Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50001885![]() ((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | n/a | n/a | 0 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50180054![]() (CHEMBL199824 | [O-methyl-11C]2-{4-[4-(7-methoxynap...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation | J Med Chem 49: 125-34 (2006) Article DOI: 10.1021/jm050725j BindingDB Entry DOI: 10.7270/Q2R49QBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50417427![]() (CHEMBL1290716) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0316 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay | Bioorg Med Chem Lett 20: 7092-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.085 BindingDB Entry DOI: 10.7270/Q2MC919V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50180054![]() (CHEMBL199824 | [O-methyl-11C]2-{4-[4-(7-methoxynap...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding | J Med Chem 49: 125-34 (2006) Article DOI: 10.1021/jm050725j BindingDB Entry DOI: 10.7270/Q2R49QBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50024580![]() (CHEMBL3330612) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a |
Stony Brook University Curated by ChEMBL | Assay Description Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry | Bioorg Med Chem Lett 24: 4759-62 (2014) Article DOI: 10.1016/j.bmcl.2014.07.048 BindingDB Entry DOI: 10.7270/Q2NZ896M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM86757![]() (CAS_0 | NSC_11603174 | [11C]MMP) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Stony Brook University Curated by ChEMBL | Assay Description Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry | Bioorg Med Chem Lett 24: 4759-62 (2014) Article DOI: 10.1016/j.bmcl.2014.07.048 BindingDB Entry DOI: 10.7270/Q2NZ896M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50151982![]() (5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50094670![]() (1-(4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]ind...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description EC50 for inhibition of 50 microM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor | J Med Chem 43: 4701-10 (2001) Article DOI: 10.1021/jm000339w BindingDB Entry DOI: 10.7270/Q2HT2NM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272610![]() (CHEMBL4129019) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | <0.140 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272735![]() (CHEMBL4126958) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | <0.140 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50024574![]() (CHEMBL3330616) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Stony Brook University Curated by ChEMBL | Assay Description Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry | Bioorg Med Chem Lett 24: 4759-62 (2014) Article DOI: 10.1016/j.bmcl.2014.07.048 BindingDB Entry DOI: 10.7270/Q2NZ896M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319716![]() (6-(2-(4-(benzo[b]thiophen-4-yl)piperidin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.223 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319709![]() (5-(2-(4-(6-fluorobenzo[b]thiophen-4-yl)piperazin-1...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.235 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50182020![]() (2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Agonist activity assessed by stimulation of [35S]GTPgammaS binding to human 5HT1A receptor expressed in CHO cells | Bioorg Med Chem Lett 16: 2101-4 (2006) Article DOI: 10.1016/j.bmcl.2006.01.052 BindingDB Entry DOI: 10.7270/Q2ZC82FS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50024605![]() (CHEMBL3330603 | US9290463, E) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
Stony Brook University Curated by ChEMBL | Assay Description Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry | Bioorg Med Chem Lett 24: 4759-62 (2014) Article DOI: 10.1016/j.bmcl.2014.07.048 BindingDB Entry DOI: 10.7270/Q2NZ896M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50274835![]() (CHEMBL511857 | trans-1-(4-(3-methoxyphenyl)cyclohe...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.324 | n/a | n/a | n/a | n/a |
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assay | Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50150086![]() (CHEMBL127171 | [3-(5-Fluoro-1H-indol-3-yl)-propyl]...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Effective concentration against binding of radioligand [35]GTPgammaS in CHO cells expressing human 5-hydroxytryptamine 1A receptor | J Med Chem 47: 3823-42 (2004) Article DOI: 10.1021/jm0304010 BindingDB Entry DOI: 10.7270/Q2S46RDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272617![]() (CHEMBL4128200) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272627![]() (CHEMBL4126644) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319733![]() (5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.379 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319734![]() (7-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.397 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM10755![]() (14C-5-hydroxy tryptamine creatinine disulfate | 2-...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation | J Med Chem 49: 125-34 (2006) Article DOI: 10.1021/jm050725j BindingDB Entry DOI: 10.7270/Q2R49QBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272632![]() (CHEMBL4128689) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319703![]() (6-(2-(4-(6-fluorobenzo[b]thiophen-4-yl)piperazin-1...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.599 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272736![]() (CHEMBL4130230) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319735![]() (N-(5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)e...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.602 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319629![]() (6-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.626 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319630![]() (6-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50454721![]() (CHEMBL4217182) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay | Bioorg Med Chem Lett 28: 606-611 (2018) BindingDB Entry DOI: 10.7270/Q2X92DWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM10755![]() (14C-5-hydroxy tryptamine creatinine disulfate | 2-...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
Columbia University College of Physicians and Surgeons Curated by ChEMBL | Assay Description Agonist activity assessed by stimulation of [35S]GTPgammaS binding to human 5HT1A receptor expressed in CHO cells | Bioorg Med Chem Lett 16: 2101-4 (2006) Article DOI: 10.1016/j.bmcl.2006.01.052 BindingDB Entry DOI: 10.7270/Q2ZC82FS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272683![]() (CHEMBL4129170) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.720 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50472594![]() (CHEMBL46539) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 0.724 | n/a | n/a | n/a | n/a |
Pierre Fabre Research Center Curated by ChEMBL | Assay Description In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor | J Med Chem 42: 1648-60 (1999) BindingDB Entry DOI: 10.7270/Q2MS3WHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50272684![]() (CHEMBL4127774) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in HEK293 cells after 60 mins by Eu-cAMP solution based ultra LANCE assay | Bioorg Med Chem 26: 3117-3125 (2018) BindingDB Entry DOI: 10.7270/Q28P631Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319743![]() ((3aR,4R,6aS)-4-(5-(4-(benzo[b]thiophen-4-yl)pipera...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319737![]() (4-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.761 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319746![]() (6-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.766 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319704![]() (5-(2-(4-(2-fluorobenzo[b]thiophen-4-yl)piperazin-1...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.770 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50033852![]() (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.776 | n/a | n/a | n/a | n/a |
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL... | Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50039824![]() (CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP | J Med Chem 40: 300-12 (1997) Article DOI: 10.1021/jm960496o BindingDB Entry DOI: 10.7270/Q27W6B96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50056029![]() (CHEMBL316960 | N-{2-[4-(2,3-Dihydro-benzo[1,4]diox...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description In vitro potency at human 5-hydroxytryptamine 1A receptor in inhibiting forskolin-stimulated accumulation of intracellular cAMP | J Med Chem 40: 300-12 (1997) Article DOI: 10.1021/jm960496o BindingDB Entry DOI: 10.7270/Q27W6B96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319736![]() (N-(7-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)e...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.787 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50274835![]() (CHEMBL511857 | trans-1-(4-(3-methoxyphenyl)cyclohe...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.794 | n/a | n/a | n/a | n/a |
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL | Assay Description Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL... | Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50024577![]() (CHEMBL3330614) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Stony Brook University Curated by ChEMBL | Assay Description Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry | Bioorg Med Chem Lett 24: 4759-62 (2014) Article DOI: 10.1016/j.bmcl.2014.07.048 BindingDB Entry DOI: 10.7270/Q2NZ896M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319624![]() (7-(2-(4-(2,3-dihydrobenzo[b]thiophen-4-yl)piperazi...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.824 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50039824![]() (CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.851 | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2) | Bioorg Med Chem Lett 8: 2457-62 (1999) Article DOI: 10.1016/s0960-894x(98)00406-5 BindingDB Entry DOI: 10.7270/Q2KS6SQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50454706![]() (CHEMBL4214528) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assay | Bioorg Med Chem Lett 28: 606-611 (2018) BindingDB Entry DOI: 10.7270/Q2X92DWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50464898![]() (CHEMBL4287980) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay | Eur J Med Chem 145: 74-85 (2018) BindingDB Entry DOI: 10.7270/Q2Z03BVS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM319621![]() (7-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 0.926 | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ... | US Patent US10174011 (2019) BindingDB Entry DOI: 10.7270/Q2VH5QX7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50094674![]() (CHEMBL142862 | [2-(4-Fluoro-5-methoxy-1H-indol-3-y...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.930 | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description EC50 for inhibition of 50 microM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor | J Med Chem 43: 4701-10 (2001) Article DOI: 10.1021/jm000339w BindingDB Entry DOI: 10.7270/Q2HT2NM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50039824![]() (CHEMBL81728 | N-{2-[4-(2,3-Dihydro-benzo[1,4]dioxi...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.955 | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1) | Bioorg Med Chem Lett 8: 2457-62 (1999) Article DOI: 10.1016/s0960-894x(98)00406-5 BindingDB Entry DOI: 10.7270/Q2KS6SQ1 | |||||||||||
More data for this Ligand-Target Pair |
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