Compile Data Set for Download or QSAR
maximum 50k data
Found 112 of ic50 data for polymerid = 50004073
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308051(US10011593, Ex. 3 | US9650366, 3)
Affinity DataIC50:  39nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308056(US10011593, Ex. 6 | US9650366, 6)
Affinity DataIC50:  66nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM364980(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Affinity DataIC50:  69nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM364980(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Affinity DataIC50:  69nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM364980(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Affinity DataIC50:  69nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308055(US10011593, Ex. 5 | US9650366, 5)
Affinity DataIC50:  76nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308057(US10011593, Ex. 8 | US9650366, 8)
Affinity DataIC50:  82nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50442163(CHEMBL2441346)
Affinity DataIC50:  99nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308054(US10011593, Ex. 4 | US9650366, 4)
Affinity DataIC50:  99nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347876(CHEMBL1802782)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347891(CHEMBL1802629)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308050(US10011593, Ex. 2 | US9650366, 2)
Affinity DataIC50:  140nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347926(CHEMBL1802778)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308060(US10011593, Ex. 11 | US9650366, 11)
Affinity DataIC50:  158nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM364984(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  167nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM364984(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  167nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM364984(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Affinity DataIC50:  167nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50466038(CHEMBL4281823)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant human PKR (252 to end residues) using RSRSRSRSRSRSRS as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50396536(CHEMBL2171122)
Affinity DataIC50:  291nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347887(CHEMBL1802769)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308063(US10011593, Ex. 14 | US9650366, 14)
Affinity DataIC50:  301nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50442162(CHEMBL2441342)
Affinity DataIC50:  359nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365353(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Affinity DataIC50:  390nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365353(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Affinity DataIC50:  390nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365353(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Affinity DataIC50:  390nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365352(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Affinity DataIC50:  551nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365352(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Affinity DataIC50:  551nMAssay Description:PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM365352(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Affinity DataIC50:  551nMAssay Description:Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308062(US10011593, Ex. 13 | US9650366, 13)
Affinity DataIC50:  558nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM7401((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347889(CHEMBL1802630)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50:  696nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM308049(US10011593, Ex. 1 | US9650366, 1)
Affinity DataIC50:  727nMAssay Description:PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347920(CHEMBL1802486)
Affinity DataIC50:  750nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50442166(CHEMBL2441340)
Affinity DataIC50:  905nMAssay Description:Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50396531(CHEMBL2171132)
Affinity DataIC50:  978nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50301356(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PKRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347927(CHEMBL1802623)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347886(CHEMBL1802771)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347902(CHEMBL1802616)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347924(CHEMBL1802728)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347905(CHEMBL1802613)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347885(CHEMBL1802773)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347875(CHEMBL1802783)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50073765(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347916(CHEMBL1802488)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50347923(CHEMBL1802729)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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