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Compile Data Set for Download or QSAR

Found 6 hits of ic50 for UniProtKB: A0A024RAV7   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50012957
PNG
(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Show SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Show InChI InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
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n/an/a 220n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes


J Med Chem 44: 1627-53 (2001)


Article DOI: 10.1021/jm000484+
BindingDB Entry DOI: 10.7270/Q218376D
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50067133
PNG
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
Show SMILES CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1
Show InChI InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay


J Med Chem 54: 7477-85 (2011)


Article DOI: 10.1021/jm2005546
BindingDB Entry DOI: 10.7270/Q2SQ90T5
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50099573
PNG
(1N-[4-methoxy-3-methylamino(thioxo)methylsulfamoyl...)
Show SMILES CNC(=S)NS(=O)(=O)c1cc(CCNC(=O)c2cc(Cl)ccc2OC)ccc1OC
Show InChI InChI=1S/C19H22ClN3O5S2/c1-21-19(29)23-30(25,26)17-10-12(4-6-16(17)28-3)8-9-22-18(24)14-11-13(20)5-7-15(14)27-2/h4-7,10-11H,8-9H2,1-3H3,(H,22,24)(H2,21,23,29)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes


J Med Chem 44: 1627-53 (2001)


Article DOI: 10.1021/jm000484+
BindingDB Entry DOI: 10.7270/Q218376D
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50357207
PNG
(CHEMBL1915364 | CHEMBL1963307)
Show SMILES OC(COc1ccc(F)cc1C(=O)CCc1ccccc1)CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H37FN2O3/c36-30-17-19-34(32(24-30)33(40)18-16-27-10-4-1-5-11-27)41-26-31(39)25-37-20-22-38(23-21-37)35(28-12-6-2-7-13-28)29-14-8-3-9-15-29/h1-15,17,19,24,31,35,39H,16,18,20-23,25-26H2
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n/an/a>5.00E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay


J Med Chem 54: 7477-85 (2011)


Article DOI: 10.1021/jm2005546
BindingDB Entry DOI: 10.7270/Q2SQ90T5
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50357204
PNG
(CHEMBL1914835 | CHEMBL1963280)
Show SMILES OC(COc1ccccc1C(=O)CCc1ccccc1)CN1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C29H33NO3/c31-26(21-30-19-17-25(18-20-30)24-11-5-2-6-12-24)22-33-29-14-8-7-13-27(29)28(32)16-15-23-9-3-1-4-10-23/h1-14,25-26,31H,15-22H2
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n/an/a>5.00E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay


J Med Chem 54: 7477-85 (2011)


Article DOI: 10.1021/jm2005546
BindingDB Entry DOI: 10.7270/Q2SQ90T5
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50357205
PNG
(CHEMBL1914844 | CHEMBL1963594)
Show SMILES Cc1ccc(cc1)N1CCN(CC(O)COc2ccccc2C(=O)CCc2ccccc2)CC1
Show InChI InChI=1S/C29H34N2O3/c1-23-11-14-25(15-12-23)31-19-17-30(18-20-31)21-26(32)22-34-29-10-6-5-9-27(29)28(33)16-13-24-7-3-2-4-8-24/h2-12,14-15,26,32H,13,16-22H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay


J Med Chem 54: 7477-85 (2011)


Article DOI: 10.1021/jm2005546
BindingDB Entry DOI: 10.7270/Q2SQ90T5
More data for this
Ligand-Target Pair