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Compile Data Set for Download or QSAR

Found 14 hits of ec50 for UniProtKB: P04303   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294522
PNG
(N-[(2-benzyloxyphenyl)methyl]- 1H-indazol-5-amine ...)
Show SMILES C(Nc1ccc2[nH]ncc2c1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C21H19N3O/c1-2-6-16(7-3-1)15-25-21-9-5-4-8-17(21)13-22-19-10-11-20-18(12-19)14-23-24-20/h1-12,14,22H,13,15H2,(H,23,24)
PDB
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UniChem
US Patent
n/an/an/an/a 7.90E+3n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294508
PNG
(5-[(2- benzyloxyphenyl)methylamino]- 1,3-dihydrobe...)
Show SMILES O=c1[nH]c2ccc(NCc3ccccc3OCc3ccccc3)cc2[nH]1
Show InChI InChI=1S/C21H17N3O2/c25-21-23-18-11-10-17(12-19(18)24-21)22-13-16-8-4-5-9-20(16)26-14-15-6-2-1-3-7-15/h1-12,22H,13-14H2
PDB
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US Patent
n/an/an/an/a 1.00E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294515
PNG
(5-[(2-benzyloxy-5-bromo- phenyl)methylamino]-1,3- ...)
Show SMILES Brc1ccc(OCc2ccccc2)c(CNc2ccc3[nH]c(=O)[nH]c3c2)c1
Show InChI InChI=1S/C21H16BrN3O2/c22-16-6-9-20(27-13-14-4-2-1-3-5-14)15(10-16)12-23-17-7-8-18-19(11-17)25-21(26)24-18/h1-11,23H,12-13H2
PDB
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UniChem
US Patent
n/an/an/an/a 1.10E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294516
PNG
(5-[[5-chloro-2-[(2- fluorophenyl)methoxy]phenyl] m...)
Show SMILES Fc1ccccc1COc1ccc(Cl)cc1CNc1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H15ClFN3O2/c22-15-5-8-20(28-12-13-3-1-2-4-17(13)23)14(9-15)11-24-16-6-7-18-19(10-16)26-21(27)25-18/h1-10,24H,11-12H2
PDB
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n/an/an/an/a 1.10E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294512
PNG
(5-[[2-[(4- chlorophenyl)methoxy]phenyl] methylamin...)
Show SMILES Clc1ccc(COc2ccccc2CNc2ccc3[nH]c(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C21H16ClN3O2/c22-16-7-5-14(6-8-16)13-27-20-4-2-1-3-15(20)12-23-17-9-10-18-19(11-17)25-21(26)24-18/h1-11,23H,12-13H2
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UniChem
US Patent
n/an/an/an/a 1.10E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294517
PNG
(4-[[2-[(3- nitrophenyl)methoxy]phenyl] methylamino...)
Show SMILES Oc1ccc(NCc2ccccc2OCc2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H18N2O4/c23-19-10-8-17(9-11-19)21-13-16-5-1-2-7-20(16)26-14-15-4-3-6-18(12-15)22(24)25/h1-12,21,23H,13-14H2
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n/an/an/an/a 1.33E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294514
PNG
(5-[[2-[(4- fluorophenyl)methoxy]phenyl] methylamin...)
Show SMILES Fc1ccc(COc2ccccc2CNc2ccc3[nH]c(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C21H16FN3O2/c22-16-7-5-14(6-8-16)13-27-20-4-2-1-3-15(20)12-23-17-9-10-18-19(11-17)25-21(26)24-18/h1-11,23H,12-13H2
PDB
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UniChem
US Patent
n/an/an/an/a 1.39E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM50431843
PNG
(CHEMBL2347241 | US10112895, Compound 3)
Show SMILES NS(=O)(=O)c1ccc(NCc2cc(Cl)ccc2OCc2ccccc2)cc1
Show InChI InChI=1S/C20H19ClN2O3S/c21-17-6-11-20(26-14-15-4-2-1-3-5-15)16(12-17)13-23-18-7-9-19(10-8-18)27(22,24)25/h1-12,23H,13-14H2,(H2,22,24,25)
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UniChem

Similars

US Patent
n/an/an/an/a 1.39E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294521
PNG
(N-[(2-benzyloxyphenyl)methyl]- 4-oxazol-5-yl-anili...)
Show SMILES C(Nc1ccc(cc1)-c1cnco1)c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C23H20N2O2/c1-2-6-18(7-3-1)16-26-22-9-5-4-8-20(22)14-25-21-12-10-19(11-13-21)23-15-24-17-27-23/h1-13,15,17,25H,14,16H2
PDB
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UniChem
US Patent
n/an/an/an/a 1.44E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294513
PNG
(5-[[2-[(2- chlorophenyl)methoxy]phenyl] methylamin...)
Show SMILES Clc1ccccc1COc1ccccc1CNc1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C21H16ClN3O2/c22-17-7-3-1-6-15(17)13-27-20-8-4-2-5-14(20)12-23-16-9-10-18-19(11-16)25-21(26)24-18/h1-11,23H,12-13H2
PDB
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UniChem
US Patent
n/an/an/an/a 1.49E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294519
PNG
(2-[[2-[(3- nitrophenyl)methoxy]phenyl] methylamino...)
Show SMILES Oc1ccccc1NCc1ccccc1OCc1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C20H18N2O4/c23-19-10-3-2-9-18(19)21-13-16-7-1-4-11-20(16)26-14-15-6-5-8-17(12-15)22(24)25/h1-12,21,23H,13-14H2
PDB
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UniChem
US Patent
n/an/an/an/a 1.77E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294520
PNG
(4-[(2- benzyloxyphenyl)methylamino]- 3-fluoro-phen...)
Show SMILES Oc1ccc(NCc2ccccc2OCc2ccccc2)c(F)c1
Show InChI InChI=1S/C20H18FNO2/c21-18-12-17(23)10-11-19(18)22-13-16-8-4-5-9-20(16)24-14-15-6-2-1-3-7-15/h1-12,22-23H,13-14H2
PDB
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UniChem
US Patent
n/an/an/an/a 1.94E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM294507
PNG
(4-[[5-bromo-2-[(4- fluorophenyl)methoxy]phenyl] me...)
Show SMILES Oc1ccc(NCc2cc(Br)ccc2OCc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H17BrFNO2/c21-16-3-10-20(25-13-14-1-4-17(22)5-2-14)15(11-16)12-23-18-6-8-19(24)9-7-18/h1-11,23-24H,12-13H2
PDB
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UniChem
US Patent
n/an/an/an/a 1.99E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair
Uracil-DNA glycosylase


(Vaccinia virus (strain Western Reserve) (VACV) (Va...)
BDBM33154
PNG
(4-[(2-benzoxybenzyl)amino]phenol | 4-[(2-phenylmet...)
Show SMILES Oc1ccc(NCc2ccccc2OCc2ccccc2)cc1
Show InChI InChI=1S/C20H19NO2/c22-19-12-10-18(11-13-19)21-14-17-8-4-5-9-20(17)23-15-16-6-2-1-3-7-16/h1-13,21-22H,14-15H2
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US Patent
n/an/an/an/a 3.56E+4n/an/a7.5n/a



The Trustees of the University of Pennsylvania

US Patent


Assay Description
Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...


US Patent US10112895 (2018)

More data for this
Ligand-Target Pair