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Compile Data Set for Download or QSAR

Found 346 hits of ic50 for UniProtKB: Q16665   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058752
PNG
(CHEMBL3335630)
Show SMILES COCCOCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1
Show InChI InChI=1S/C41H50N4O3/c1-30-26-44(27-33-7-12-39(42-25-33)29-48-18-17-47-2)15-16-45(30)28-32-3-8-37(9-4-32)40(46)43-38-10-5-31(6-11-38)13-14-41-22-34-19-35(23-41)21-36(20-34)24-41/h3-12,25,30,34-36H,15-24,26-29H2,1-2H3,(H,43,46)/t30-,34?,35?,36?,41?/m0/s1
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n/an/a 0.470n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1 alpha


(Homo sapiens (Human))
BDBM50179011
PNG
(CHEMBL380456 | Moracin P)
Show SMILES CC1(C)Oc2cc3oc(cc3cc2CC1O)-c1cc(O)cc(O)c1
Show InChI InChI=1S/C19H18O5/c1-19(2)18(22)7-11-3-10-6-15(23-16(10)9-17(11)24-19)12-4-13(20)8-14(21)5-12/h3-6,8-9,18,20-22H,7H2,1-2H3
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n/an/a 0.650n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus FabI-mediated trans-2-octenoyl N-acetylcysteamine (t-o-NAC thioester) substrate reduction assessed as decrease in...


Eur J Med Chem 90: 379-93 (2015)


Article DOI: 10.1016/j.ejmech.2014.11.047
BindingDB Entry DOI: 10.7270/Q2GF0W5F
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058757
PNG
(CHEMBL3335423)
Show SMILES O=C(Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C36H40N4O/c41-35(33-7-3-28(4-8-33)25-39-14-16-40(17-15-39)26-29-2-1-13-37-24-29)38-34-9-5-27(6-10-34)11-12-36-21-30-18-31(22-36)20-32(19-30)23-36/h1-10,13,24,30-32H,14-23,25-26H2,(H,38,41)
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n/an/a 0.970n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346783
PNG
(CHEMBL1795446)
Show SMILES CC(C)(O)[C@H]1Cc2cc3cc(oc3cc2O1)-c1ccc(O)cc1
Show InChI InChI=1S/C19H18O4/c1-19(2,21)18-9-13-7-12-8-15(11-3-5-14(20)6-4-11)22-16(12)10-17(13)23-18/h3-8,10,18,20-21H,9H2,1-2H3/t18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058753
PNG
(CHEMBL3335427)
Show SMILES COCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1
Show InChI InChI=1S/C39H46N4O2/c1-28-24-42(25-31-7-12-37(27-45-2)40-23-31)15-16-43(28)26-30-3-8-35(9-4-30)38(44)41-36-10-5-29(6-11-36)13-14-39-20-32-17-33(21-39)19-34(18-32)22-39/h3-12,23,28,32-34H,15-22,24-27H2,1-2H3,(H,41,44)/t28-,32?,33?,34?,39?/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058754
PNG
(CHEMBL3335426)
Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C37H42N4O/c1-27-24-40(25-30-3-2-14-38-23-30)15-16-41(27)26-29-4-8-34(9-5-29)36(42)39-35-10-6-28(7-11-35)12-13-37-20-31-17-32(21-37)19-33(18-31)22-37/h2-11,14,23,27,31-33H,15-22,24-26H2,1H3,(H,39,42)/t27-,31?,32?,33?,37?/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50401029
PNG
(CHEMBL2205734)
Show SMILES Cc1cc(nn1Cc1ccc(C)cc1)-c1nc2cc(ccc2[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H21ClN4/c1-16-3-5-18(6-4-16)15-30-17(2)13-24(29-30)25-27-22-12-9-20(14-23(22)28-25)19-7-10-21(26)11-8-19/h3-14H,15H2,1-2H3,(H,27,28)
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n/an/a 3n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of HIF-1alpha in human HCT116 cells under hypoxia condition by HRE-luciferase reporter gene assay


Eur J Med Chem 49: 24-40 (2012)


Article DOI: 10.1016/j.ejmech.2012.01.033
BindingDB Entry DOI: 10.7270/Q26D5V4N
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058760
PNG
(CHEMBL3335421)
Show SMILES O=C(Nc1ccc(cc1)C#CC1CCCCC1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C32H36N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h4,7,10-18,23,26H,1-3,5-6,19-22,24-25H2,(H,34,37)
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n/an/a 3.10n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058766
PNG
(CHEMBL3335415)
Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346783
PNG
(CHEMBL1795446)
Show SMILES CC(C)(O)[C@H]1Cc2cc3cc(oc3cc2O1)-c1ccc(O)cc1
Show InChI InChI=1S/C19H18O4/c1-19(2,21)18-9-13-7-12-8-15(11-3-5-14(20)6-4-11)22-16(12)10-17(13)23-18/h3-8,10,18,20-21H,9H2,1-2H3/t18-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058755
PNG
(CHEMBL3335425)
Show SMILES Nc1ncccc1C(=O)N1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C#CC23CC4CC(CC(C4)C2)C3)CC1
Show InChI InChI=1S/C36H39N5O2/c37-33-32(2-1-13-38-33)35(43)41-16-14-40(15-17-41)24-26-3-7-30(8-4-26)34(42)39-31-9-5-25(6-10-31)11-12-36-21-27-18-28(22-36)20-29(19-27)23-36/h1-10,13,27-29H,14-24H2,(H2,37,38)(H,39,42)
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n/an/a 5.80n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50179013
PNG
(CHEMBL205924 | moracin O)
Show SMILES CC(C)(O)C1Cc2cc3cc(oc3cc2O1)-c1cc(O)cc(O)c1
Show InChI InChI=1S/C19H18O5/c1-19(2,22)18-7-11-3-10-6-15(23-16(10)9-17(11)24-18)12-4-13(20)8-14(21)5-12/h3-6,8-9,18,20-22H,7H2,1-2H3
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n/an/a 6.76n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346796
PNG
(CHEMBL1795432)
Show SMILES CC(C)(O)[C@H]1Cc2cc3cc(oc3cc2O1)-c1cc(O)cc(O)c1
Show InChI InChI=1S/C19H18O5/c1-19(2,22)18-7-11-3-10-6-15(23-16(10)9-17(11)24-18)12-4-13(20)8-14(21)5-12/h3-6,8-9,18,20-22H,7H2,1-2H3/t18-/m1/s1
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n/an/a 6.76n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346790
PNG
(CHEMBL1795439)
Show SMILES COc1cccc(c1)-c1cc2cc3CC(Oc3cc2o1)C(C)(C)O
Show InChI InChI=1S/C20H20O4/c1-20(2,21)19-10-14-7-13-9-16(23-17(13)11-18(14)24-19)12-5-4-6-15(8-12)22-3/h4-9,11,19,21H,10H2,1-3H3
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n/an/a 7n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058770
PNG
(CHEMBL3335411)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccncc4)CC3)cc2)cc1
Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-5-7-23(8-6-22)30-24(33)21-3-1-19(2-4-21)17-31-13-15-32(16-14-31)18-20-9-11-29-12-10-20/h1-12H,13-18H2,(H,30,33)
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n/an/a 7.90n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058762
PNG
(CHEMBL3335419)
Show SMILES O=C(Nc1ccc(cc1)C#Cc1ccccc1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C32H30N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h1-7,10-18,23H,19-22,24-25H2,(H,34,37)
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n/an/a 7.90n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346795
PNG
(CHEMBL1795433)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cc3CC(Oc3cc2o1)C(C)(C)O
Show InChI InChI=1S/C21H22O5/c1-21(2,22)20-9-13-5-12-8-17(25-18(12)11-19(13)26-20)14-6-15(23-3)10-16(7-14)24-4/h5-8,10-11,20,22H,9H2,1-4H3
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n/an/a 10n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50179011
PNG
(CHEMBL380456 | Moracin P)
Show SMILES CC1(C)Oc2cc3oc(cc3cc2CC1O)-c1cc(O)cc(O)c1
Show InChI InChI=1S/C19H18O5/c1-19(2)18(22)7-11-3-10-6-15(23-16(10)9-17(11)24-19)12-4-13(20)8-14(21)5-12/h3-6,8-9,18,20-22H,7H2,1-2H3
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n/an/a 10.7n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058765
PNG
(CHEMBL3335416)
Show SMILES C[C@@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058771
PNG
(CHEMBL3335410)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccccc4)CC3)cc2)cc1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)23-10-12-24(13-11-23)30-25(33)22-8-6-21(7-9-22)19-32-16-14-31(15-17-32)18-20-4-2-1-3-5-20/h1-13H,14-19H2,(H,30,33)
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n/an/a 13n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058768
PNG
(CHEMBL3335413)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4cccnc4)CC3)cc2)cc1
Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-7-9-23(10-8-22)30-24(33)21-5-3-19(4-6-21)17-31-12-14-32(15-13-31)18-20-2-1-11-29-16-20/h1-11,16H,12-15,17-18H2,(H,30,33)
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n/an/a 14n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50426548
PNG
(CHEMBL2323956)
Show SMILES C1c2ccccc2-c2n[nH]c(Nc3ccc4OCCOc4c3)c12
Show InChI InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21)
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n/an/a 14n/an/an/an/an/an/a



Gakushuin University

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...


ACS Med Chem Lett 4: 297-301 (2013)


Article DOI: 10.1021/ml3004632
BindingDB Entry DOI: 10.7270/Q2R212P9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058756
PNG
(CHEMBL3335424)
Show SMILES Nc1ncccc1C(=O)N1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C#Cc2ccccc2)CC1
Show InChI InChI=1S/C32H29N5O2/c33-30-29(7-4-18-34-30)32(39)37-21-19-36(20-22-37)23-26-10-14-27(15-11-26)31(38)35-28-16-12-25(13-17-28)9-8-24-5-2-1-3-6-24/h1-7,10-18H,19-23H2,(H2,33,34)(H,35,38)
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n/an/a 21n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058764
PNG
(CHEMBL3335417)
Show SMILES C[C@@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1
Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(13-14-33(19)18-21-3-2-12-30-15-21)17-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346784
PNG
(CHEMBL1795445)
Show SMILES Cn1cncc1-c1cc2cc3CC(Oc3cc2o1)C(C)(C)O
Show InChI InChI=1S/C17H18N2O3/c1-17(2,20)16-6-11-4-10-5-15(12-8-18-9-19(12)3)21-13(10)7-14(11)22-16/h4-5,7-9,16,20H,6H2,1-3H3
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n/an/a>30n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50426547
PNG
(CHEMBL2323957)
Show SMILES COc1cccc-2c1Cc1c(Nc3ccc4OCCOc4c3)[nH]nc-21
Show InChI InChI=1S/C19H17N3O3/c1-23-15-4-2-3-12-13(15)10-14-18(12)21-22-19(14)20-11-5-6-16-17(9-11)25-8-7-24-16/h2-6,9H,7-8,10H2,1H3,(H2,20,21,22)
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n/an/a 34n/an/an/an/an/an/a



Gakushuin University

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...


ACS Med Chem Lett 4: 297-301 (2013)


Article DOI: 10.1021/ml3004632
BindingDB Entry DOI: 10.7270/Q2R212P9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058761
PNG
(CHEMBL3335420)
Show SMILES O=C(Nc1ccc(cc1)C#Cc1cccnc1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1
Show InChI InChI=1S/C31H29N5O/c37-31(34-30-13-9-25(10-14-30)5-6-26-3-1-15-32-21-26)29-11-7-27(8-12-29)23-35-17-19-36(20-18-35)24-28-4-2-16-33-22-28/h1-4,7-16,21-22H,17-20,23-24H2,(H,34,37)
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n/an/a 34n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058763
PNG
(CHEMBL3335418)
Show SMILES C[C@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1
Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(13-14-33(19)18-21-3-2-12-30-15-21)17-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50315537
PNG
(CHEMBL1089316 | chaetocin)
Show SMILES CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21
Show InChI InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3/t19-,20-,25+,26+,27+,28+,29+,30+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of HIF-1alpha-mediated VEGF expression in human Hep3b cells by luciferase reporter gene assay


Eur J Med Chem 49: 24-40 (2012)


Article DOI: 10.1016/j.ejmech.2012.01.033
BindingDB Entry DOI: 10.7270/Q26D5V4N
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346794
PNG
(CHEMBL1795434)
Show SMILES CC(C)(O)C1Cc2cc3cc(oc3cc2O1)-c1cccc(O)c1
Show InChI InChI=1S/C19H18O4/c1-19(2,21)18-9-13-6-12-8-15(11-4-3-5-14(20)7-11)22-16(12)10-17(13)23-18/h3-8,10,18,20-21H,9H2,1-2H3
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n/an/a 46n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346788
PNG
(CHEMBL1795441)
Show SMILES CC(C)(O)C1Cc2cc3cc(oc3cc2O1)-c1ccccc1
Show InChI InChI=1S/C19H18O3/c1-19(2,20)18-10-14-8-13-9-15(12-6-4-3-5-7-12)21-16(13)11-17(14)22-18/h3-9,11,18,20H,10H2,1-2H3
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n/an/a 54n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346793
PNG
(CHEMBL1795436)
Show SMILES CCOC(=O)COc1ccc(cc1)-c1cc2cc3CC(Oc3cc2o1)C(C)(C)O
Show InChI InChI=1S/C23H24O6/c1-4-26-22(24)13-27-17-7-5-14(6-8-17)18-10-15-9-16-11-21(23(2,3)25)29-20(16)12-19(15)28-18/h5-10,12,21,25H,4,11,13H2,1-3H3
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n/an/a 54n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50008935
PNG
((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
Show InChI InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Piramal Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 6426-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.083
BindingDB Entry DOI: 10.7270/Q2HX1CXM
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50354121
PNG
(CHEMBL1836238)
Show SMILES CCOc1ccccc1-n1c(CN2CCNCC2)nc2ccccc2c1=O
Show InChI InChI=1S/C21H24N4O2/c1-2-27-19-10-6-5-9-18(19)25-20(15-24-13-11-22-12-14-24)23-17-8-4-3-7-16(17)21(25)26/h3-10,22H,2,11-15H2,1H3
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n/an/a 90n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay


Bioorg Med Chem Lett 21: 5239-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.043
BindingDB Entry DOI: 10.7270/Q2H70G65
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50315537
PNG
(CHEMBL1089316 | chaetocin)
Show SMILES CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21
Show InChI InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3/t19-,20-,25+,26+,27+,28+,29+,30+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of HIF-1alpha-mediated VEGF secretion in human Hep3b cells by ELISA


Eur J Med Chem 49: 24-40 (2012)


Article DOI: 10.1016/j.ejmech.2012.01.033
BindingDB Entry DOI: 10.7270/Q26D5V4N
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346789
PNG
(CHEMBL1795440)
Show SMILES COc1ccc(cc1)-c1cc2cc3CC(Oc3cc2o1)C(C)(C)O
Show InChI InChI=1S/C20H20O4/c1-20(2,21)19-10-14-8-13-9-16(23-17(13)11-18(14)24-19)12-4-6-15(22-3)7-5-12/h4-9,11,19,21H,10H2,1-3H3
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n/an/a 110n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058769
PNG
(CHEMBL3335412)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CC3CCN(Cc4ccncc4)CC3)cc2)cc1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)23-5-7-24(8-6-23)31-25(33)22-3-1-19(2-4-22)17-20-11-15-32(16-12-20)18-21-9-13-30-14-10-21/h1-10,13-14,20H,11-12,15-18H2,(H,31,33)
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n/an/a 110n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50400081
PNG
(CHEMBL2178399)
Show SMILES O=C(Nc1cccc(c1)C(=O)OCCN1CCOCC1)\C=C\Oc1ccc(cc1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C32H38N2O5/c35-30(33-28-3-1-2-26(19-28)31(36)39-15-11-34-9-13-37-14-10-34)8-12-38-29-6-4-27(5-7-29)32-20-23-16-24(21-32)18-25(17-23)22-32/h1-8,12,19,23-25H,9-11,13-18,20-22H2,(H,33,35)/b12-8+
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n/an/a 120n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assay


J Med Chem 55: 10564-71 (2012)


Article DOI: 10.1021/jm301419d
BindingDB Entry DOI: 10.7270/Q2QR4Z8D
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058767
PNG
(CHEMBL3335414)
Show SMILES CN(CCN(C)Cc1cccnc1)Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O/c1-31(14-15-32(2)18-20-4-3-13-29-16-20)17-19-5-7-21(8-6-19)24(33)30-23-11-9-22(10-12-23)25(26,27)28/h3-13,16H,14-15,17-18H2,1-2H3,(H,30,33)
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n/an/a 120n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50354120
PNG
(CHEMBL1836239)
Show SMILES CCOc1ccccc1-n1c(CN2CCCNCC2)nc2ccccc2c1=O
Show InChI InChI=1S/C22H26N4O2/c1-2-28-20-11-6-5-10-19(20)26-21(16-25-14-7-12-23-13-15-25)24-18-9-4-3-8-17(18)22(26)27/h3-6,8-11,23H,2,7,12-16H2,1H3
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n/an/a 160n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay


Bioorg Med Chem Lett 21: 5239-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.043
BindingDB Entry DOI: 10.7270/Q2H70G65
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058758
PNG
(CHEMBL3335422)
Show SMILES OC1(CCCCC1)C#Cc1ccc(NC(=O)c2ccc(CN3CCN(Cc4cccnc4)CC3)cc2)cc1
Show InChI InChI=1S/C32H36N4O2/c37-31(34-30-12-8-26(9-13-30)14-17-32(38)15-2-1-3-16-32)29-10-6-27(7-11-29)24-35-19-21-36(22-20-35)25-28-5-4-18-33-23-28/h4-13,18,23,38H,1-3,15-16,19-22,24-25H2,(H,34,37)
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n/an/a>200n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50354128
PNG
(CHEMBL1836179)
Show SMILES COc1ccc(cc1-n1c(CN2CCNCC2)nc2ccccc2c1=O)C(F)(F)F
Show InChI InChI=1S/C21H21F3N4O2/c1-30-18-7-6-14(21(22,23)24)12-17(18)28-19(13-27-10-8-25-9-11-27)26-16-5-3-2-4-15(16)20(28)29/h2-7,12,25H,8-11,13H2,1H3
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n/an/a 200n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay


Bioorg Med Chem Lett 21: 5239-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.043
BindingDB Entry DOI: 10.7270/Q2H70G65
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50226373
PNG
(1-(4-Amino-phenyl)-3-(3-benzo[1,3]dioxol-5-yl-4-ox...)
Show SMILES Nc1ccc(NC(=O)Nc2cccc3-c4[nH]nc(c4C(=O)c23)-c2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C24H17N5O4/c25-13-5-7-14(8-6-13)26-24(31)27-16-3-1-2-15-19(16)23(30)20-21(28-29-22(15)20)12-4-9-17-18(10-12)33-11-32-17/h1-10H,11,25H2,(H,28,29)(H2,26,27,31)
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n/an/a 214n/an/an/an/an/an/a



Gakushuin University

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...


ACS Med Chem Lett 4: 297-301 (2013)


Article DOI: 10.1021/ml3004632
BindingDB Entry DOI: 10.7270/Q2R212P9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058778
PNG
(CHEMBL3335403)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cn2)cc1
Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)14-2-4-15(5-3-14)23-17(25)16-6-1-13(11-22-16)12-24-7-9-26-10-8-24/h1-6,11H,7-10,12H2,(H,23,25)
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n/an/a 230n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50426549
PNG
(CHEMBL2323955)
Show SMILES C1Oc2ccc(Nc3[nH]nc-4c3Cc3ccccc-43)cc2O1
Show InChI InChI=1S/C17H13N3O2/c1-2-4-12-10(3-1)7-13-16(12)19-20-17(13)18-11-5-6-14-15(8-11)22-9-21-14/h1-6,8H,7,9H2,(H2,18,19,20)
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n/an/a 270n/an/an/an/an/an/a



Gakushuin University

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...


ACS Med Chem Lett 4: 297-301 (2013)


Article DOI: 10.1021/ml3004632
BindingDB Entry DOI: 10.7270/Q2R212P9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50058783
PNG
(CHEMBL3335135)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)16-5-7-17(8-6-16)23-18(25)15-3-1-14(2-4-15)13-24-9-11-26-12-10-24/h1-8H,9-13H2,(H,23,25)
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n/an/a 280n/an/an/an/an/an/a



Eisai Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay


Bioorg Med Chem 22: 5513-29 (2014)


Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346787
PNG
(CHEMBL1795442)
Show SMILES Cc1ccc(cc1)-c1cc2cc3CC(Oc3cc2o1)C(C)(C)O
Show InChI InChI=1S/C20H20O3/c1-12-4-6-13(7-5-12)16-9-14-8-15-10-19(20(2,3)21)23-18(15)11-17(14)22-16/h4-9,11,19,21H,10H2,1-3H3
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n/an/a 310n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50206613
PNG
(3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzo...)
Show SMILES OC(=O)c1cccc(NC(=O)COc2ccc(cc2)C23CC4CC(CC(C4)C2)C3)c1
Show InChI InChI=1S/C25H27NO4/c27-23(26-21-3-1-2-19(11-21)24(28)29)15-30-22-6-4-20(5-7-22)25-12-16-8-17(13-25)10-18(9-16)14-25/h1-7,11,16-18H,8-10,12-15H2,(H,26,27)(H,28,29)
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n/an/a 350n/an/an/an/an/an/a



Molecular Cancer Research Center

Curated by ChEMBL


Assay Description
Inhibition of hypoxia induced HIF1alpha transcriptional activity in human AGS cells by reporter gene assay


Bioorg Med Chem Lett 17: 6305-10 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.005
BindingDB Entry DOI: 10.7270/Q2PR7VQT
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50346786
PNG
(CHEMBL1795443)
Show SMILES CC(C)(O)C1Cc2cc3cc(oc3cc2O1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C19H16F2O3/c1-19(2,22)18-7-11-3-10-6-15(23-16(10)9-17(11)24-18)12-4-13(20)8-14(21)5-12/h3-6,8-9,18,22H,7H2,1-2H3
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n/an/a 360n/an/an/an/an/an/a



Dongguk University-Seoul

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assay


Eur J Med Chem 46: 2386-96 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.022
BindingDB Entry DOI: 10.7270/Q2WD40XF
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50206613
PNG
(3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzo...)
Show SMILES OC(=O)c1cccc(NC(=O)COc2ccc(cc2)C23CC4CC(CC(C4)C2)C3)c1
Show InChI InChI=1S/C25H27NO4/c27-23(26-21-3-1-2-19(11-21)24(28)29)15-30-22-6-4-20(5-7-22)25-12-16-8-17(13-25)10-18(9-16)14-25/h1-7,11,16-18H,8-10,12-15H2,(H,26,27)(H,28,29)
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n/an/a 400n/an/an/an/an/an/a



Molecular Cancer Research Center

Curated by ChEMBL


Assay Description
Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Hep3B cells by reporter gene assay


Bioorg Med Chem Lett 17: 6305-10 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.005
BindingDB Entry DOI: 10.7270/Q2PR7VQT
More data for this
Ligand-Target Pair
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