-2)79(134)119-69(42-72(93)128)86(141)117-67(40-52-43-105-57-21-13-12-18-56(52)57)84(139)108-58(17-9-3)82(137)121-73(48(5)123)88(143)114-63(24-16-37-104-91(99)100)77(132)113-64(33-34-71(92)127)81(136)110-61(22-14-35-102-89(95)96)78(133)115-65(74(94)129)38-50-25-29-54(125)30-26-50/h12-13,18,21,25-32,43-44,46-48,58-70,73,105,122-123,125-126H,7-11,14-17,19-20,22-24,33-42,45H2,1-6H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,139)(H,109,131)(H,110,136)(H,111,138)(H,112,142)(H,113,132)(H,114,143)(H,115,133)(H,116,140)(H,117,141)(H,118,135)(H,119,134)(H,120,130)(H,121,137)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-/m0/s1
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n/an/a 3.73n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091671
PNG
(CHEMBL425095 | N-alpha-Ac-[Ala26,Phe27]PYY(22-36)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C83H137N27O21/c1-40(2)33-56(106-78(129)61(39-111)108-67(118)44(9)96-47(12)113)73(124)99-51(21-16-30-93-81(87)88)69(120)97-45(10)68(119)103-59(37-48-19-14-13-15-20-48)75(126)104-57(34-41(3)4)74(125)107-60(38-63(85)116)76(127)105-58(35-42(5)6)77(128)109-64(43(7)8)79(130)110-65(46(11)112)80(131)101-53(23-18-32-95-83(91)92)70(121)100-54(28-29-62(84)115)72(123)98-52(22-17-31-94-82(89)90)71(122)102-55(66(86)117)36-49-24-26-50(114)27-25-49/h13-15,19-20,24-27,40-46,51-61,64-65,111-112,114H,16-18,21-23,28-39H2,1-12H3,(H2,84,115)(H2,85,116)(H2,86,117)(H,96,113)(H,97,120)(H,98,123)(H,99,124)(H,100,121)(H,101,131)(H,102,122)(H,103,119)(H,104,126)(H,105,127)(H,106,129)(H,107,125)(H,108,118)(H,109,128)(H,110,130)(H4,87,88,93)(H4,89,90,94)(H4,91,92,95)/t44-,45-,46+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1
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n/an/a 3.84n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50205093
PNG
(CHEMBL428017 | LRHYLNLLTRQRY-NH2)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C81H131N27O19/c1-40(2)30-56(96-45(10)110)71(120)98-52(15-12-28-93-80(87)88)69(118)106-61(36-48-38-91-39-95-48)75(124)105-60(35-47-19-23-50(112)24-20-47)74(123)102-58(32-42(5)6)73(122)107-62(37-64(83)114)76(125)103-57(31-41(3)4)72(121)104-59(33-43(7)8)77(126)108-65(44(9)109)78(127)100-53(16-13-29-94-81(89)90)67(116)99-54(25-26-63(82)113)70(119)97-51(14-11-27-92-79(85)86)68(117)101-55(66(84)115)34-46-17-21-49(111)22-18-46/h17-24,38-44,51-62,65,109,111-112H,11-16,25-37H2,1-10H3,(H2,82,113)(H2,83,114)(H2,84,115)(H,91,95)(H,96,110)(H,97,119)(H,98,120)(H,99,116)(H,100,127)(H,101,117)(H,102,123)(H,103,125)(H,104,121)(H,105,124)(H,106,118)(H,107,122)(H,108,126)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t44-,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,65+/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at neuropeptide Y Y2 receptor in human SMS-KAN cells


J Med Chem 58: 4180-93 (2015)


Article DOI: 10.1021/jm501702q
BindingDB Entry DOI: 10.7270/Q2P84DNK
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50281775
PNG
(Ac-RHYINL-(Cha)-TRQRY | CHEMBL414482)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C77H121N25O19/c1-7-40(4)60(100-70(116)54(33-43-19-23-47(105)24-20-43)96-67(113)55(35-46-37-86-38-90-46)97-63(109)49(91-42(6)104)16-11-29-87-75(80)81)71(117)98-56(36-59(79)108)68(114)95-53(32-39(2)3)69(115)102-62(45-14-9-8-10-15-45)73(119)101-61(41(5)103)72(118)94-51(18-13-31-89-77(84)85)64(110)93-52(27-28-58(78)107)66(112)92-50(17-12-30-88-76(82)83)65(111)99-57(74(120)121)34-44-21-25-48(106)26-22-44/h19-26,37-41,45,49-57,60-62,103,105-106H,7-18,27-36H2,1-6H3,(H2,78,107)(H2,79,108)(H,86,90)(H,91,104)(H,92,112)(H,93,110)(H,94,118)(H,95,114)(H,96,113)(H,97,109)(H,98,117)(H,99,111)(H,100,116)(H,101,119)(H,102,115)(H,120,121)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t40-,41+,49-,50-,51-,52-,53-,54-,55-,56-,57-,60-,61-,62-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against human neuropeptide Y2 receptor expressing LN319 cells


Bioorg Med Chem Lett 3: 937-942 (1993)


Article DOI: 10.1016/S0960-894X(00)80696-4
BindingDB Entry DOI: 10.7270/Q2H9954N
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091677
PNG
(CHEMBL405527 | N-alpha-Ac-[Phe22,27]PYY(22-36)-NH2...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C92H143N29O21/c1-47(2)36-63(115-87(140)70(45-122)119-82(135)66(107-52(10)124)40-53-20-13-11-14-21-53)80(133)109-59(25-18-34-104-91(98)99)78(131)117-68(42-56-44-102-46-106-56)84(137)116-67(41-54-22-15-12-16-23-54)83(136)113-64(37-48(3)4)81(134)118-69(43-72(94)127)85(138)114-65(38-49(5)6)86(139)120-73(50(7)8)88(141)121-74(51(9)123)89(142)111-60(26-19-35-105-92(100)101)76(129)110-61(31-32-71(93)126)79(132)108-58(24-17-33-103-90(96)97)77(130)112-62(75(95)128)39-55-27-29-57(125)30-28-55/h11-16,20-23,27-30,44,46-51,58-70,73-74,122-123,125H,17-19,24-26,31-43,45H2,1-10H3,(H2,93,126)(H2,94,127)(H2,95,128)(H,102,106)(H,107,124)(H,108,132)(H,109,133)(H,110,129)(H,111,142)(H,112,130)(H,113,136)(H,114,138)(H,115,140)(H,116,137)(H,117,131)(H,118,134)(H,119,135)(H,120,139)(H,121,141)(H4,96,97,103)(H4,98,99,104)(H4,100,101,105)/t51-,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,68+,69+,70+,73+,74+/m1/s1
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n/an/a 5.61n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50352371
PNG
(CHEMBL1823342)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)
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n/an/a 6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting


Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50352371
PNG
(CHEMBL1823342)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)
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n/an/a 6n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-NPY from NPYY2 receptor (unknown origin)


Bioorg Med Chem Lett 24: 430-41 (2014)


Article DOI: 10.1016/j.bmcl.2013.11.061
BindingDB Entry DOI: 10.7270/Q2H133HQ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50445648
PNG
(CHEMBL3104181)
Show SMILES CCC(CC)C(=O)Nc1ccc(N2CCN(CC2)C(c2ncco2)c2cccc(F)c2)c(c1)C#N
Show InChI InChI=1S/C27H30FN5O2/c1-3-19(4-2)26(34)31-23-8-9-24(21(17-23)18-29)32-11-13-33(14-12-32)25(27-30-10-15-35-27)20-6-5-7-22(28)16-20/h5-10,15-17,19,25H,3-4,11-14H2,1-2H3,(H,31,34)
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n/an/a 7n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor


Bioorg Med Chem Lett 24: 430-41 (2014)


Article DOI: 10.1016/j.bmcl.2013.11.061
BindingDB Entry DOI: 10.7270/Q2H133HQ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50437018
PNG
(CHEMBL2403023)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C35H37FN4O2/c1-3-39(4-2)35(42)33(25-11-6-5-7-12-25)26-18-21-40(22-19-26)32-17-16-28(23-31(32)36)38-34(41)30-15-9-8-14-29(30)27-13-10-20-37-24-27/h5-17,20,23-24,26,33H,3-4,18-19,21-22H2,1-2H3,(H,38,41)
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n/an/a 7n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis


Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091660
PNG
(CHEMBL429698 | N-alpha-Ac-[Nal27]PYY(22-36)-NH2(N-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C90H141N29O21/c1-44(2)34-62(113-85(138)68(42-120)117-74(127)48(9)105-50(11)122)79(132)107-58(23-16-32-102-89(96)97)77(130)115-66(39-54-41-100-43-104-54)82(135)114-65(38-53-20-14-19-52-18-12-13-21-56(52)53)81(134)111-63(35-45(3)4)80(133)116-67(40-70(92)125)83(136)112-64(36-46(5)6)84(137)118-71(47(7)8)86(139)119-72(49(10)121)87(140)109-59(24-17-33-103-90(98)99)75(128)108-60(29-30-69(91)124)78(131)106-57(22-15-31-101-88(94)95)76(129)110-61(73(93)126)37-51-25-27-55(123)28-26-51/h12-14,18-21,25-28,41,43-49,57-68,71-72,120-121,123H,15-17,22-24,29-40,42H2,1-11H3,(H2,91,124)(H2,92,125)(H2,93,126)(H,100,104)(H,105,122)(H,106,131)(H,107,132)(H,108,128)(H,109,140)(H,110,129)(H,111,134)(H,112,136)(H,113,138)(H,114,135)(H,115,130)(H,116,133)(H,117,127)(H,118,137)(H,119,139)(H4,94,95,101)(H4,96,97,102)(H4,98,99,103)/t48-,49+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,71-,72-/m0/s1
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n/an/a 7.08n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50281778
PNG
(Ac-RHYIN-(Cha)-ITRQRY | CHEMBL415176)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C77H121N25O19/c1-7-39(3)59(99-68(114)53(33-43-20-24-47(105)25-21-43)95-67(113)54(35-46-37-86-38-90-46)96-63(109)49(91-42(6)104)17-12-30-87-75(80)81)70(116)97-55(36-58(79)108)69(115)102-62(45-15-10-9-11-16-45)73(119)100-60(40(4)8-2)71(117)101-61(41(5)103)72(118)94-51(19-14-32-89-77(84)85)64(110)93-52(28-29-57(78)107)66(112)92-50(18-13-31-88-76(82)83)65(111)98-56(74(120)121)34-44-22-26-48(106)27-23-44/h20-27,37-41,45,49-56,59-62,103,105-106H,7-19,28-36H2,1-6H3,(H2,78,107)(H2,79,108)(H,86,90)(H,91,104)(H,92,112)(H,93,110)(H,94,118)(H,95,113)(H,96,109)(H,97,116)(H,98,111)(H,99,114)(H,100,119)(H,101,117)(H,102,115)(H,120,121)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t39-,40-,41+,49-,50-,51-,52-,53-,54-,55-,56-,59-,60-,61-,62-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against human neuropeptide Y2 receptor expressing LN319 cells


Bioorg Med Chem Lett 3: 937-942 (1993)


Article DOI: 10.1016/S0960-894X(00)80696-4
BindingDB Entry DOI: 10.7270/Q2H9954N
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50352388
PNG
(CHEMBL1823359)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1C#N)c1ccccc1
Show InChI InChI=1S/C36H37N5O2/c1-3-39(4-2)36(43)34(28-15-9-6-10-16-28)41-23-21-40(22-24-41)33-20-19-30(25-29(33)26-37)38-35(42)32-18-12-11-17-31(32)27-13-7-5-8-14-27/h5-20,25,34H,3-4,21-24H2,1-2H3,(H,38,42)
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n/an/a 8n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting


Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50281776
PNG
(Ac-RHYIN-(Cha)-(Cha)-TRQRY | CHEMBL268351)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C79H123N25O19/c1-5-41(2)61(101-70(116)55(35-44-22-26-49(107)27-23-44)97-69(115)56(37-48-39-88-40-92-48)98-65(111)51(93-43(4)106)19-12-32-89-77(82)83)72(118)99-57(38-60(81)110)71(117)103-63(46-15-8-6-9-16-46)75(121)104-64(47-17-10-7-11-18-47)74(120)102-62(42(3)105)73(119)96-53(21-14-34-91-79(86)87)66(112)95-54(30-31-59(80)109)68(114)94-52(20-13-33-90-78(84)85)67(113)100-58(76(122)123)36-45-24-28-50(108)29-25-45/h22-29,39-42,46-47,51-58,61-64,105,107-108H,5-21,30-38H2,1-4H3,(H2,80,109)(H2,81,110)(H,88,92)(H,93,106)(H,94,114)(H,95,112)(H,96,119)(H,97,115)(H,98,111)(H,99,118)(H,100,113)(H,101,116)(H,102,120)(H,103,117)(H,104,121)(H,122,123)(H4,82,83,89)(H4,84,85,90)(H4,86,87,91)/t41-,42+,51-,52-,53-,54-,55-,56-,57-,58-,61-,62-,63-,64-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against Y2 receptor of rabbit kidney membrane


Bioorg Med Chem Lett 3: 937-942 (1993)


Article DOI: 10.1016/S0960-894X(00)80696-4
BindingDB Entry DOI: 10.7270/Q2H9954N
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50089438
PNG
(CHEMBL3578016)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C143H215N39O28/c1-78(2)63-105(172-124(194)98(164-84(12)184)40-23-26-58-157-119(190)44-17-14-25-59-158-123(193)102(53-55-116(146)187)167-130(200)106(64-79(3)4)174-136(206)113(72-90-75-162-97-39-21-20-37-95(90)97)179-134(204)110(69-85-31-15-13-16-32-85)177-135(205)112(171-122(192)96(145)38-22-24-57-144)71-89-35-27-34-88-33-18-19-36-94(88)89)129(199)166-100(42-29-61-160-142(152)153)127(197)180-114(73-91-76-156-77-163-91)137(207)178-111(70-87-47-51-93(186)52-48-87)133(203)173-108(66-81(7)8)132(202)181-115(74-118(148)189)138(208)175-107(65-80(5)6)131(201)176-109(67-82(9)10)139(209)182-120(83(11)183)140(210)169-101(43-30-62-161-143(154)155)125(195)168-103(54-56-117(147)188)128(198)165-99(41-28-60-159-141(150)151)126(196)170-104(121(149)191)68-86-45-49-92(185)50-46-86/h13,15-16,18-21,27,31-37,39,45-52,75-83,96,98-115,120,162,183,185-186H,14,17,22-26,28-30,38,40-44,53-74,144-145H2,1-12H3,(H2,146,187)(H2,147,188)(H2,148,189)(H2,149,191)(H,156,163)(H,157,190)(H,158,193)(H,164,184)(H,165,198)(H,166,199)(H,167,200)(H,168,195)(H,169,210)(H,170,196)(H,171,192)(H,172,194)(H,173,203)(H,174,206)(H,175,208)(H,176,201)(H,177,205)(H,178,207)(H,179,204)(H,180,197)(H,181,202)(H,182,209)(H4,150,151,159)(H4,152,153,160)(H4,154,155,161)/t83-,96+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112-,113-,114+,115+,120+/m1/s1
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n/an/a 8.90n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human neuropeptide Y Y2 receptor expressed in HEK293 cells cotransfected with eYFP fusion protein after 2 hrs by compe...


J Med Chem 58: 4180-93 (2015)


Article DOI: 10.1021/jm501702q
BindingDB Entry DOI: 10.7270/Q2P84DNK
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50089438
PNG
(CHEMBL3578016)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C143H215N39O28/c1-78(2)63-105(172-124(194)98(164-84(12)184)40-23-26-58-157-119(190)44-17-14-25-59-158-123(193)102(53-55-116(146)187)167-130(200)106(64-79(3)4)174-136(206)113(72-90-75-162-97-39-21-20-37-95(90)97)179-134(204)110(69-85-31-15-13-16-32-85)177-135(205)112(171-122(192)96(145)38-22-24-57-144)71-89-35-27-34-88-33-18-19-36-94(88)89)129(199)166-100(42-29-61-160-142(152)153)127(197)180-114(73-91-76-156-77-163-91)137(207)178-111(70-87-47-51-93(186)52-48-87)133(203)173-108(66-81(7)8)132(202)181-115(74-118(148)189)138(208)175-107(65-80(5)6)131(201)176-109(67-82(9)10)139(209)182-120(83(11)183)140(210)169-101(43-30-62-161-143(154)155)125(195)168-103(54-56-117(147)188)128(198)165-99(41-28-60-159-141(150)151)126(196)170-104(121(149)191)68-86-45-49-92(185)50-46-86/h13,15-16,18-21,27,31-37,39,45-52,75-83,96,98-115,120,162,183,185-186H,14,17,22-26,28-30,38,40-44,53-74,144-145H2,1-12H3,(H2,146,187)(H2,147,188)(H2,148,189)(H2,149,191)(H,156,163)(H,157,190)(H,158,193)(H,164,184)(H,165,198)(H,166,199)(H,167,200)(H,168,195)(H,169,210)(H,170,196)(H,171,192)(H,172,194)(H,173,203)(H,174,206)(H,175,208)(H,176,201)(H,177,205)(H,178,207)(H,179,204)(H,180,197)(H,181,202)(H,182,209)(H4,150,151,159)(H4,152,153,160)(H4,154,155,161)/t83-,96+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112-,113-,114+,115+,120+/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human neuropeptide Y Y2 receptor expressed in HEK293 cells cotransfected with eYFP fusion protein after 2 hrs by compe...


J Med Chem 58: 4180-93 (2015)


Article DOI: 10.1021/jm501702q
BindingDB Entry DOI: 10.7270/Q2P84DNK
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50352392
PNG
(CHEMBL1823577)
Show SMILES CCN(CC)C(=O)[C@H](N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)/t32-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting


Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50089440
PNG
(CHEMBL3578018)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)NCC(NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(N)=O
Show InChI InChI=1S/C145H218N40O29/c1-77(2)60-103(122(150)194)172-131(203)106(62-79(5)6)175-137(209)113(70-90-73-162-96-37-21-20-36-95(90)96)182-135(207)110(67-85-30-16-15-17-31-85)179-136(208)112(69-89-34-26-33-88-32-18-19-35-94(88)89)181-127(199)98(39-23-25-56-147)167-124(196)97(38-22-24-55-146)166-120(193)54-53-119(192)163-75-116(165-84(14)187)141(213)178-105(61-78(3)4)130(202)169-100(41-28-58-160-144(154)155)128(200)183-114(71-91-74-158-76-164-91)138(210)180-111(68-87-45-49-93(189)50-46-87)134(206)174-108(64-81(9)10)133(205)184-115(72-118(149)191)139(211)176-107(63-80(7)8)132(204)177-109(65-82(11)12)140(212)185-121(83(13)186)142(214)171-101(42-29-59-161-145(156)157)125(197)170-102(51-52-117(148)190)129(201)168-99(40-27-57-159-143(152)153)126(198)173-104(123(151)195)66-86-43-47-92(188)48-44-86/h15-21,26,30-37,43-50,73-74,76-83,97-116,121,162,186,188-189H,22-25,27-29,38-42,51-72,75,146-147H2,1-14H3,(H2,148,190)(H2,149,191)(H2,150,194)(H2,151,195)(H,158,164)(H,163,192)(H,165,187)(H,166,193)(H,167,196)(H,168,201)(H,169,202)(H,170,197)(H,171,214)(H,172,203)(H,173,198)(H,174,206)(H,175,209)(H,176,211)(H,177,204)(H,178,213)(H,179,208)(H,180,210)(H,181,199)(H,182,207)(H,183,200)(H,184,205)(H,185,212)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)/t83-,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113-,114+,115+,116?,121+/m1/s1
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n/an/a 9.5n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human neuropeptide Y Y2 receptor expressed in HEK293 cells cotransfected with eYFP fusion protein after 2 hrs by compe...


J Med Chem 58: 4180-93 (2015)


Article DOI: 10.1021/jm501702q
BindingDB Entry DOI: 10.7270/Q2P84DNK
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50089440
PNG
(CHEMBL3578018)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)NCC(NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(N)=O
Show InChI InChI=1S/C145H218N40O29/c1-77(2)60-103(122(150)194)172-131(203)106(62-79(5)6)175-137(209)113(70-90-73-162-96-37-21-20-36-95(90)96)182-135(207)110(67-85-30-16-15-17-31-85)179-136(208)112(69-89-34-26-33-88-32-18-19-35-94(88)89)181-127(199)98(39-23-25-56-147)167-124(196)97(38-22-24-55-146)166-120(193)54-53-119(192)163-75-116(165-84(14)187)141(213)178-105(61-78(3)4)130(202)169-100(41-28-58-160-144(154)155)128(200)183-114(71-91-74-158-76-164-91)138(210)180-111(68-87-45-49-93(189)50-46-87)134(206)174-108(64-81(9)10)133(205)184-115(72-118(149)191)139(211)176-107(63-80(7)8)132(204)177-109(65-82(11)12)140(212)185-121(83(13)186)142(214)171-101(42-29-59-161-145(156)157)125(197)170-102(51-52-117(148)190)129(201)168-99(40-27-57-159-143(152)153)126(198)173-104(123(151)195)66-86-43-47-92(188)48-44-86/h15-21,26,30-37,43-50,73-74,76-83,97-116,121,162,186,188-189H,22-25,27-29,38-42,51-72,75,146-147H2,1-14H3,(H2,148,190)(H2,149,191)(H2,150,194)(H2,151,195)(H,158,164)(H,163,192)(H,165,187)(H,166,193)(H,167,196)(H,168,201)(H,169,202)(H,170,197)(H,171,214)(H,172,203)(H,173,198)(H,174,206)(H,175,209)(H,176,211)(H,177,204)(H,178,213)(H,179,208)(H,180,210)(H,181,199)(H,182,207)(H,183,200)(H,184,205)(H,185,212)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)/t83-,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113-,114+,115+,116?,121+/m1/s1
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n/an/a 9.70n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human neuropeptide Y Y2 receptor expressed in HEK293 cells cotransfected with eYFP fusion protein after 2 hrs by compe...


J Med Chem 58: 4180-93 (2015)


Article DOI: 10.1021/jm501702q
BindingDB Entry DOI: 10.7270/Q2P84DNK
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50352389
PNG
(CHEMBL1823360)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C35H37FN4O2/c1-3-38(4-2)35(42)33(27-15-9-6-10-16-27)40-23-21-39(22-24-40)32-20-19-28(25-31(32)36)37-34(41)30-18-12-11-17-29(30)26-13-7-5-8-14-26/h5-20,25,33H,3-4,21-24H2,1-2H3,(H,37,41)
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n/an/a 10n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting


Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50091682
PNG
(CHEMBL262221 | N-alpha-Ac-[Dip27]PYY(22-36)-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C92H143N29O21/c1-46(2)37-63(114-86(139)68(44-122)118-76(129)50(9)107-52(11)124)81(134)109-59(26-19-35-104-91(98)99)79(132)115-66(41-56-43-102-45-106-56)85(138)121-74(71(54-21-14-12-15-22-54)55-23-16-13-17-24-55)89(142)117-64(38-47(3)4)82(135)116-67(42-70(94)127)83(136)113-65(39-48(5)6)84(137)119-72(49(7)8)87(140)120-73(51(10)123)88(141)111-60(27-20-36-105-92(100)101)77(130)110-61(32-33-69(93)126)80(133)108-58(25-18-34-103-90(96)97)78(131)112-62(75(95)128)40-53-28-30-57(125)31-29-53/h12-17,21-24,28-31,43,45-51,58-68,71-74,122-123,125H,18-20,25-27,32-42,44H2,1-11H3,(H2,93,126)(H2,94,127)(H2,95,128)(H,102,106)(H,107,124)(H,108,133)(H,109,134)(H,110,130)(H,111,141)(H,112,131)(H,113,136)(H,114,139)(H,115,132)(H,116,135)(H,117,142)(H,118,129)(H,119,137)(H,120,140)(H,121,138)(H4,96,97,103)(H4,98,99,104)(H4,100,101,105)/t50-,51+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,72-,73-,74-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



University of Cincinnati Medical Center

Curated by ChEMBL


Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line


J Med Chem 43: 3420-7 (2000)


Article DOI: 10.1021/jm000052z
BindingDB Entry DOI: 10.7270/Q2QR4WCX
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50352383
PNG
(CHEMBL1823354)
Show SMILES CCNC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1C#N)c1ccccc1
Show InChI InChI=1S/C34H33N5O2/c1-2-36-34(41)32(26-13-7-4-8-14-26)39-21-19-38(20-22-39)31-18-17-28(23-27(31)24-35)37-33(40)30-16-10-9-15-29(30)25-11-5-3-6-12-25/h3-18,23,32H,2,19-22H2,1H3,(H,36,41)(H,37,40)
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n/an/a 11n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting


Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50445649
PNG
(CHEMBL3104180)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(cc1C#N)-c1nc(no1)C(C)C)c1ccccc1
Show InChI InChI=1S/C28H34N6O2/c1-5-32(6-2)28(35)25(21-10-8-7-9-11-21)34-16-14-33(15-17-34)24-13-12-22(18-23(24)19-29)27-30-26(20(3)4)31-36-27/h7-13,18,20,25H,5-6,14-17H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor


Bioorg Med Chem Lett 24: 430-41 (2014)


Article DOI: 10.1016/j.bmcl.2013.11.061
BindingDB Entry DOI: 10.7270/Q2H133HQ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50445637
PNG
(CHEMBL3104200)
Show SMILES CCC(CC)C(=O)Nc1ccc(N2CCC(CC2)C(C(=O)N(CC)CC)c2ccccc2)c(F)c1
Show InChI InChI=1S/C29H40FN3O2/c1-5-21(6-2)28(34)31-24-14-15-26(25(30)20-24)33-18-16-23(17-19-33)27(22-12-10-9-11-13-22)29(35)32(7-3)8-4/h9-15,20-21,23,27H,5-8,16-19H2,1-4H3,(H,31,34)
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n/an/a 12n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor


Bioorg Med Chem Lett 24: 430-41 (2014)


Article DOI: 10.1016/j.bmcl.2013.11.061
BindingDB Entry DOI: 10.7270/Q2H133HQ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50437017
PNG
(CHEMBL2402905)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H34FN3O2/c1-2-36-34(40)32(25-13-7-4-8-14-25)26-19-21-38(22-20-26)31-18-17-27(23-30(31)35)37-33(39)29-16-10-9-15-28(29)24-11-5-3-6-12-24/h3-18,23,26,32H,2,19-22H2,1H3,(H,36,40)(H,37,39)
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n/an/a 12n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis


Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50437008
PNG
(CHEMBL2403028)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)noc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C29H36FN5O3/c1-5-34(6-2)28(36)26(21-10-8-7-9-11-21)22-14-16-35(17-15-22)25-13-12-23(18-24(25)30)31-29(37)32-27-19(3)33-38-20(27)4/h7-13,18,22,26H,5-6,14-17H2,1-4H3,(H2,31,32,37)
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n/an/a 12n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis


Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
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