Compile Data Set for Download or QSAR
maximum 50k data
Found 194 of ec50 for UniProtKB: Q16665
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332051((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
Affinity DataEC50:  130nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332034((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3- trif...)
Affinity DataEC50:  170nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393295(CHEMBL2135309)
Affinity DataEC50:  500nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332048((E)-N'-(4-N,N-diethylamino- 2-hydroxybenzal)-2-{N-...)
Affinity DataEC50:  530nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332038((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(4-isopr...)
Affinity DataEC50:  560nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332033((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Affinity DataEC50:  600nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393292(CHEMBL2138065 | cid_46742345)
Affinity DataEC50:  600nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332041((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Affinity DataEC50:  760nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332031((E)-N'-(4-N,N- diethylamino-2- hydroxybenzal)-2-{N...)
Affinity DataEC50:  780nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332035((E)-N'-[(3-ethoxy-2- hydroxybenzal)methylene]- 2-{...)
Affinity DataEC50:  800nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332042((E)-N'-(2,3- dihydroxybenzal)-2-{N-{2- [N-(3-metho...)
Affinity DataEC50:  820nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332030((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Affinity DataEC50:  830nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332044((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Affinity DataEC50:  980nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332036((E)-N'-[(2- hydroxynaphthalen-1- yl)methylene]-2-{...)
Affinity DataEC50:  1.02E+3nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393296(CHEMBL2144958)
Affinity DataEC50:  1.12E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393292(CHEMBL2138065 | cid_46742345)
Affinity DataEC50:  1.12E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393282(CHEMBL2139663)
Affinity DataEC50:  1.19E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482301(US10919843, Compound X)
Affinity DataEC50:  1.20E+3nMAssay Description:HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393284(CHEMBL2132069)
Affinity DataEC50:  1.20E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393296(CHEMBL2144958)
Affinity DataEC50:  1.40E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482300(US10919843, Compound IX)
Affinity DataEC50:  1.40E+3nMAssay Description:HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482299(US10919843, Compound VIII)
Affinity DataEC50:  1.40E+3nMAssay Description:HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393289(CHEMBL2137226)
Affinity DataEC50:  1.49E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM271481(2-(7-(2-chloro-4-fluorophenoxy)-4-hydroxy-1-methyl...)
Affinity DataEC50:  1.51E+3nMAssay Description:The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482295(US10919843, Compound IV)
Affinity DataEC50:  1.60E+3nMAssay Description:HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393296(CHEMBL2144958)
Affinity DataEC50:  1.63E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM271462(2-(4-hydroxy-1-methyl-7-(naphthalen-2-yloxy)-2-oxo...)
Affinity DataEC50:  1.63E+3nMAssay Description:The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482294(US10919843, Compound III)
Affinity DataEC50:  1.70E+3nMAssay Description:HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393292(CHEMBL2138065 | cid_46742345)
Affinity DataEC50:  1.71E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482296(US10919843, Compound V)
Affinity DataEC50:  1.80E+3nMAssay Description:NIH3T3-EPO-luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393288(CHEMBL2142554)
Affinity DataEC50:  1.85E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332050((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2-[N- (4-...)
Affinity DataEC50:  1.86E+3nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393284(CHEMBL2132069)
Affinity DataEC50:  1.88E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482296(US10919843, Compound V)
Affinity DataEC50:  1.90E+3nMAssay Description:HaCaT-EPO-Luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM271483(2-(7-(2,3-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Affinity DataEC50:  1.97E+3nMAssay Description:The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393283(CHEMBL2144203)
Affinity DataEC50:  2.06E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332029((E)-N'-(3-ethoxy-2- hydroxybenzal)-2-{N-{2- [N-(na...)
Affinity DataEC50:  2.11E+3nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM271488(2-(7-(2,5-dichlorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Affinity DataEC50:  2.25E+3nMAssay Description:The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM271472(2-(7-(2,5-difluorophenoxy)-4-hydroxy-1-methyl-2-ox...)
Affinity DataEC50:  2.26E+3nMAssay Description:The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332039((E)-N'-(3-bromo-6- hydroxybenzal)-2-{N-{2- [N-(4-i...)
Affinity DataEC50:  2.28E+3nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM332027((E)-N'-(3-methoxy-2- hydroxybenzal)-2-{N-{2-[N- (n...)
Affinity DataEC50:  2.29E+3nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393288(CHEMBL2142554)
Affinity DataEC50:  2.30E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393289(CHEMBL2137226)
Affinity DataEC50:  2.33E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393281(CHEMBL2139973)
Affinity DataEC50:  2.39E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393300(CHEMBL2130568)
Affinity DataEC50:  2.46E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393301(CHEMBL2141722)
Affinity DataEC50:  2.48E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393295(CHEMBL2135309)
Affinity DataEC50:  2.49E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM482300(US10919843, Compound IX)
Affinity DataEC50:  2.50E+3nMAssay Description:NIH3T3-EPO-luc cells were maintained at 37° C. in a humidified atmosphere containing 5% CO2 in DMEM supplemented with 10% fetal calf serum (FBS), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM271463(2-(4-hydroxy-1-methyl-6-(naphthalen-2-yloxy)-2-oxo...)
Affinity DataEC50:  2.52E+3nMAssay Description:The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50393283(CHEMBL2144203)
Affinity DataEC50:  2.55E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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