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Compile Data Set for Download or QSAR

Found 8 hits of ic50 for UniProtKB: P00573   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase using salmon sperm DNA and [3H]UTP at 25 degree C after 30 mins by liquid scintillation counting


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase using salmon sperm DNA and [3H]UTP at 25 degree C after 30 mins by liquid scintillation counting


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50448689
PNG
(CHEMBL3127730)
Show SMILES CCCC[C@@H](O)\C=C(/C)\C=C\C=C/C(=O)N1CCCC1=O
Show InChI InChI=1/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6-,14-13+/t15-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins


Bioorg Med Chem 22: 1070-6 (2014)


Article DOI: 10.1016/j.bmc.2013.12.038
BindingDB Entry DOI: 10.7270/Q22V2HMW
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50448690
PNG
(CHEMBL3127728)
Show SMILES CCCCC(=O)C=C(C)C=CCCC(=O)N1CCCC1=O
Show InChI InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5,8,13H,3-4,6-7,9-12H2,1-2H3/b8-5+,14-13+
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins


Bioorg Med Chem 22: 1070-6 (2014)


Article DOI: 10.1016/j.bmc.2013.12.038
BindingDB Entry DOI: 10.7270/Q22V2HMW
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50448691
PNG
(CHEMBL3127729)
Show SMILES C\C(\C=C\CCC(=O)N1CCCC1=O)=C/C1CCCCO1
Show InChI InChI=1/C17H25NO3/c1-14(13-15-8-4-5-12-21-15)7-2-3-9-16(19)18-11-6-10-17(18)20/h2,7,13,15H,3-6,8-12H2,1H3/b7-2+,14-13+
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins


Bioorg Med Chem 22: 1070-6 (2014)


Article DOI: 10.1016/j.bmc.2013.12.038
BindingDB Entry DOI: 10.7270/Q22V2HMW
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50448688
PNG
(PECILOCIN | Pecilocin | Variotin)
Show SMILES CCCC[C@@H](O)\C=C(/C)\C=C\C=C\C(=O)N1CCCC1=O
Show InChI InChI=1/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6+,14-13+/t15-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins


Bioorg Med Chem 22: 1070-6 (2014)


Article DOI: 10.1016/j.bmc.2013.12.038
BindingDB Entry DOI: 10.7270/Q22V2HMW
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50262634
PNG
(CHEMBL4076797)
Show SMILES [Na+].[Na+].[Na+].Nc1nc(OCc2ccccc2[N+]([O-])=O)c2ncn([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1/C17H21N6O16P3.3Na/c18-17-20-14-11(15(21-17)35-5-8-3-1-2-4-9(8)23(26)27)19-7-22(14)16-13(25)12(24)10(37-16)6-36-41(31,32)39-42(33,34)38-40(28,29)30;;;/h1-4,7,10,12-13,16,24-25H,5-6H2,(H,31,32)(H,33,34)(H2,18,20,21)(H2,28,29,30);;;/q;3*+1/p-3/t10-,12-,13-,16-;;;/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 5.00E+6n/an/an/an/an/an/a



Tokyo Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase assessed as reduction in RNA product formation using double stranded DNA as substrate after 4 hrs in presence of NTPs...


Bioorg Med Chem 25: 6007-6015 (2017)

More data for this
Ligand-Target Pair
DNA-directed RNA polymerase


(Enterobacteria phage T7)
BDBM50262635
PNG
(CHEMBL4095030)
Show SMILES [Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)n1ccc(OCc2ccccc2[N+]([O-])=O)nc1=O
Show InChI InChI=1/C16H20N3O17P3.3Na/c20-13-11(8-33-38(28,29)36-39(30,31)35-37(25,26)27)34-15(14(13)21)18-6-5-12(17-16(18)22)32-7-9-3-1-2-4-10(9)19(23)24;;;/h1-6,11,13-15,20-21H,7-8H2,(H,28,29)(H,30,31)(H2,25,26,27);;;/q;3*+1/p-3/t11-,13-,14-,15-;;;/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 5.00E+6n/an/an/an/an/an/a



Tokyo Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of T7 RNA polymerase assessed as reduction in RNA product formation using double stranded DNA as substrate after 4 hrs in presence of NTPs...


Bioorg Med Chem 25: 6007-6015 (2017)

More data for this
Ligand-Target Pair