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Compile Data Set for Download or QSAR

Found 140 hits of ic50 data for polymerid = 50000366,50006329   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413565
PNG
(US10414765, Example 49)
Show SMILES COc1ccc(C)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H28ClN5O2/c1-18-6-11-25(36-2)31-26(18)28(35)33-15-20-13-32(14-21(20)16-33)17-23-27(19-7-9-22(29)10-8-19)30-24-5-3-4-12-34(23)24/h3-12,20-21H,13-17H2,1-2H3
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n/an/a 4.60n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Rattus norvegicus)
BDBM50426570
PNG
(CHEMBL2324344)
Show SMILES CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
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n/an/a 10n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of rat TASK3 expressed in (FRT) epithelial cells by chamber based electrophysiology assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413514
PNG
(US10414765, Example 17)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H27ClN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 21.8n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50426570
PNG
(CHEMBL2324344)
Show SMILES CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
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n/an/a 35n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50426570
PNG
(CHEMBL2324344)
Show SMILES CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
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n/an/a 35n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of human TASK3 expressed in HEK293 cells by Qpatch HT platform based assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Rattus norvegicus)
BDBM50123519
PNG
(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Show SMILES COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C30H26F2N2O3/c1-37-24-14-10-20(11-15-24)16-29(35)33-18-21-6-2-3-7-25(21)26-8-4-5-9-27(26)30(36)34-19-22-12-13-23(31)17-28(22)32/h2-15,17H,16,18-19H2,1H3,(H,33,35)(H,34,36)
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n/an/a 36n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of rat TASK3 expressed in (FRT) epithelial cells by chamber based electrophysiology assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 38n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413516
PNG
(US10414765, Example 25)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3
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n/an/a 44.1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050542
PNG
(CHEMBL3183497)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C23H22N2O4/c1-3-29-21-14-7-5-12-19(21)23(27)25-17-10-8-9-16(15-17)24-22(26)18-11-4-6-13-20(18)28-2/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 66n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50123519
PNG
(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Show SMILES COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C30H26F2N2O3/c1-37-24-14-10-20(11-15-24)16-29(35)33-18-21-6-2-3-7-25(21)26-8-4-5-9-27(26)30(36)34-19-22-12-13-23(31)17-28(22)32/h2-15,17H,16,18-19H2,1H3,(H,33,35)(H,34,36)
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n/an/a 70n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of human TASK3 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50505300
PNG
(CHEMBL4458347)
Show SMILES Br.CO[C@H]1CCC2CCN3CCC4=C(CC(=O)OC4)[C@]23C1
Show InChI InChI=1S/C16H23NO3.BrH/c1-19-13-3-2-12-5-7-17-6-4-11-10-20-15(18)8-14(11)16(12,17)9-13;/h12-13H,2-10H2,1H3;1H/t12?,13-,16-;/m0./s1
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n/an/a 74n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413564
PNG
(US10414765, Example 48)
Show SMILES COc1ccc(F)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H32FN5O2/c1-19(2)20-7-9-21(10-8-20)28-25(36-13-5-4-6-26(36)32-28)18-34-14-22-16-35(17-23(22)15-34)30(37)29-24(31)11-12-27(33-29)38-3/h4-13,19,22-23H,14-18H2,1-3H3
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n/an/a 79n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413567
PNG
(US10414765, Example 51)
Show SMILES COc1ccc(Cl)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H25Cl2N5O2/c1-36-24-10-9-21(29)26(31-24)27(35)33-14-18-12-32(13-19(18)15-33)16-22-25(17-5-7-20(28)8-6-17)30-23-4-2-3-11-34(22)23/h2-11,18-19H,12-16H2,1H3
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n/an/a 80n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413542
PNG
(US10414765, Example 23)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H24ClF3N4O/c29-23-9-7-18(8-10-23)26-24(36-11-2-1-6-25(36)33-26)17-34-13-20-15-35(16-21(20)14-34)27(37)19-4-3-5-22(12-19)28(30,31)32/h1-12,20-21H,13-17H2
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n/an/a 100n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413566
PNG
(US10414765, Example 50)
Show SMILES COc1ccc(F)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H25ClFN5O2/c1-36-24-10-9-21(29)26(31-24)27(35)33-14-18-12-32(13-19(18)15-33)16-22-25(17-5-7-20(28)8-6-17)30-23-4-2-3-11-34(22)23/h2-11,18-19H,12-16H2,1H3
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n/an/a 110n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050546
PNG
(CHEMBL3182699)
Show SMILES CC(C)Oc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O4/c1-15(2)32-20-12-5-3-10-18(20)22(30)28-16-8-7-9-17(14-16)29-23(31)19-11-4-6-13-21(19)33-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 110n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050495
PNG
(CHEMBL3185736)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-6-3-8-17(12-15)21(25)23-19-10-5-11-20(14-19)24-22(26)18-9-4-7-16(2)13-18/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 150n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413545
PNG
(US10414765, Example 27)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C31H34N4O2/c1-21(2)22-10-12-23(13-11-22)30-28(35-14-5-4-9-29(35)32-30)20-33-16-25-18-34(19-26(25)17-33)31(36)24-7-6-8-27(15-24)37-3/h4-15,21,25-26H,16-20H2,1-3H3
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n/an/a 170n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413546
PNG
(US10414765, Example 28)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCC1
Show InChI InChI=1S/C29H36N4O/c1-20(2)21-10-12-22(13-11-21)28-26(33-14-6-5-9-27(33)30-28)19-31-15-24-17-32(18-25(24)16-31)29(34)23-7-3-4-8-23/h5-6,9-14,20,23-25H,3-4,7-8,15-19H2,1-2H3
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n/an/a 190n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413540
PNG
(US10414765, Example 21)
Show SMILES Cc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H26ClFN4O/c1-18-5-10-23(30)12-24(18)28(35)33-15-20-13-32(14-21(20)16-33)17-25-27(19-6-8-22(29)9-7-19)31-26-4-2-3-11-34(25)26/h2-12,20-21H,13-17H2,1H3
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n/an/a 230n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413563
PNG
(US10414765, Example 47)
Show SMILES Fc1ccc(NC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)cc1
Show InChI InChI=1S/C27H25BrFN5O/c28-21-6-4-18(5-7-21)26-24(34-12-2-1-3-25(34)31-26)17-32-13-19-15-33(16-20(19)14-32)27(35)30-23-10-8-22(29)9-11-23/h1-12,19-20H,13-17H2,(H,30,35)
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n/an/a 240n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50426570
PNG
(CHEMBL2324344)
Show SMILES CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
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n/an/a 243n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of human TASK3 expressed in Xenopus oocytes by whole cell voltage clamp assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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n/an/a 250n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413512
PNG
(US10414765, Example 4 | [5-{[2-(4-Chlorophenyl)imi...)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C27H26ClN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 256n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050547
PNG
(CHEMBL3182449)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-2-31-20-13-6-4-11-18(20)22(30)28-16-9-7-8-15(14-16)27-21(29)17-10-3-5-12-19(17)23(24,25)26/h3-14H,2H2,1H3,(H,27,29)(H,28,30)
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n/an/a 300n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413544
PNG
(US10414765, Example 26)
Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)c1ccccc1F
Show InChI InChI=1S/C30H31FN4O/c1-20(2)21-10-12-22(13-11-21)29-27(35-14-6-5-9-28(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-3-4-8-26(25)31/h3-14,20,23-24H,15-19H2,1-2H3
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n/an/a 310n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50123519
PNG
(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Show SMILES COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C30H26F2N2O3/c1-37-24-14-10-20(11-15-24)16-29(35)33-18-21-6-2-3-7-25(21)26-8-4-5-9-27(26)30(36)34-19-22-12-13-23(31)17-28(22)32/h2-15,17H,16,18-19H2,1H3,(H,33,35)(H,34,36)
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n/an/a 318n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of human TASK3 expressed in Xenopus oocytes by whole cell voltage clamp assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413541
PNG
(US10414765, Example 22)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1
Show InChI InChI=1S/C28H24ClF3N4O2/c29-22-9-7-18(8-10-22)26-24(36-11-2-1-6-25(36)33-26)17-34-13-20-15-35(16-21(20)14-34)27(37)19-4-3-5-23(12-19)38-28(30,31)32/h1-12,20-21H,13-17H2
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n/an/a 320n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050538
PNG
(CHEMBL3182091)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccs2)c1
Show InChI InChI=1S/C19H16N2O2S/c1-13-5-2-6-14(11-13)18(22)20-15-7-3-8-16(12-15)21-19(23)17-9-4-10-24-17/h2-12H,1H3,(H,20,22)(H,21,23)
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n/an/a 330n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50312105
PNG
(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 390n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413516
PNG
(US10414765, Example 25)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1
Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3
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n/an/a 410n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050503
PNG
(CHEMBL3187482)
Show SMILES CCOc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
Show InChI InChI=1S/C23H22N2O3/c1-3-28-21-13-5-4-12-20(21)23(27)25-19-11-7-10-18(15-19)24-22(26)17-9-6-8-16(2)14-17/h4-15H,3H2,1-2H3,(H,24,26)(H,25,27)
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n/an/a 410n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050541
PNG
(CHEMBL3188749)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O4/c1-30-18-11-4-2-9-16(18)20(28)26-14-7-6-8-15(13-14)27-21(29)17-10-3-5-12-19(17)31-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 410n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50505299
PNG
(CHEMBL1557966)
Show SMILES CC(C1CC2CCC1C2)n1c(S)nnc1-c1ccco1
Show InChI InChI=1S/C15H19N3OS/c1-9(12-8-10-4-5-11(12)7-10)18-14(16-17-15(18)20)13-3-2-6-19-13/h2-3,6,9-12H,4-5,7-8H2,1H3,(H,17,20)
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n/an/a 413n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of human TASK3 expressed in HEK293 by whole cell voltage clamp assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413554
PNG
(US10414765, Example 36)
Show SMILES FC(F)(F)c1cccc(OC(=O)N2CC3CN(Cc4c(nc5ccccn45)-c4ccc(Br)cc4)CC3C2)c1
Show InChI InChI=1S/C28H24BrF3N4O2/c29-22-9-7-18(8-10-22)26-24(36-11-2-1-6-25(36)33-26)17-34-13-19-15-35(16-20(19)14-34)27(37)38-23-5-3-4-21(12-23)28(30,31)32/h1-12,19-20H,13-17H2
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n/an/a 450n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50312125
PNG
(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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n/an/a 480n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413513
PNG
(US10414765, Example 10)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 485n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050522
PNG
(CHEMBL3182551)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(F)c2)c1
Show InChI InChI=1S/C21H17FN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26)
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University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413530
PNG
(US10414765, Example 9)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCC1
Show InChI InChI=1S/C25H27BrN4O/c26-21-9-7-17(8-10-21)24-22(30-11-2-1-6-23(30)27-24)16-28-12-19-14-29(15-20(19)13-28)25(31)18-4-3-5-18/h1-2,6-11,18-20H,3-5,12-16H2
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n/an/a 660n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050157
PNG
(CHEMBL1310568)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H18N2O2/c1-15-7-5-10-17(13-15)21(25)23-19-12-6-11-18(14-19)22-20(24)16-8-3-2-4-9-16/h2-14H,1H3,(H,22,24)(H,23,25)
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n/an/a 690n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050540
PNG
(CHEMBL3182359)
Show SMILES COc1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC)c1
Show InChI InChI=1S/C22H20N2O4/c1-27-19-12-5-3-10-17(19)21(25)23-15-8-7-9-16(14-15)24-22(26)18-11-4-6-13-20(18)28-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 710n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in HEK293 cells by QPatch assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050545
PNG
(CHEMBL3186000)
Show SMILES CC(C)c1ccccc1C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C24H21F3N2O3/c1-15(2)18-10-3-4-11-19(18)22(30)28-16-8-7-9-17(14-16)29-23(31)20-12-5-6-13-21(20)32-24(25,26)27/h3-15H,1-2H3,(H,28,30)(H,29,31)
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n/an/a 730n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050504
PNG
(CHEMBL3182725)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C22H17F3N2O3/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)30-22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)
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n/an/a 750n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413543
PNG
(US10414765, Example 24)
Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C27H26BrN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3
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n/an/a 800n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413529
PNG
(US10414765, Example 8)
Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CC2CN(CC2C1)C(=O)C1CCCCC1
Show InChI InChI=1S/C27H31BrN4O/c28-23-11-9-19(10-12-23)26-24(32-13-5-4-8-25(32)29-26)18-30-14-21-16-31(17-22(21)15-30)27(33)20-6-2-1-3-7-20/h4-5,8-13,20-22H,1-3,6-7,14-18H2
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n/an/a 810n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50505292
PNG
(CHEMBL4592278)
Show SMILES CCCCS(=O)(=O)Nc1ccccc1C(=O)NC(CC)c1ccc(OC)nc1
Show InChI InChI=1S/C20H27N3O4S/c1-4-6-13-28(25,26)23-18-10-8-7-9-16(18)20(24)22-17(5-2)15-11-12-19(27-3)21-14-15/h7-12,14,17,23H,4-6,13H2,1-3H3,(H,22,24)
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n/an/a 950n/an/an/an/an/an/a



Universidad de Talca

Curated by ChEMBL


Assay Description
Inhibition of human TASK3 expressed in Xenopus oocytes by whole cell voltage clamp assay


J Med Chem 62: 10044-10058 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00248
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413532
PNG
(US10414765, Example 12)
Show SMILES COc1ccc(F)cc1C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H26BrFN4O2/c1-36-25-10-9-22(30)12-23(25)28(35)33-15-19-13-32(14-20(19)16-33)17-24-27(18-5-7-21(29)8-6-18)31-26-4-2-3-11-34(24)26/h2-12,19-20H,13-17H2,1H3
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n/an/a 960n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM50050494
PNG
(CHEMBL3181939)
Show SMILES Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C22H20N2O2/c1-15-7-5-9-17(13-15)21(25)23-18-10-6-11-19(14-18)24-22(26)20-12-4-3-8-16(20)2/h3-14H,1-2H3,(H,23,25)(H,24,26)
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n/an/a 960n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of TASK-3 (unknown origin) expressed in CHO cells by thallium flux assay


Bioorg Med Chem Lett 24: 3968-73 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.032
BindingDB Entry DOI: 10.7270/Q2805487
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 9


(Homo sapiens (Human))
BDBM413513
PNG
(US10414765, Example 10)
Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1
Show InChI InChI=1S/C28H27BrN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3
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n/an/a 970n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...


US Patent US10414765 (2019)


BindingDB Entry DOI: 10.7270/Q2QJ7KNV
More data for this
Ligand-Target Pair
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