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Compile Data Set for Download or QSAR

Found 150 hits of ki data for polymerid = 4998,5039,7025,7431,7622,8207,9974   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50269559
PNG
(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc(c(O)c1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-6,16-19H
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0.610 -12.8n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


J Enzyme Inhib Med Chem 23: 922-30 (2008)


Article DOI: 10.1080/14756360701810207
BindingDB Entry DOI: 10.7270/Q2P849G3
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50134709
PNG
(CHEMBL3747057)
Show SMILES COc1c2C[C@@H](COc2cc2OC(C)(C)C=Cc12)c1ccc(O)cc1O
Show InChI InChI=1S/C21H22O5/c1-21(2)7-6-15-19(26-21)10-18-16(20(15)24-3)8-12(11-25-18)14-5-4-13(22)9-17(14)23/h4-7,9-10,12,22-23H,8,11H2,1-3H3/t12-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Time dependent inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate measured every 30 secs by Morrison and Walsh...


Bioorg Med Chem 24: 153-9 (2016)


Article DOI: 10.1016/j.bmc.2015.11.040
BindingDB Entry DOI: 10.7270/Q2RN39PT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50134709
PNG
(CHEMBL3747057)
Show SMILES COc1c2C[C@@H](COc2cc2OC(C)(C)C=Cc12)c1ccc(O)cc1O
Show InChI InChI=1S/C21H22O5/c1-21(2)7-6-15-19(26-21)10-18-16(20(15)24-3)8-12(11-25-18)14-5-4-13(22)9-17(14)23/h4-7,9-10,12,22-23H,8,11H2,1-3H3/t12-/m0/s1
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19n/an/an/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Competitive inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated for 5 to 60 mins by Lineweaver-Bur...


Bioorg Med Chem 24: 153-9 (2016)


Article DOI: 10.1016/j.bmc.2015.11.040
BindingDB Entry DOI: 10.7270/Q2RN39PT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50330795
PNG
(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Show SMILES CC(C)c1ccc(O)c(=O)cc1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-5-9(11)10(12)6-4-8/h3-7H,1-2H3,(H,11,12)
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20n/an/an/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysis


Bioorg Med Chem 18: 8112-8 (2010)


Article DOI: 10.1016/j.bmc.2010.08.056
BindingDB Entry DOI: 10.7270/Q2JH3MF5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50343137
PNG
(CHEMBL1770313 | Cyclomorusin | Cycolmorusin, 2)
Show SMILES CC(C)=CC1Oc2cc(O)ccc2-c2oc3c4C=CC(C)(C)Oc4cc(O)c3c(=O)c12
Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3
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46.4 -10.2n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


J Enzyme Inhib Med Chem 23: 922-30 (2008)


Article DOI: 10.1080/14756360701810207
BindingDB Entry DOI: 10.7270/Q2P849G3
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254430
PNG
(CHEMBL468906 | broussonin C)
Show SMILES CC(C)=CCc1cc(CCCc2ccc(O)cc2O)ccc1O
Show InChI InChI=1S/C20H24O3/c1-14(2)6-8-17-12-15(7-11-19(17)22)4-3-5-16-9-10-18(21)13-20(16)23/h6-7,9-13,21-23H,3-5,8H2,1-2H3
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48.5n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase by kinetic based assay


Bioorg Med Chem 17: 35-41 (2008)


Article DOI: 10.1016/j.bmc.2008.11.022
BindingDB Entry DOI: 10.7270/Q2GH9HTH
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM91591
PNG
(Mormin, 1)
Show SMILES C\C(CO)=C/Cc1c(oc2c3C=CC(C)(CO)Oc3cc(O)c2c1=O)-c1ccc(O)cc1O
Show InChI InChI=1S/C25H24O8/c1-13(11-26)3-5-17-22(31)21-19(30)10-20-16(7-8-25(2,12-27)33-20)24(21)32-23(17)15-6-4-14(28)9-18(15)29/h3-4,6-10,26-30H,5,11-12H2,1-2H3/b13-3+
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49.2 -10.1n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


J Enzyme Inhib Med Chem 23: 922-30 (2008)


Article DOI: 10.1080/14756360701810207
BindingDB Entry DOI: 10.7270/Q2P849G3
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50330794
PNG
(2-Hydroxy-4-isopropyl-cyclohepta-2,4,6-trienone | ...)
Show SMILES CC(C)c1cccc(=O)c(O)c1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12)
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60n/an/an/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysis


Bioorg Med Chem 18: 8112-8 (2010)


Article DOI: 10.1016/j.bmc.2010.08.056
BindingDB Entry DOI: 10.7270/Q2JH3MF5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50242015
PNG
(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Show SMILES CC(C)=CCc1c(O)cc(O)c2c1oc(-c1ccc(O)cc1O)c(CC=C(C)C)c2=O
Show InChI InChI=1S/C25H26O6/c1-13(2)5-8-17-20(28)12-21(29)22-23(30)18(9-6-14(3)4)24(31-25(17)22)16-10-7-15(26)11-19(16)27/h5-7,10-12,26-29H,8-9H2,1-4H3
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80.5 -9.83n/an/an/an/an/an/a30



Gyeongsang National University



Assay Description
Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...


J Enzyme Inhib Med Chem 23: 922-30 (2008)


Article DOI: 10.1080/14756360701810207
BindingDB Entry DOI: 10.7270/Q2P849G3
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50134709
PNG
(CHEMBL3747057)
Show SMILES COc1c2C[C@@H](COc2cc2OC(C)(C)C=Cc12)c1ccc(O)cc1O
Show InChI InChI=1S/C21H22O5/c1-21(2)7-6-15-19(26-21)10-18-16(20(15)24-3)8-12(11-25-18)14-5-4-13(22)9-17(14)23/h4-7,9-10,12,22-23H,8,11H2,1-3H3/t12-/m0/s1
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130n/an/an/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Competitive inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated for 5 to 60 mins by Lineweaver-Burk and ...


Bioorg Med Chem 24: 153-9 (2016)


Article DOI: 10.1016/j.bmc.2015.11.040
BindingDB Entry DOI: 10.7270/Q2RN39PT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50134710
PNG
(CHEMBL3745886)
Show SMILES CC(C)=CCC\C(C)=C\Cc1c(O)ccc(C2COc3cc(O)cc(O)c3C2=O)c1O
Show InChI InChI=1S/C25H28O6/c1-14(2)5-4-6-15(3)7-8-18-20(27)10-9-17(24(18)29)19-13-31-22-12-16(26)11-21(28)23(22)25(19)30/h5,7,9-12,19,26-29H,4,6,8,13H2,1-3H3/b15-7+
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151n/an/an/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Time dependent inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate measured every 30 secs by Morrison and Walsh...


Bioorg Med Chem 24: 153-9 (2016)


Article DOI: 10.1016/j.bmc.2015.11.040
BindingDB Entry DOI: 10.7270/Q2RN39PT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50251001
PNG
(CHEMBL457677 | Kazinol F)
Show SMILES CC(C)=CCc1c(CCCc2ccc(O)cc2O)cc(O)c(O)c1CC=C(C)C
Show InChI InChI=1S/C25H32O4/c1-16(2)8-12-21-19(7-5-6-18-10-11-20(26)15-23(18)27)14-24(28)25(29)22(21)13-9-17(3)4/h8-11,14-15,26-29H,5-7,12-13H2,1-4H3
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181n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase by kinetic based assay


Bioorg Med Chem 17: 35-41 (2008)


Article DOI: 10.1016/j.bmc.2008.11.022
BindingDB Entry DOI: 10.7270/Q2GH9HTH
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304605
PNG
(5-(4-hydroxyphenyl)-1,3,4-thiadiazole-2(3H)-thione...)
Show SMILES Oc1ccc(cc1)-c1nnc(S)s1
Show InChI InChI=1S/C8H6N2OS2/c11-6-3-1-5(2-4-6)7-9-10-8(12)13-7/h1-4,11H,(H,10,12)
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190n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254430
PNG
(CHEMBL468906 | broussonin C)
Show SMILES CC(C)=CCc1cc(CCCc2ccc(O)cc2O)ccc1O
Show InChI InChI=1S/C20H24O3/c1-14(2)6-8-17-12-15(7-11-19(17)22)4-3-5-16-9-10-18(21)13-20(16)23/h6-7,9-13,21-23H,3-5,8H2,1-2H3
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230n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot based kinetic assay


Bioorg Med Chem 17: 35-41 (2008)


Article DOI: 10.1016/j.bmc.2008.11.022
BindingDB Entry DOI: 10.7270/Q2GH9HTH
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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290 -8.97n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254430
PNG
(CHEMBL468906 | broussonin C)
Show SMILES CC(C)=CCc1cc(CCCc2ccc(O)cc2O)ccc1O
Show InChI InChI=1S/C20H24O3/c1-14(2)6-8-17-12-15(7-11-19(17)22)4-3-5-16-9-10-18(21)13-20(16)23/h6-7,9-13,21-23H,3-5,8H2,1-2H3
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290n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of diphenolase activity of mushroom tyrosinase using as L-DOPA substrate by Lineweaver-Burk plot based kinetic assay


Bioorg Med Chem 17: 35-41 (2008)


Article DOI: 10.1016/j.bmc.2008.11.022
BindingDB Entry DOI: 10.7270/Q2GH9HTH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205807
PNG
(CHEMBL3978212)
Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1
Show InChI InChI=1S/C14H9NO5/c16-9-2-3-10-11(6-9)20-12(14(10)18)5-8-1-4-13(17)15(19)7-8/h1-7,16,19H/b12-5-
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350n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50251001
PNG
(CHEMBL457677 | Kazinol F)
Show SMILES CC(C)=CCc1c(CCCc2ccc(O)cc2O)cc(O)c(O)c1CC=C(C)C
Show InChI InChI=1S/C25H32O4/c1-16(2)8-12-21-19(7-5-6-18-10-11-20(26)15-23(18)27)14-24(28)25(29)22(21)13-9-17(3)4/h8-11,14-15,26-29H,5-7,12-13H2,1-4H3
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410n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot based kinetic assay


Bioorg Med Chem 17: 35-41 (2008)


Article DOI: 10.1016/j.bmc.2008.11.022
BindingDB Entry DOI: 10.7270/Q2GH9HTH
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320717
PNG
(5,5'-methylenebis(1,3,4-thiadiazole-2(3H)-thione) ...)
Show SMILES Sc1nnc(Cc2nnc(S)s2)s1
Show InChI InChI=1S/C5H4N4S4/c10-4-8-6-2(12-4)1-3-7-9-5(11)13-3/h1H2,(H,8,10)(H,9,11)
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490n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304602
PNG
(5-(4-(tert-butyldimethylsilyloxy)phenyl)-1,3,4-thi...)
Show SMILES CC(C)(C)[Si](C)(C)Oc1ccc(cc1)-c1nnc(S)s1
Show InChI InChI=1S/C14H20N2OS2Si/c1-14(2,3)20(4,5)17-11-8-6-10(7-9-11)12-15-16-13(18)19-12/h6-9H,1-5H3,(H,16,18)
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530n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM33932
PNG
(4-(3H-1,3-benzothiazol-2-ylidene)-1-cyclohexa-2,5-...)
Show SMILES Oc1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C13H9NOS/c15-10-7-5-9(6-8-10)13-14-11-3-1-2-4-12(11)16-13/h1-8,15H
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567n/an/an/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 1.25 uM by Lineweaver-burk plot analysis


Bioorg Med Chem Lett 21: 2445-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.064
BindingDB Entry DOI: 10.7270/Q2PN95XZ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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640 -8.50n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50339940
PNG
(4-(Benzo[d]thiazol-2-yl)benzene-1,3-diol | CHEMBL1...)
Show SMILES Oc1ccc(-c2nc3ccccc3s2)c(O)c1
Show InChI InChI=1S/C13H9NO2S/c15-8-5-6-9(11(16)7-8)13-14-10-3-1-2-4-12(10)17-13/h1-7,15-16H
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673n/an/an/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 1.25 uM by Lineweaver-burk plot analysis


Bioorg Med Chem Lett 21: 2445-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.064
BindingDB Entry DOI: 10.7270/Q2PN95XZ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50251001
PNG
(CHEMBL457677 | Kazinol F)
Show SMILES CC(C)=CCc1c(CCCc2ccc(O)cc2O)cc(O)c(O)c1CC=C(C)C
Show InChI InChI=1S/C25H32O4/c1-16(2)8-12-21-19(7-5-6-18-10-11-20(26)15-23(18)27)14-24(28)25(29)22(21)13-9-17(3)4/h8-11,14-15,26-29H,5-7,12-13H2,1-4H3
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770n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of diphenolase activity of mushroom tyrosinase using as L-DOPA substrate by Lineweaver-Burk plot based kinetic assay


Bioorg Med Chem 17: 35-41 (2008)


Article DOI: 10.1016/j.bmc.2008.11.022
BindingDB Entry DOI: 10.7270/Q2GH9HTH
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50324036
PNG
(2-[5-(2,4-Dimethoxy-phenyl)-1H-pyrazol-3-yl]-6-(2-...)
Show SMILES COc1ccc(-c2cc([nH]n2)-c2c(OC)cc(OC)c(C3CCN(C)C3CO)c2O)c(OC)c1
Show InChI InChI=1S/C25H31N3O6/c1-28-9-8-16(19(28)13-29)23-21(33-4)12-22(34-5)24(25(23)30)18-11-17(26-27-18)15-7-6-14(31-2)10-20(15)32-3/h6-7,10-12,16,19,29-30H,8-9,13H2,1-5H3,(H,26,27)
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840n/an/an/an/an/an/an/an/a



Solapur University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 6149-55 (2010)


Article DOI: 10.1016/j.bmc.2010.06.046
BindingDB Entry DOI: 10.7270/Q2GQ6XXR
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50254431
PNG
(5'-(2-methylbut-3-en-2-yl)-6''-(3-methylbut-2-enyl...)
Show SMILES CC(C)=CCc1c(CCCc2cc(c(O)cc2O)C(C)(C)C=C)cc(O)c(O)c1CC1OC1(C)C
Show InChI InChI=1S/C30H40O5/c1-8-29(4,5)23-14-20(24(31)17-25(23)32)11-9-10-19-15-26(33)28(34)22(16-27-30(6,7)35-27)21(19)13-12-18(2)3/h8,12,14-15,17,27,31-34H,1,9-11,13,16H2,2-7H3
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870n/an/an/an/an/an/an/an/a



Graduate School of Gyeongsang National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase by kinetic based assay


Bioorg Med Chem 17: 35-41 (2008)


Article DOI: 10.1016/j.bmc.2008.11.022
BindingDB Entry DOI: 10.7270/Q2GH9HTH
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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950 -8.54n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50324036
PNG
(2-[5-(2,4-Dimethoxy-phenyl)-1H-pyrazol-3-yl]-6-(2-...)
Show SMILES COc1ccc(-c2cc([nH]n2)-c2c(OC)cc(OC)c(C3CCN(C)C3CO)c2O)c(OC)c1
Show InChI InChI=1S/C25H31N3O6/c1-28-9-8-16(19(28)13-29)23-21(33-4)12-22(34-5)24(25(23)30)18-11-17(26-27-18)15-7-6-14(31-2)10-20(15)32-3/h6-7,10-12,16,19,29-30H,8-9,13H2,1-5H3,(H,26,27)
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960n/an/an/an/an/an/an/an/a



Solapur University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase assessed as oxidation of L-DOPA


Bioorg Med Chem 18: 6149-55 (2010)


Article DOI: 10.1016/j.bmc.2010.06.046
BindingDB Entry DOI: 10.7270/Q2GQ6XXR
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320721
PNG
(4-Amino-5-pyridin-4-yl-4H-[1,2,4]triazole-3-thiol ...)
Show SMILES Nn1c(n[nH]c1=S)-c1ccncc1
Show InChI InChI=1S/C7H7N5S/c8-12-6(10-11-7(12)13)5-1-3-9-4-2-5/h1-4H,8H2,(H,11,13)
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1.01E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205815
PNG
(CHEMBL3907670)
Show SMILES Oc1cccc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c12
Show InChI InChI=1S/C14H9NO5/c16-9-2-1-3-10-13(9)14(18)11(20-10)6-8-4-5-12(17)15(19)7-8/h1-7,16,19H/b11-6-
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1.02E+3n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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1.05E+3 -8.48n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50336361
PNG
(4-Hydroxybenzyl 2,4-dihydroxybenzoate | CHEMBL1668...)
Show SMILES Oc1ccc(COC(=O)c2ccc(O)cc2O)cc1
Show InChI InChI=1S/C14H12O5/c15-10-3-1-9(2-4-10)8-19-14(18)12-6-5-11(16)7-13(12)17/h1-7,15-17H,8H2
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1.11E+3n/an/an/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase by Lineweaver-Burk plot analysis


Bioorg Med Chem 19: 1167-71 (2011)


Article DOI: 10.1016/j.bmc.2010.12.051
BindingDB Entry DOI: 10.7270/Q2RJ4JRZ
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50205806
PNG
(CHEMBL3969839)
Show SMILES Oc1cc2O\C(=C/c3ccc(=O)n(O)c3)C(=O)c2c(O)c1
Show InChI InChI=1S/C14H9NO6/c16-8-4-9(17)13-10(5-8)21-11(14(13)19)3-7-1-2-12(18)15(20)6-7/h1-6,16-17,20H/b11-3-
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1.20E+3n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50183699
PNG
(CHEMBL437510 | N-(2,4-dihydroxybenzyl)-3,5-dihydro...)
Show SMILES Oc1ccc(CNC(=O)c2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H13NO5/c16-10-2-1-8(13(19)6-10)7-15-14(20)9-3-11(17)5-12(18)4-9/h1-6,16-19H,7H2,(H,15,20)
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1.30E+3n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem Lett 16: 2682-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.018
BindingDB Entry DOI: 10.7270/Q2Z31Z7F
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320718
PNG
(5-phenyl-1,3,4-thiadiazole-2(3H)-thione | CHEMBL59...)
Show SMILES Sc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C8H6N2S2/c11-8-10-9-7(12-8)6-4-2-1-3-5-6/h1-5H,(H,10,11)
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1.31E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304606
PNG
(5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Sc1nnc(o1)-c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H12N2O2S/c20-15-17-16-14(19-15)12-6-8-13(9-7-12)18-10-11-4-2-1-3-5-11/h1-9H,10H2,(H,17,20)
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1.35E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM33932
PNG
(4-(3H-1,3-benzothiazol-2-ylidene)-1-cyclohexa-2,5-...)
Show SMILES Oc1ccc(cc1)-c1nc2ccccc2s1
Show InChI InChI=1S/C13H9NOS/c15-10-7-5-9(6-8-10)13-14-11-3-1-2-4-12(11)16-13/h1-8,15H
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1.70E+3n/an/an/an/an/an/an/an/a



Pusan National University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase at 20 uM by Lineweaver-burk plot analysis


Bioorg Med Chem Lett 21: 2445-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.064
BindingDB Entry DOI: 10.7270/Q2PN95XZ
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320723
PNG
(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol | 5-(4-h...)
Show SMILES Oc1ccc(cc1)-c1nnc(S)o1
Show InChI InChI=1S/C8H6N2O2S/c11-6-3-1-5(2-4-6)7-9-10-8(13)12-7/h1-4,11H,(H,10,13)
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1.77E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50134710
PNG
(CHEMBL3745886)
Show SMILES CC(C)=CCC\C(C)=C\Cc1c(O)ccc(C2COc3cc(O)cc(O)c3C2=O)c1O
Show InChI InChI=1S/C25H28O6/c1-14(2)5-4-6-15(3)7-8-18-20(27)10-9-17(24(18)29)19-13-31-22-12-16(26)11-21(28)23(22)25(19)30/h5,7,9-12,19,26-29H,4,6,8,13H2,1-3H3/b15-7+
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1.80E+3n/an/an/an/an/an/an/an/a



Gyeongsang National University

Curated by ChEMBL


Assay Description
Competitive inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated for 5 to 60 mins by Lineweaver-Bur...


Bioorg Med Chem 24: 153-9 (2016)


Article DOI: 10.1016/j.bmc.2015.11.040
BindingDB Entry DOI: 10.7270/Q2RN39PT
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304608
PNG
(5,5'-(propane-1,3-diyl)bis(1,3,4-oxadiazole-2(3H)-...)
Show SMILES Sc1nnc(CCCc2nnc(S)o2)o1
Show InChI InChI=1S/C7H8N4O2S2/c14-6-10-8-4(12-6)2-1-3-5-9-11-7(15)13-5/h1-3H2,(H,10,14)(H,11,15)
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1.90E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320722
PNG
(4-amino-3-(4-hydroxyphenyl)-1H-1,2,4-triazole-5(4H...)
Show SMILES Nn1c(n[nH]c1=S)-c1ccc(O)cc1
Show InChI InChI=1S/C8H8N4OS/c9-12-7(10-11-8(12)14)5-1-3-6(13)4-2-5/h1-4,13H,9H2,(H,11,14)
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2.40E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304604
PNG
(5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3H)-thione | ...)
Show SMILES Sc1nnc(s1)-c1ccncc1
Show InChI InChI=1S/C7H5N3S2/c11-7-10-9-6(12-7)5-1-3-8-4-2-5/h1-4H,(H,10,11)
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2.47E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50066275
PNG
(CHEMBL3401548)
Show SMILES OC(\C=C\c1ccccn1)c1ccccc1O
Show InChI InChI=1S/C14H13NO2/c16-13-7-2-1-6-12(13)14(17)9-8-11-5-3-4-10-15-11/h1-10,14,16-17H/b9-8+
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2.62E+3n/an/an/an/an/an/an/an/a



University of Technology Sydney

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase assessed as inhibition of L-DOPA oxidase activity at 5 uM active compound by Lineweaver-Burk plot analy...


Bioorg Med Chem Lett 25: 1753-6 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.060
BindingDB Entry DOI: 10.7270/Q2T72K42
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320719
PNG
(2,2'-bi(1,3,4-thiadiazole)-5,5'(4H,4'H)-dithione |...)
Show SMILES Sc1nnc(s1)-c1nnc(S)s1
Show InChI InChI=1S/C4H2N4S4/c9-3-7-5-1(11-3)2-6-8-4(10)12-2/h(H,7,9)(H,8,10)
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2.90E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50068224
PNG
((E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis...)
Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1
Show InChI InChI=1S/C15H12O3/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,16-17H/b10-3+
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2.90E+3n/an/an/an/an/an/an/an/a



Department of Functional Crop

Curated by ChEMBL


Assay Description
Competitive inhibition of monophenolase activity of mushroom tyrosinase using as L-tyrosine substrate by Lineweaver-Burk plot analysis


Eur J Med Chem 45: 2010-7 (2010)


Article DOI: 10.1016/j.ejmech.2010.01.049
BindingDB Entry DOI: 10.7270/Q2H70FZM
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50203986
PNG
(2,2',4,4',6'-pentahydroxychalcone | CHEMBL244249)
Show SMILES Oc1ccc(\C=C\C(=O)c2c(O)cc(O)cc2O)c(O)c1
Show InChI InChI=1S/C15H12O6/c16-9-3-1-8(12(19)5-9)2-4-11(18)15-13(20)6-10(17)7-14(15)21/h1-7,16-17,19-21H/b4-2+
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3.10E+3n/an/an/an/an/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase


Bioorg Med Chem 15: 2396-402 (2007)


Article DOI: 10.1016/j.bmc.2007.01.017
BindingDB Entry DOI: 10.7270/Q2R78DWH
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50330793
PNG
(2-hydroxy-3-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Show SMILES CC(C)c1ccccc(=O)c1O
Show InChI InChI=1S/C10H12O2/c1-7(2)8-5-3-4-6-9(11)10(8)12/h3-7H,1-2H3,(H,11,12)
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3.30E+3n/an/an/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Bulk plot analysis


Bioorg Med Chem 18: 8112-8 (2010)


Article DOI: 10.1016/j.bmc.2010.08.056
BindingDB Entry DOI: 10.7270/Q2JH3MF5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50304607
PNG
(5-(3-(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3H)-thi...)
Show SMILES Sc1nnc(o1)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C15H12N2O2S/c20-15-17-16-14(19-15)12-7-4-8-13(9-12)18-10-11-5-2-1-3-6-11/h1-9H,10H2,(H,17,20)
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3.64E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50320724
PNG
(5-benzyl-1,3,4-oxadiazole-2(3H)-thione | CHEMBL116...)
Show SMILES Sc1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C9H8N2OS/c13-9-11-10-8(12-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,13)
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3.67E+3n/an/an/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of mashroom tyrosinase


Bioorg Med Chem 18: 4042-8 (2010)


Article DOI: 10.1016/j.bmc.2010.04.021
BindingDB Entry DOI: 10.7270/Q2FJ2GZ8
More data for this
Ligand-Target Pair
Tyrosinase


(Mus musculus (Mouse))
BDBM50414514
PNG
(PROTOCATECHUAMIDE)
Show SMILES NC(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C7H7NO3/c8-7(11)4-1-2-5(9)6(10)3-4/h1-3,9-10H,(H2,8,11)
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3.70E+3n/an/an/an/an/an/an/an/a



National Institute of Advanced Industrial Science and Technology

Curated by ChEMBL


Assay Description
Apparent noncompetitive inhibition of catecholase activity of tyrosinase in mouse B16 cells by Lineweaver-Burke plot analysis


Bioorg Med Chem Lett 19: 4178-82 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.115
BindingDB Entry DOI: 10.7270/Q2BR8S70
More data for this
Ligand-Target Pair
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