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Found 116 of ic50 for UniProtKB: O88867
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072078(CHEMBL3407905)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072081(CHEMBL3407922)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072079(CHEMBL3407913)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072080(CHEMBL3407919)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061924(4-Amino-N-[4-(2-fluoro-5-trifluoromethyl-phenyl)-t...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072083(CHEMBL3407929)
Affinity DataIC50:  20nMAssay Description:Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072083(CHEMBL3407929)
Affinity DataIC50:  20nMAssay Description:Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50126147(CHEMBL3629571)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061922(CHEMBL140071 | N-[4-(2-Fluoro-5-trifluoromethyl-ph...)
Affinity DataIC50:  39nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061911(4-Amino-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzen...)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061906(4-Methyl-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benze...)
Affinity DataIC50:  48nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061917(4-Methoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benz...)
Affinity DataIC50:  51nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061918(CHEMBL136265 | N-[4-(3,4-Dichloro-phenyl)-thiazol-...)
Affinity DataIC50:  56nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061923(CHEMBL335326 | N-[4-(4-Chloro-phenyl)-thiazol-2-yl...)
Affinity DataIC50:  56nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072081(CHEMBL3407922)
Affinity DataIC50:  72nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061909(4-Methyl-N-(4-p-tolyl-thiazol-2-yl)-benzenesulfona...)
Affinity DataIC50:  76nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061913(4-Chloro-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benze...)
Affinity DataIC50:  84nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072078(CHEMBL3407905)
Affinity DataIC50:  86nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072079(CHEMBL3407913)
Affinity DataIC50:  100nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072077(CHEMBL3407866)
Affinity DataIC50:  105nMAssay Description:Inhibition of KMO in rat microglia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061910(CHEMBL138010 | N-[4-(4-Hydroxy-3-methyl-phenyl)-th...)
Affinity DataIC50:  114nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072244((Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061925(3,4-Dichloro-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-b...)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072257(2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  180nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat KMOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061912(CHEMBL343363 | N-[4-(3-Nitro-phenyl)-thiazol-2-yl]...)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)
Affinity DataIC50:  237nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061914(CHEMBL342434 | N-[4-(4-Methoxy-phenyl)-thiazol-2-y...)
Affinity DataIC50:  240nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083948(4-(3-Chloro-4-fluoro-phenyl)-2-hydroxy-4-oxo-but-2...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072242(4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyric ac...)
Affinity DataIC50:  300nMAssay Description:Compound was evaluated for inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083940(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061915(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)
Affinity DataIC50:  330nMAssay Description:Compound was evaluated for the inhibition of rat liver KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072248((S)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyri...)
Affinity DataIC50:  420nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072244((Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  440nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061921(4-Methyl-N-(4-phenyl-thiazol-2-yl)-benzenesulfonam...)
Affinity DataIC50:  470nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072249(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-butyric acid |...)
Affinity DataIC50:  480nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083950((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...)
Affinity DataIC50:  500nMAssay Description:Tested for inhibitory activity against kynurenine 3-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083931(4-(3-Fluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)
Affinity DataIC50:  580nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061907((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  774nMAssay Description:Inhibition of rat kidney Kynurenine 3-hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083933(2-Amino-4-(3-chloro-4-fluoro-phenyl)-4-oxo-but-2-e...)
Affinity DataIC50:  820nMAssay Description:Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072245(4-(3,4-Dichloro-phenyl)-4-oxo-butyric acid | CHEMB...)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50072254((E)-4-(3,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid...)
Affinity DataIC50:  900nMAssay Description:Compound was evaluated for inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083950((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...)
Affinity DataIC50:  900nMAssay Description:Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50083950((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...)
Affinity DataIC50:  900nMAssay Description:Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061907((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50061907((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  900nMAssay Description:Ability to inhibit kynurenine-3-hydroxylase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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