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Compile Data Set for Download or QSAR

Found 2643 hits of ic50 data for polymerid = 50001175,575,633   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132222
PNG
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-18-24-23(17-25(26)35-2)27(30-19-29-24)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34)
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n/an/a 0.0100n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132206
PNG
(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-17-23-24(18-25(26)35-2)29-19-30-27(23)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50115301
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 0.0900n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265774
PNG
(4-Amino-3-benzimidazol-2-yl-5-(1-methyl(3-piperidy...)
Show SMILES CN1CCCC(C1)Oc1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12
Show InChI InChI=1S/C22H23N5O2/c1-27-11-5-6-13(12-27)29-17-10-4-9-16-18(17)20(23)19(22(28)26-16)21-24-14-7-2-3-8-15(14)25-21/h2-4,7-10,13H,5-6,11-12H2,1H3,(H,24,25)(H3,23,26,28)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265746
PNG
(CHEMBL526507 | {4-Amino-3-[6-(4-methylpiperazinyl)...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(ccc2[nH]c1=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C29H29N7O2/c1-35-11-13-36(14-12-35)20-8-10-23-24(16-20)33-27(32-23)25-26(30)21-15-19(7-9-22(21)34-29(25)38)28(37)31-17-18-5-3-2-4-6-18/h2-10,15-16H,11-14,17H2,1H3,(H,31,37)(H,32,33)(H3,30,34,38)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132229
PNG
(4-(7-Methyl-quinazolin-4-yl)-piperazine-1-carboxyl...)
Show SMILES Cc1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H25N5O2/c1-19-7-12-23-24(17-19)27-18-28-25(23)30-13-15-31(16-14-30)26(32)29-20-8-10-22(11-9-20)33-21-5-3-2-4-6-21/h2-12,17-18H,13-16H2,1H3,(H,29,32)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132227
PNG
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O2S/c1-3-30-21-14-19-18(13-20(21)29-2)22(26-16-25-19)27-9-11-28(12-10-27)23(31)24-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,24,31)
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n/an/a 0.150n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132210
PNG
(4-(6-Amino-7-chloro-quinazolin-4-yl)-piperazine-1-...)
Show SMILES Nc1cc2c(ncnc2cc1Cl)N1CCN(CC1)C(=S)NCc1ccccc1
Show InChI InChI=1S/C20H21ClN6S/c21-16-11-18-15(10-17(16)22)19(25-13-24-18)26-6-8-27(9-7-26)20(28)23-12-14-4-2-1-3-5-14/h1-5,10-11,13H,6-9,12,22H2,(H,23,28)
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n/an/a 0.160n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132211
PNG
(4-(7-Ethylamino-6-nitro-quinazolin-4-yl)-piperazin...)
Show SMILES CCNc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1[N+]([O-])=O
Show InChI InChI=1S/C27H27N7O4/c1-2-28-24-17-23-22(16-25(24)34(36)37)26(30-18-29-23)32-12-14-33(15-13-32)27(35)31-19-8-10-21(11-9-19)38-20-6-4-3-5-7-20/h3-11,16-18,28H,2,12-15H2,1H3,(H,31,35)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265574
PNG
(3-(1H-benzo[d]imidazol-2-yl)-4-(4-ethyl-1-methylpi...)
Show SMILES CCC1CCN(C)C(C1)Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C24H27N5O/c1-3-15-12-13-29(2)20(14-15)28-22-16-8-4-5-9-17(16)27-24(30)21(22)23-25-18-10-6-7-11-19(18)26-23/h4-11,15,20H,3,12-14H2,1-2H3,(H,25,26)(H2,27,28,30)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381945
PNG
(CHEMBL2023477)
Show SMILES COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C
Show InChI InChI=1S/C25H25N3O6/c1-14-15(2)34-28-25(14)27-24(29)10-16-6-7-17(11-21(16)30-3)33-20-8-9-26-19-13-23(32-5)22(31-4)12-18(19)20/h6-9,11-13H,10H2,1-5H3,(H,27,28,29)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381946
PNG
(CHEMBL2023485)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)[nH]n1
Show InChI InChI=1S/C25H26N4O5/c1-5-16-11-24(29-28-16)27-25(30)10-15-6-7-17(12-21(15)31-2)34-20-8-9-26-19-14-23(33-4)22(32-3)13-18(19)20/h6-9,11-14H,5,10H2,1-4H3,(H2,27,28,29,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265678
PNG
(4-Amino-5-chloro-3-[6-(4-methylpiperazinyl)benzimi...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(Cl)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21ClN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265773
PNG
(4-Amino-3-benzimidazol-2-yl-5-(4-methylpiperazinyl...)
Show SMILES CN1CCN(CC1)c1cccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N)c12
Show InChI InChI=1S/C21H22N6O/c1-26-9-11-27(12-10-26)16-8-4-7-15-17(16)19(22)18(21(28)25-15)20-23-13-5-2-3-6-14(13)24-20/h2-8H,9-12H2,1H3,(H,23,24)(H3,22,25,28)
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381931
PNG
(CHEMBL2023476)
Show SMILES COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1
Show InChI InChI=1S/C23H21N3O4S/c1-14-13-25-23(31-14)26-22(27)10-15-4-5-17(12-21(15)29-3)30-20-8-9-24-19-11-16(28-2)6-7-18(19)20/h4-9,11-13H,10H2,1-3H3,(H,25,26,27)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50362065
PNG
(CHEMBL1940109)
Show SMILES COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC
Show InChI InChI=1S/C24H25N5O6/c1-31-7-8-34-22-11-20-19(10-21(22)33-3)24(26-15-25-20)35-18-12-27-29(13-18)14-23(30)28-16-5-4-6-17(9-16)32-2/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,28,30)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.019
BindingDB Entry DOI: 10.7270/Q24F1R6H
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132215
PNG
(4-(6-Fluoro-quinazolin-4-yl)-piperazine-1-carboxyl...)
Show SMILES Fc1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C25H22FN5O2/c26-18-6-11-23-22(16-18)24(28-17-27-23)30-12-14-31(15-13-30)25(32)29-19-7-9-21(10-8-19)33-20-4-2-1-3-5-20/h1-11,16-17H,12-15H2,(H,29,32)
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n/an/a 0.350n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132232
PNG
(4-Quinazolin-4-yl-piperazine-1-carboxylic acid (4-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2ccccc12
Show InChI InChI=1S/C25H23N5O2/c31-25(28-19-10-12-21(13-11-19)32-20-6-2-1-3-7-20)30-16-14-29(15-17-30)24-22-8-4-5-9-23(22)26-18-27-24/h1-13,18H,14-17H2,(H,28,31)
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n/an/a 0.380n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381947
PNG
(CHEMBL2023482)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1
Show InChI InChI=1S/C24H23N3O5/c1-4-16-14-23(27-32-16)26-24(28)11-15-5-6-18(13-22(15)30-3)31-21-9-10-25-20-12-17(29-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H,26,27,28)
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n/an/a 0.400n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50362089
PNG
(CHEMBL1940273)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-7-18(8-6-16)32-21-9-10-25-20-13-23(31-3)22(30-2)12-19(20)21/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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n/an/a 0.400n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.019
BindingDB Entry DOI: 10.7270/Q24F1R6H
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50117334
PNG
(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccc5ccccc5c4)cc3)c2cc1OCCOC
Show InChI InChI=1S/C35H37N5O6/c1-42-17-19-44-32-22-30-31(23-33(32)45-20-18-43-2)36-24-37-34(30)39-13-15-40(16-14-39)35(41)38-27-8-11-28(12-9-27)46-29-10-7-25-5-3-4-6-26(25)21-29/h3-12,21-24H,13-20H2,1-2H3,(H,38,41)
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n/an/a 0.400n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma


J Med Chem 45: 3772-93 (2002)


Article DOI: 10.1021/jm020143r
BindingDB Entry DOI: 10.7270/Q2WW7JD9
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50117342
PNG
(4-[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-pip...)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4cccc5cnccc45)cc3)c2cc1OCCOC
Show InChI InChI=1S/C34H36N6O6/c1-42-16-18-44-31-20-28-29(21-32(31)45-19-17-43-2)36-23-37-33(28)39-12-14-40(15-13-39)34(41)38-25-6-8-26(9-7-25)46-30-5-3-4-24-22-35-11-10-27(24)30/h3-11,20-23H,12-19H2,1-2H3,(H,38,41)
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n/an/a 0.400n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma


J Med Chem 45: 3772-93 (2002)


Article DOI: 10.1021/jm020143r
BindingDB Entry DOI: 10.7270/Q2WW7JD9
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50431812
PNG
(CHEMBL2347053)
Show SMILES [O-][N+](=O)c1ccccc1-c1n[nH]cc1C=C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C18H12N4O3/c23-18-14(12-5-1-3-7-15(12)20-18)9-11-10-19-21-17(11)13-6-2-4-8-16(13)22(24)25/h1-10H,(H,19,21)(H,20,23)
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n/an/a 0.400n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) after 10 mins by mobility shift assay


Bioorg Med Chem 21: 1724-34 (2013)


Article DOI: 10.1016/j.bmc.2013.01.047
BindingDB Entry DOI: 10.7270/Q2GQ704N
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265750
PNG
(4-Amino-7-fluoro-3-[6-(4-methylpiperazinyl)benzimi...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccc(F)cc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-6-8-28(9-7-27)13-3-5-15-17(11-13)25-20(24-15)18-19(23)14-4-2-12(22)10-16(14)26-21(18)29/h2-5,10-11H,6-9H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.430n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRbeta by kinase inhibition assay


Eur J Med Chem 103: 29-43 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.027
BindingDB Entry DOI: 10.7270/Q2G162MG
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227812
PNG
(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-({[...)
Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CNCCc5ccncc5)cc4NC(=O)c23)cc1O
Show InChI InChI=1S/C27H25FN6O2/c1-16-12-19(28)22(14-24(16)35)32-21-7-11-31-26-25(21)27(36)34-23-13-18(2-3-20(23)33-26)15-30-10-6-17-4-8-29-9-5-17/h2-5,7-9,11-14,30,35H,6,10,15H2,1H3,(H,34,36)(H2,31,32,33)
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US Patent
n/an/a 0.475n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227786
PNG
(8-{[Ethyl(methyl)amino]methyl}-4-[(2-fluoro-5-hydr...)
Show SMILES CCN(C)Cc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1
Show InChI InChI=1S/C23H24FN5O2/c1-4-29(3)12-14-5-6-16-19(10-14)28-23(31)21-17(7-8-25-22(21)27-16)26-18-11-20(30)13(2)9-15(18)24/h5-11,30H,4,12H2,1-3H3,(H,28,31)(H2,25,26,27)
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n/an/a 0.487n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4817
PNG
(N-[2-(dimethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo...)
Show SMILES CN(C)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C20H23FN4O2/c1-11-17(23-12(2)18(11)20(27)22-7-8-25(3)4)10-15-14-9-13(21)5-6-16(14)24-19(15)26/h5-6,9-10,23H,7-8H2,1-4H3,(H,22,27)(H,24,26)/b15-10-
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n/an/a 0.5n/an/an/an/an/an/a



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...


J Med Chem 46: 1116-9 (2003)


Article DOI: 10.1021/jm0204183
BindingDB Entry DOI: 10.7270/Q2D50K5B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM112876
PNG
(US9695181, IIb)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2nn(CCCCCCCC(=O)NO)c3ncnc(N)c23)c1
Show InChI InChI=1S/C27H31FN8O3/c1-17-8-13-20(28)21(15-17)33-27(38)32-19-11-9-18(10-12-19)24-23-25(29)30-16-31-26(23)36(34-24)14-6-4-2-3-5-7-22(37)35-39/h8-13,15-16,39H,2-7,14H2,1H3,(H,35,37)(H2,29,30,31)(H2,32,33,38)
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n/an/a 0.5n/an/an/an/an/an/a



DOUBLE RIDER MEDICINE CO., LTD.

US Patent


Assay Description
Inhibition of Compound IIa, IIb, IIc and IId on the Activity of Catalyzing Substrate Phosphorylation of KDR (VEGFR2) Protein Tyrosine Kinase at the M...


US Patent US9695181 (2017)


BindingDB Entry DOI: 10.7270/Q2RX9971
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381948
PNG
(CHEMBL2023486)
Show SMILES CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)[nH]n1
Show InChI InChI=1S/C24H24N4O4/c1-4-16-12-23(28-27-16)26-24(29)11-15-5-6-18(14-22(15)31-3)32-21-9-10-25-20-13-17(30-2)7-8-19(20)21/h5-10,12-14H,4,11H2,1-3H3,(H2,26,27,28,29)
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n/an/a 0.5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132213
PNG
(4-(6-Methoxy-quinazolin-4-yl)-piperazine-1-carboxy...)
Show SMILES COc1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C26H25N5O3/c1-33-22-11-12-24-23(17-22)25(28-18-27-24)30-13-15-31(16-14-30)26(32)29-19-7-9-21(10-8-19)34-20-5-3-2-4-6-20/h2-12,17-18H,13-16H2,1H3,(H,29,32)
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n/an/a 0.5n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132224
PNG
(4-(6-Methyl-quinazolin-4-yl)-piperazine-1-carboxyl...)
Show SMILES Cc1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C26H25N5O2/c1-19-7-12-24-23(17-19)25(28-18-27-24)30-13-15-31(16-14-30)26(32)29-20-8-10-22(11-9-20)33-21-5-3-2-4-6-21/h2-12,17-18H,13-16H2,1H3,(H,29,32)
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n/an/a 0.540n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a 0.550n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265745
PNG
(4-Amino-6-(benzylamino)-3-(6-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2cc(NCc3ccccc3)ccc2[nH]c1=O
Show InChI InChI=1S/C28H29N7O/c1-34-11-13-35(14-12-34)20-8-10-23-24(16-20)32-27(31-23)25-26(29)21-15-19(7-9-22(21)33-28(25)36)30-17-18-5-3-2-4-6-18/h2-10,15-16,30H,11-14,17H2,1H3,(H,31,32)(H3,29,33,36)
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n/an/a 0.600n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin) incubated for 1 hr by spectrophotometric analysis


Bioorg Med Chem 24: 3483-93 (2016)


Article DOI: 10.1016/j.bmc.2016.05.057
BindingDB Entry DOI: 10.7270/Q29G5PQT
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132220
PNG
(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=S)NCc1ccccc1
Show InChI InChI=1S/C23H27N5O2S/c1-3-30-21-13-18-19(14-20(21)29-2)25-16-26-22(18)27-9-11-28(12-10-27)23(31)24-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,24,31)
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n/an/a 0.620n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227930
PNG
(US10047096, 191 | cis-Ethyl 3-[({4-[(2-fluoro-5-hy...)
Show SMILES CCOC(=O)[C@@H]1C[C@@H](C1)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1
Show InChI InChI=1S/C27H28FN5O4/c1-3-37-27(36)16-10-17(11-16)30-13-15-4-5-19-22(9-15)33-26(35)24-20(6-7-29-25(24)32-19)31-21-12-23(34)14(2)8-18(21)28/h4-9,12,16-17,30,34H,3,10-11,13H2,1-2H3,(H,33,35)(H2,29,31,32)/t16-,17+
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n/an/a 0.626n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227801
PNG
(4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(...)
Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5C[C@H](O)C[C@H]5CO)cc4NC(=O)c23)cc1O
Show InChI InChI=1S/C25H26FN5O4/c1-13-6-17(26)20(9-22(13)34)28-19-4-5-27-24-23(19)25(35)30-21-7-14(2-3-18(21)29-24)10-31-11-16(33)8-15(31)12-32/h2-7,9,15-16,32-34H,8,10-12H2,1H3,(H,30,35)(H2,27,28,29)/t15-,16+/m0/s1
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n/an/a 0.680n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50381949
PNG
(CHEMBL2023118)
Show SMILES CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1
Show InChI InChI=1S/C24H24N4O4/c1-4-28-15-17(14-26-28)27-24(29)11-16-5-6-19(13-23(16)31-3)32-22-9-10-25-21-12-18(30-2)7-8-20(21)22/h5-10,12-15H,4,11H2,1-3H3,(H,27,29)
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n/an/a 0.700n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 22: 3050-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.074
BindingDB Entry DOI: 10.7270/Q298881Z
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50115295
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC
Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28)
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n/an/a 0.700n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50265679
PNG
(4-Amino-5-methyl-3-[6-(4-methylpiperazinyl)benzimi...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(C)cccc2[nH]c1=O
Show InChI InChI=1S/C22H24N6O/c1-13-4-3-5-16-18(13)20(23)19(22(29)26-16)21-24-15-7-6-14(12-17(15)25-21)28-10-8-27(2)9-11-28/h3-7,12H,8-11H2,1-2H3,(H,24,25)(H3,23,26,29)
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n/an/a 0.700n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDGFRbeta


J Med Chem 52: 278-92 (2009)


Article DOI: 10.1021/jm800790t
BindingDB Entry DOI: 10.7270/Q2TD9X7X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227939
PNG
(8-{[(2-Aminoethyl)(ethyl)amino]methyl}-4-[(2-fluor...)
Show SMILES CCN(CCN)Cc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1
Show InChI InChI=1S/C24H27FN6O2/c1-3-31(9-7-26)13-15-4-5-17-20(11-15)30-24(33)22-18(6-8-27-23(22)29-17)28-19-12-21(32)14(2)10-16(19)25/h4-6,8,10-12,32H,3,7,9,13,26H2,1-2H3,(H,30,33)(H2,27,28,29)
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n/an/a 0.727n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227948
PNG
(8-{[(2-Aminoethyl)(methyl)amino]methyl}-4-[(2-fluo...)
Show SMILES CN(CCN)Cc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1
Show InChI InChI=1S/C23H25FN6O2/c1-13-9-15(24)18(11-20(13)31)27-17-5-7-26-22-21(17)23(32)29-19-10-14(3-4-16(19)28-22)12-30(2)8-6-25/h3-5,7,9-11,31H,6,8,12,25H2,1-2H3,(H,29,32)(H2,26,27,28)
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n/an/a 0.739n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132202
PNG
(4-[4-(4-Phenoxy-phenylcarbamoyl)-piperazin-1-yl]-q...)
Show SMILES COC(=O)c1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H25N5O4/c1-35-26(33)19-7-12-23-24(17-19)28-18-29-25(23)31-13-15-32(16-14-31)27(34)30-20-8-10-22(11-9-20)36-21-5-3-2-4-6-21/h2-12,17-18H,13-16H2,1H3,(H,30,34)
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n/an/a>0.75n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227829
PNG
(4-[(4-Chloro-2-fluoro-5-hydroxyphenyl)amino]-8-{[e...)
Show SMILES CCN(CCO)Cc1ccc2Nc3nccc(Nc4cc(O)c(Cl)cc4F)c3C(=O)Nc2c1
Show InChI InChI=1S/C23H23ClFN5O3/c1-2-30(7-8-31)12-13-3-4-16-19(9-13)29-23(33)21-17(5-6-26-22(21)28-16)27-18-11-20(32)14(24)10-15(18)25/h3-6,9-11,31-32H,2,7-8,12H2,1H3,(H,29,33)(H2,26,27,28)
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n/an/a 0.793n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50362064
PNG
(CHEMBL1940108)
Show SMILES COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)c1
Show InChI InChI=1S/C22H21N5O5/c1-29-15-6-4-5-14(7-15)26-21(28)12-27-11-16(10-25-27)32-22-17-8-19(30-2)20(31-3)9-18(17)23-13-24-22/h4-11,13H,12H2,1-3H3,(H,26,28)
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n/an/a 0.800n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta phosphorylation by cell based assay


Bioorg Med Chem Lett 22: 262-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.019
BindingDB Entry DOI: 10.7270/Q24F1R6H
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132225
PNG
(4-(7-Methoxy-quinazolin-4-yl)-piperazine-1-carboxy...)
Show SMILES COc1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H25N5O3/c1-33-22-11-12-23-24(17-22)27-18-28-25(23)30-13-15-31(16-14-30)26(32)29-19-7-9-21(10-8-19)34-20-5-3-2-4-6-20/h2-12,17-18H,13-16H2,1H3,(H,29,32)
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n/an/a 0.820n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells


Bioorg Med Chem Lett 13: 3001-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00634-6
BindingDB Entry DOI: 10.7270/Q2668CKR
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227813
PNG
(US10047096, 75 | rac-4-[(2-Fluoro-5-hydroxy-4-meth...)
Show SMILES CC(C)C(CO)NCc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1
Show InChI InChI=1S/C25H28FN5O3/c1-13(2)21(12-32)28-11-15-4-5-17-20(9-15)31-25(34)23-18(6-7-27-24(23)30-17)29-19-10-22(33)14(3)8-16(19)26/h4-10,13,21,28,32-33H,11-12H2,1-3H3,(H,31,34)(H2,27,29,30)
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n/an/a 0.826n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227951
PNG
(8-{[(3R)-3-Aminopiperidin-1-yl]methyl}-4-[(2-fluor...)
Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5CCC[C@@H](N)C5)cc4NC(=O)c23)cc1O
Show InChI InChI=1S/C25H27FN6O2/c1-14-9-17(26)20(11-22(14)33)29-19-6-7-28-24-23(19)25(34)31-21-10-15(4-5-18(21)30-24)12-32-8-2-3-16(27)13-32/h4-7,9-11,16,33H,2-3,8,12-13,27H2,1H3,(H,31,34)(H2,28,29,30)/t16-/m1/s1
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n/an/a 0.829n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair
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