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Compile Data Set for Download or QSAR

Found 16 hits of ki for UniProtKB: A0A024RAV7   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062397
PNG
(3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...)
Show SMILES CCC(C)(C)NC(NC#N)=Nc1cccnc1
Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
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27n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062402
PNG
(1N-cyanoimino(tert-pentylamino)methyl-3-azido-4-io...)
Show SMILES CCC(C)(C)NC(Nc1ccc(I)c(c1)N=[N+]=[N-])=NC#N
Show InChI InChI=1S/C13H16IN7/c1-4-13(2,3)19-12(17-8-15)18-9-5-6-10(14)11(7-9)20-21-16/h5-7H,4H2,1-3H3,(H2,17,18,19)
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57n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062394
PNG
(1N-cyanoimino(tert-pentylamino)methyl-4-iodoanilin...)
Show SMILES CCC(C)(C)NC(Nc1ccc(I)cc1)=NC#N
Show InChI InChI=1S/C13H17IN4/c1-4-13(2,3)18-12(16-9-15)17-11-7-5-10(14)6-8-11/h5-8H,4H2,1-3H3,(H2,16,17,18)
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74n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062396
PNG
(4-cyanoimino(1,2,2-trimethylpropylamino)methylamin...)
Show SMILES CC(NC(Nc1ccc(cc1)C#N)=NC#N)C(C)(C)C
Show InChI InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)
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99n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50012957
PNG
(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Show SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Show InChI InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
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130n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062398
PNG
(4-cyanoimino(tert-pentylamino)methylaminobenzonitr...)
Show SMILES CCC(C)(C)NC(Nc1ccc(cc1)C#N)=NC#N
Show InChI InChI=1S/C14H17N5/c1-4-14(2,3)19-13(17-10-16)18-12-7-5-11(9-15)6-8-12/h5-8H,4H2,1-3H3,(H2,17,18,19)
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160n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50240750
PNG
(()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylprop...)
Show SMILES CC(NC(NC#N)=Nc1ccncc1)C(C)(C)C
Show InChI InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
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320n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062393
PNG
(3-cyanoimino(1,2,2-trimethylpropylamino)methylamin...)
Show SMILES CC(NC(Nc1cccc(c1)C#N)=NC#N)C(C)(C)C
Show InChI InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-6-12(8-13)9-16/h5-8,11H,1-4H3,(H2,18,19,20)
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350n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062399
PNG
(4-[tert-butylamino(cyanoimino)methylamino]benzonit...)
Show SMILES CC(C)(C)NC(Nc1ccc(cc1)C#N)=NC#N
Show InChI InChI=1S/C13H15N5/c1-13(2,3)18-12(16-9-15)17-11-6-4-10(8-14)5-7-11/h4-7H,1-3H3,(H2,16,17,18)
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480n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062400
PNG
(1N-cyanoimino(1,2,2-trimethylpropylamino)methylani...)
Show SMILES CC(NC(Nc1ccccc1)=NC#N)C(C)(C)C
Show InChI InChI=1S/C14H20N4/c1-11(14(2,3)4)17-13(16-10-15)18-12-8-6-5-7-9-12/h5-9,11H,1-4H3,(H2,16,17,18)
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680n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50044253
PNG
((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062392
PNG
(4-isopropylamino(cyanoimino)methylaminobenzonitril...)
Show SMILES CC(C)NC(Nc1ccc(cc1)C#N)=NC#N
Show InChI InChI=1S/C12H13N5/c1-9(2)16-12(15-8-14)17-11-5-3-10(7-13)4-6-11/h3-6,9H,1-2H3,(H2,15,16,17)
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7.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062395
PNG
(1N-cyanoimino(tert-pentylamino)methyl-3-hexahydro-...)
Show SMILES CCC(C)(C)NC(Nc1cccc(c1)S(=O)(=O)N1CCCCC1)=NC#N
Show InChI InChI=1S/C18H27N5O2S/c1-4-18(2,3)22-17(20-14-19)21-15-9-8-10-16(13-15)26(24,25)23-11-6-5-7-12-23/h8-10,13H,4-7,11-12H2,1-3H3,(H2,20,21,22)
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>3.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062391
PNG
(1N-cyanoimino(tert-pentylamino)methyl-4-hexahydro-...)
Show SMILES CCC(C)(C)NC(Nc1ccc(cc1)S(=O)(=O)N1CCCCC1)=NC#N
Show InChI InChI=1S/C18H27N5O2S/c1-4-18(2,3)22-17(20-14-19)21-15-8-10-16(11-9-15)26(24,25)23-12-6-5-7-13-23/h8-11H,4-7,12-13H2,1-3H3,(H2,20,21,22)
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>3.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50062401
PNG
(4-methylamino(cyanoimino)methylaminobenzonitrile |...)
Show SMILES CNC(Nc1ccc(cc1)C#N)=NC#N
Show InChI InChI=1S/C10H9N5/c1-13-10(14-7-12)15-9-4-2-8(6-11)3-5-9/h2-5H,1H3,(H2,13,14,15)
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>3.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50044253
PNG
((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1
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7.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair