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Compile Data Set for Download or QSAR

Found 950 hits of ic50 data for polymerid = 4998   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073373
PNG
(CHEMBL3408633)
Show SMILES C\C(=N/NC(N)=S)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H16N4OS/c1-11(19-20-16(17)22)12-7-9-14(10-8-12)18-15(21)13-5-3-2-4-6-13/h2-10H,1H3,(H,18,21)(H3,17,20,22)/b19-11+
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n/an/a 0.291n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073375
PNG
(CHEMBL3408631)
Show SMILES CCCCCCC(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C16H24N4OS/c1-3-4-5-6-7-15(21)18-14-10-8-13(9-11-14)12(2)19-20-16(17)22/h8-11H,3-7H2,1-2H3,(H,18,21)(H3,17,20,22)/b19-12+
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n/an/a 0.356n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073380
PNG
(CHEMBL3408626)
Show SMILES CCC(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C12H16N4OS/c1-3-11(17)14-10-6-4-9(5-7-10)8(2)15-16-12(13)18/h4-7H,3H2,1-2H3,(H,14,17)(H3,13,16,18)/b15-8+
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n/an/a 0.372n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50192743
PNG
(3,4-Dihydroxybenzaldehyde | CHEBI:50205 | PROTOCAT...)
Show SMILES Oc1ccc(C=O)cc1O
Show InChI InChI=1S/C7H6O3/c8-4-5-1-2-6(9)7(10)3-5/h1-4,9-10H
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n/an/a 0.400n/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Non-competitive inhibition of mushroom tyrosinase


Bioorg Med Chem 22: 6193-200 (2014)


Article DOI: 10.1016/j.bmc.2014.08.027
BindingDB Entry DOI: 10.7270/Q2DV1MG2
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073381
PNG
(CHEMBL3408625)
Show SMILES C\C(=N/NC(N)=S)c1ccc(NC(=O)C(Cl)(Cl)Cl)cc1
Show InChI InChI=1S/C11H11Cl3N4OS/c1-6(17-18-10(15)20)7-2-4-8(5-3-7)16-9(19)11(12,13)14/h2-5H,1H3,(H,16,19)(H3,15,18,20)/b17-6+
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n/an/a 0.406n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073377
PNG
(CHEMBL3408629)
Show SMILES CCCCC(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C14H20N4OS/c1-3-4-5-13(19)16-12-8-6-11(7-9-12)10(2)17-18-14(15)20/h6-9H,3-5H2,1-2H3,(H,16,19)(H3,15,18,20)/b17-10+
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n/an/a 0.492n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073374
PNG
(CHEMBL3408632)
Show SMILES COC(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C11H14N4O2S/c1-7(14-15-10(12)18)8-3-5-9(6-4-8)13-11(16)17-2/h3-6H,1-2H3,(H,13,16)(H3,12,15,18)/b14-7+
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n/an/a 0.498n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073383
PNG
(CHEMBL3408483)
Show SMILES CC(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C11H14N4OS/c1-7(14-15-11(12)17)9-3-5-10(6-4-9)13-8(2)16/h3-6H,1-2H3,(H,13,16)(H3,12,15,17)/b14-7+
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n/an/a 0.508n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073335
PNG
(CHEMBL3408636)
Show SMILES C\C(=N/NC(N)=S)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C17H18N4OS/c1-12(20-21-17(18)23)14-7-9-15(10-8-14)19-16(22)11-13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,19,22)(H3,18,21,23)/b20-12+
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n/an/a 0.578n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073372
PNG
(CHEMBL3408634)
Show SMILES C\C(=N/NC(N)=S)c1ccc(NC(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C16H15FN4OS/c1-10(20-21-16(18)23)11-4-8-14(9-5-11)19-15(22)12-2-6-13(17)7-3-12/h2-9H,1H3,(H,19,22)(H3,18,21,23)/b20-10+
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n/an/a 0.610n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073379
PNG
(CHEMBL3408627)
Show SMILES CCCC(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C13H18N4OS/c1-3-4-12(18)15-11-7-5-10(6-8-11)9(2)16-17-13(14)19/h5-8H,3-4H2,1-2H3,(H,15,18)(H3,14,17,19)/b16-9+
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n/an/a 0.644n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073376
PNG
(CHEMBL3408630)
Show SMILES CCCCCC(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C15H22N4OS/c1-3-4-5-6-14(20)17-13-9-7-12(8-10-13)11(2)18-19-15(16)21/h7-10H,3-6H2,1-2H3,(H,17,20)(H3,16,19,21)/b18-11+
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n/an/a 0.762n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073378
PNG
(CHEMBL3408628)
Show SMILES CC(C)C(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C13H18N4OS/c1-8(2)12(18)15-11-6-4-10(5-7-11)9(3)16-17-13(14)19/h4-8H,1-3H3,(H,15,18)(H3,14,17,19)/b16-9+
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n/an/a 0.814n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073371
PNG
(CHEMBL3408635)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(cc1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C17H18N4O2S/c1-11(20-21-17(18)24)12-3-7-14(8-4-12)19-16(22)13-5-9-15(23-2)10-6-13/h3-10H,1-2H3,(H,19,22)(H3,18,21,24)/b20-11+
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n/an/a 1.10n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073382
PNG
(CHEMBL3408624)
Show SMILES C\C(=N/NC(N)=S)c1ccc(NC(=O)C(F)(F)F)cc1
Show InChI InChI=1S/C11H11F3N4OS/c1-6(17-18-10(15)20)7-2-4-8(5-3-7)16-9(19)11(12,13)14/h2-5H,1H3,(H,16,19)(H3,15,18,20)/b17-6+
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n/an/a 1.30n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234121
PNG
(CHEMBL4069921)
Show SMILES Oc1ccc(CNn2c(SCc3cc(=O)c(O)co3)nnc2-c2ccccc2)c(O)c1
Show InChI InChI=1S/C21H18N4O5S/c26-15-7-6-14(17(27)8-15)10-22-25-20(13-4-2-1-3-5-13)23-24-21(25)31-12-16-9-18(28)19(29)11-30-16/h1-9,11,22,26-27,29H,10,12H2
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n/an/a 1.40n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234127
PNG
(CHEMBL4088997)
Show SMILES Oc1ccccc1CNn1c(SCc2cc(=O)c(O)co2)nnc1-c1ccccc1
Show InChI InChI=1S/C21H18N4O4S/c26-17-9-5-4-8-15(17)11-22-25-20(14-6-2-1-3-7-14)23-24-21(25)30-13-16-10-18(27)19(28)12-29-16/h1-10,12,22,26,28H,11,13H2
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n/an/a 1.5n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073240
PNG
(CHEMBL3408639)
Show SMILES CCCCC(=O)Nc1cccc(c1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C14H20N4OS/c1-3-4-8-13(19)16-12-7-5-6-11(9-12)10(2)17-18-14(15)20/h5-7,9H,3-4,8H2,1-2H3,(H,16,19)(H3,15,18,20)/b17-10+
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n/an/a 1.5n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073236
PNG
(CHEMBL3408642)
Show SMILES C\C(=N/NC(N)=S)c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C16H16N4OS/c1-11(19-20-16(17)22)13-8-5-9-14(10-13)18-15(21)12-6-3-2-4-7-12/h2-10H,1H3,(H,18,21)(H3,17,20,22)/b19-11+
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n/an/a 1.5n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234119
PNG
(CHEMBL4067785)
Show SMILES Oc1ccccc1CNn1c(SCc2cc(=O)c(O)co2)nnc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN4O4S/c22-15-7-5-13(6-8-15)20-24-25-21(31-12-16-9-18(28)19(29)11-30-16)26(20)23-10-14-3-1-2-4-17(14)27/h1-9,11,23,27,29H,10,12H2
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n/an/a 1.70n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073238
PNG
(CHEMBL3407512)
Show SMILES CCCCCC(=O)Nc1cccc(c1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C15H22N4OS/c1-3-4-5-9-14(20)17-13-8-6-7-12(10-13)11(2)18-19-15(16)21/h6-8,10H,3-5,9H2,1-2H3,(H,17,20)(H3,16,19,21)/b18-11+
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n/an/a 1.70n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073234
PNG
(CHEMBL3408643)
Show SMILES C\C(=N/NC(N)=S)c1cccc(NC(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C17H18N4OS/c1-12(20-21-17(18)23)14-8-5-9-15(11-14)19-16(22)10-13-6-3-2-4-7-13/h2-9,11H,10H2,1H3,(H,19,22)(H3,18,21,23)/b20-12+
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n/an/a 1.80n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073237
PNG
(CHEMBL3408641)
Show SMILES CCCCCCC(=O)Nc1cccc(c1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C16H24N4OS/c1-3-4-5-6-10-15(21)18-14-9-7-8-13(11-14)12(2)19-20-16(17)22/h7-9,11H,3-6,10H2,1-2H3,(H,18,21)(H3,17,20,22)/b19-12+
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n/an/a 2.20n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234120
PNG
(CHEMBL4096695)
Show SMILES Oc1ccccc1CNn1c(SCc2cc(=O)c(O)co2)nnc1-c1cccc(Cl)c1
Show InChI InChI=1S/C21H17ClN4O4S/c22-15-6-3-5-13(8-15)20-24-25-21(31-12-16-9-18(28)19(29)11-30-16)26(20)23-10-14-4-1-2-7-17(14)27/h1-9,11,23,27,29H,10,12H2
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n/an/a 2.5n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073385
PNG
(CHEMBL2420104)
Show SMILES C\C(=N/NC(N)=S)c1ccc(N)cc1
Show InChI InChI=1S/C9H12N4S/c1-6(12-13-9(11)14)7-2-4-8(10)5-3-7/h2-5H,10H2,1H3,(H3,11,13,14)/b12-6+
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n/an/a 2.60n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073241
PNG
(CHEMBL3408638)
Show SMILES CC(C)C(=O)Nc1cccc(c1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C13H18N4OS/c1-8(2)12(18)15-11-6-4-5-10(7-11)9(3)16-17-13(14)19/h4-8H,1-3H3,(H,15,18)(H3,14,17,19)/b16-9+
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n/an/a 3.60n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234125
PNG
(CHEMBL4078679)
Show SMILES Cc1ccc(cc1)-c1nnc(SCc2cc(=O)c(O)co2)n1NCc1ccccc1O
Show InChI InChI=1S/C22H20N4O4S/c1-14-6-8-15(9-7-14)21-24-25-22(31-13-17-10-19(28)20(29)12-30-17)26(21)23-11-16-4-2-3-5-18(16)27/h2-10,12,23,27,29H,11,13H2,1H3
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n/an/a 3.80n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073260
PNG
(CHEMBL3190695)
Show SMILES CC(=O)Nc1cccc(c1)C(\C)=N\NC(N)=S
Show InChI InChI=1S/C11H14N4OS/c1-7(14-15-11(12)17)9-4-3-5-10(6-9)13-8(2)16/h3-6H,1-2H3,(H,13,16)(H3,12,15,17)/b14-7+
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n/an/a 4.10n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073239
PNG
(CHEMBL3408640)
Show SMILES C\C(=N/NC(N)=S)c1cccc(NC(=O)C(C)(C)C)c1
Show InChI InChI=1S/C14H20N4OS/c1-9(17-18-13(15)20)10-6-5-7-11(8-10)16-12(19)14(2,3)4/h5-8H,1-4H3,(H,16,19)(H3,15,18,20)/b17-9+
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n/an/a 4.40n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234118
PNG
(CHEMBL4105366)
Show SMILES Oc1ccc(\C=N\n2c(SCc3cc(=O)c(O)co3)nnc2-c2ccccc2Cl)cc1O
Show InChI InChI=1S/C21H15ClN4O5S/c22-15-4-2-1-3-14(15)20-24-25-21(32-11-13-8-18(29)19(30)10-31-13)26(20)23-9-12-5-6-16(27)17(28)7-12/h1-10,27-28,30H,11H2/b23-9+
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n/an/a 5.20n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073242
PNG
(CHEMBL3408637)
Show SMILES C\C(=N/NC(N)=S)c1cccc(NC(=O)C(F)(F)F)c1
Show InChI InChI=1S/C11H11F3N4OS/c1-6(17-18-10(15)20)7-3-2-4-8(5-7)16-9(19)11(12,13)14/h2-5H,1H3,(H,16,19)(H3,15,18,20)/b17-6+
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n/an/a 5.80n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234115
PNG
(CHEMBL4060236)
Show SMILES Cc1nnc(SCc2cc(=O)c(O)co2)n1NCc1ccc(O)cc1O
Show InChI InChI=1S/C16H16N4O5S/c1-9-18-19-16(26-8-12-5-14(23)15(24)7-25-12)20(9)17-6-10-2-3-11(21)4-13(10)22/h2-5,7,17,21-22,24H,6,8H2,1H3
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n/an/a 5.80n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234123
PNG
(CHEMBL4080599)
Show SMILES Oc1ccccc1CNn1cnnc1SCc1cc(=O)c(O)co1
Show InChI InChI=1S/C15H14N4O4S/c20-12-4-2-1-3-10(12)6-17-19-9-16-18-15(19)24-8-11-5-13(21)14(22)7-23-11/h1-5,7,9,17,20,22H,6,8H2
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n/an/a 5.90n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50073334
PNG
(CHEMBL2420105)
Show SMILES C\C(=N/NC(N)=S)c1cccc(N)c1
Show InChI InChI=1S/C9H12N4S/c1-6(12-13-9(11)14)7-3-2-4-8(10)5-7/h2-5H,10H2,1H3,(H3,11,13,14)/b12-6+
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n/an/a 6.10n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234126
PNG
(CHEMBL4098634)
Show SMILES CCc1nnc(SCc2cc(=O)c(O)co2)n1NCc1ccccc1O
Show InChI InChI=1S/C17H18N4O4S/c1-2-16-19-20-17(26-10-12-7-14(23)15(24)9-25-12)21(16)18-8-11-5-3-4-6-13(11)22/h3-7,9,18,22,24H,2,8,10H2,1H3
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n/an/a 7.60n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234113
PNG
(CHEMBL4081109)
Show SMILES Oc1ccc(\C=N\n2cnnc2SCc2cc(=O)c(O)co2)cc1
Show InChI InChI=1S/C15H12N4O4S/c20-11-3-1-10(2-4-11)6-17-19-9-16-18-15(19)24-8-12-5-13(21)14(22)7-23-12/h1-7,9,20,22H,8H2/b17-6+
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n/an/a 8.5n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50026374
PNG
(CHEMBL3331164)
Show SMILES CCCOC1Cc2c(O1)c1ccccc1c(O)c2C(C)=O
Show InChI InChI=1S/C17H18O4/c1-3-8-20-14-9-13-15(10(2)18)16(19)11-6-4-5-7-12(11)17(13)21-14/h4-7,14,19H,3,8-9H2,1-2H3
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n/an/a 8.90n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 2 mins by spectrophotometry


Eur J Med Chem 86: 605-12 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.025
BindingDB Entry DOI: 10.7270/Q2X92CW2
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234117
PNG
(CHEMBL4097661)
Show SMILES Oc1ccc(\C=N\n2cnnc2SCc2cc(=O)c(O)co2)c(O)c1
Show InChI InChI=1S/C15H12N4O5S/c20-10-2-1-9(12(21)3-10)5-17-19-8-16-18-15(19)25-7-11-4-13(22)14(23)6-24-11/h1-6,8,20-21,23H,7H2/b17-5+
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n/an/a 9.60n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 10n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 2 mins by spectrophotometry


Eur J Med Chem 86: 605-12 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.025
BindingDB Entry DOI: 10.7270/Q2X92CW2
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234124
PNG
(CHEMBL4088468)
Show SMILES Cc1nnc(SCc2cc(=O)c(O)co2)n1NCc1ccccc1O
Show InChI InChI=1S/C16H16N4O4S/c1-10-18-19-16(25-9-12-6-14(22)15(23)8-24-12)20(10)17-7-11-4-2-3-5-13(11)21/h2-6,8,17,21,23H,7,9H2,1H3
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n/an/a 10n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50339940
PNG
(4-(Benzo[d]thiazol-2-yl)benzene-1,3-diol | CHEMBL1...)
Show SMILES Oc1ccc(-c2nc3ccccc3s2)c(O)c1
Show InChI InChI=1S/C13H9NO2S/c15-8-5-6-9(11(16)7-8)13-14-10-3-1-2-4-12(10)17-13/h1-7,15-16H
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n/an/a 10n/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-tyrosine as a substrate


Bioorg Med Chem Lett 21: 2445-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.064
BindingDB Entry DOI: 10.7270/Q2PN95XZ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234122
PNG
(CHEMBL4090907)
Show SMILES Cc1nnc(SCc2cc(=O)c(O)co2)n1NCc1cccc(O)c1
Show InChI InChI=1S/C16H16N4O4S/c1-10-18-19-16(25-9-13-6-14(22)15(23)8-24-13)20(10)17-7-11-3-2-4-12(21)5-11/h2-6,8,17,21,23H,7,9H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50234116
PNG
(CHEMBL4070486)
Show SMILES COc1cc(\C=N\n2cnnc2SCc2cc(=O)c(O)co2)ccc1O
Show InChI InChI=1S/C16H14N4O5S/c1-24-15-4-10(2-3-12(15)21)6-18-20-9-17-19-16(20)26-8-11-5-13(22)14(23)7-25-11/h2-7,9,21,23H,8H2,1H3/b18-6+
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n/an/a 18n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 20n/an/an/an/an/an/a



Hunan University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated for 20 mi...


Bioorg Med Chem Lett 27: 530-532 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.027
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50027482
PNG
(CHEMBL1256531)
Show SMILES Oc1ccc(\C=C\C(=O)c2ccccc2O)c(O)c1
Show InChI InChI=1S/C15H12O4/c16-11-7-5-10(15(19)9-11)6-8-14(18)12-3-1-2-4-13(12)17/h1-9,16-17,19H/b8-6+
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n/an/a 29n/an/an/an/an/an/a



Jiangnan University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-tyrosine as substrate after 20 mins by spectrophotometric method


Bioorg Med Chem Lett 26: 795-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.092
BindingDB Entry DOI: 10.7270/Q29Z96RT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 29n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for...


Eur J Med Chem 93: 255-62 (2015)


Article DOI: 10.1016/j.ejmech.2015.02.013
BindingDB Entry DOI: 10.7270/Q23X88C4
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50134709
PNG
(CHEMBL3747057)
Show SMILES COc1c2C[C@@H](COc2cc2OC(C)(C)C=Cc12)c1ccc(O)cc1O
Show InChI InChI=1S/C21H22O5/c1-21(2)7-6-15-19(26-21)10-18-16(20(15)24-3)8-12(11-25-18)14-5-4-13(22)9-17(14)23/h4-7,9-10,12,22-23H,8,11H2,1-3H3/t12-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated with substrate for 10 mins followed by protein...


Bioorg Med Chem 24: 153-9 (2016)


Article DOI: 10.1016/j.bmc.2015.11.040
BindingDB Entry DOI: 10.7270/Q2RN39PT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50026379
PNG
(CHEMBL3331266)
Show SMILES CCO[C@H]1Oc2c([C@@H]1C)c(C(C)=O)c(O)c1ccccc21
Show InChI InChI=1S/C17H18O4/c1-4-20-17-9(2)13-14(10(3)18)15(19)11-7-5-6-8-12(11)16(13)21-17/h5-9,17,19H,4H2,1-3H3/t9-,17-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 2 mins by spectrophotometry


Eur J Med Chem 86: 605-12 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.025
BindingDB Entry DOI: 10.7270/Q2X92CW2
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50197244
PNG
(4-(6-hydroxynaphthalen-2-yl)benzene-1,3-diol | CHE...)
Show SMILES Oc1ccc(c(O)c1)-c1ccc2cc(O)ccc2c1
Show InChI InChI=1S/C16H12O3/c17-13-4-3-10-7-12(2-1-11(10)8-13)15-6-5-14(18)9-16(15)19/h1-9,17-19H
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n/an/a 34n/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem Lett 17: 461-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.025
BindingDB Entry DOI: 10.7270/Q20P0ZNM
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50026381
PNG
(CHEMBL3331268)
Show SMILES CC(=O)c1c2[C@@H]3CCCO[C@@H]3Oc2c2ccccc2c1O
Show InChI InChI=1S/C17H16O4/c1-9(18)13-14-12-7-4-8-20-17(12)21-16(14)11-6-3-2-5-10(11)15(13)19/h2-3,5-6,12,17,19H,4,7-8H2,1H3/t12-,17+/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase using L-DOPA as substrate after 2 mins by spectrophotometry


Eur J Med Chem 86: 605-12 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.025
BindingDB Entry DOI: 10.7270/Q2X92CW2
More data for this
Ligand-Target Pair
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