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Compile Data Set for Download or QSAR

Found 6 hits of ki for UniProtKB: P05186   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299523
PNG
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
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UniProtKB/SwissProt

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PC sid
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Article
PubMed
340n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNAP using CDP-star as substrate by non-competitive Lineweaver-Burk plot


J Med Chem 52: 6919-25 (2009)


Article DOI: 10.1021/jm900383s
BindingDB Entry DOI: 10.7270/Q2WS8T9M
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50299523
PNG
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
KEGG

UniProtKB/SwissProt

DrugBank
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CHEMBL
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PC sid
UniChem

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Article
PubMed
590n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNAP using DEA as substrate by non-competitive Lineweaver-Burk plot


J Med Chem 52: 6919-25 (2009)


Article DOI: 10.1021/jm900383s
BindingDB Entry DOI: 10.7270/Q2WS8T9M
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
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CHEMBL
DrugBank
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PC cid
PC sid
UniChem

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Article
PubMed
1.60E+4n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Bioorg Med Chem Lett 19: 222-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.107
BindingDB Entry DOI: 10.7270/Q2CR5T64
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
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CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

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Article
PubMed
1.60E+4n/an/an/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of human tissue non-specific alkaline phosphatase at pH 9.8


Bioorg Med Chem 17: 7290-300 (2009)


Article DOI: 10.1016/j.bmc.2009.08.048
BindingDB Entry DOI: 10.7270/Q2VM4CB4
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM10847
PNG
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Show SMILES Cn1c2nc[nH]c2c(=O)n(C)c1=O
Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
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UniProtKB/SwissProt

DrugBank
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CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


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Article
PubMed
8.20E+4n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of TNSALP (unknown origin)


Bioorg Med Chem Lett 19: 222-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.107
BindingDB Entry DOI: 10.7270/Q2CR5T64
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens)
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
9.30E+4n/an/an/an/an/an/an/an/a



Universit£ Claude Bernard-Lyon 1

Curated by ChEMBL


Assay Description
Inhibition of recombinant TNAP


Bioorg Med Chem Lett 21: 2297-301 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.089
BindingDB Entry DOI: 10.7270/Q2V988CR
More data for this
Ligand-Target Pair