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Compile Data Set for Download or QSAR

Found 452 hits of ic50 data for polymerid = 49001019,6827   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294254
PNG
((4R,7S,10S,13R,16S,19R)-19-((R)-2-amino-3-(4-hydro...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@H](N)Cc2ccc(O)cc2)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C64H75N11O11S2/c1-37(2)67-34-43-21-19-42(20-22-43)32-50-58(80)68-49(30-39-13-7-5-8-14-39)59(81)72-53(62(84)73-54(38(3)76)55(66)78)36-88-87-35-52(71-57(79)48(65)29-41-23-27-47(77)28-24-41)61(83)69-51(31-40-15-9-6-10-16-40)60(82)74-56(63(85)70-50)75(4)64(86)46-26-25-44-17-11-12-18-45(44)33-46/h5-28,33,37-38,48-54,56,67,76-77H,29-32,34-36,65H2,1-4H3,(H2,66,78)(H,68,80)(H,69,83)(H,70,85)(H,71,79)(H,72,81)(H,73,84)(H,74,82)/t38-,48-,49+,50+,51+,52+,53+,54+,56-/m1/s1
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PubMed
n/an/a 0.190n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294232
PNG
((4R,7S,10S,13R,16S,19R)-19-((S)-2-amino-3-(4-hydro...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC2=O)C(=O)N[C@H]([C@@H](C)O)C(N)=O)NC(=O)[C@@H](N)Cc2ccc(O)cc2I)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C64H74IN11O11S2/c1-36(2)68-33-41-21-19-40(20-22-41)29-50-58(81)69-49(27-38-13-7-5-8-14-38)59(82)73-53(62(85)74-54(37(3)77)55(67)79)35-89-88-34-52(72-57(80)48(66)31-44-25-26-46(78)32-47(44)65)61(84)70-51(28-39-15-9-6-10-16-39)60(83)75-56(63(86)71-50)76(4)64(87)45-24-23-42-17-11-12-18-43(42)30-45/h5-26,30,32,36-37,48-54,56,68,77-78H,27-29,31,33-35,66H2,1-4H3,(H2,67,79)(H,69,81)(H,70,84)(H,71,86)(H,72,80)(H,73,82)(H,74,85)(H,75,83)/t37-,48+,49+,50+,51+,52+,53+,54-,56-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159422
PNG
(CHEMBL408338 | Des-AA5-[D-Trp8]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C72H98N16O17S2/c1-40(75)61(93)77-36-58(92)78-56-38-106-107-39-57(72(104)105)86-68(100)55(37-89)85-71(103)60(42(3)91)88-67(99)53(33-45-23-11-6-12-24-45)84-70(102)59(41(2)90)87-63(95)50(28-16-18-30-74)79-66(98)54(34-46-35-76-48-26-14-13-25-47(46)48)83-65(97)52(32-44-21-9-5-10-22-44)82-64(96)51(31-43-19-7-4-8-20-43)81-62(94)49(80-69(56)101)27-15-17-29-73/h4-14,19-26,35,40-42,49-57,59-60,76,89-91H,15-18,27-34,36-39,73-75H2,1-3H3,(H,77,93)(H,78,92)(H,79,98)(H,80,101)(H,81,94)(H,82,96)(H,83,97)(H,84,102)(H,85,103)(H,86,100)(H,87,95)(H,88,99)(H,104,105)/t40-,41+,42+,49+,50-,51+,52-,53-,54-,55-,56+,57-,59+,60+/m0/s1
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n/an/a 0.980n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50100728
PNG
(CHEMBL409100 | Des-Asn5-[DTrp8]-SRIF)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CSSC[C@@H](NC(=O)[C@@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C72H98N16O17S2/c1-40(75)61(93)77-36-58(92)78-56-38-106-107-39-57(72(104)105)86-68(100)55(37-89)85-71(103)60(42(3)91)88-67(99)53(33-45-23-11-6-12-24-45)84-70(102)59(41(2)90)87-63(95)50(28-16-18-30-74)79-66(98)54(34-46-35-76-48-26-14-13-25-47(46)48)83-65(97)52(32-44-21-9-5-10-22-44)82-64(96)51(31-43-19-7-4-8-20-43)81-62(94)49(80-69(56)101)27-15-17-29-73/h4-14,19-26,35,40-42,49-57,59-60,76,89-91H,15-18,27-34,36-39,73-75H2,1-3H3,(H,77,93)(H,78,92)(H,79,98)(H,80,101)(H,81,94)(H,82,96)(H,83,97)(H,84,102)(H,85,103)(H,86,100)(H,87,95)(H,88,99)(H,104,105)/t40-,41+,42+,49+,50+,51-,52+,53+,54-,55+,56+,57+,59-,60-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) recept...


J Med Chem 44: 2238-46 (2001)


Article DOI: 10.1021/jm010037+
BindingDB Entry DOI: 10.7270/Q21R6PSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294232
PNG
((4R,7S,10S,13R,16S,19R)-19-((S)-2-amino-3-(4-hydro...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC2=O)C(=O)N[C@H]([C@@H](C)O)C(N)=O)NC(=O)[C@@H](N)Cc2ccc(O)cc2I)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C64H74IN11O11S2/c1-36(2)68-33-41-21-19-40(20-22-41)29-50-58(81)69-49(27-38-13-7-5-8-14-38)59(82)73-53(62(85)74-54(37(3)77)55(67)79)35-89-88-34-52(72-57(80)48(66)31-44-25-26-46(78)32-47(44)65)61(84)70-51(28-39-15-9-6-10-16-39)60(83)75-56(63(86)71-50)76(4)64(87)45-24-23-42-17-11-12-18-43(42)30-45/h5-26,30,32,36-37,48-54,56,68,77-78H,27-29,31,33-35,66H2,1-4H3,(H2,67,79)(H,69,81)(H,70,84)(H,71,86)(H,72,80)(H,73,82)(H,74,85)(H,75,83)/t37-,48+,49+,50+,51+,52+,53+,54-,56-/m1/s1
KEGG

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n/an/a 1n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Binding affinity to sst1 receptor in human prostate cancer cells by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294252
PNG
((4R,7S,10S,13R,16S,19R)-19-amino-N-((2S,3R)-1-amin...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C55H66N10O9S2/c1-32(2)58-29-37-21-19-36(20-22-37)27-43-50(69)60-42(25-34-13-7-5-8-14-34)51(70)62-45(53(72)63-46(33(3)66)47(57)67)31-76-75-30-41(56)49(68)59-44(26-35-15-9-6-10-16-35)52(71)64-48(54(73)61-43)65(4)55(74)40-24-23-38-17-11-12-18-39(38)28-40/h5-24,28,32-33,41-46,48,58,66H,25-27,29-31,56H2,1-4H3,(H2,57,67)(H,59,68)(H,60,69)(H,61,73)(H,62,70)(H,63,72)(H,64,71)/t33-,41+,42+,43+,44+,45+,46+,48-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM81767
PNG
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



Vrije Universiteit Brussel

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombinant sst1 receptor expressed in chinese hamster CCL39 cells


J Med Chem 52: 95-104 (2009)


Article DOI: 10.1021/jm801205x
BindingDB Entry DOI: 10.7270/Q27W6D3B
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
KEGG

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UniChem

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PubMed
n/an/a 2.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human sst1 receptor expressed in CHOK1 cells by autoradiography


J Med Chem 51: 2676-81 (2008)


Article DOI: 10.1021/jm701445q
BindingDB Entry DOI: 10.7270/Q2H70GQW
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM82547
PNG
(SRIF-D-Trp8)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55+,56-,57-,58-,59-,62-,63-/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
KEGG

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n/an/a 2.30n/an/an/an/an/an/a



University of Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]-[LTT] SIRF-28 from human SST1 receptor expressed in CHO cells by autoradiography


J Med Chem 53: 6188-97 (2010)


Article DOI: 10.1021/jm1005868
BindingDB Entry DOI: 10.7270/Q2NC625N
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



University of Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I](Leu8,D-Trp22,Tyr25)-SRIF28 from human sst1 receptor


J Med Chem 51: 512-20 (2008)


Article DOI: 10.1021/jm070886i
BindingDB Entry DOI: 10.7270/Q26974D8
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294236
PNG
((4R,7S,10S,13S,16S,19S,22R,25S,28S,31S,34R)-34-ami...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)c(I)c3)NC(=O)[C@@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(N)=O)cc1
Show InChI InChI=1S/C74H96IN15O15S2/c1-40(2)79-35-46-24-22-45(23-25-46)32-56-70(101)89-62(41(3)92)73(104)86-57(33-47-26-27-61(94)50(75)29-47)71(102)90-63(42(4)93)74(105)87-59(37-91)72(103)88-60(64(78)95)39-107-106-38-51(77)65(96)81-53(21-13-14-28-76)66(97)82-54(30-43-15-7-5-8-16-43)67(98)83-55(31-44-17-9-6-10-18-44)68(99)85-58(69(100)84-56)34-48-36-80-52-20-12-11-19-49(48)52/h5-12,15-20,22-27,29,36,40-42,51,53-60,62-63,79-80,91-94H,13-14,21,28,30-35,37-39,76-77H2,1-4H3,(H2,78,95)(H,81,96)(H,82,97)(H,83,98)(H,84,100)(H,85,99)(H,86,104)(H,87,105)(H,88,103)(H,89,101)(H,90,102)/t41-,42-,51+,53+,54+,55+,56+,57+,58-,59+,60+,62+,63+/m1/s1
KEGG

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n/an/a 2.5n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159389
PNG
(CHEMBL413419 | Des-AA1,2,5-[D-Trp8,IAmp9,m-I-Tyr11...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3I)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(N)=O)cc1
Show InChI InChI=1S/C74H96IN15O15S2/c1-40(2)79-35-46-24-22-45(23-25-46)31-57-70(101)89-62(41(3)92)73(104)86-58(32-47-26-27-49(94)34-51(47)75)71(102)90-63(42(4)93)74(105)87-60(37-91)72(103)88-61(64(78)95)39-107-106-38-52(77)65(96)81-54(21-13-14-28-76)66(97)82-55(29-43-15-7-5-8-16-43)67(98)83-56(30-44-17-9-6-10-18-44)68(99)85-59(69(100)84-57)33-48-36-80-53-20-12-11-19-50(48)53/h5-12,15-20,22-27,34,36,40-42,52,54-63,79-80,91-94H,13-14,21,28-33,35,37-39,76-77H2,1-4H3,(H2,78,95)(H,81,96)(H,82,97)(H,83,98)(H,84,100)(H,85,99)(H,86,104)(H,87,105)(H,88,103)(H,89,101)(H,90,102)/t41-,42-,52-,54-,55-,56+,57+,58+,59+,60+,61+,62-,63-/m1/s1
KEGG

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n/an/a 2.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50100731
PNG
(CHEMBL263340 | Des-AA1,2,5-[DTrp8,IAmp9,ITyr11]-Cb...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)c(I)c3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)NC(N)=O)cc1
Show InChI InChI=1S/C75H96IN15O17S2/c1-40(2)79-35-46-24-22-45(23-25-46)32-55-68(100)90-62(41(3)93)72(104)86-56(33-47-26-27-61(95)50(76)29-47)69(101)91-63(42(4)94)73(105)87-58(37-92)70(102)88-60(74(106)107)39-110-109-38-59(89-75(78)108)71(103)81-52(21-13-14-28-77)64(96)82-53(30-43-15-7-5-8-16-43)65(97)83-54(31-44-17-9-6-10-18-44)66(98)85-57(67(99)84-55)34-48-36-80-51-20-12-11-19-49(48)51/h5-12,15-20,22-27,29,36,40-42,52-60,62-63,79-80,92-95H,13-14,21,28,30-35,37-39,77H2,1-4H3,(H,81,103)(H,82,96)(H,83,97)(H,84,99)(H,85,98)(H,86,104)(H,87,105)(H,88,102)(H,90,100)(H,91,101)(H,106,107)(H3,78,89,108)/t41-,42-,52-,53-,54+,55+,56+,57-,58+,59-,60+,62-,63-/m1/s1
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n/an/a 2.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) recept...


J Med Chem 44: 2238-46 (2001)


Article DOI: 10.1021/jm010037+
BindingDB Entry DOI: 10.7270/Q21R6PSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50352480
PNG
(CHEMBL1824051)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C78H105N17O19S2/c1-43(81)66(101)83-39-63(100)84-60-41-115-116-42-61(78(113)114)93-74(109)59(40-96)92-77(112)65(45(3)98)95-73(108)56(36-48-23-11-6-12-24-48)91-76(111)64(44(2)97)94-68(103)53(28-16-18-32-80)85-69(104)57(37-49-29-30-50-25-13-14-26-51(50)33-49)89-71(106)54(34-46-19-7-4-8-20-46)87-70(105)55(35-47-21-9-5-10-22-47)88-72(107)58(38-62(82)99)90-67(102)52(86-75(60)110)27-15-17-31-79/h4-14,19-26,29-30,33,43-45,52-61,64-65,96-98H,15-18,27-28,31-32,34-42,79-81H2,1-3H3,(H2,82,99)(H,83,101)(H,84,100)(H,85,104)(H,86,110)(H,87,105)(H,88,107)(H,89,106)(H,90,102)(H,91,111)(H,92,112)(H,93,109)(H,94,103)(H,95,108)(H,113,114)/t43-,44+,45+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Displacement of [125I][LTT]SRIF28 from human cloned sst1 receptor by autoradiography


J Med Chem 51: 4030-7 (2008)


Article DOI: 10.1021/jm701618q
BindingDB Entry DOI: 10.7270/Q22J6CSW
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50136768
PNG
(CHEMBL442315 | Peptide analogue | Somatostatin ana...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)C(N)C(C)=C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@@H](NC(=O)[C@@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C139H209N41O38S3/c1-70(2)108(146)132(212)157-73(5)113(193)167-94(61-103(143)185)125(205)174-97(66-181)127(207)173-96(63-105(145)187)136(216)180-55-30-44-101(180)130(210)156-72(4)112(192)160-89(48-56-219-9)115(195)158-74(6)135(215)179-54-29-45-102(179)131(211)166-87(43-28-53-152-139(149)150)117(197)165-88(46-47-107(189)190)119(199)162-86(42-27-52-151-138(147)148)116(196)161-83(39-21-24-49-140)114(194)155-71(3)111(191)154-65-106(188)159-99-68-220-221-69-100(137(217)218)176-128(208)98(67-182)175-134(214)110(76(8)184)178-126(206)92(59-79-35-17-12-18-36-79)172-133(213)109(75(7)183)177-120(200)85(41-23-26-51-142)163-123(203)93(60-80-64-153-82-38-20-19-37-81(80)82)170-122(202)91(58-78-33-15-11-16-34-78)168-121(201)90(57-77-31-13-10-14-32-77)169-124(204)95(62-104(144)186)171-118(198)84(164-129(99)209)40-22-25-50-141/h10-20,31-38,64,71-76,83-102,108-110,153,181-184H,1,21-30,39-63,65-69,140-142,146H2,2-9H3,(H2,143,185)(H2,144,186)(H2,145,187)(H,154,191)(H,155,194)(H,156,210)(H,157,212)(H,158,195)(H,159,188)(H,160,192)(H,161,196)(H,162,199)(H,163,203)(H,164,209)(H,165,197)(H,166,211)(H,167,193)(H,168,201)(H,169,204)(H,170,202)(H,171,198)(H,172,213)(H,173,207)(H,174,205)(H,175,214)(H,176,208)(H,177,200)(H,178,206)(H,189,190)(H,217,218)(H4,147,148,151)(H4,149,150,152)/t71-,72-,73-,74-,75+,76+,83-,84+,85-,86-,87-,88-,89-,90+,91-,92+,93+,94-,95-,96-,97-,98+,99+,100+,101-,102-,108?,109+,110-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 1 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159392
PNG
((4R,7R,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-37...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73+,74+,80-,82-,83+,84-,85-,86-,87-,88-,89+,90-,91-,92+,93-,94-,95-,96-,97-,98+,99-,100-,101-,107+,108+/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-[Leu8, DTrp22, Tyr25]SRIF28 from human cloned sst1 receptor


J Med Chem 51: 2668-75 (2008)


Article DOI: 10.1021/jm701444y
BindingDB Entry DOI: 10.7270/Q2CF9R1G
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159432
PNG
(CHEMBL428295 | Des-AA1,2,5-[D-Agl8(NbetaMe,2-napht...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C77H98N14O17S2/c1-43(2)80-39-50-25-23-48(24-26-50)36-59-70(100)88-63(44(3)93)73(103)84-58(37-49-27-31-54(95)32-28-49)69(99)89-64(45(4)94)74(104)86-61(40-92)72(102)87-62(77(107)108)42-110-109-41-55(79)66(96)81-56(22-14-15-33-78)67(97)82-57(34-46-16-8-6-9-17-46)68(98)83-60(35-47-18-10-7-11-19-47)71(101)90-65(75(105)85-59)91(5)76(106)53-30-29-51-20-12-13-21-52(51)38-53/h6-13,16-21,23-32,38,43-45,55-65,80,92-95H,14-15,22,33-37,39-42,78-79H2,1-5H3,(H,81,96)(H,82,97)(H,83,98)(H,84,103)(H,85,105)(H,86,104)(H,87,102)(H,88,100)(H,89,99)(H,90,101)(H,107,108)/t44-,45-,55-,56-,57-,58+,59+,60+,61+,62+,63-,64-,65+/m1/s1
KEGG

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n/an/a 3.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294238
PNG
((4R,7S,10S,13S,16S,19S,22R,25S,28S,31S,34R)-34-ami...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C77H98N14O17S2/c1-43(2)80-39-50-25-23-48(24-26-50)36-59-70(100)88-63(44(3)93)73(103)84-58(37-49-27-31-54(95)32-28-49)69(99)89-64(45(4)94)74(104)86-61(40-92)72(102)87-62(77(107)108)42-110-109-41-55(79)66(96)81-56(22-14-15-33-78)67(97)82-57(34-46-16-8-6-9-17-46)68(98)83-60(35-47-18-10-7-11-19-47)71(101)90-65(75(105)85-59)91(5)76(106)53-30-29-51-20-12-13-21-52(51)38-53/h6-13,16-21,23-32,38,43-45,55-65,80,92-95H,14-15,22,33-37,39-42,78-79H2,1-5H3,(H,81,96)(H,82,97)(H,83,98)(H,84,103)(H,85,105)(H,86,104)(H,87,102)(H,88,100)(H,89,99)(H,90,101)(H,107,108)/t44-,45-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65-/m1/s1
KEGG

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n/an/a 3.30n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294235
PNG
((4R,7S,10S,13S,16S,19S,22R,25S,28S,31S,34R)-34-ami...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)c(I)c3)NC(=O)[C@@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)cc1
Show InChI InChI=1S/C74H95IN14O16S2/c1-40(2)78-35-46-24-22-45(23-25-46)32-56-69(99)88-62(41(3)91)72(102)85-57(33-47-26-27-61(93)50(75)29-47)70(100)89-63(42(4)92)73(103)86-59(37-90)71(101)87-60(74(104)105)39-107-106-38-51(77)64(94)80-53(21-13-14-28-76)65(95)81-54(30-43-15-7-5-8-16-43)66(96)82-55(31-44-17-9-6-10-18-44)67(97)84-58(68(98)83-56)34-48-36-79-52-20-12-11-19-49(48)52/h5-12,15-20,22-27,29,36,40-42,51,53-60,62-63,78-79,90-93H,13-14,21,28,30-35,37-39,76-77H2,1-4H3,(H,80,94)(H,81,95)(H,82,96)(H,83,98)(H,84,97)(H,85,102)(H,86,103)(H,87,101)(H,88,99)(H,89,100)(H,104,105)/t41-,42-,51+,53+,54+,55+,56+,57+,58-,59+,60+,62+,63+/m1/s1
KEGG

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n/an/a 3.60n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50370285
PNG
(CHEMBL1907758)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@H](C)O)[C@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(153-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)155-114(195)88(46-54-218-7)158-110(191)71(3)154-129(210)100-42-28-53-178(100)134(215)95(62-104(144)186)171-126(207)96(65-180)172-124(205)93(60-102(142)184)165-111(192)70(2)152-112(193)80(141)64-179)109(190)151-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(59-79-58-78-35-17-18-36-81(78)156-79)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(61-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,58,69-74,80,82-101,107-108,156,179-183H,19-28,37-57,59-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,151,190)(H,152,193)(H,153,194)(H,154,210)(H,155,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73-,74-,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-/m0/s1
KEGG

UniProtKB/SwissProt

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UniChem

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n/an/a 3.60n/an/an/an/an/an/a



Technische Universit£t M£nchen

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 1 expressed in CHO-K1 cells; (n=5)


J Med Chem 48: 2778-89 (2005)


Article DOI: 10.1021/jm040794i
BindingDB Entry DOI: 10.7270/Q26T0ND0
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50100723
PNG
(CHEMBL386922 | Des-AA1,2,5-[DTrp8,IAmp9,ITyr11]-SR...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)c(I)c3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)cc1
Show InChI InChI=1S/C74H95IN14O16S2/c1-40(2)78-35-46-24-22-45(23-25-46)32-56-69(99)88-62(41(3)91)72(102)85-57(33-47-26-27-61(93)50(75)29-47)70(100)89-63(42(4)92)73(103)86-59(37-90)71(101)87-60(74(104)105)39-107-106-38-51(77)64(94)80-53(21-13-14-28-76)65(95)81-54(30-43-15-7-5-8-16-43)66(96)82-55(31-44-17-9-6-10-18-44)67(97)84-58(68(98)83-56)34-48-36-79-52-20-12-11-19-49(48)52/h5-12,15-20,22-27,29,36,40-42,51,53-60,62-63,78-79,90-93H,13-14,21,28,30-35,37-39,76-77H2,1-4H3,(H,80,94)(H,81,95)(H,82,96)(H,83,98)(H,84,97)(H,85,102)(H,86,103)(H,87,101)(H,88,99)(H,89,100)(H,104,105)/t41-,42-,51-,53-,54-,55+,56+,57+,58-,59+,60+,62-,63-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
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n/an/a 3.60n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) recept...


J Med Chem 44: 2238-46 (2001)


Article DOI: 10.1021/jm010037+
BindingDB Entry DOI: 10.7270/Q21R6PSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50370285
PNG
(CHEMBL1907758)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@H](C)O)[C@H](C)O)C(O)=O
Show InChI InChI=1S/C137H207N41O39S3/c1-69(153-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)155-114(195)88(46-54-218-7)158-110(191)71(3)154-129(210)100-42-28-53-178(100)134(215)95(62-104(144)186)171-126(207)96(65-180)172-124(205)93(60-102(142)184)165-111(192)70(2)152-112(193)80(141)64-179)109(190)151-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(59-79-58-78-35-17-18-36-81(78)156-79)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(61-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,58,69-74,80,82-101,107-108,156,179-183H,19-28,37-57,59-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,151,190)(H,152,193)(H,153,194)(H,154,210)(H,155,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)/t69-,70-,71-,72-,73-,74-,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-/m0/s1
KEGG

UniProtKB/SwissProt

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UniChem

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n/an/a 3.80n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity at human Somatostatin receptor type 1 by [125I][Leu8,D-Trp22,Tyr25]SRIF-28 displacement.


J Med Chem 46: 5587-96 (2003)


Article DOI: 10.1021/jm0302445
BindingDB Entry DOI: 10.7270/Q2FX7B50
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50136768
PNG
(CHEMBL442315 | Peptide analogue | Somatostatin ana...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)C(N)C(C)=C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]1CSSC[C@@H](NC(=O)[C@@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC1=O)[C@@H](C)O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C139H209N41O38S3/c1-70(2)108(146)132(212)157-73(5)113(193)167-94(61-103(143)185)125(205)174-97(66-181)127(207)173-96(63-105(145)187)136(216)180-55-30-44-101(180)130(210)156-72(4)112(192)160-89(48-56-219-9)115(195)158-74(6)135(215)179-54-29-45-102(179)131(211)166-87(43-28-53-152-139(149)150)117(197)165-88(46-47-107(189)190)119(199)162-86(42-27-52-151-138(147)148)116(196)161-83(39-21-24-49-140)114(194)155-71(3)111(191)154-65-106(188)159-99-68-220-221-69-100(137(217)218)176-128(208)98(67-182)175-134(214)110(76(8)184)178-126(206)92(59-79-35-17-12-18-36-79)172-133(213)109(75(7)183)177-120(200)85(41-23-26-51-142)163-123(203)93(60-80-64-153-82-38-20-19-37-81(80)82)170-122(202)91(58-78-33-15-11-16-34-78)168-121(201)90(57-77-31-13-10-14-32-77)169-124(204)95(62-104(144)186)171-118(198)84(164-129(99)209)40-22-25-50-141/h10-20,31-38,64,71-76,83-102,108-110,153,181-184H,1,21-30,39-63,65-69,140-142,146H2,2-9H3,(H2,143,185)(H2,144,186)(H2,145,187)(H,154,191)(H,155,194)(H,156,210)(H,157,212)(H,158,195)(H,159,188)(H,160,192)(H,161,196)(H,162,199)(H,163,203)(H,164,209)(H,165,197)(H,166,211)(H,167,193)(H,168,201)(H,169,204)(H,170,202)(H,171,198)(H,172,213)(H,173,207)(H,174,205)(H,175,214)(H,176,208)(H,177,200)(H,178,206)(H,189,190)(H,217,218)(H4,147,148,151)(H4,149,150,152)/t71-,72-,73-,74-,75+,76+,83-,84+,85-,86-,87-,88-,89-,90+,91-,92+,93+,94-,95-,96-,97-,98+,99+,100+,101-,102-,108?,109+,110-/m0/s1
KEGG

UniProtKB/SwissProt

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n/an/a 3.90n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 1 using 125I-[Leu,DTrp,Tyr]SRIF-28 as radioligand


J Med Chem 46: 5579-86 (2003)


Article DOI: 10.1021/jm030243c
BindingDB Entry DOI: 10.7270/Q2KP82W9
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50352489
PNG
(CHEMBL1824052)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Show InChI InChI=1S/C78H105N17O19S2/c1-43(81)66(101)83-39-63(100)84-60-41-115-116-42-61(78(113)114)93-74(109)59(40-96)92-77(112)65(45(3)98)95-73(108)56(36-48-23-11-6-12-24-48)91-76(111)64(44(2)97)94-68(103)53(28-16-18-32-80)85-69(104)57(37-49-29-30-50-25-13-14-26-51(50)33-49)89-71(106)54(34-46-19-7-4-8-20-46)87-70(105)55(35-47-21-9-5-10-22-47)88-72(107)58(38-62(82)99)90-67(102)52(86-75(60)110)27-15-17-31-79/h4-14,19-26,29-30,33,43-45,52-61,64-65,96-98H,15-18,27-28,31-32,34-42,79-81H2,1-3H3,(H2,82,99)(H,83,101)(H,84,100)(H,85,104)(H,86,110)(H,87,105)(H,88,107)(H,89,106)(H,90,102)(H,91,111)(H,92,112)(H,93,109)(H,94,103)(H,95,108)(H,113,114)/t43-,44+,45+,52-,53-,54-,55-,56-,57+,58-,59-,60-,61-,64-,65-/m0/s1
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n/an/a 4.10n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294225
PNG
((4R,7S,10S,13R,16S,19R)-19-amino-16-benzyl-7-(4-hy...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC2=O)C(N)=O)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C51H59N9O8S2/c1-30(2)54-27-34-15-13-32(14-16-34)24-41-47(64)56-40(25-33-17-21-38(61)22-18-33)48(65)58-43(44(53)62)29-70-69-28-39(52)46(63)55-42(23-31-9-5-4-6-10-31)49(66)59-45(50(67)57-41)60(3)51(68)37-20-19-35-11-7-8-12-36(35)26-37/h4-22,26,30,39-43,45,54,61H,23-25,27-29,52H2,1-3H3,(H2,53,62)(H,55,63)(H,56,64)(H,57,67)(H,58,65)(H,59,66)/t39-,40-,41-,42-,43-,45+/m0/s1
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n/an/a 4.70n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159425
PNG
(CHEMBL410048 | Des-AA1,2,5-[D-Agl8(NbetaMe,2-napht...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3I)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(N)=O)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C77H98IN15O16S2/c1-42(2)82-38-48-25-23-47(24-26-48)34-58-70(102)90-63(43(3)95)74(106)86-60(36-51-29-30-53(97)37-54(51)78)71(103)91-64(44(4)96)75(107)88-61(39-94)73(105)89-62(65(81)98)41-111-110-40-55(80)67(99)83-56(22-14-15-31-79)68(100)84-57(32-45-16-8-6-9-17-45)69(101)85-59(33-46-18-10-7-11-19-46)72(104)92-66(76(108)87-58)93(5)77(109)52-28-27-49-20-12-13-21-50(49)35-52/h6-13,16-21,23-30,35,37,42-44,55-64,66,82,94-97H,14-15,22,31-34,36,38-41,79-80H2,1-5H3,(H2,81,98)(H,83,99)(H,84,100)(H,85,101)(H,86,106)(H,87,108)(H,88,107)(H,89,105)(H,90,102)(H,91,103)(H,92,104)/t43-,44-,55-,56-,57-,58+,59+,60+,61+,62+,63-,64-,66+/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159393
PNG
(CHEMBL407051 | Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3I)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)cc1
Show InChI InChI=1S/C75H97IN14O16S2/c1-41(2)79-36-47-25-23-46(24-26-47)32-62-71(101)89-64(43(4)93)72(102)84-58(33-48-27-28-50(94)35-52(48)76)69(99)88-63(42(3)92)73(103)86-60(38-91)70(100)87-61(75(105)106)40-108-107-39-53(78)65(95)81-55(22-14-15-29-77)66(96)82-56(30-44-16-8-6-9-17-44)67(97)83-57(31-45-18-10-7-11-19-45)68(98)85-59(74(104)90(62)5)34-49-37-80-54-21-13-12-20-51(49)54/h6-13,16-21,23-28,35,37,41-43,53,55-64,79-80,91-94H,14-15,22,29-34,36,38-40,77-78H2,1-5H3,(H,81,95)(H,82,96)(H,83,97)(H,84,102)(H,85,98)(H,86,103)(H,87,100)(H,88,99)(H,89,101)(H,105,106)/t42-,43-,53-,55-,56-,57+,58+,59+,60+,61+,62+,63-,64-/m1/s1
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n/an/a 5.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159451
PNG
(CHEMBL216992 | Des-AA1,2,5,12,13-[D-Trp8]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C60H78N12O11S2/c1-36(73)51-59(81)70-48(31-39-21-9-4-10-22-39)57(79)71-50(60(82)83)35-85-84-34-42(63)52(74)65-44(25-13-15-27-61)53(75)67-46(29-37-17-5-2-6-18-37)55(77)68-47(30-38-19-7-3-8-20-38)56(78)69-49(32-40-33-64-43-24-12-11-23-41(40)43)58(80)66-45(54(76)72-51)26-14-16-28-62/h2-12,17-24,33,36,42,44-51,64,73H,13-16,25-32,34-35,61-63H2,1H3,(H,65,74)(H,66,80)(H,67,75)(H,68,77)(H,69,78)(H,70,81)(H,71,79)(H,72,76)(H,82,83)/t36-,42-,44-,45+,46-,47+,48+,49+,50+,51-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 515-22 (2005)


Article DOI: 10.1021/jm049519m
BindingDB Entry DOI: 10.7270/Q2QV3N9S
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50352482
PNG
(CHEMBL1824055)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38+,40+,41+,42+,43+,44+,45+,46+/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography


J Med Chem 54: 5981-7 (2011)


Article DOI: 10.1021/jm200307v
BindingDB Entry DOI: 10.7270/Q2BV7H1N
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50136812
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41-,42+,43+,44-,45+,46-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 1 using 125I-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand


J Med Chem 46: 5606-18 (2003)


Article DOI: 10.1021/jm030246p
BindingDB Entry DOI: 10.7270/Q2GT5MMN
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50136765
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-...)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40-,41-,42-,43-,44+,45-,46+/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human Somatostatin receptor type 1 using 125I-[Leu,DTrp,Tyr]SRIF-28 as radioligand


J Med Chem 46: 5579-86 (2003)


Article DOI: 10.1021/jm030243c
BindingDB Entry DOI: 10.7270/Q2KP82W9
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50136812
PNG
((S)-25-Amino-13-(4-amino-butyl)-7,19,22-tribenzyl-...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O10S2/c1-32(65)46-53(72)62-43(27-35-19-9-4-10-20-35)51(70)63-45(54(73)74)31-76-75-30-38(56)47(66)59-41(25-33-15-5-2-6-16-33)49(68)60-42(26-34-17-7-3-8-18-34)50(69)61-44(28-36-29-57-39-22-12-11-21-37(36)39)52(71)58-40(48(67)64-46)23-13-14-24-55/h2-12,15-22,29,32,38,40-46,57,65H,13-14,23-28,30-31,55-56H2,1H3,(H,58,71)(H,59,66)(H,60,68)(H,61,69)(H,62,72)(H,63,70)(H,64,67)(H,73,74)/t32-,38-,40+,41-,42+,43+,44-,45+,46-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 1 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50100750
PNG
(CHEMBL410824 | Des-AA1,2-[DTrp8]-SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSCC(NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C71H96N16O17S2/c1-39(89)58-69(101)83-52(32-43-22-10-5-11-23-43)67(99)87-59(40(2)90)70(102)84-55(36-88)68(100)85-56(71(103)104)38-106-105-37-46(74)60(92)77-48(26-14-16-28-72)61(93)82-54(34-57(75)91)66(98)80-50(30-41-18-6-3-7-19-41)63(95)79-51(31-42-20-8-4-9-21-42)64(96)81-53(33-44-35-76-47-25-13-12-24-45(44)47)65(97)78-49(62(94)86-58)27-15-17-29-73/h3-13,18-25,35,39-40,46,48-56,58-59,76,88-90H,14-17,26-34,36-38,72-74H2,1-2H3,(H2,75,91)(H,77,92)(H,78,97)(H,79,95)(H,80,98)(H,81,96)(H,82,93)(H,83,101)(H,84,102)(H,85,100)(H,86,94)(H,87,99)(H,103,104)/t39-,40-,46-,48-,49+,50-,51+,52+,53-,54+,55+,56?,58-,59-/m1/s1
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n/an/a 5.40n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) recept...


J Med Chem 44: 2238-46 (2001)


Article DOI: 10.1021/jm010037+
BindingDB Entry DOI: 10.7270/Q21R6PSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159429
PNG
(CHEMBL406197 | Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(N)=O)cc1
Show InChI InChI=1S/C75H99N15O15S2/c1-42(2)79-37-49-25-23-48(24-26-49)35-62-72(102)89-64(44(4)93)73(103)84-58(34-47-27-29-51(94)30-28-47)70(100)88-63(43(3)92)74(104)86-60(39-91)71(101)87-61(65(78)95)41-107-106-40-53(77)66(96)81-55(22-14-15-31-76)67(97)82-56(32-45-16-8-6-9-17-45)68(98)83-57(33-46-18-10-7-11-19-46)69(99)85-59(75(105)90(62)5)36-50-38-80-54-21-13-12-20-52(50)54/h6-13,16-21,23-30,38,42-44,53,55-64,79-80,91-94H,14-15,22,31-37,39-41,76-77H2,1-5H3,(H2,78,95)(H,81,96)(H,82,97)(H,83,98)(H,84,103)(H,85,99)(H,86,104)(H,87,101)(H,88,100)(H,89,102)/t43-,44-,53-,55-,56-,57+,58+,59+,60+,61+,62+,63-,64-/m1/s1
KEGG

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n/an/a 5.80n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159469
PNG
(CHEMBL437348 | cyclo(7-12) Des-AA1,2,5-[Glu7,D-Trp...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCC(=O)NCCCCCC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4I)NC(=O)[C@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](N)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc2ccccc2)C(=O)N3)C(N)=O)cc1
Show InChI InChI=1S/C74H101IN16O15S2/c1-41(2)80-36-45-23-21-44(22-24-45)32-57-72(104)91-63(42(3)93)74(106)88-58(33-46-25-26-48(94)35-50(46)75)70(102)83-54-19-9-4-5-14-30-79-62(95)28-27-55(68(100)87-59(71(103)86-57)34-47-37-81-52-18-11-10-17-49(47)52)84-69(101)56(31-43-15-7-6-8-16-43)85-66(98)53(20-12-13-29-76)82-65(97)51(77)39-107-108-40-61(64(78)96)90-73(105)60(38-92)89-67(54)99/h6-8,10-11,15-18,21-26,35,37,41-42,51,53-61,63,80-81,92-94H,4-5,9,12-14,19-20,27-34,36,38-40,76-77H2,1-3H3,(H2,78,96)(H,79,95)(H,82,97)(H,83,102)(H,84,101)(H,85,98)(H,86,103)(H,87,100)(H,88,106)(H,89,99)(H,90,105)(H,91,104)/t42-,51-,53-,54+,55-,56-,57+,58+,59+,60+,61+,63-/m1/s1
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n/an/a 6.10n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of 125I-[Leu8,D-Trp22,Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 515-22 (2005)


Article DOI: 10.1021/jm049519m
BindingDB Entry DOI: 10.7270/Q2QV3N9S
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294237
PNG
((4R,7S,10S,13S,16S,19S,22R,25S,28S,31S,34R)-34-ami...)
Show SMILES CCCCCCC[C@@H]1NC(=O)[C@H](Cc2ccc(O)c(I)c2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(CNC(C)C)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(N)=O)[C@@H](C)O
Show InChI InChI=1S/C75H105IN16O15S2/c1-5-6-7-8-12-21-54-68(100)90-60(39-93)74(106)91-61(65(80)97)41-109-108-40-51(78)66(98)83-53(22-15-16-31-77)67(99)86-56(33-44-17-10-9-11-18-44)70(102)85-55(28-30-63(79)96)69(101)88-59(36-48-38-82-52-20-14-13-19-49(48)52)72(104)87-57(34-45-23-25-46(26-24-45)37-81-42(2)3)73(105)92-64(43(4)94)75(107)89-58(71(103)84-54)35-47-27-29-62(95)50(76)32-47/h9-11,13-14,17-20,23-27,29,32,38,42-43,51,53-61,64,81-82,93-95H,5-8,12,15-16,21-22,28,30-31,33-37,39-41,77-78H2,1-4H3,(H2,79,96)(H2,80,97)(H,83,98)(H,84,103)(H,85,102)(H,86,99)(H,87,104)(H,88,101)(H,89,107)(H,90,100)(H,91,106)(H,92,105)/t43-,51+,53+,54+,55+,56+,57+,58+,59-,60+,61+,64+/m1/s1
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n/an/a 6.10n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50136820
PNG
((4R,7S,10R,13S,16R,19S,22R,25S)-25-Amino-13-(4-ami...)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(O)=O
Show InChI InChI=1S/C54H66N10O11S2/c1-31(65)46-53(73)62-43(26-34-19-21-36(66)22-20-34)51(71)63-45(54(74)75)30-77-76-29-38(56)47(67)59-41(24-32-12-4-2-5-13-32)49(69)60-42(25-33-14-6-3-7-15-33)50(70)61-44(27-35-28-57-39-17-9-8-16-37(35)39)52(72)58-40(48(68)64-46)18-10-11-23-55/h2-9,12-17,19-22,28,31,38,40-46,57,65-66H,10-11,18,23-27,29-30,55-56H2,1H3,(H,58,72)(H,59,67)(H,60,69)(H,61,70)(H,62,73)(H,63,71)(H,64,68)(H,74,75)/t31-,38-,40+,41-,42+,43+,44-,45+,46-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Binding affinity towards human somatostatin receptor type 1 using [125I]-[Leu8,DTrp22,Tyr25]SRIF-28 as radioligand.


J Med Chem 46: 5597-605 (2003)


Article DOI: 10.1021/jm030245x
BindingDB Entry DOI: 10.7270/Q2MK6C9X
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159395
PNG
(CHEMBL440618 | Des-AA1,2,5-[D-Agl8(NbetaMe,2-napht...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3I)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C77H97IN14O17S2/c1-42(2)81-38-48-25-23-47(24-26-48)34-58-69(100)89-63(43(3)94)73(104)85-60(36-51-29-30-53(96)37-54(51)78)70(101)90-64(44(4)95)74(105)87-61(39-93)72(103)88-62(77(108)109)41-111-110-40-55(80)66(97)82-56(22-14-15-31-79)67(98)83-57(32-45-16-8-6-9-17-45)68(99)84-59(33-46-18-10-7-11-19-46)71(102)91-65(75(106)86-58)92(5)76(107)52-28-27-49-20-12-13-21-50(49)35-52/h6-13,16-21,23-30,35,37,42-44,55-65,81,93-96H,14-15,22,31-34,36,38-41,79-80H2,1-5H3,(H,82,97)(H,83,98)(H,84,99)(H,85,104)(H,86,106)(H,87,105)(H,88,103)(H,89,100)(H,90,101)(H,91,102)(H,108,109)/t43-,44-,55-,56-,57-,58+,59+,60+,61+,62+,63-,64-,65+/m1/s1
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n/an/a 6.70n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159421
PNG
(CHEMBL411860 | Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)cc1
Show InChI InChI=1S/C75H98N14O16S2/c1-42(2)78-37-49-25-23-48(24-26-49)35-62-71(100)88-64(44(4)92)72(101)83-58(34-47-27-29-51(93)30-28-47)69(98)87-63(43(3)91)73(102)85-60(39-90)70(99)86-61(75(104)105)41-107-106-40-53(77)65(94)80-55(22-14-15-31-76)66(95)81-56(32-45-16-8-6-9-17-45)67(96)82-57(33-46-18-10-7-11-19-46)68(97)84-59(74(103)89(62)5)36-50-38-79-54-21-13-12-20-52(50)54/h6-13,16-21,23-30,38,42-44,53,55-64,78-79,90-93H,14-15,22,31-37,39-41,76-77H2,1-5H3,(H,80,94)(H,81,95)(H,82,96)(H,83,101)(H,84,97)(H,85,102)(H,86,99)(H,87,98)(H,88,100)(H,104,105)/t43-,44-,53-,55-,56-,57+,58+,59+,60+,61+,62+,63-,64-/m1/s1
KEGG

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n/an/a 7.20n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159415
PNG
(CHEMBL414717 | Des-AA1,2,5-[D-Trp8,IAmp9,Tyr11]Cbm...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(N)=O)cc1
Show InChI InChI=1S/C74H97N15O15S2/c1-41(2)78-36-48-24-22-46(23-25-48)33-57-70(100)88-62(42(3)91)73(103)85-58(34-47-26-28-50(93)29-27-47)71(101)89-63(43(4)92)74(104)86-60(38-90)72(102)87-61(64(77)94)40-106-105-39-52(76)65(95)80-54(21-13-14-30-75)66(96)81-55(31-44-15-7-5-8-16-44)67(97)82-56(32-45-17-9-6-10-18-45)68(98)84-59(69(99)83-57)35-49-37-79-53-20-12-11-19-51(49)53/h5-12,15-20,22-29,37,41-43,52,54-63,78-79,90-93H,13-14,21,30-36,38-40,75-76H2,1-4H3,(H2,77,94)(H,80,95)(H,81,96)(H,82,97)(H,83,99)(H,84,98)(H,85,103)(H,86,104)(H,87,102)(H,88,100)(H,89,101)/t42-,43-,52-,54-,55-,56+,57+,58+,59+,60+,61+,62-,63-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50100724
PNG
(CHEMBL408654 | Des-AA1,2,5-[DTrp8,IAmp9,Tyr11]-Cbm...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCNC(N)=O)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)cc1
Show InChI InChI=1S/C75H97N15O17S2/c1-41(2)79-36-48-24-22-46(23-25-48)33-57-69(100)89-62(42(3)92)72(103)86-58(34-47-26-28-50(94)29-27-47)70(101)90-63(43(4)93)73(104)87-60(38-91)71(102)88-61(74(105)106)40-109-108-39-52(76)64(95)81-54(21-13-14-30-78-75(77)107)65(96)82-55(31-44-15-7-5-8-16-44)66(97)83-56(32-45-17-9-6-10-18-45)67(98)85-59(68(99)84-57)35-49-37-80-53-20-12-11-19-51(49)53/h5-12,15-20,22-29,37,41-43,52,54-63,79-80,91-94H,13-14,21,30-36,38-40,76H2,1-4H3,(H,81,95)(H,82,96)(H,83,97)(H,84,99)(H,85,98)(H,86,103)(H,87,104)(H,88,102)(H,89,100)(H,90,101)(H,105,106)(H3,77,78,107)/t42-,43-,52-,54-,55-,56+,57+,58+,59-,60+,61+,62-,63-/m1/s1
KEGG

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n/an/a 8.10n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) recept...


J Med Chem 44: 2238-46 (2001)


Article DOI: 10.1021/jm010037+
BindingDB Entry DOI: 10.7270/Q21R6PSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50294229
PNG
((4R,7S,10S,13R,16S,19S)-19-((S)-2-amino-3-(4-hydro...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(N)=O)NC(=O)[C@@H](N)Cc2ccc(O)cc2)N(C)C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C73H79N11O10S2/c1-44(2)76-41-49-24-22-48(23-25-49)38-60-67(88)78-59(36-45-14-6-4-7-15-45)68(89)82-63(70(91)77-58(64(75)86)39-50-26-29-51-18-10-12-20-53(51)34-50)43-96-95-42-62(81-66(87)57(74)35-47-27-32-56(85)33-28-47)71(92)79-61(37-46-16-8-5-9-17-46)69(90)83-65(72(93)80-60)84(3)73(94)55-31-30-52-19-11-13-21-54(52)40-55/h4-34,40,44,57-63,65,76,85H,35-39,41-43,74H2,1-3H3,(H2,75,86)(H,77,91)(H,78,88)(H,79,92)(H,80,93)(H,81,87)(H,82,89)(H,83,90)/t57-,58-,59-,60-,61-,62+,63-,65+/m0/s1
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n/an/a 8.20n/an/an/an/an/an/a



The Clayton Foundation Laboratories for Peptide Biology

Curated by ChEMBL


Assay Description
Displacement of [125I]LTT-SRIF-28 from human sst1 receptor by autoradiography


J Med Chem 52: 2733-46 (2009)


Article DOI: 10.1021/jm801314f
BindingDB Entry DOI: 10.7270/Q2CV4JPR
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159402
PNG
(CHEMBL384855 | Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccc(O)cc3I)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(N)=O)cc1
Show InChI InChI=1S/C75H98IN15O15S2/c1-41(2)80-36-47-25-23-46(24-26-47)32-62-72(103)90-64(43(4)94)73(104)85-58(33-48-27-28-50(95)35-52(48)76)70(101)89-63(42(3)93)74(105)87-60(38-92)71(102)88-61(65(79)96)40-108-107-39-53(78)66(97)82-55(22-14-15-29-77)67(98)83-56(30-44-16-8-6-9-17-44)68(99)84-57(31-45-18-10-7-11-19-45)69(100)86-59(75(106)91(62)5)34-49-37-81-54-21-13-12-20-51(49)54/h6-13,16-21,23-28,35,37,41-43,53,55-64,80-81,92-95H,14-15,22,29-34,36,38-40,77-78H2,1-5H3,(H2,79,96)(H,82,97)(H,83,98)(H,84,99)(H,85,104)(H,86,100)(H,87,105)(H,88,102)(H,89,101)(H,90,103)/t42-,43-,53-,55-,56-,57+,58+,59+,60+,61+,62+,63-,64-/m1/s1
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PubMed
n/an/a 8.5n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159419
PNG
(CHEMBL262379 | Des-AA1,2,5-[D-Trp8,Tyr11]SRIF)
Show SMILES C[C@@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C67H90N14O16S2/c1-37(83)55-65(94)77-51(31-41-23-25-43(85)26-24-41)63(92)81-56(38(2)84)66(95)78-53(34-82)64(93)79-54(67(96)97)36-99-98-35-45(70)57(86)72-47(21-11-13-27-68)58(87)74-49(29-39-15-5-3-6-16-39)60(89)75-50(30-40-17-7-4-8-18-40)61(90)76-52(32-42-33-71-46-20-10-9-19-44(42)46)62(91)73-48(59(88)80-55)22-12-14-28-69/h3-10,15-20,23-26,33,37-38,45,47-56,71,82-85H,11-14,21-22,27-32,34-36,68-70H2,1-2H3,(H,72,86)(H,73,91)(H,74,87)(H,75,89)(H,76,90)(H,77,94)(H,78,95)(H,79,93)(H,80,88)(H,81,92)(H,96,97)/t37-,38-,45-,47-,48+,49-,50+,51+,52+,53+,54+,55-,56-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
Somatostatin receptor type 1


(Homo sapiens (Human))
BDBM50159405
PNG
(CHEMBL425465 | Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9...)
Show SMILES CC(C)NCc1ccc(C[C@@H]2N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)cc1
Show InChI InChI=1S/C75H98N14O15S2/c1-43(2)78-38-50-30-28-49(29-31-50)36-62-71(99)88-64(45(4)92)72(100)83-58(35-48-23-13-8-14-24-48)69(97)87-63(44(3)91)73(101)85-60(40-90)70(98)86-61(75(103)104)42-106-105-41-53(77)65(93)80-55(27-17-18-32-76)66(94)81-56(33-46-19-9-6-10-20-46)67(95)82-57(34-47-21-11-7-12-22-47)68(96)84-59(74(102)89(62)5)37-51-39-79-54-26-16-15-25-52(51)54/h6-16,19-26,28-31,39,43-45,53,55-64,78-79,90-92H,17-18,27,32-38,40-42,76-77H2,1-5H3,(H,80,93)(H,81,94)(H,82,95)(H,83,100)(H,84,96)(H,85,101)(H,86,98)(H,87,97)(H,88,99)(H,103,104)/t44-,45-,53-,55-,56-,57+,58+,59+,60+,61+,62+,63-,64-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of [Leu8,D-Trp22,125I-Tyr25]SRIF-28 binding to human somatostatin receptor type 1


J Med Chem 48: 507-14 (2005)


Article DOI: 10.1021/jm049520l
BindingDB Entry DOI: 10.7270/Q2QR4WNH
More data for this
Ligand-Target Pair
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