Compile Data Set for Download or QSAR
Found 81 of ic50 for UniProtKB: P13631
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50075879(4-(2,2-Dimethyl-4-p-tolyl-2H-1-thia-anthracen-6-yl...)
Show SMILES Cc1ccc(cc1)C1=CC(C)(C)Sc2cc3ccc(cc3cc12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H24O2S/c1-18-4-6-20(7-5-18)26-17-29(2,3)32-27-16-23-13-12-22(14-24(23)15-25(26)27)19-8-10-21(11-9-19)28(30)31/h4-17H,1-3H3,(H,30,31)
Affinity DataIC50: 0.5nMAssay Description:Antagonistic activity against RAR gamma in transcriptional activation assay with 3.2 nM TTNPBMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataIC50: 0.620nMAssay Description:Binding affinity against Retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084832(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Show SMILES CC1(C)CCC(C)(C)c2nc(cnc12)-c1cc(cs1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H24N2O2S/c1-22(2)9-10-23(3,4)20-19(22)24-12-17(25-20)18-11-16(13-28-18)14-5-7-15(8-6-14)21(26)27/h5-8,11-13H,9-10H2,1-4H3,(H,26,27)
Affinity DataIC50: 2nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50075880(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-anthracen-2-...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2cc3ccc(cc3cc12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C30H26O2/c1-19-4-6-21(7-5-19)26-14-15-30(2,3)28-18-24-13-12-23(16-25(24)17-27(26)28)20-8-10-22(11-9-20)29(31)32/h4-14,16-18H,15H2,1-3H3,(H,31,32)
Affinity DataIC50: 2nMAssay Description:Binding affinity of [3H]- RA to baculovirus expressed human Retinoic acid receptor betaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50075877(4-[5,5-Dimethyl-8-(5-methyl-thiophen-2-yl)-5,6-dih...)
Show SMILES Cc1ccc(s1)C1=CCC(C)(C)c2cc3ccc(cc3cc12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2S/c1-17-4-11-26(31-17)23-12-13-28(2,3)25-16-21-10-9-20(14-22(21)15-24(23)25)18-5-7-19(8-6-18)27(29)30/h4-12,14-16H,13H2,1-3H3,(H,29,30)
Affinity DataIC50: 2nMAssay Description:Antagonistic activity against RAR alpha in transcriptional activation assay with 32 nM TTNPBMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50075878(4-(2,2-Dimethyl-4-p-tolyl-2H-benzo[g]chromen-7-yl)...)
Show SMILES Cc1ccc(cc1)C1=CC(C)(C)Oc2cc3ccc(cc3cc12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C29H24O3/c1-18-4-6-20(7-5-18)26-17-29(2,3)32-27-16-23-13-12-22(14-24(23)15-25(26)27)19-8-10-21(11-9-19)28(30)31/h4-17H,1-3H3,(H,30,31)
Affinity DataIC50: 2nMAssay Description:Binding affinity of [3H]- RA to baculovirus expressed human Retinoic acid receptor betaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50097821(4-{(E)-4-[2-(4-Ethyl-phenyl)-6,6-dimethyl-cyclohex...)
Show SMILES CCc1ccc(cc1)C1=C(\C=C\C#Cc2ccc(cc2)C(O)=O)C(C)(C)CCC1
Show InChI InChI=1S/C27H28O2/c1-4-20-11-15-22(16-12-20)24-9-7-19-27(2,3)25(24)10-6-5-8-21-13-17-23(18-14-21)26(28)29/h6,10-18H,4,7,9,19H2,1-3H3,(H,28,29)/b10-6+
Affinity DataIC50: 3nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor betaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)
Affinity DataIC50: 3nMAssay Description:Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligandMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084830(4-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Show SMILES CC1(C)CCC(C)(C)c2nc(cnc12)-c1csc(n1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H23N3O2S/c1-21(2)9-10-22(3,4)18-17(21)23-11-15(24-18)16-12-28-19(25-16)13-5-7-14(8-6-13)20(26)27/h5-8,11-12H,9-10H2,1-4H3,(H,26,27)
Affinity DataIC50: 3.60nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50075876(4-[2,2-Dimethyl-4-(5-methyl-thiophen-2-yl)-2H-benz...)
Show SMILES Cc1ccc(s1)C1=CC(C)(C)Oc2cc3ccc(cc3cc12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22O3S/c1-16-4-11-25(31-16)23-15-27(2,3)30-24-14-20-10-9-19(12-21(20)13-22(23)24)17-5-7-18(8-6-17)26(28)29/h4-15H,1-3H3,(H,28,29)
Affinity DataIC50: 4nMAssay Description:Antagonistic activity against RAR gamma in transcriptional activation assay with 3.2 nM TTNPBMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084831(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Show SMILES CC1(C)CCC(C)(C)c2nc(cnc12)-c1ccc(o1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H24N2O3/c1-22(2)11-12-23(3,4)20-19(22)24-13-16(25-20)18-10-9-17(28-18)14-5-7-15(8-6-14)21(26)27/h5-10,13H,11-12H2,1-4H3,(H,26,27)
Affinity DataIC50: 4.60nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50097823(4-[(E)-4-(6,6-Dimethyl-2-p-tolyl-cyclohex-1-enyl)-...)
Show SMILES Cc1ccc(cc1)C1=C(\C=C\C#Cc2ccc(cc2)C(O)=O)C(C)(C)CCC1
Show InChI InChI=1S/C26H26O2/c1-19-10-14-21(15-11-19)23-8-6-18-26(2,3)24(23)9-5-4-7-20-12-16-22(17-13-20)25(27)28/h5,9-17H,6,8,18H2,1-3H3,(H,27,28)/b9-5+
Affinity DataIC50: 5nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
Affinity DataIC50: 17nMAssay Description:Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084829(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Show SMILES CC1(C)CCC(C)(C)c2nc(cnc12)-c1ccc(s1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H24N2O2S/c1-22(2)11-12-23(3,4)20-19(22)24-13-16(25-20)18-10-9-17(28-18)14-5-7-15(8-6-14)21(26)27/h5-10,13H,11-12H2,1-4H3,(H,26,27)
Affinity DataIC50: 17nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
Affinity DataIC50: 18nMAssay Description:Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084833(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-napht...)
Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)-c1ccc([nH]1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H27NO2/c1-24(2)13-14-25(3,4)20-15-18(9-10-19(20)24)22-12-11-21(26-22)16-5-7-17(8-6-16)23(27)28/h5-12,15,26H,13-14H2,1-4H3,(H,27,28)
Affinity DataIC50: 21nMAssay Description:Binding affinity for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50032219((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+
Affinity DataIC50: 26nMAssay Description:Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084834(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Show SMILES CC1(C)CCC(C)(C)c2nc(cnc12)-c1cc(co1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H24N2O3/c1-22(2)9-10-23(3,4)20-19(22)24-12-17(25-20)18-11-16(13-28-18)14-5-7-15(8-6-14)21(26)27/h5-8,11-13H,9-10H2,1-4H3,(H,26,27)
Affinity DataIC50: 27nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50097820(4-[(E)-4-(3,3-Dimethyl-6-p-tolyl-cyclohexa-1,5-die...)
Show SMILES Cc1ccc(cc1)C1=CCC(C)(C)C=C1\C=C\C#Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H24O2/c1-19-8-12-21(13-9-19)24-16-17-26(2,3)18-23(24)7-5-4-6-20-10-14-22(15-11-20)25(27)28/h5,7-16,18H,17H2,1-3H3,(H,27,28)/b7-5+
Affinity DataIC50: 31nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor alphaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50296049((2E,4E)-2,4-dimethyl-5-(6,6,9,9-tetramethyl-4-oxo-...)
Show SMILES C\C(\C=C(/C)C(O)=O)=C/c1coc2cc3c(cc2c1=O)C(C)(C)CCC3(C)C
Show InChI InChI=1S/C24H28O4/c1-14(9-15(2)22(26)27)10-16-13-28-20-12-19-18(11-17(20)21(16)25)23(3,4)7-8-24(19,5)6/h9-13H,7-8H2,1-6H3,(H,26,27)/b14-10+,15-9+
Affinity DataIC50: 40nMAssay Description:Displacement of radioligand from RARgamma receptorMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084837(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Show SMILES CC1(C)CCC(C)(C)c2nc(cnc12)-c1cc(c[nH]1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H25N3O2/c1-22(2)9-10-23(3,4)20-19(22)25-13-18(26-20)17-11-16(12-24-17)14-5-7-15(8-6-14)21(27)28/h5-8,11-13,24H,9-10H2,1-4H3,(H,27,28)
Affinity DataIC50: 150nMAssay Description:Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50044099(4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetr...)
Show SMILES CCc1cc2c(cc1\C(C)=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C26H32O2/c1-7-19-15-22-23(26(5,6)13-12-25(22,3)4)16-21(19)17(2)14-18-8-10-20(11-9-18)24(27)28/h8-11,14-16H,7,12-13H2,1-6H3,(H,27,28)/b17-14+
Affinity DataIC50: 250nMAssay Description:Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50084835(4-[5-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-quino...)
Show SMILES CC1(C)CCC(C)(C)c2nc(cnc12)-c1ccc([nH]1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H25N3O2/c1-22(2)11-12-23(3,4)20-19(22)24-13-18(26-20)17-10-9-16(25-17)14-5-7-15(8-6-14)21(27)28/h5-10,13,25H,11-12H2,1-4H3,(H,27,28)
Affinity DataIC50: 310nMAssay Description:Binding affinity for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50097822(4-{(E)-4-[2-(4-tert-Butyl-phenyl)-6,6-dimethyl-cyc...)
Show SMILES CC(C)(C)c1ccc(cc1)C1=C(\C=C\C#Cc2ccc(cc2)C(O)=O)C(C)(C)CCC1
Show InChI InChI=1S/C29H32O2/c1-28(2,3)24-18-16-22(17-19-24)25-10-8-20-29(4,5)26(25)11-7-6-9-21-12-14-23(15-13-21)27(30)31/h7,11-19H,8,10,20H2,1-5H3,(H,30,31)/b11-7+
Affinity DataIC50: 331nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50032221(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1cc2c(cc1C)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C25H30O2/c1-16(13-18-7-9-19(10-8-18)23(26)27)20-15-22-21(14-17(20)2)24(3,4)11-12-25(22,5)6/h7-10,13-15H,11-12H2,1-6H3,(H,26,27)/b16-13+
Affinity DataIC50: 645nMAssay Description:Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203459(CHEMBL3894222)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Oc2c(Cl)cccc2Cl)c2c(F)cccc12
Show InChI InChI=1S/C20H11Cl2FN2O3/c21-13-3-1-4-14(22)18(13)28-19-17-15(23)5-2-6-16(17)25(24-19)12-9-7-11(8-10-12)20(26)27/h1-10H,(H,26,27)
Affinity DataIC50: 800nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50044098(4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-...)
Show SMILES CC(C)c1cc2c(cc1\C(C)=C\c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
Show InChI InChI=1S/C27H34O2/c1-17(2)21-15-23-24(27(6,7)13-12-26(23,4)5)16-22(21)18(3)14-19-8-10-20(11-9-19)25(28)29/h8-11,14-17H,12-13H2,1-7H3,(H,28,29)/b18-14+
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against retinoic Acid gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203544(CHEMBL3928131)
Show SMILES Cc1cccc2n(nc(Oc3c(Cl)cccc3Cl)c12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H14Cl2N2O3/c1-12-4-2-7-17-18(12)20(28-19-15(22)5-3-6-16(19)23)24-25(17)14-10-8-13(9-11-14)21(26)27/h2-11H,1H3,(H,26,27)
Affinity DataIC50: 1.10E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203542(CHEMBL3218921)
Show SMILES OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2Cl)c2ccccc12
Show InChI InChI=1S/C21H12Cl2N2O3/c22-15-5-3-6-16(23)18(15)20(26)25-17-7-2-1-4-14(17)19(24-25)12-8-10-13(11-9-12)21(27)28/h1-11H,(H,27,28)
Affinity DataIC50: 1.30E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203508(CHEMBL3968165)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Oc2c(Cl)cccc2Cl)c2ccccc12
Show InChI InChI=1S/C20H12Cl2N2O3/c21-15-5-3-6-16(22)18(15)27-19-14-4-1-2-7-17(14)24(23-19)13-10-8-12(9-11-13)20(25)26/h1-11H,(H,25,26)
Affinity DataIC50: 1.40E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203514(CHEMBL3977144)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Oc2c(Cl)cccc2Cl)c2cc(ccc12)C#N
Show InChI InChI=1S/C21H11Cl2N3O3/c22-16-2-1-3-17(23)19(16)29-20-15-10-12(11-24)4-9-18(15)26(25-20)14-7-5-13(6-8-14)21(27)28/h1-10H,(H,27,28)
Affinity DataIC50: 1.40E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203516(CHEMBL3967961)
Show SMILES OC(=O)c1ccc(nc1)-n1nc(Oc2c(Cl)cccc2Cl)c2ccccc12
Show InChI InChI=1S/C19H11Cl2N3O3/c20-13-5-3-6-14(21)17(13)27-18-12-4-1-2-7-15(12)24(23-18)16-9-8-11(10-22-16)19(25)26/h1-10H,(H,25,26)
Affinity DataIC50: 1.90E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203543(CHEMBL3951385)
Show SMILES CNC(=O)c1ccc2n(nc(Sc3c(Cl)cccc3Cl)c2c1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H15Cl2N3O3S/c1-25-20(28)13-7-10-18-15(11-13)21(31-19-16(23)3-2-4-17(19)24)26-27(18)14-8-5-12(6-9-14)22(29)30/h2-11H,1H3,(H,25,28)(H,29,30)
Affinity DataIC50: 2.70E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50099474(4-[5-(8-Isopropyl-4-phenyl-quinolin-2-yl)-1H-pyrro...)
Show SMILES CC(C)c1cccc2c(cc(nc12)-c1ccc([nH]1)-c1ccc(cc1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C29H24N2O2/c1-18(2)22-9-6-10-23-24(19-7-4-3-5-8-19)17-27(31-28(22)23)26-16-15-25(30-26)20-11-13-21(14-12-20)29(32)33/h3-18,30H,1-2H3,(H,32,33)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonistic activity of the compound was evaluated in terms of inhibition of Retinoic acid receptor gamma transactivation by ATRA (50 nM); Not detec...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203509(CHEMBL3948459)
Show SMILES CN(C)C(=O)c1ccc2n(nc(Sc3ccccc3)c2c1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H19N3O3S/c1-25(2)22(27)16-10-13-20-19(14-16)21(30-18-6-4-3-5-7-18)24-26(20)17-11-8-15(9-12-17)23(28)29/h3-14H,1-2H3,(H,28,29)
Affinity DataIC50: 3.50E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203504(CHEMBL3938404)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Oc2c(Cl)cccc2Cl)c2cccnc12
Show InChI InChI=1S/C19H11Cl2N3O3/c20-14-4-1-5-15(21)16(14)27-18-13-3-2-10-22-17(13)24(23-18)12-8-6-11(7-9-12)19(25)26/h1-10H,(H,25,26)
Affinity DataIC50: 3.80E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203490(CHEMBL3905660)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Sc2c(Cl)cccc2Cl)c2cc(ccc12)C(=O)N1CCC1
Show InChI InChI=1S/C24H17Cl2N3O3S/c25-18-3-1-4-19(26)21(18)33-22-17-13-15(23(30)28-11-2-12-28)7-10-20(17)29(27-22)16-8-5-14(6-9-16)24(31)32/h1,3-10,13H,2,11-12H2,(H,31,32)
Affinity DataIC50: 4.10E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203539(CHEMBL3950318)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Sc2c(Cl)cccc2Cl)c2cc(ccc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H19Cl2N3O4S/c26-19-2-1-3-20(27)22(19)35-23-18-14-16(24(31)29-10-12-34-13-11-29)6-9-21(18)30(28-23)17-7-4-15(5-8-17)25(32)33/h1-9,14H,10-13H2,(H,32,33)
Affinity DataIC50: 4.20E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203518(CHEMBL3942787)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Sc2c(Cl)cccc2Cl)c2ccccc12
Show InChI InChI=1S/C20H12Cl2N2O2S/c21-15-5-3-6-16(22)18(15)27-19-14-4-1-2-7-17(14)24(23-19)13-10-8-12(9-11-13)20(25)26/h1-11H,(H,25,26)
Affinity DataIC50: 4.40E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203499(CHEMBL3947885)
Show SMILES CS(=O)(=O)c1ccc2n(nc(Oc3c(Cl)cccc3Cl)c2c1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H14Cl2N2O5S/c1-31(28,29)14-9-10-18-15(11-14)20(30-19-16(22)3-2-4-17(19)23)24-25(18)13-7-5-12(6-8-13)21(26)27/h2-11H,1H3,(H,26,27)
Affinity DataIC50: 4.50E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203517(CHEMBL3933815)
Show SMILES OC(=O)c1ccc(cc1)-n1nc([S+]([O-])c2c(Cl)cccc2Cl)c2ccccc12
Show InChI InChI=1S/C20H12Cl2N2O3S/c21-15-5-3-6-16(22)18(15)28(27)19-14-4-1-2-7-17(14)24(23-19)13-10-8-12(9-11-13)20(25)26/h1-11H,(H,25,26)
Affinity DataIC50: 5.60E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203503(CHEMBL3982499)
Show SMILES Clc1cccc(Cl)c1Oc1n[nH]c2ccccc12
Show InChI InChI=1S/C13H8Cl2N2O/c14-9-5-3-6-10(15)12(9)18-13-8-4-1-2-7-11(8)16-17-13/h1-7H,(H,16,17)
Affinity DataIC50: 5.70E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203515(CHEMBL3920454)
Show SMILES Cc1cc(ccc1-n1nc(Oc2c(Cl)cccc2Cl)c2ccccc12)C(O)=O
Show InChI InChI=1S/C21H14Cl2N2O3/c1-12-11-13(21(26)27)9-10-17(12)25-18-8-3-2-5-14(18)20(24-25)28-19-15(22)6-4-7-16(19)23/h2-11H,1H3,(H,26,27)
Affinity DataIC50: 6.20E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203460(CHEMBL3956929)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Oc2c(Cl)cccc2Cl)c2ncccc12
Show InChI InChI=1S/C19H11Cl2N3O3/c20-13-3-1-4-14(21)17(13)27-18-16-15(5-2-10-22-16)24(23-18)12-8-6-11(7-9-12)19(25)26/h1-10H,(H,25,26)
Affinity DataIC50: 6.80E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203488(CHEMBL3957141)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Cc2c(Cl)cccc2Cl)c2ccccc12
Show InChI InChI=1S/C21H14Cl2N2O2/c22-17-5-3-6-18(23)16(17)12-19-15-4-1-2-7-20(15)25(24-19)14-10-8-13(9-11-14)21(26)27/h1-11H,12H2,(H,26,27)
Affinity DataIC50: 6.80E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203462(CHEMBL3931161)
Show SMILES CN(C)C(=O)c1ccc2n(nc(Oc3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H17ClF3N3O4/c1-30(2)22(32)14-8-11-19-16(12-14)21(29-31(19)15-9-6-13(7-10-15)23(33)34)35-20-17(24(26,27)28)4-3-5-18(20)25/h3-12H,1-2H3,(H,33,34)
Affinity DataIC50: 7.20E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203513(CHEMBL3913238)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(Oc2c(Cl)cccc2Cl)c2cccc(F)c12
Show InChI InChI=1S/C20H11Cl2FN2O3/c21-14-4-2-5-15(22)18(14)28-19-13-3-1-6-16(23)17(13)25(24-19)12-9-7-11(8-10-12)20(26)27/h1-10H,(H,26,27)
Affinity DataIC50: 7.60E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203502(CHEMBL3940207)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2n(nc(Sc3c(Cl)cccc3Cl)c2c1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H22Cl2N4O3S/c1-30-11-13-31(14-12-30)25(33)17-7-10-22-19(15-17)24(36-23-20(27)3-2-4-21(23)28)29-32(22)18-8-5-16(6-9-18)26(34)35/h2-10,15H,11-14H2,1H3,(H,34,35)
Affinity DataIC50: 7.70E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Eisai Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50203500(CHEMBL3986751)
Show SMILES OC(=O)c1ccc(cc1)-n1nc(c2ccccc12)S(=O)(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H12Cl2N2O4S/c21-15-5-3-6-16(22)18(15)29(27,28)19-14-4-1-2-7-17(14)24(23-19)13-10-8-12(9-11-13)20(25)26/h1-11H,(H,25,26)
Affinity DataIC50: 8.40E+3nMAssay Description:Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
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