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Compile Data Set for Download or QSAR

Found 25 hits of ic50 data for polymerid = 50000457   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510034
PNG
(CHEMBL4593063)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-4-3-5-16(19)10-15)13(2)22(21-12)17-8-6-14(11-20)7-9-17/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510057
PNG
(CHEMBL4538655)
Show SMILES COc1ccc(cc1)-c1c(C)nn(c1C)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-19(16-6-10-18(23-3)11-7-16)14(2)22(21-13)17-8-4-15(12-20)5-9-17/h4-11H,12,20H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510035
PNG
(CHEMBL4528810)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc2CNCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(14-4-3-5-17(20)8-14)13(2)23(22-12)18-7-6-15-10-21-11-16(15)9-18/h3-9,21H,10-11H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510038
PNG
(CHEMBL4518161)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510039
PNG
(CHEMBL4456021)
Show SMILES Cc1nn(c(C)c1-c1ccc(Cl)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18ClN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510040
PNG
(CHEMBL4469611)
Show SMILES Cc1nn(c(C)c1-c1ccc(cc1)C(F)(F)F)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H18F3N3/c1-12-18(15-5-7-16(8-6-15)19(20,21)22)13(2)25(24-12)17-9-3-14(11-23)4-10-17/h3-10H,11,23H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510041
PNG
(CHEMBL4476781)
Show SMILES Cc1nn(c(C)c1-c1ccc(CN)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H22N4/c1-13-19(17-7-3-15(11-20)4-8-17)14(2)23(22-13)18-9-5-16(12-21)6-10-18/h3-10H,11-12,20-21H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510042
PNG
(CHEMBL4593172)
Show SMILES NCc1ccc(cc1)-n1cc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H14FN3/c17-15-5-3-13(4-6-15)14-10-19-20(11-14)16-7-1-12(9-18)2-8-16/h1-8,10-11H,9,18H2
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510043
PNG
(CHEMBL4524195)
Show SMILES Cc1nn(Cc2ccc(CN)cc2)c(C)c1-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3/c1-13-19(17-7-9-18(20)10-8-17)14(2)23(22-13)12-16-5-3-15(11-21)4-6-16/h3-10H,11-12,21H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510044
PNG
(CHEMBL4462808)
Show SMILES CC(N)c1ccc(cc1)-n1nc(C)c(c1C)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3/c1-12(21)15-6-10-18(11-7-15)23-14(3)19(13(2)22-23)16-4-8-17(20)9-5-16/h4-12H,21H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510045
PNG
(CHEMBL4587871)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CNCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(14-3-6-17(20)7-4-14)13(2)23(22-12)18-8-5-15-10-21-11-16(15)9-18/h3-9,21H,10-11H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510046
PNG
(CHEMBL4440380)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(15-3-6-16(20)7-4-15)13(2)23(22-12)17-8-5-14-9-10-21-18(14)11-17/h3-8,11,21H,9-10H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510047
PNG
(CHEMBL4517411)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)nc1
Show InChI InChI=1S/C17H17FN4/c1-11-17(13-3-5-14(18)6-4-13)12(2)22(21-11)16-8-7-15(9-19)20-10-16/h3-8,10H,9,19H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510048
PNG
(CHEMBL4442568)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ncnc2CNCc12
Show InChI InChI=1S/C17H16FN5/c1-10-16(12-3-5-13(18)6-4-12)11(2)23(22-10)17-14-7-19-8-15(14)20-9-21-17/h3-6,9,19H,7-8H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510037
PNG
(CHEMBL4463769)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ncnc2CNCc12
Show InChI InChI=1S/C17H16FN5/c1-10-16(12-4-3-5-13(18)6-12)11(2)23(22-10)17-14-7-19-8-15(14)20-9-21-17/h3-6,9,19H,7-8H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510036
PNG
(CHEMBL4555958)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1cccc(CN)c1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-6-8-16(19)9-7-15)13(2)22(21-12)17-5-3-4-14(10-17)11-20/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510054
PNG
(CHEMBL4445209)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)cn1
Show InChI InChI=1S/C17H17FN4/c1-11-17(14-4-6-15(18)7-5-14)12(2)22(21-11)16-8-3-13(9-19)10-20-16/h3-8,10H,9,19H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510053
PNG
(CHEMBL4591499)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)nc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H20N4/c1-12-4-7-16(11-20-12)18-13(2)21-22(14(18)3)17-8-5-15(10-19)6-9-17/h4-9,11H,10,19H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510051
PNG
(CHEMBL4527919)
Show SMILES CN1Cc2ncnc(c2C1)-n1nc(C)c(c1C)-c1cccc(F)c1
Show InChI InChI=1S/C18H18FN5/c1-11-17(13-5-4-6-14(19)7-13)12(2)24(22-11)18-15-8-23(3)9-16(15)20-10-21-18/h4-7,10H,8-9H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510049
PNG
(CHEMBL4590631)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H21N3/c1-13-4-8-17(9-5-13)19-14(2)21-22(15(19)3)18-10-6-16(12-20)7-11-18/h4-11H,12,20H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510052
PNG
(CHEMBL4446500)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)c(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H20FN3/c1-12-4-7-16(10-18(12)20)19-13(2)22-23(14(19)3)17-8-5-15(11-21)6-9-17/h4-10H,11,21H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510056
PNG
(CHEMBL4450681)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CCN)cc1
Show InChI InChI=1S/C19H20FN3/c1-13-19(16-5-7-17(20)8-6-16)14(2)23(22-13)18-9-3-15(4-10-18)11-12-21/h3-10H,11-12,21H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510050
PNG
(CHEMBL4463485)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc2NCCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(15-4-3-5-16(20)10-15)13(2)23(22-12)17-6-7-18-14(11-17)8-9-21-18/h3-7,10-11,21H,8-9H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510055
PNG
(CHEMBL4440787)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H14FN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50000999
PNG
(CHEBI:81724 | DIMINAZENE)
Show SMILES NC(=N)c1ccc(N\N=N\c2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 5.69E+4n/an/an/an/an/an/a



Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair