TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated trans-2-octenoyl N-acetylcysteamine (t-o-NAC thioester) substrate reduction assessed as decrease in...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of HIF-1alpha in human U373 cellsMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Activation of HIF1 in human T47D cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells under hypoxia condition by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 6.76nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 6.76nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 10.7nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Activation of HIF1 in human T47D cellsMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Activation of HIF1 in human T47D cellsMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: >30nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of HIF-1alpha-mediated VEGF expression in human Hep3b cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Binding affinity to Cys255 residue of C-terminal Avi/FLAG-tagged HIF-1alpha (unknown origin) after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of HIF-1alpha-mediated VEGF secretion in human Hep3b cells by ELISAMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human Hep3B cells co-transfected with luciferase reporter plasmid containing six ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Korean Research Institute Of Biosciences And Biotechnology
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair