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Compile Data Set for Download or QSAR

Found 5407 hits of ic50 for UniProtKB: A0A024R759   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50021574
PNG
(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 0.0190n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297394
PNG
(CHEMBL4171115)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)c(F)c3)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C33H32F3N5O5S/c1-44-28-17-21-26(18-29(28)45-15-5-14-40-12-2-3-13-40)37-11-10-27(21)46-20-8-9-25(24(36)16-20)38-33(43)39-41-30(42)19-47-32(41)31-22(34)6-4-7-23(31)35/h4,6-11,16-18,32H,2-3,5,12-15,19H2,1H3,(H2,38,39,43)
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n/an/a 0.0210n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297565
PNG
(CHEMBL4160512)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)cc3F)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C33H32F3N5O5S/c1-44-28-17-21-25(18-29(28)45-15-5-14-40-12-2-3-13-40)37-11-10-26(21)46-27-9-8-20(16-24(27)36)38-33(43)39-41-30(42)19-47-32(41)31-22(34)6-4-7-23(31)35/h4,6-11,16-18,32H,2-3,5,12-15,19H2,1H3,(H2,38,39,43)
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n/an/a 0.0300n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297346
PNG
(CHEMBL4167741)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)cc3)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C33H33F2N5O5S/c1-43-28-18-23-26(19-29(28)44-17-5-16-39-14-2-3-15-39)36-13-12-27(23)45-22-10-8-21(9-11-22)37-33(42)38-40-30(41)20-46-32(40)31-24(34)6-4-7-25(31)35/h4,6-13,18-19,32H,2-3,5,14-17,20H2,1H3,(H2,37,38,42)
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n/an/a 0.0370n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297285
PNG
(CHEMBL4161786)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)cc3)ccnc2cc1OCCCN1CCCCC1C
Show InChI InChI=1S/C35H37F2N5O5S/c1-22-7-3-4-16-41(22)17-6-18-46-31-20-28-25(19-30(31)45-2)29(14-15-38-28)47-24-12-10-23(11-13-24)39-35(44)40-42-32(43)21-48-34(42)33-26(36)8-5-9-27(33)37/h5,8-15,19-20,22,34H,3-4,6-7,16-18,21H2,1-2H3,(H2,39,40,44)
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n/an/a 0.0460n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296469
PNG
(CHEMBL4166652)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H33F2N5O6S/c1-43-28-18-23-26(19-29(28)45-15-3-12-39-13-16-44-17-14-39)36-11-10-27(23)46-22-8-6-21(7-9-22)37-33(42)38-40-30(41)20-47-32(40)31-24(34)4-2-5-25(31)35/h2,4-11,18-19,32H,3,12-17,20H2,1H3,(H2,37,38,42)
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n/an/a 0.0500n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297158
PNG
(CHEMBL4175371)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccccc4F)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H34FN5O6S/c1-42-29-19-25-27(20-30(29)44-16-4-13-38-14-17-43-18-15-38)35-12-11-28(25)45-23-9-7-22(8-10-23)36-33(41)37-39-31(40)21-46-32(39)24-5-2-3-6-26(24)34/h2-3,5-12,19-20,32H,4,13-18,21H2,1H3,(H2,36,37,41)
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n/an/a 0.0610n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296409
PNG
(CHEMBL4163825)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cc(F)cc4F)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H32F3N5O6S/c1-44-28-17-23-26(18-29(28)46-12-2-9-40-10-13-45-14-11-40)37-8-7-27(23)47-22-5-3-21(4-6-22)38-33(43)39-41-30(42)19-48-32(41)31-24(35)15-20(34)16-25(31)36/h3-8,15-18,32H,2,9-14,19H2,1H3,(H2,38,39,43)
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n/an/a 0.0940n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297512
PNG
(CHEMBL4174964)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccccc4)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H35N5O6S/c1-41-29-20-26-27(21-30(29)43-17-5-14-37-15-18-42-19-16-37)34-13-12-28(26)44-25-10-8-24(9-11-25)35-33(40)36-38-31(39)22-45-32(38)23-6-3-2-4-7-23/h2-4,6-13,20-21,32H,5,14-19,22H2,1H3,(H2,35,36,40)
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n/an/a 0.0970n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297344
PNG
(CHEMBL4175612)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)cc3)ccnc2cc1OCCCN1CC(C)CC(C)C1
Show InChI InChI=1S/C36H39F2N5O5S/c1-22-16-23(2)20-42(19-22)14-5-15-47-32-18-29-26(17-31(32)46-3)30(12-13-39-29)48-25-10-8-24(9-11-25)40-36(45)41-43-33(44)21-49-35(43)34-27(37)6-4-7-28(34)38/h4,6-13,17-18,22-23,35H,5,14-16,19-21H2,1-3H3,(H2,40,41,45)
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n/an/a 0.114n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.128n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146167
PNG
(CAPMATINIB | Capmatinib | INC-280 | INCB-28060 | N...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
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n/an/a 0.130n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50091353
PNG
(CHEMBL3582305)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H16FN7O/c1-24-21(31)16-6-5-15(11-17(16)23)19-12-26-22-28-27-20(30(22)29-19)10-13-4-7-18-14(9-13)3-2-8-25-18/h2-9,11-12H,10H2,1H3,(H,24,31)
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n/an/a 0.130n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometry


ACS Med Chem Lett 6: 507-12 (2015)


Article DOI: 10.1021/ml5004876
BindingDB Entry DOI: 10.7270/Q2QV3P79
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50297405
PNG
(CHEMBL4168185)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccc(F)cc4F)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H33F2N5O6S/c1-43-29-18-25-27(19-30(29)45-14-2-11-39-12-15-44-16-13-39)36-10-9-28(25)46-23-6-4-22(5-7-23)37-33(42)38-40-31(41)20-47-32(40)24-8-3-21(34)17-26(24)35/h3-10,17-19,32H,2,11-16,20H2,1H3,(H2,37,38,42)
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n/an/a 0.141n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296346
PNG
(CHEMBL4172427)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)cc3)ccnc2cc1OCCCN1CCSCC1
Show InChI InChI=1S/C33H33F2N5O5S2/c1-43-28-18-23-26(19-29(28)44-15-3-12-39-13-16-46-17-14-39)36-11-10-27(23)45-22-8-6-21(7-9-22)37-33(42)38-40-30(41)20-47-32(40)31-24(34)4-2-5-25(31)35/h2,4-11,18-19,32H,3,12-17,20H2,1H3,(H2,37,38,42)
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n/an/a 0.154n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296407
PNG
(CHEMBL4160448)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccccc4Cl)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H34ClN5O6S/c1-42-29-19-25-27(20-30(29)44-16-4-13-38-14-17-43-18-15-38)35-12-11-28(25)45-23-9-7-22(8-10-23)36-33(41)37-39-31(40)21-46-32(39)24-5-2-3-6-26(24)34/h2-3,5-12,19-20,32H,4,13-18,21H2,1H3,(H2,36,37,41)
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n/an/a 0.169n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50165469
PNG
(CHEMBL3797911)
Show SMILES COc1ccc2c(OCc3nnc4ncc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H16N6O2/c1-28-15-7-8-16-17(11-15)22-10-9-19(16)29-13-20-24-25-21-23-12-18(26-27(20)21)14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 0.190n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA


Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296471
PNG
(CHEMBL4160268)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccc(F)cc4)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H34FN5O6S/c1-42-29-19-26-27(20-30(29)44-16-2-13-38-14-17-43-18-15-38)35-12-11-28(26)45-25-9-7-24(8-10-25)36-33(41)37-39-31(40)21-46-32(39)22-3-5-23(34)6-4-22/h3-12,19-20,32H,2,13-18,21H2,1H3,(H2,36,37,41)
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n/an/a 0.196n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347672
PNG
(CHEMBL1802904)
Show SMILES CCN1CCC(CC1)n1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C26H30N6O3S/c1-4-31-11-9-22(10-12-31)32-17-20(16-28-32)19-13-24-25(27-15-19)8-6-18-5-7-21(14-23(18)26(24)33)29-36(34,35)30(2)3/h5-8,13-17,22,29H,4,9-12H2,1-3H3
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n/an/a 0.200n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
BindingDB Entry DOI: 10.7270/Q2X34ZFZ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384024
PNG
(CHEMBL2032280 | CHEMBL2079349)
Show SMILES Cc1c(O)ccc2nc(oc12)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-18(28)3-2-17-19(12)29-21(26-17)16-8-13(9-24-20(16)22)14-10-25-27(11-14)15-4-6-23-7-5-15/h2-3,8-11,15,23,28H,4-7H2,1H3,(H2,22,24)
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n/an/a 0.200n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM344393
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl...)
Show SMILES CC\C(=N/N(C(N)=O)c1ccc(Oc2ccnc3cc(OCCCN4CCCCC4)c(OC)cc23)c(F)c1)c1ccccc1
Show InChI InChI=1S/C34H38FN5O4/c1-3-28(24-11-6-4-7-12-24)38-40(34(36)41)25-13-14-31(27(35)21-25)44-30-15-16-37-29-23-33(32(42-2)22-26(29)30)43-20-10-19-39-17-8-5-9-18-39/h4,6-7,11-16,21-23H,3,5,8-10,17-20H2,1-2H3,(H2,36,41)/b38-28+
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n/an/a 0.200n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...


US Patent US9783499 (2017)


BindingDB Entry DOI: 10.7270/Q2DV1N1N
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99280
PNG
(US8497368, 72)
Show SMILES CC(=NNC(N)=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1
Show InChI InChI=1S/C17H14FN9O/c1-9(23-25-17(19)28)14-7-21-15-16(22-14)27(26-24-15)8-11-5-10-3-2-4-20-13(10)6-12(11)18/h2-7H,8H2,1H3,(H3,19,25,28)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99254
PNG
(US8497368, 46)
Show SMILES C[C@H](c1nnc2ccc(nn12)C(C)=NNC(N)=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C19H18N8O/c1-11(13-5-6-16-14(10-13)4-3-9-21-16)18-24-23-17-8-7-15(26-27(17)18)12(2)22-25-19(20)28/h3-11H,1-2H3,(H3,20,25,28)/t11-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99273
PNG
(US8497368, 65)
Show SMILES NC(=O)NNC(=N)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H14N10O/c17-13(22-24-16(18)27)12-7-20-14-15(21-12)26(25-23-14)8-9-3-4-11-10(6-9)2-1-5-19-11/h1-7H,8H2,(H2,17,22)(H3,18,24,27)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296399
PNG
(CHEMBL4175433)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(Cc5ccccc5)SCC4=O)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H37N5O6S/c1-42-30-21-27-28(22-31(30)44-17-5-14-38-15-18-43-19-16-38)35-13-12-29(27)45-26-10-8-25(9-11-26)36-34(41)37-39-32(40)23-46-33(39)20-24-6-3-2-4-7-24/h2-4,6-13,21-22,33H,5,14-20,23H2,1H3,(H2,36,37,41)
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n/an/a 0.205n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50165465
PNG
(CHEMBL3797579)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H11F3N6/c21-15-6-3-12(4-7-15)17-11-25-19-27-26-18(29(19)28-17)20(22,23)14-5-8-16-13(10-14)2-1-9-24-16/h1-11H
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n/an/a 0.240n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA


Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50242005
PNG
(CHEMBL4104884)
Show SMILES CC(c1c(F)cc2ncc(cc2c1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1ccc(C(N)=O)c(F)c1
Show InChI InChI=1S/C26H18F3N9O/c1-12(22-19(28)7-20-17(23(22)29)5-14(8-31-20)15-9-33-37(2)11-15)38-26-25(35-36-38)32-10-21(34-26)13-3-4-16(24(30)39)18(27)6-13/h3-12H,1-2H3,(H2,30,39)
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n/an/a 0.300n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...


Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50242000
PNG
(CHEMBL4061378)
Show SMILES CC(c1ccc2ncc(cc2c1)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1ccncc1
Show InChI InChI=1S/C24H19N9/c1-15(33-24-23(30-31-33)27-13-22(29-24)16-5-7-25-8-6-16)17-3-4-21-18(9-17)10-19(11-26-21)20-12-28-32(2)14-20/h3-15H,1-2H3
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n/an/a 0.300n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...


Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99274
PNG
(US8497368, 66)
Show SMILES NC(=O)NN=Cc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H13N9O/c17-16(26)23-20-8-12-7-19-14-15(21-12)25(24-22-14)9-10-3-4-13-11(6-10)2-1-5-18-13/h1-8H,9H2,(H3,17,23,26)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99248
PNG
(US8497368, 40)
Show SMILES CC(=NNC(N)=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C18H14F2N8O/c1-9(23-26-18(21)29)13-4-5-15-24-25-16(28(15)27-13)7-11-12(19)8-14-10(17(11)20)3-2-6-22-14/h2-6,8H,7H2,1H3,(H3,21,26,29)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296750
PNG
(CHEMBL4164749)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4cccc(F)c4)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H34FN5O6S/c1-42-29-19-26-27(20-30(29)44-15-3-12-38-13-16-43-17-14-38)35-11-10-28(26)45-25-8-6-24(7-9-25)36-33(41)37-39-31(40)21-46-32(39)22-4-2-5-23(34)18-22/h2,4-11,18-20,32H,3,12-17,21H2,1H3,(H2,36,37,41)
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n/an/a 0.308n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296402
PNG
(CHEMBL4166841)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccncc4)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C32H34N6O6S/c1-41-28-19-25-26(20-29(28)43-16-2-13-37-14-17-42-18-15-37)34-12-9-27(25)44-24-5-3-23(4-6-24)35-32(40)36-38-30(39)21-45-31(38)22-7-10-33-11-8-22/h3-12,19-20,31H,2,13-18,21H2,1H3,(H2,35,36,40)
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n/an/a 0.320n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432878
PNG
(CHEMBL2376640)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)NC1CCOCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C19H19Cl2FN2O4/c1-10(16-14(20)2-3-15(22)17(16)21)28-12-8-13(18(25)23-9-12)19(26)24-11-4-6-27-7-5-11/h2-3,8-11H,4-7H2,1H3,(H,23,25)(H,24,26)/t10-/m1/s1
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n/an/a 0.320n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296398
PNG
(CHEMBL4164120)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(CCc5ccccc5)SCC4=O)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C35H39N5O6S/c1-43-31-22-28-29(23-32(31)45-19-5-16-39-17-20-44-21-18-39)36-15-14-30(28)46-27-11-9-26(10-12-27)37-35(42)38-40-33(41)24-47-34(40)13-8-25-6-3-2-4-7-25/h2-4,6-7,9-12,14-15,22-23,34H,5,8,13,16-21,24H2,1H3,(H2,37,38,42)
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n/an/a 0.331n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296470
PNG
(CHEMBL4177280)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccc(F)c(F)c4)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H33F2N5O6S/c1-43-29-18-24-27(19-30(29)45-14-2-11-39-12-15-44-16-13-39)36-10-9-28(24)46-23-6-4-22(5-7-23)37-33(42)38-40-31(41)20-47-32(40)21-3-8-25(34)26(35)17-21/h3-10,17-19,32H,2,11-16,20H2,1H3,(H2,37,38,42)
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n/an/a 0.337n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296408
PNG
(CHEMBL4168353)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccc(Cl)cc4)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H34ClN5O6S/c1-42-29-19-26-27(20-30(29)44-16-2-13-38-14-17-43-18-15-38)35-12-11-28(26)45-25-9-7-24(8-10-25)36-33(41)37-39-31(40)21-46-32(39)22-3-5-23(34)6-4-22/h3-12,19-20,32H,2,13-18,21H2,1H3,(H2,36,37,41)
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n/an/a 0.348n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50296404
PNG
(CHEMBL4175145)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4ccccc4C(F)(F)F)cc3)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F3N5O6S/c1-45-29-19-25-27(20-30(29)47-16-4-13-41-14-17-46-18-15-41)38-12-11-28(25)48-23-9-7-22(8-10-23)39-33(44)40-42-31(43)21-49-32(42)24-5-2-3-6-26(24)34(35,36)37/h2-3,5-12,19-20,32H,4,13-18,21H2,1H3,(H2,39,40,44)
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n/an/a 0.358n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.061
BindingDB Entry DOI: 10.7270/Q2BP059Q
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin)


Eur J Med Chem 158: 814-831 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.050
BindingDB Entry DOI: 10.7270/Q25H7JZ5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human full length MET by scintillation counting method in presence of 33P-gammaATP


J Med Chem 59: 3593-608 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01273
BindingDB Entry DOI: 10.7270/Q24M96FS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to...


Eur J Med Chem 123: 431-446 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.059
BindingDB Entry DOI: 10.7270/Q2KK9DR0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of NH2-terminal His-tagged MET kinase domain (1051 to 1348 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells p...


J Med Chem 59: 8712-8756 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00472
BindingDB Entry DOI: 10.7270/Q29G5PR8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)


Eur J Med Chem 64: 62-73 (2013)


Article DOI: 10.1016/j.ejmech.2013.04.001
BindingDB Entry DOI: 10.7270/Q27082SZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146167
PNG
(CAPMATINIB | Capmatinib | INC-280 | INCB-28060 | N...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
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n/an/a 0.400n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...


Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50242011
PNG
(CHEMBL4070258)
Show SMILES CC(c1c(F)cc2ncc(cc2c1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C24H20F2N10O/c1-13(36-24-23(32-33-36)28-10-20(31-24)16-9-30-35(12-16)3-4-37)21-18(25)6-19-17(22(21)26)5-14(7-27-19)15-8-29-34(2)11-15/h5-13,37H,3-4H2,1-2H3
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n/an/a 0.400n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity by displacement of [3H]- DAMPGO from opioid receptor mu by using opioid radioligand binding assay


Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50242021
PNG
(CHEMBL4097173)
Show SMILES CC(c1c(F)cc2ncc(cc2c1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1cnn(C)c1
Show InChI InChI=1S/C23H18F2N10/c1-12(35-23-22(31-32-35)27-9-19(30-23)15-8-29-34(3)11-15)20-17(24)5-18-16(21(20)25)4-13(6-26-18)14-7-28-33(2)10-14/h4-12H,1-3H3
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n/an/a 0.400n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...


Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99228
PNG
(US8497368, 20)
Show SMILES CC(=NNC(N)=O)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C19H15F2N7O/c1-10(25-26-19(22)29)15-4-5-17-24-9-11(28(17)27-15)7-13-14(20)8-16-12(18(13)21)3-2-6-23-16/h2-6,8-9H,7H2,1H3,(H3,22,26,29)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99238
PNG
(US8497368, 30)
Show SMILES C[C@H](c1cnc2ccc(nn12)C(C)=NNC(N)=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H19N7O/c1-12(14-5-6-17-15(10-14)4-3-9-22-17)18-11-23-19-8-7-16(26-27(18)19)13(2)24-25-20(21)28/h3-12H,1-2H3,(H3,21,25,28)/t12-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM99281
PNG
(US8497368, 73)
Show SMILES CC(=O)NN=C(C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1
Show InChI InChI=1S/C18H15FN8O/c1-10(23-24-11(2)28)16-8-21-17-18(22-16)27(26-25-17)9-13-6-12-4-3-5-20-15(12)7-14(13)19/h3-8H,9H2,1-2H3,(H,24,28)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM100728
PNG
(US8507676, 78)
Show SMILES CC(N=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C17H12F2N6O/c1-9(24-26)13-4-5-15-21-22-16(25(15)23-13)7-11-12(18)8-14-10(17(11)19)3-2-6-20-14/h2-6,8-9H,7H2,1H3
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Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...


US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)


Eur J Med Chem 80: 254-66 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.056
BindingDB Entry DOI: 10.7270/Q2930VQ6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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