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Compile Data Set for Download or QSAR

Found 2480 hits of ic50 data for polymerid = 4953   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50185287
PNG
(CHEMBL3823268)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1)P(C)(C)=O
Show InChI InChI=1S/C20H21ClN5O3P/c1-29-17-10-12(30(2,3)28)8-9-16(17)25-20-23-11-14(21)19(26-20)24-15-7-5-4-6-13(15)18(22)27/h4-11H,1-3H3,(H2,22,27)(H2,23,24,25,26)
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Article
PubMed
n/an/a 0.110n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hr


J Med Chem 59: 4948-64 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00306
BindingDB Entry DOI: 10.7270/Q2NK3H0Q
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122557
PNG
(US8735386, I-27)
Show SMILES COc1cc(OCCN2CCCC2)ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl
Show InChI InChI=1S/C29H31ClN6O2/c1-35-28(21-7-3-4-8-22(21)30)26-24(34-35)11-9-19-18-31-29(33-27(19)26)32-23-12-10-20(17-25(23)37-2)38-16-15-36-13-5-6-14-36/h3-4,7-8,10,12,17-18H,5-6,9,11,13-16H2,1-2H3,(H,31,32,33)
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n/an/a 0.180n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122640
PNG
(US8735386, I-110)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)N1CCN(C)CC1
Show InChI InChI=1S/C28H30ClN7O/c1-34-12-14-36(15-13-34)19-9-11-22(24(16-19)37-3)31-28-30-17-18-8-10-23-25(26(18)32-28)27(35(2)33-23)20-6-4-5-7-21(20)29/h4-7,9,11,16-17H,8,10,12-15H2,1-3H3,(H,30,31,32)
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n/an/a 0.190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122627
PNG
(US8735386, I-97)
Show SMILES COc1cc(ccc1Nc1ncc2C(C)Cc3nn(C)c(c3-c2n1)-c1ccccc1Cl)N1CCN(C)CC1
Show InChI InChI=1S/C29H32ClN7O/c1-18-15-24-26(28(36(3)34-24)20-7-5-6-8-22(20)30)27-21(18)17-31-29(33-27)32-23-10-9-19(16-25(23)38-4)37-13-11-35(2)12-14-37/h5-10,16-18H,11-15H2,1-4H3,(H,31,32,33)
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US Patent
n/an/a 0.190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265871
PNG
(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-4,4-di...)
Show SMILES COc1cc2c(cc1Nc1nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n1)N(CCC2(C)C)C(=O)CN(C)C
Show InChI InChI=1S/C27H32N8O3S/c1-27(2)8-10-35(21(36)14-34(3)4)19-13-18(20(38-5)12-16(19)27)31-26-32-24-15(6-9-29-24)25(33-26)30-17-7-11-39-22(17)23(28)37/h6-7,9,11-13H,8,10,14H2,1-5H3,(H2,28,37)(H3,29,30,31,32,33)
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n/an/a 0.200n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122701
PNG
(US8735386, I-171)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C22H22ClN7O/c1-29-21(14-3-6-16(23)7-4-14)19-17(27-29)8-5-15-13-24-22(26-20(15)19)25-18-9-10-30(28-18)11-12-31-2/h3-4,6-7,9-10,13H,5,8,11-12H2,1-2H3,(H,24,25,26,28)
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n/an/a 0.200n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122699
PNG
(US8735386, I-169)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)cn1
Show InChI InChI=1S/C24H25ClN8OS/c1-14(34)32-8-5-17(6-9-32)33-13-16(12-27-33)28-24-26-11-15-3-4-19-20(21(15)29-24)22(31(2)30-19)23-18(25)7-10-35-23/h7,10-13,17H,3-6,8-9H2,1-2H3,(H,26,28,29)
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n/an/a 0.200n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122952
PNG
(US8735386, IV-5)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C32H39N7O/c1-5-40-29-20-25(39-17-15-38(16-18-39)22(2)3)12-14-26(29)34-32-33-21-24-11-13-27-30(31(24)35-32)28(37(4)36-27)19-23-9-7-6-8-10-23/h6-10,12,14,20-22H,5,11,13,15-19H2,1-4H3,(H,33,34,35)
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n/an/a 0.260n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122860
PNG
(US8735386, III-22)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)N[C@H]1CC[C@@H](CC1)N1CCOCC1
Show InChI InChI=1S/C34H38ClN7O3/c1-41-32(25-5-3-4-6-26(25)35)30-28(40-41)14-8-22-20-36-34(39-31(22)30)38-27-13-7-21(19-29(27)44-2)33(43)37-23-9-11-24(12-10-23)42-15-17-45-18-16-42/h3-7,13,19-20,23-24H,8-12,14-18H2,1-2H3,(H,37,43)(H,36,38,39)/t23-,24-
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n/an/a 0.270n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122941
PNG
(US8735386, III-103)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(-c4sccc4Cl)c3-c2n1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H30ClN7O2S/c1-35-11-8-18(9-12-35)31-27(37)16-4-6-20(22(14-16)38-3)32-28-30-15-17-5-7-21-23(24(17)33-28)25(36(2)34-21)26-19(29)10-13-39-26/h4,6,10,13-15,18H,5,7-9,11-12H2,1-3H3,(H,31,37)(H,30,32,33)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265847
PNG
(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)
Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2ccoc2C(N)=O)c2cc[nH]c2n1
Show InChI InChI=1S/C25H28N8O4/c1-32(2)13-20(34)33-9-4-5-14-11-19(36-3)17(12-18(14)33)29-25-30-23-15(6-8-27-23)24(31-25)28-16-7-10-37-21(16)22(26)35/h6-8,10-12H,4-5,9,13H2,1-3H3,(H2,26,35)(H3,27,28,29,30,31)
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n/an/a 0.300n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122702
PNG
(US8735386, I-172)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5C)c4-c3n2)n1
Show InChI InChI=1S/C20H21N7S/c1-4-27-9-7-15(25-27)22-20-21-11-13-5-6-14-16(17(13)23-20)18(26(3)24-14)19-12(2)8-10-28-19/h7-11H,4-6H2,1-3H3,(H,21,22,23,25)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122703
PNG
(US8735386, I-173)
Show SMILES Cn1cc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)cn1
Show InChI InChI=1S/C18H16ClN7S/c1-25-9-11(8-21-25)22-18-20-7-10-3-4-13-14(15(10)23-18)16(26(2)24-13)17-12(19)5-6-27-17/h5-9H,3-4H2,1-2H3,(H,20,22,23)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27826
PNG
(4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 9 | 4...)
Show SMILES CCCN1CCC(CC1)c1ccc(Nc2nc(Nc3cc(F)ccc3C(N)=O)c3cc[nH]c3n2)c(OC)c1
Show InChI InChI=1S/C28H32FN7O2/c1-3-12-36-13-9-17(10-14-36)18-4-7-22(24(15-18)38-2)33-28-34-26-21(8-11-31-26)27(35-28)32-23-16-19(29)5-6-20(23)25(30)37/h4-8,11,15-17H,3,9-10,12-14H2,1-2H3,(H2,30,37)(H3,31,32,33,34,35)
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n/an/a 0.300n/an/an/an/a7.522



GSK



Assay Description
Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...


Bioorg Med Chem Lett 19: 469-73 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.046
BindingDB Entry DOI: 10.7270/Q2J67F88
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122672
PNG
(US8735386, I-142)
Show SMILES COc1ccc(-c2c-3c(CCc4cnc(Nc5ccc(cc5OC)N5CCN(C)CC5)nc-34)nn2C)c(Cl)c1
Show InChI InChI=1S/C29H32ClN7O2/c1-35-11-13-37(14-12-35)19-6-10-23(25(15-19)39-4)32-29-31-17-18-5-9-24-26(27(18)33-29)28(36(2)34-24)21-8-7-20(38-3)16-22(21)30/h6-8,10,15-17H,5,9,11-14H2,1-4H3,(H,31,32,33)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265869
PNG
(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2ccsc2C(N)=O)c2cc[nH]c2n1
Show InChI InChI=1S/C24H26N8O3S/c1-31(2)12-19(33)32-8-5-13-10-18(35-3)16(11-17(13)32)28-24-29-22-14(4-7-26-22)23(30-24)27-15-6-9-36-20(15)21(25)34/h4,6-7,9-11H,5,8,12H2,1-3H3,(H2,25,34)(H3,26,27,28,29,30)
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n/an/a 0.300n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122951
PNG
(US8735386, IV-4)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C30H35N7O/c1-4-38-27-19-23(37-16-14-35(2)15-17-37)11-13-24(27)32-30-31-20-22-10-12-25-28(29(22)33-30)26(36(3)34-25)18-21-8-6-5-7-9-21/h5-9,11,13,19-20H,4,10,12,14-18H2,1-3H3,(H,31,32,33)
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n/an/a 0.310n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/a 0.350n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hr


J Med Chem 59: 4948-64 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00306
BindingDB Entry DOI: 10.7270/Q2NK3H0Q
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27825
PNG
(4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 8 | 4...)
Show SMILES CCCN1CCCC(C1)c1ccc(Nc2nc(Nc3cc(F)ccc3C(N)=O)c3cc[nH]c3n2)c(OC)c1
Show InChI InChI=1S/C28H32FN7O2/c1-3-12-36-13-4-5-18(16-36)17-6-9-22(24(14-17)38-2)33-28-34-26-21(10-11-31-26)27(35-28)32-23-15-19(29)7-8-20(23)25(30)37/h6-11,14-15,18H,3-5,12-13,16H2,1-2H3,(H2,30,37)(H3,31,32,33,34,35)
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n/an/a 0.400n/an/an/an/a7.522



GSK



Assay Description
Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...


Bioorg Med Chem Lett 19: 469-73 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.046
BindingDB Entry DOI: 10.7270/Q2J67F88
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122673
PNG
(US8735386, I-143)
Show SMILES COc1ccc(-c2c-3c(CCc4cnc(Nc5ccc(cc5OC)C(=O)NC5CCN(C)CC5)nc-34)nn2C)c(Cl)c1
Show InChI InChI=1S/C31H34ClN7O3/c1-38-13-11-20(12-14-38)34-30(40)18-5-9-24(26(15-18)42-4)35-31-33-17-19-6-10-25-27(28(19)36-31)29(39(2)37-25)22-8-7-21(41-3)16-23(22)32/h5,7-9,15-17,20H,6,10-14H2,1-4H3,(H,34,40)(H,33,35,36)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122704
PNG
(US8735386, I-174)
Show SMILES Cn1nc2CCc3cnc(Nc4ccccc4)nc3-c2c1-c1sccc1Cl
Show InChI InChI=1S/C20H16ClN5S/c1-26-18(19-14(21)9-10-27-19)16-15(25-26)8-7-12-11-22-20(24-17(12)16)23-13-5-3-2-4-6-13/h2-6,9-11H,7-8H2,1H3,(H,22,23,24)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122705
PNG
(US8735386, I-175)
Show SMILES CN(C)C1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccccc3)n2)CC1
Show InChI InChI=1S/C28H35N9/c1-34(2)22-11-14-36(15-12-22)17-18-37-16-13-24(33-37)30-28-29-19-21-9-10-23-25(26(21)31-28)27(35(3)32-23)20-7-5-4-6-8-20/h4-8,13,16,19,22H,9-12,14-15,17-18H2,1-3H3,(H,29,30,31,33)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122706
PNG
(US8735386, I-176)
Show SMILES COc1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(c4)C4CCN(CC4)C(C)=O)nc-23)nn1C
Show InChI InChI=1S/C27H30N8O2/c1-17(36)34-12-10-21(11-13-34)35-16-20(15-29-35)30-27-28-14-19-6-9-23-24(25(19)31-27)26(33(2)32-23)18-4-7-22(37-3)8-5-18/h4-5,7-8,14-16,21H,6,9-13H2,1-3H3,(H,28,30,31)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122942
PNG
(US8735386, III-104)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4Cl)c3-c2n1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C31H34ClN7O2/c1-38-14-12-22(13-15-38)34-30(40)20-8-10-24(27(17-20)41-3)35-31-33-18-21-9-11-25-28(29(21)36-31)26(39(2)37-25)16-19-6-4-5-7-23(19)32/h4-8,10,17-18,22H,9,11-16H2,1-3H3,(H,34,40)(H,33,35,36)
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n/an/a 0.400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50185286
PNG
(CHEMBL3823256)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1)P(C)(C)=O
Show InChI InChI=1S/C20H22ClN4O4PS/c1-29-17-11-13(30(2,3)26)9-10-15(17)24-20-22-12-14(21)19(25-20)23-16-7-5-6-8-18(16)31(4,27)28/h5-12H,1-4H3,(H2,22,23,24,25)
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n/an/a 0.400n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hr


J Med Chem 59: 4948-64 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00306
BindingDB Entry DOI: 10.7270/Q2NK3H0Q
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122950
PNG
(US8735386, IV-3)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C34H41N7O2/c1-3-43-31-22-27(41-17-15-40(16-18-41)26-13-19-42-20-14-26)10-12-28(31)36-34-35-23-25-9-11-29-32(33(25)37-34)30(39(2)38-29)21-24-7-5-4-6-8-24/h4-8,10,12,22-23,26H,3,9,11,13-21H2,1-2H3,(H,35,36,37)
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n/an/a 0.430n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50185288
PNG
(CHEMBL3824326)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)=O)n1)P(C)(C)=O
Show InChI InChI=1S/C21H22ClN4O3P/c1-13(27)15-7-5-6-8-17(15)24-20-16(22)12-23-21(26-20)25-18-10-9-14(30(3,4)28)11-19(18)29-2/h5-12H,1-4H3,(H2,23,24,25,26)
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n/an/a 0.470n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hr


J Med Chem 59: 4948-64 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00306
BindingDB Entry DOI: 10.7270/Q2NK3H0Q
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265849
PNG
(2-(dimethylamino)-1-(7-(4-(indolin-1-yl)-7H-pyrrol...)
Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(N2CCc3ccccc23)c2cc[nH]c2n1
Show InChI InChI=1S/C28H31N7O2/c1-33(2)17-25(36)34-13-6-8-19-15-24(37-3)21(16-23(19)34)30-28-31-26-20(10-12-29-26)27(32-28)35-14-11-18-7-4-5-9-22(18)35/h4-5,7,9-10,12,15-16H,6,8,11,13-14,17H2,1-3H3,(H2,29,30,31,32)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122708
PNG
(US8735386, I-178)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(Cc5ccccc5C)c4-c3n2)cn1
Show InChI InChI=1S/C28H32N8O/c1-18-6-4-5-7-20(18)14-25-26-24(33-34(25)3)9-8-21-15-29-28(32-27(21)26)31-22-16-30-36(17-22)23-10-12-35(13-11-23)19(2)37/h4-7,15-17,23H,8-14H2,1-3H3,(H,29,31,32)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122707
PNG
(US8735386, I-177)
Show SMILES CN(C)CCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)n1
Show InChI InChI=1S/C21H23ClN8S/c1-28(2)9-10-30-8-6-16(27-30)24-21-23-12-13-4-5-15-17(18(13)25-21)19(29(3)26-15)20-14(22)7-11-31-20/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,23,24,25,27)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122670
PNG
(US8735386, I-140)
Show SMILES COc1ccc(-c2c-3c(CCc4cnc(Nc5ccc(OCCN6CCCC6)cc5OC)nc-34)nn2C)c(Cl)c1
Show InChI InChI=1S/C30H33ClN6O3/c1-36-29(22-9-7-20(38-2)16-23(22)31)27-25(35-36)10-6-19-18-32-30(34-28(19)27)33-24-11-8-21(17-26(24)39-3)40-15-14-37-12-4-5-13-37/h7-9,11,16-18H,4-6,10,12-15H2,1-3H3,(H,32,33,34)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27842
PNG
(4,5-difluoro-2-{[2-({2-methoxy-4-[4-(propan-2-yl)p...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cc(F)c(F)cc2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C27H30F2N8O2/c1-15(2)36-8-10-37(11-9-36)16-4-5-21(23(12-16)39-3)33-27-34-25-17(6-7-31-25)26(35-27)32-22-14-20(29)19(28)13-18(22)24(30)38/h4-7,12-15H,8-11H2,1-3H3,(H2,30,38)(H3,31,32,33,34,35)
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n/an/a 0.5n/an/an/an/a7.522



GSK



Assay Description
Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...


Bioorg Med Chem Lett 19: 469-73 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.046
BindingDB Entry DOI: 10.7270/Q2J67F88
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122955
PNG
(US8735386, IV-8)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(Cl)c4)c3-c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C31H36ClN7O/c1-20(2)38-12-14-39(15-13-38)24-9-11-25(28(18-24)40-4)34-31-33-19-22-8-10-26-29(30(22)35-31)27(37(3)36-26)17-21-6-5-7-23(32)16-21/h5-7,9,11,16,18-20H,8,10,12-15,17H2,1-4H3,(H,33,34,35)
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n/an/a 0.5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27793
PNG
(2-{[2-({5-[2-(dimethylamino)acetamido]-2-methoxy-4...)
Show SMILES COc1cc(C)c(NC(=O)CN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1
Show InChI InChI=1S/C25H27FN8O3/c1-13-10-19(37-4)18(11-17(13)29-20(35)12-34(2)3)31-25-32-23-14(8-9-28-23)24(33-25)30-16-7-5-6-15(26)21(16)22(27)36/h5-11H,12H2,1-4H3,(H2,27,36)(H,29,35)(H3,28,30,31,32,33)
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GSK



Assay Description
Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...


Bioorg Med Chem Lett 19: 360-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.077
BindingDB Entry DOI: 10.7270/Q2NZ85ZT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265872
PNG
(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)
Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccnc2C(N)=O)c2cc[nH]c2n1
Show InChI InChI=1S/C26H29N9O3/c1-34(2)14-21(36)35-11-5-6-15-12-20(38-3)18(13-19(15)35)31-26-32-24-16(8-10-29-24)25(33-26)30-17-7-4-9-28-22(17)23(27)37/h4,7-10,12-13H,5-6,11,14H2,1-3H3,(H2,27,37)(H3,29,30,31,32,33)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122859
PNG
(US8735386, III-21)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccccc1Cl)C(=O)NC1CCN(CCO)CC1
Show InChI InChI=1S/C31H34ClN7O3/c1-38-29(22-5-3-4-6-23(22)32)27-25(37-38)10-8-20-18-33-31(36-28(20)27)35-24-9-7-19(17-26(24)42-2)30(41)34-21-11-13-39(14-12-21)15-16-40/h3-7,9,17-18,21,40H,8,10-16H2,1-2H3,(H,34,41)(H,33,35,36)
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n/an/a 0.540n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122898
PNG
(US8735386, III-60)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)C(=O)NC1CN(C)C1
Show InChI InChI=1S/C30H33N7O2/c1-4-39-26-15-20(29(38)32-22-17-36(2)18-22)10-12-23(26)33-30-31-16-21-11-13-24-27(28(21)34-30)25(37(3)35-24)14-19-8-6-5-7-9-19/h5-10,12,15-16,22H,4,11,13-14,17-18H2,1-3H3,(H,32,38)(H,31,33,34)
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US Patent
n/an/a 0.570n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122697
PNG
(US8735386, I-167)
Show SMILES COCCN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccccc3)n2)CC1
Show InChI InChI=1S/C28H35N9O/c1-34-27(21-6-4-3-5-7-21)25-23(32-34)9-8-22-20-29-28(31-26(22)25)30-24-10-11-37(33-24)17-16-35-12-14-36(15-13-35)18-19-38-2/h3-7,10-11,20H,8-9,12-19H2,1-2H3,(H,29,30,31,33)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122711
PNG
(US8735386, I-181)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)n1
Show InChI InChI=1S/C19H18ClN7S/c1-3-27-8-6-14(25-27)22-19-21-10-11-4-5-13-15(16(11)23-19)17(26(2)24-13)18-12(20)7-9-28-18/h6-10H,3-5H2,1-2H3,(H,21,22,23,25)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122712
PNG
(US8735386, I-182)
Show SMILES Cn1nc2CCc3cnc(Nc4ccn(CCN5CCNCC5)n4)nc3-c2c1-c1ccccc1
Show InChI InChI=1S/C25H29N9/c1-32-24(18-5-3-2-4-6-18)22-20(30-32)8-7-19-17-27-25(29-23(19)22)28-21-9-12-34(31-21)16-15-33-13-10-26-11-14-33/h2-6,9,12,17,26H,7-8,10-11,13-16H2,1H3,(H,27,28,29,31)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50437357
PNG
(CHEMBL3037909)
Show SMILES CCOc1cc(nc2cc(ccc12)-c1nc([C@H]2C[C@@](C)(O)C2)n2ccnc(N)c12)-c1ccccc1
Show InChI InChI=1S/C28H27N5O2/c1-3-35-23-14-21(17-7-5-4-6-8-17)31-22-13-18(9-10-20(22)23)24-25-26(29)30-11-12-33(25)27(32-24)19-15-28(2,34)16-19/h4-14,19,34H,3,15-16H2,1-2H3,(H2,29,30)/t19-,28+
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n/an/a 0.600n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...


ACS Med Chem Lett 4: 627-31 (2013)


Article DOI: 10.1021/ml400160a
BindingDB Entry DOI: 10.7270/Q2S75HR4
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122696
PNG
(US8735386, I-166)
Show SMILES Cn1nc2CCc3cnc(Nc4ccn(CCN5CCN(CCO)CC5)n4)nc3-c2c1-c1ccccc1
Show InChI InChI=1S/C27H33N9O/c1-33-26(20-5-3-2-4-6-20)24-22(31-33)8-7-21-19-28-27(30-25(21)24)29-23-9-10-36(32-23)16-15-34-11-13-35(14-12-34)17-18-37/h2-6,9-10,19,37H,7-8,11-18H2,1H3,(H,28,29,30,32)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122710
PNG
(US8735386, I-180)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(-c5sccc5Cl)c4-c3n2)n1
Show InChI InChI=1S/C20H20ClN7OS/c1-27-18(19-13(21)6-10-30-19)16-14(25-27)4-3-12-11-22-20(24-17(12)16)23-15-5-7-28(26-15)8-9-29-2/h5-7,10-11H,3-4,8-9H2,1-2H3,(H,22,23,24,26)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27822
PNG
(2-[(2-{[2-methoxy-4-(1-propyl-1,2,5,6-tetrahydropy...)
Show SMILES CCCN1CCC=C(C1)c1ccc(Nc2nc(Nc3ccccc3C(N)=O)c3cc[nH]c3n2)c(OC)c1
Show InChI InChI=1S/C28H31N7O2/c1-3-14-35-15-6-7-19(17-35)18-10-11-23(24(16-18)37-2)32-28-33-26-21(12-13-30-26)27(34-28)31-22-9-5-4-8-20(22)25(29)36/h4-5,7-13,16H,3,6,14-15,17H2,1-2H3,(H2,29,36)(H3,30,31,32,33,34)
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n/an/a 0.600n/an/an/an/a7.522



GSK



Assay Description
Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...


Bioorg Med Chem Lett 19: 469-73 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.046
BindingDB Entry DOI: 10.7270/Q2J67F88
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122709
PNG
(US8735386, I-179)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(-c5sccc5C)c4-c3n2)cn1
Show InChI InChI=1S/C25H28N8OS/c1-15-8-11-35-24(15)23-21-20(30-31(23)3)5-4-17-12-26-25(29-22(17)21)28-18-13-27-33(14-18)19-6-9-32(10-7-19)16(2)34/h8,11-14,19H,4-7,9-10H2,1-3H3,(H,26,28,29)
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n/an/a 0.600n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122948
PNG
(US8735386, IV-1)
Show SMILES CCOc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4ccccc4)c3-c2n1)N1CCNCC1
Show InChI InChI=1S/C29H33N7O/c1-3-37-26-18-22(36-15-13-30-14-16-36)10-12-23(26)32-29-31-19-21-9-11-24-27(28(21)33-29)25(35(2)34-24)17-20-7-5-4-6-8-20/h4-8,10,12,18-19,30H,3,9,11,13-17H2,1-2H3,(H,31,32,33)
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n/an/a 0.630n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM122578
PNG
(US8735386, I-48)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c([C@@H](C)c4ccccc4)c3-c2n1)N1CCN(C)CC1
Show InChI InChI=1S/C30H35N7O/c1-20(21-8-6-5-7-9-21)29-27-25(34-36(29)3)12-10-22-19-31-30(33-28(22)27)32-24-13-11-23(18-26(24)38-4)37-16-14-35(2)15-17-37/h5-9,11,13,18-20H,10,12,14-17H2,1-4H3,(H,31,32,33)/t20-/m0/s1
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n/an/a 0.690n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...


US Patent US8735386 (2014)


BindingDB Entry DOI: 10.7270/Q2C827Z0
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50437358
PNG
(CHEMBL3037908)
Show SMILES COc1cc(nc2cc(ccc12)-c1nc([C@H]2C[C@@](C)(O)C2)n2ccnc(N)c12)-c1ccccc1
Show InChI InChI=1S/C27H25N5O2/c1-27(33)14-18(15-27)26-31-23(24-25(28)29-10-11-32(24)26)17-8-9-19-21(12-17)30-20(13-22(19)34-2)16-6-4-3-5-7-16/h3-13,18,33H,14-15H2,1-2H3,(H2,28,29)/t18-,27+
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n/an/a 0.700n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...


ACS Med Chem Lett 4: 627-31 (2013)


Article DOI: 10.1021/ml400160a
BindingDB Entry DOI: 10.7270/Q2S75HR4
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27828
PNG
(4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 11 | ...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cc(F)ccc2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C27H31FN8O2/c1-16(2)35-10-12-36(13-11-35)18-5-7-21(23(15-18)38-3)32-27-33-25-20(8-9-30-25)26(34-27)31-22-14-17(28)4-6-19(22)24(29)37/h4-9,14-16H,10-13H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34)
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n/an/a 0.700n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265850
PNG
(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccnc2C(N)=O)c2cc[nH]c2n1
Show InChI InChI=1S/C25H27N9O3/c1-33(2)13-20(35)34-10-7-14-11-19(37-3)17(12-18(14)34)30-25-31-23-15(6-9-28-23)24(32-25)29-16-5-4-8-27-21(16)22(26)36/h4-6,8-9,11-12H,7,10,13H2,1-3H3,(H2,26,36)(H3,28,29,30,31,32)
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n/an/a 0.700n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
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