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Compile Data Set for Download or QSAR

Found 91 hits of ic50 for UniProtKB: P06766   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA polymerase beta


(Rattus norvegicus)
BDBM50250427
PNG
((+)-Myristinin D | CHEMBL448072)
Show SMILES Oc1ccc(cc1)[C@@H]1C[C@H](c2ccc(O)cc2O1)c1c(O)cc(O)c(C(=O)CCCCCCCCc2ccccc2)c1O
Show InChI InChI=1S/C36H38O7/c37-25-16-14-24(15-17-25)32-21-28(27-19-18-26(38)20-33(27)43-32)34-30(40)22-31(41)35(36(34)42)29(39)13-9-4-2-1-3-6-10-23-11-7-5-8-12-23/h5,7-8,11-12,14-20,22,28,32,37-38,40-42H,1-4,6,9-10,13,21H2/t28-,32+/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta in absence of bovine serum albumin


J Nat Prod 68: 1625-8 (2005)


Article DOI: 10.1021/np058064g
BindingDB Entry DOI: 10.7270/Q2Q2400B
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259787
PNG
(3-trans-p-coumaroyl maslinic acid | CHEMBL453751)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](OC(=O)\C=C\c6ccccc6)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-34(2)19-21-39(33(42)43)22-20-37(6)26(27(39)23-34)14-15-30-36(5)24-28(40)32(35(3,4)29(36)17-18-38(30,37)7)44-31(41)16-13-25-11-9-8-10-12-25/h8-14,16,27-30,32,40H,15,17-24H2,1-7H3,(H,42,43)/b16-13+/t27-,28+,29-,30+,32-,36-,37+,38+,39-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1660-3 (2000)


Article DOI: 10.1021/np990326p
BindingDB Entry DOI: 10.7270/Q2QF8SNP
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259782
PNG
(3beta-hydroxyrus-18,20(30)-dien-28-oic acid | CHEM...)
Show SMILES CC1=C2[C@H]3CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@]2(CCC1=C)C(O)=O
Show InChI InChI=1S/C30H46O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h20-23,31H,1,8-17H2,2-7H3,(H,32,33)/t20-,21+,22-,23+,27+,28-,29-,30+/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250426
PNG
((+)-Myristinin A | CHEMBL465365)
Show SMILES CCCCCCCCCCCC(=O)c1c(O)cc(O)c([C@@H]2C[C@H](Oc3cc(O)ccc23)c2ccc(O)cc2)c1O
Show InChI InChI=1S/C33H40O7/c1-2-3-4-5-6-7-8-9-10-11-26(36)32-28(38)20-27(37)31(33(32)39)25-19-29(21-12-14-22(34)15-13-21)40-30-18-23(35)16-17-24(25)30/h12-18,20,25,29,34-35,37-39H,2-11,19H2,1H3/t25-,29+/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta in absence of bovine serum albumin


J Nat Prod 68: 1625-8 (2005)


Article DOI: 10.1021/np058064g
BindingDB Entry DOI: 10.7270/Q2Q2400B
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250305
PNG
(3alpha-O-trans-p-coumaroyl-7-labden-15-oic acid | ...)
Show SMILES C[C@@H](CC[C@@H]1[C@H]2CC[C@H](OC(=O)\C=C\c3ccc(O)cc3)C(C)(C)[C@@H]2CC=C1C)CC(O)=O
Show InChI InChI=1S/C28H38O5/c1-18(17-26(30)31)5-12-22-19(2)6-14-24-23(22)13-15-25(28(24,3)4)33-27(32)16-9-20-7-10-21(29)11-8-20/h6-11,16,18,22-25,29H,5,12-15,17H2,1-4H3,(H,30,31)/b16-9+/t18-,22-,23+,24+,25-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1000-2 (1999)


Article DOI: 10.1021/np990099r
BindingDB Entry DOI: 10.7270/Q2RF5TRM
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259781
PNG
(3beta-hydroxyrus-12,19(29)-dien-28-oic acid | CHEM...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1=C)C(O)=O
Show InChI InChI=1S/C30H46O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18,21-24,31H,2,9-17H2,1,3-7H3,(H,32,33)/t18-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50079577
PNG
((4aS,6aS,6bR,10S,12aR,14bS)-10-Hydroxy-2,2,6a,6b,9...)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21?,22?,23-,27-,28+,29+,30-/m0/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259787
PNG
(3-trans-p-coumaroyl maslinic acid | CHEMBL453751)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](OC(=O)\C=C\c6ccccc6)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-34(2)19-21-39(33(42)43)22-20-37(6)26(27(39)23-34)14-15-30-36(5)24-28(40)32(35(3,4)29(36)17-18-38(30,37)7)44-31(41)16-13-25-11-9-8-10-12-25/h8-14,16,27-30,32,40H,15,17-24H2,1-7H3,(H,42,43)/b16-13+/t27-,28+,29-,30+,32-,36-,37+,38+,39-/m0/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of 0.1 mg/mL BSA


J Nat Prod 62: 1660-3 (2000)


Article DOI: 10.1021/np990326p
BindingDB Entry DOI: 10.7270/Q2QF8SNP
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250427
PNG
((+)-Myristinin D | CHEMBL448072)
Show SMILES Oc1ccc(cc1)[C@@H]1C[C@H](c2ccc(O)cc2O1)c1c(O)cc(O)c(C(=O)CCCCCCCCc2ccccc2)c1O
Show InChI InChI=1S/C36H38O7/c37-25-16-14-24(15-17-25)32-21-28(27-19-18-26(38)20-33(27)43-32)34-30(40)22-31(41)35(36(34)42)29(39)13-9-4-2-1-3-6-10-23-11-7-5-8-12-23/h5,7-8,11-12,14-20,22,28,32,37-38,40-42H,1-4,6,9-10,13,21H2/t28-,32+/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta in presence of bovine serum albumin


J Nat Prod 68: 1625-8 (2005)


Article DOI: 10.1021/np058064g
BindingDB Entry DOI: 10.7270/Q2Q2400B
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250305
PNG
(3alpha-O-trans-p-coumaroyl-7-labden-15-oic acid | ...)
Show SMILES C[C@@H](CC[C@@H]1[C@H]2CC[C@H](OC(=O)\C=C\c3ccc(O)cc3)C(C)(C)[C@@H]2CC=C1C)CC(O)=O
Show InChI InChI=1S/C28H38O5/c1-18(17-26(30)31)5-12-22-19(2)6-14-24-23(22)13-15-25(28(24,3)4)33-27(32)16-9-20-7-10-21(29)11-8-20/h6-11,16,18,22-25,29H,5,12-15,17H2,1-4H3,(H,30,31)/b16-9+/t18-,22-,23+,24+,25-/m0/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of BSA


J Nat Prod 62: 1000-2 (1999)


Article DOI: 10.1021/np990099r
BindingDB Entry DOI: 10.7270/Q2RF5TRM
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50148911
PNG
((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259781
PNG
(3beta-hydroxyrus-12,19(29)-dien-28-oic acid | CHEM...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1=C)C(O)=O
Show InChI InChI=1S/C30H46O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18,21-24,31H,2,9-17H2,1,3-7H3,(H,32,33)/t18-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259782
PNG
(3beta-hydroxyrus-18,20(30)-dien-28-oic acid | CHEM...)
Show SMILES CC1=C2[C@H]3CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@]2(CCC1=C)C(O)=O
Show InChI InChI=1S/C30H46O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h20-23,31H,1,8-17H2,2-7H3,(H,32,33)/t20-,21+,22-,23+,27+,28-,29-,30+/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50203241
PNG
(1, 3-dihydroxy-5-[14'-(3' ',5' '-dihydroxyphenyl)t...)
Show SMILES Oc1cc(O)cc(CCCCCCCCCCCCCCc2cc(O)cc(O)c2)c1
Show InChI InChI=1S/C26H38O4/c27-23-15-21(16-24(28)19-23)13-11-9-7-5-3-1-2-4-6-8-10-12-14-22-17-25(29)20-26(30)18-22/h15-20,27-30H,1-14H2
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n/an/a 5.80E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta assessed as [3H]TTP incorporation after 60 mins by scintillation counting in presence of bovine serum albumin


J Nat Prod 62: 477-80 (1999)


Article DOI: 10.1021/np980522g
BindingDB Entry DOI: 10.7270/Q20Z731M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50241611
PNG
(1, 3-dihydroxy-5-[14'-(3' ',5' '-dihydroxyphenyl)-...)
Show SMILES Oc1cc(O)cc(CCCCCC\C=C/CCCCCCc2cc(O)cc(O)c2)c1
Show InChI InChI=1S/C26H36O4/c27-23-15-21(16-24(28)19-23)13-11-9-7-5-3-1-2-4-6-8-10-12-14-22-17-25(29)20-26(30)18-22/h1-2,15-20,27-30H,3-14H2/b2-1-
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta assessed as [3H]TTP incorporation after 60 mins by scintillation counting in presence of bovine serum albumin


J Nat Prod 62: 477-80 (1999)


Article DOI: 10.1021/np980522g
BindingDB Entry DOI: 10.7270/Q20Z731M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM23208
PNG
((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-17-hydroxy-1,...)
Show SMILES CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1660-3 (2000)


Article DOI: 10.1021/np990326p
BindingDB Entry DOI: 10.7270/Q2QF8SNP
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50079577
PNG
((4aS,6aS,6bR,10S,12aR,14bS)-10-Hydroxy-2,2,6a,6b,9...)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21?,22?,23-,27-,28+,29+,30-/m0/s1
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n/an/a 7.50E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259786
PNG
(3-cis-p-coumaroyl maslinic acid | CHEMBL463995)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](OC(=O)\C=C/c6ccccc6)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-34(2)19-21-39(33(42)43)22-20-37(6)26(27(39)23-34)14-15-30-36(5)24-28(40)32(35(3,4)29(36)17-18-38(30,37)7)44-31(41)16-13-25-11-9-8-10-12-25/h8-14,16,27-30,32,40H,15,17-24H2,1-7H3,(H,42,43)/b16-13-/t27-,28+,29-,30+,32-,36-,37+,38+,39-/m0/s1
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n/an/a 7.50E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in absence of BSA


J Nat Prod 62: 1660-3 (2000)


Article DOI: 10.1021/np990326p
BindingDB Entry DOI: 10.7270/Q2QF8SNP
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50241610
PNG
(1,3-dihydroxy-5-[14'-(3' ',5' '-dihydroxyphenyl)-c...)
Show SMILES Oc1cc(O)cc(CCCCCCCCC\C=C/CCCc2cc(O)cc(O)c2)c1
Show InChI InChI=1S/C26H36O4/c27-23-15-21(16-24(28)19-23)13-11-9-7-5-3-1-2-4-6-8-10-12-14-22-17-25(29)20-26(30)18-22/h5,7,15-20,27-30H,1-4,6,8-14H2/b7-5-
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n/an/a 7.50E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta assessed as [3H]TTP incorporation after 60 mins by scintillation counting in presence of bovine serum albumin


J Nat Prod 62: 477-80 (1999)


Article DOI: 10.1021/np980522g
BindingDB Entry DOI: 10.7270/Q20Z731M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of rat pol beta using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50148911
PNG
((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
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n/an/a 8.50E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of BSA


J Nat Prod 62: 1624-6 (2000)


Article DOI: 10.1021/np990240w
BindingDB Entry DOI: 10.7270/Q2V69JBZ
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50020659
PNG
(CHEMBL3290498)
Show SMILES CC[C@@H](C)[C@H]1O[C@]1(C)[C@H]1[C@@H](\C=C\C=C\C=C\C(O)=O)[C@@H]2CC=C(C)C[C@H]2C=C1C
Show InChI InChI=1S/C26H36O3/c1-6-18(3)25-26(5,29-25)24-19(4)16-20-15-17(2)13-14-21(20)22(24)11-9-7-8-10-12-23(27)28/h7-13,16,18,20-22,24-25H,6,14-15H2,1-5H3,(H,27,28)/b8-7+,11-9+,12-10+/t18-,20+,21-,22+,24-,25-,26-/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta expressed in Escherichia coli JMpbeta5 cells assessed as incorporation of [3H]dTTP into poly(dA)/ol...


J Nat Prod 77: 1404-12 (2014)


Article DOI: 10.1021/np500143k
BindingDB Entry DOI: 10.7270/Q24M9639
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50241570
PNG
((24E)-3beta-hydroxy-7,24-euphadien-26-oic acid | C...)
Show SMILES C[C@@H](CC\C=C(/C)C(O)=O)[C@]1(C)CC[C@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]12C
Show InChI InChI=1S/C31H50O3/c1-20(26(33)34)10-9-11-21(2)29(6)18-19-30(7)23-12-13-24-27(3,4)25(32)15-16-28(24,5)22(23)14-17-31(29,30)8/h10,12,21-22,24-25,32H,9,11,13-19H2,1-8H3,(H,33,34)/b20-10+/t21-,22-,24-,25-,28+,29-,30+,31-/m0/s1
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n/an/a 9.70E+3n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta after 60 mins


J Nat Prod 63: 1356-60 (2000)


Article DOI: 10.1021/np000129m
BindingDB Entry DOI: 10.7270/Q2X066S2
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50153117
PNG
((S)-4-((5R,10R,13R,17R)-3-Hydroxy-5,10,13-trimethy...)
Show SMILES C[C@@H](CCC(O)=O)[C@H]1CCC2C3CC[C@]4(C)CC(O)CC[C@]4(C)C3CC[C@]12C
Show InChI InChI=1S/C25H42O3/c1-16(5-8-22(27)28)19-6-7-20-18-10-12-23(2)15-17(26)9-14-25(23,4)21(18)11-13-24(19,20)3/h16-21,26H,5-15H2,1-4H3,(H,27,28)/t16-,17?,18?,19+,20?,21?,23+,24+,25+/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat DNA polymerase beta incubated with 0.05 units


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA Polymerase beta


(Rattus norvegicus)
BDBM33388
PNG
(dehydroaltenusin derivative, 16)
Show SMILES CCCCCCCCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C26H34O6/c1-3-4-5-6-7-8-9-10-11-12-13-31-18-14-19-20-16-21(27)23(29)17-26(20,2)32-25(30)24(19)22(28)15-18/h14-16,28H,3-13,17H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50109030
PNG
(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Show SMILES C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16?,17+,18+,19-,20+,21+,23+,24-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound on the activity of rat DNA polymerase beta was determined by inhibitory dose curves


Bioorg Med Chem Lett 12: 287-90 (2002)


Article DOI: 10.1016/s0960-894x(01)00725-9
BindingDB Entry DOI: 10.7270/Q2K936TC
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 1.15E+4n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of rat pol beta using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50375301
PNG
(CHEMBL260980)
Show SMILES COc1cc(O)c2c(c1)c1C(C)CC(=O)c1oc2=O
Show InChI InChI=1S/C14H12O5/c1-6-3-10(16)13-11(6)8-4-7(18-2)5-9(15)12(8)14(17)19-13/h4-6,15H,3H2,1-2H3
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n/an/a 1.19E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


Bioorg Med Chem 16: 2939-44 (2008)


Article DOI: 10.1016/j.bmc.2007.12.044
BindingDB Entry DOI: 10.7270/Q2J67HST
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250426
PNG
((+)-Myristinin A | CHEMBL465365)
Show SMILES CCCCCCCCCCCC(=O)c1c(O)cc(O)c([C@@H]2C[C@H](Oc3cc(O)ccc23)c2ccc(O)cc2)c1O
Show InChI InChI=1S/C33H40O7/c1-2-3-4-5-6-7-8-9-10-11-26(36)32-28(38)20-27(37)31(33(32)39)25-19-29(21-12-14-22(34)15-13-21)40-30-18-23(35)16-17-24(25)30/h12-18,20,25,29,34-35,37-39H,2-11,19H2,1H3/t25-,29+/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta in presence of bovine serum albumin


J Nat Prod 68: 1625-8 (2005)


Article DOI: 10.1021/np058064g
BindingDB Entry DOI: 10.7270/Q2Q2400B
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM23208
PNG
((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-17-hydroxy-1,...)
Show SMILES CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of 0.1 mg/mL BSA


J Nat Prod 62: 1660-3 (2000)


Article DOI: 10.1021/np990326p
BindingDB Entry DOI: 10.7270/Q2QF8SNP
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50259786
PNG
(3-cis-p-coumaroyl maslinic acid | CHEMBL463995)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](OC(=O)\C=C/c6ccccc6)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-34(2)19-21-39(33(42)43)22-20-37(6)26(27(39)23-34)14-15-30-36(5)24-28(40)32(35(3,4)29(36)17-18-38(30,37)7)44-31(41)16-13-25-11-9-8-10-12-25/h8-14,16,27-30,32,40H,15,17-24H2,1-7H3,(H,42,43)/b16-13-/t27-,28+,29-,30+,32-,36-,37+,38+,39-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta in presence of 0.1 mg/mL BSA


J Nat Prod 62: 1660-3 (2000)


Article DOI: 10.1021/np990326p
BindingDB Entry DOI: 10.7270/Q2QF8SNP
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250362
PNG
(3-Oximo-olean-12-en-29-oic acid | CHEMBL490347)
Show SMILES CC1(C)C(CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC=C2[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)N=O
Show InChI InChI=1S/C30H47NO3/c1-25(2)21-10-13-30(7)22(28(21,5)12-11-23(25)31-34)9-8-19-20-18-27(4,24(32)33)15-14-26(20,3)16-17-29(19,30)6/h8,20-23H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23?,26+,27+,28-,29+,30+/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Virginia Charlottesville

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


J Nat Prod 62: 1110-3 (1999)


Article DOI: 10.1021/np990104r
BindingDB Entry DOI: 10.7270/Q2C8293M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50375300
PNG
(TALAROFLAVONE)
Show SMILES COc1cc2c(C(=O)OC22C(C)CC(=O)C2=O)c(O)c1
Show InChI InChI=1S/C14H12O6/c1-6-3-10(16)12(17)14(6)8-4-7(19-2)5-9(15)11(8)13(18)20-14/h4-6,15H,3H2,1-2H3
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n/an/a 1.63E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


Bioorg Med Chem 16: 2939-44 (2008)


Article DOI: 10.1016/j.bmc.2007.12.044
BindingDB Entry DOI: 10.7270/Q2J67HST
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM23417
PNG
(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Show SMILES O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
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PubMed
n/an/a 1.85E+4n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of lyase activity of rat DNA polymerase beta after 30 mins by deoxyribose phosphate excision assay


J Nat Prod 67: 1744-7 (2004)


Article DOI: 10.1021/np040057p
BindingDB Entry DOI: 10.7270/Q2251K28
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50020663
PNG
(CHEMBL3290502)
Show SMILES CC[C@@H](C)[C@H]1O[C@H](\C=C\C=C\C(O)=O)[C@@H](O)[C@H]2[C@@H]3CC=C(C)C[C@H]3C=C(C)[C@H]2C1=C
Show InChI InChI=1S/C26H36O4/c1-6-16(3)26-18(5)23-17(4)14-19-13-15(2)11-12-20(19)24(23)25(29)21(30-26)9-7-8-10-22(27)28/h7-11,14,16,19-21,23-26,29H,5-6,12-13H2,1-4H3,(H,27,28)/b9-7+,10-8+/t16-,19+,20-,21-,23+,24+,25-,26-/m1/s1
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n/an/a 1.95E+4n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta expressed in Escherichia coli JMpbeta5 cells assessed as incorporation of [3H]dTTP into poly(dA)/ol...


J Nat Prod 77: 1404-12 (2014)


Article DOI: 10.1021/np500143k
BindingDB Entry DOI: 10.7270/Q24M9639
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250352
PNG
(3,4-seco-olean-4(23),12-diene-3,30-dioic acid | CH...)
Show SMILES CC(=C)[C@@H]1CC[C@]2(C)[C@H](CC=C3[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]23C)C(O)=O)[C@@]1(C)CCC(O)=O
Show InChI InChI=1S/C30H46O4/c1-19(2)20-10-13-30(7)23(28(20,5)12-11-24(31)32)9-8-21-22-18-27(4,25(33)34)15-14-26(22,3)16-17-29(21,30)6/h8,20,22-23H,1,9-18H2,2-7H3,(H,31,32)(H,33,34)/t20-,22-,23+,26+,27-,28-,29+,30+/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Virginia Charlottesville

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


J Nat Prod 62: 1110-3 (1999)


Article DOI: 10.1021/np990104r
BindingDB Entry DOI: 10.7270/Q2C8293M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250348
PNG
(3-oxo-olean-12-en-29-oic acid | 3-oxoolean-12-en-2...)
Show SMILES CC1(C)[C@@H]2CC[C@]3(C)[C@H](CC=C4[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CCC1=O
Show InChI InChI=1S/C30H46O3/c1-25(2)21-10-13-30(7)22(28(21,5)12-11-23(25)31)9-8-19-20-18-27(4,24(32)33)15-14-26(20,3)16-17-29(19,30)6/h8,20-22H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,26+,27+,28-,29+,30+/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Virginia Charlottesville

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


J Nat Prod 62: 1110-3 (1999)


Article DOI: 10.1021/np990104r
BindingDB Entry DOI: 10.7270/Q2C8293M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50237597
PNG
(7-hydroxy-3,7'-dicoumaryl ether | 7-hydroxy-3-(2-o...)
Show SMILES Oc1ccc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2c1
Show InChI InChI=1S/C18H10O6/c19-12-4-1-11-7-16(18(21)24-14(11)8-12)22-13-5-2-10-3-6-17(20)23-15(10)9-13/h1-9,19H
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n/an/a 2.25E+4n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of lyase activity of rat DNA polymerase beta after 30 mins


J Nat Prod 67: 1608-10 (2004)


Article DOI: 10.1021/np040127s
BindingDB Entry DOI: 10.7270/Q2JH3KZG
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50241570
PNG
((24E)-3beta-hydroxy-7,24-euphadien-26-oic acid | C...)
Show SMILES C[C@@H](CC\C=C(/C)C(O)=O)[C@]1(C)CC[C@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]12C
Show InChI InChI=1S/C31H50O3/c1-20(26(33)34)10-9-11-21(2)29(6)18-19-30(7)23-12-13-24-27(3,4)25(32)15-16-28(24,5)22(23)14-17-31(29,30)8/h10,12,21-22,24-25,32H,9,11,13-19H2,1-8H3,(H,33,34)/b20-10+/t21-,22-,24-,25-,28+,29-,30+,31-/m0/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta after 60 mins in presence of 0.1 mg/mL BSA


J Nat Prod 63: 1356-60 (2000)


Article DOI: 10.1021/np000129m
BindingDB Entry DOI: 10.7270/Q2X066S2
More data for this
Ligand-Target Pair
DNA Polymerase beta


(Rattus norvegicus)
BDBM33387
PNG
(dehydroaltenusin derivative, 15)
Show SMILES CCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C20H22O6/c1-3-4-5-6-7-25-12-8-13-14-10-15(21)17(23)11-20(14,2)26-19(24)18(13)16(22)9-12/h8-10,22H,3-7,11H2,1-2H3
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n/an/a 2.40E+4n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50251277
PNG
(CHEMBL458178 | Kasanosin A)
Show SMILES COc1cc(C)c(C(=O)O[C@H]2CC3=C(COC(\C=C\CO)=C3)C(=O)[C@@]2(C)O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(26)30-18-9-13-8-14(5-4-6-23)29-11-16(13)20(25)22(18,2)27/h4-5,7-8,10,18,23-24,27H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 2.73E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


Bioorg Med Chem 16: 4594-9 (2008)


Article DOI: 10.1016/j.bmc.2008.02.037
BindingDB Entry DOI: 10.7270/Q2X066TH
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50020676
PNG
(CHEBI:41846 | CHEMBL566812)
Show SMILES Cc1cn([C@H]2CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H17N2O13P3/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/t7-,8+/m0/s1
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n/an/a 3.08E+4n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta expressed in Escherichia coli JMpbeta5 cells assessed as incorporation of [3H]dTTP into poly(dA)/ol...


J Nat Prod 77: 1404-12 (2014)


Article DOI: 10.1021/np500143k
BindingDB Entry DOI: 10.7270/Q24M9639
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50109031
PNG
(4-(10,13-Dimethyl-3-{3-[5-(2-oxo-hexahydro-thieno[...)
Show SMILES C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCNC(=O)CCCCC1SCC2NC(=O)NC12
Show InChI InChI=1S/C37H59N3O6S/c1-22(8-13-32(42)43)26-11-12-27-25-10-9-23-20-24(14-17-36(23,2)28(25)15-18-37(26,27)3)46-33(44)16-19-38-31(41)7-5-4-6-30-34-29(21-47-30)39-35(45)40-34/h22-30,34H,4-21H2,1-3H3,(H,38,41)(H,42,43)(H2,39,40,45)/t22-,23?,24+,25+,26-,27+,28+,29?,30?,34?,36+,37-/m1/s1
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PubMed
n/an/a 3.10E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound on the activity of rat DNA polymerase beta was determined by inhibitory dose curves


Bioorg Med Chem Lett 12: 287-90 (2002)


Article DOI: 10.1016/s0960-894x(01)00725-9
BindingDB Entry DOI: 10.7270/Q2K936TC
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50109029
PNG
(4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...)
Show SMILES C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCCC1SCC2NC(=O)NC12
Show InChI InChI=1S/C49H81N5O8S/c1-32(16-21-44(58)59)36-19-20-37-35-18-17-33-30-34(22-25-48(33,2)38(35)23-26-49(36,37)3)62-45(60)24-29-52-43(57)14-7-5-11-27-50-41(55)13-6-4-10-28-51-42(56)15-9-8-12-40-46-39(31-63-40)53-47(61)54-46/h32-40,46H,4-31H2,1-3H3,(H,50,55)(H,51,56)(H,52,57)(H,58,59)(H2,53,54,61)/t32-,33?,34+,35+,36-,37+,38+,39?,40?,46?,48+,49-/m1/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibitory effect of the compound on the activity of mammalian DNA polymerase beta was determined by inhibitory dose curves


Bioorg Med Chem Lett 12: 287-90 (2002)


Article DOI: 10.1016/s0960-894x(01)00725-9
BindingDB Entry DOI: 10.7270/Q2K936TC
More data for this
Ligand-Target Pair
DNA Polymerase beta


(Rattus norvegicus)
BDBM33386
PNG
(dehydroaltenusin derivative, 14)
Show SMILES CCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C17H16O6/c1-3-4-22-9-5-10-11-7-12(18)14(20)8-17(11,2)23-16(21)15(10)13(19)6-9/h5-7,19H,3-4,8H2,1-2H3
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n/an/a 3.50E+4n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250360
PNG
(3-benzyloximo-olean-12-en-29-oic acid | CHEMBL4557...)
Show SMILES C[C@]12CC[C@](C)(C[C@H]1C1=CC[C@@H]3[C@@]4(C)CC\C(=N\OCc5ccccc5)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O
Show InChI InChI=1S/C37H53NO3/c1-32(2)28-15-18-37(7)29(35(28,5)17-16-30(32)38-41-24-25-11-9-8-10-12-25)14-13-26-27-23-34(4,31(39)40)20-19-33(27,3)21-22-36(26,37)6/h8-13,27-29H,14-24H2,1-7H3,(H,39,40)/b38-30-/t27-,28-,29+,33+,34+,35-,36+,37+/m0/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Virginia Charlottesville

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


J Nat Prod 62: 1110-3 (1999)


Article DOI: 10.1021/np990104r
BindingDB Entry DOI: 10.7270/Q2C8293M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50448689
PNG
(CHEMBL3127730)
Show SMILES CCCC[C@@H](O)\C=C(/C)\C=C\C=C/C(=O)N1CCCC1=O
Show InChI InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6-,14-13+/t15-/m1/s1
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n/an/a 3.56E+4n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA...


Bioorg Med Chem 22: 1070-6 (2014)


Article DOI: 10.1016/j.bmc.2013.12.038
BindingDB Entry DOI: 10.7270/Q22V2HMW
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250361
PNG
(3-methyloximo-olean-12-en-29-oic acid | CHEMBL5241...)
Show SMILES CO\N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC=C2[C@@H]4C[C@@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C
Show InChI InChI=1S/C31H49NO3/c1-26(2)22-11-14-31(7)23(29(22,5)13-12-24(26)32-35-8)10-9-20-21-19-28(4,25(33)34)16-15-27(21,3)17-18-30(20,31)6/h9,21-23H,10-19H2,1-8H3,(H,33,34)/b32-24-/t21-,22-,23+,27+,28+,29-,30+,31+/m0/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Virginia Charlottesville

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


J Nat Prod 62: 1110-3 (1999)


Article DOI: 10.1021/np990104r
BindingDB Entry DOI: 10.7270/Q2C8293M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50250349
PNG
(3alpha-hydroxyolean-12-en-29-oic acid | CHEMBL4905...)
Show SMILES CC1(C)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC=C2[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O
Show InChI InChI=1S/C30H48O3/c1-25(2)21-10-13-30(7)22(28(21,5)12-11-23(25)31)9-8-19-20-18-27(4,24(32)33)15-14-26(20,3)16-17-29(19,30)6/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23+,26+,27+,28-,29+,30+/m0/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Virginia Charlottesville

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


J Nat Prod 62: 1110-3 (1999)


Article DOI: 10.1021/np990104r
BindingDB Entry DOI: 10.7270/Q2C8293M
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50020661
PNG
(CHEMBL3290500)
Show SMILES C[C@@H]1CCO[C@]2(C)[C@@H]1O[C@H](\C=C\C=C\C(O)=O)[C@@H](O)[C@H]1[C@@H]3CC=C(C)C[C@H]3C=C(C)[C@@H]21
Show InChI InChI=1S/C26H36O5/c1-15-9-10-19-18(13-15)14-17(3)23-22(19)24(29)20(7-5-6-8-21(27)28)31-25-16(2)11-12-30-26(23,25)4/h5-9,14,16,18-20,22-25,29H,10-13H2,1-4H3,(H,27,28)/b7-5+,8-6+/t16-,18+,19-,20-,22+,23-,24-,25-,26+/m1/s1
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n/an/a 3.79E+4n/an/an/an/an/an/a



Kobe Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant DNA polymerase beta expressed in Escherichia coli JMpbeta5 cells assessed as incorporation of [3H]dTTP into poly(dA)/ol...


J Nat Prod 77: 1404-12 (2014)


Article DOI: 10.1021/np500143k
BindingDB Entry DOI: 10.7270/Q24M9639
More data for this
Ligand-Target Pair
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