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Compile Data Set for Download or QSAR

Found 102 hits of kd data for polymerid = 50006636   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019866
PNG
(CHEMBL3286930)
Show SMILES O=C(OC[C@H](C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C40H42N6O2/c47-39(32-21-25-44(26-22-32)40-43-33-15-7-9-17-35(33)45(40)27-29-11-3-1-4-12-29)48-28-37(30-19-23-41-24-20-30)46-36-18-10-8-16-34(36)42-38(46)31-13-5-2-6-14-31/h1-18,30,32,37,41H,19-28H2/t37-/m1/s1
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n/an/an/a 0.0770n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to PDE-delta (unknown origin) by SPR analysis


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249988
PNG
(CHEMBL4061005)
Show SMILES Cc1n(nc2c1c(C)nn(CCC(=O)N1CCC(CC1)N1C(Nc3ccccc3C1=O)c1ccccc1F)c2=O)-c1ccc(C)cc1
Show InChI InChI=1S/C36H36FN7O3/c1-22-12-14-26(15-13-22)44-24(3)32-23(2)39-42(36(47)33(32)40-44)21-18-31(45)41-19-16-25(17-20-41)43-34(27-8-4-6-10-29(27)37)38-30-11-7-5-9-28(30)35(43)46/h4-15,25,34,38H,16-21H2,1-3H3
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n/an/an/a 0.600n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019865
PNG
(CHEMBL3286929)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1)[C@H](C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1
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n/an/an/a 1.10n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to PDE-delta (unknown origin) by time-resolved fluorescence anisotropic analysis


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50249988
PNG
(CHEMBL4061005)
Show SMILES Cc1n(nc2c1c(C)nn(CCC(=O)N1CCC(CC1)N1C(Nc3ccccc3C1=O)c1ccccc1F)c2=O)-c1ccc(C)cc1
Show InChI InChI=1S/C36H36FN7O3/c1-22-12-14-26(15-13-22)44-24(3)32-23(2)39-42(36(47)33(32)40-44)21-18-31(45)41-19-16-25(17-20-41)43-34(27-8-4-6-10-29(27)37)38-30-11-7-5-9-28(30)35(43)46/h4-15,25,34,38H,16-21H2,1-3H3
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n/an/an/a 2n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249989
PNG
(CHEMBL1387422)
Show SMILES CC(CNC(=O)CCCn1nc(C)c2c(C)n(nc2c1=O)-c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C27H31N5O2/c1-18-12-14-23(15-13-18)32-21(4)25-20(3)29-31(27(34)26(25)30-32)16-8-11-24(33)28-17-19(2)22-9-6-5-7-10-22/h5-7,9-10,12-15,19H,8,11,16-17H2,1-4H3,(H,28,33)
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n/an/an/a 2.20n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249992
PNG
(CHEMBL4090695)
Show SMILES Fc1ccccc1[C@@H]1Nc2ccccc2C(=O)N1CCN1CCC(CC1)N1[C@@H](Nc2ccccc2C1=O)c1ccccc1F
Show InChI InChI=1S/C35H33F2N5O2/c36-28-13-5-1-9-24(28)32-38-30-15-7-3-11-26(30)34(43)41(32)22-21-40-19-17-23(18-20-40)42-33(25-10-2-6-14-29(25)37)39-31-16-8-4-12-27(31)35(42)44/h1-16,23,32-33,38-39H,17-22H2/t32-,33-/m1/s1
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n/an/an/a 2.30n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249987
PNG
(CHEMBL4082888)
Show SMILES Cc1n(nc2c1c(C)nn(CCCN1CCC(CC1)N1C(Nc3ccccc3C1=O)c1ccccc1F)c2=O)-c1ccc(C)cc1
Show InChI InChI=1S/C36H38FN7O2/c1-23-13-15-27(16-14-23)44-25(3)32-24(2)39-42(36(46)33(32)40-44)20-8-19-41-21-17-26(18-22-41)43-34(28-9-4-6-11-30(28)37)38-31-12-7-5-10-29(31)35(43)45/h4-7,9-16,26,34,38H,8,17-22H2,1-3H3
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n/an/an/a 4n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249979
PNG
(CHEMBL4061982)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CCCCCCN1C(Nc2ccccc2C1=O)c1ccccc1F
Show InChI InChI=1S/C34H32F2N4O2/c35-27-17-7-3-13-23(27)31-37-29-19-9-5-15-25(29)33(41)39(31)21-11-1-2-12-22-40-32(24-14-4-8-18-28(24)36)38-30-20-10-6-16-26(30)34(40)42/h3-10,13-20,31-32,37-38H,1-2,11-12,21-22H2
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n/an/an/a 4n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256259
PNG
(CHEMBL4073926)
Show SMILES Fc1ccc2NC(N(CCOc3ccc(cc3)-c3nc4ccccc4n3Cc3ccncc3)C(=O)c2c1)c1ccccc1F
Show InChI InChI=1S/C35H27F2N5O2/c36-25-11-14-30-28(21-25)35(43)41(34(39-30)27-5-1-2-6-29(27)37)19-20-44-26-12-9-24(10-13-26)33-40-31-7-3-4-8-32(31)42(33)22-23-15-17-38-18-16-23/h1-18,21,34,39H,19-20,22H2
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n/an/an/a 4.5n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019850
PNG
(CHEMBL3286915)
Show SMILES Cc1nc2ccccc2n1CCOC(=O)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-22-31-25-11-5-7-13-27(25)34(22)19-20-37-29(36)24-15-17-33(18-16-24)30-32-26-12-6-8-14-28(26)35(30)21-23-9-3-2-4-10-23/h2-14,24H,15-21H2,1H3
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n/an/an/a 6n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019849
PNG
(CHEMBL3286914)
Show SMILES O=C(OCCn1ccnc1-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C31H31N5O2/c37-30(38-22-21-34-20-17-32-29(34)25-11-5-2-6-12-25)26-15-18-35(19-16-26)31-33-27-13-7-8-14-28(27)36(31)23-24-9-3-1-4-10-24/h1-14,17,20,26H,15-16,18-19,21-23H2
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n/an/an/a 7n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019852
PNG
(CHEMBL3286917)
Show SMILES C(Cn1ccnc1-c1ccccc1)Oc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C31H26N4O/c1-3-9-24(10-4-1)23-35-29-14-8-7-13-28(29)33-31(35)26-15-17-27(18-16-26)36-22-21-34-20-19-32-30(34)25-11-5-2-6-12-25/h1-20H,21-23H2
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n/an/an/a 7n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019843
PNG
(CHEMBL3286909)
Show SMILES O=C(OC[C@H](C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccsc1
Show InChI InChI=1S/C38H40N6O2S/c45-37(30-16-21-42(22-17-30)38-41-31-10-4-6-12-33(31)43(38)24-27-18-23-47-26-27)46-25-35(28-14-19-39-20-15-28)44-34-13-7-5-11-32(34)40-36(44)29-8-2-1-3-9-29/h1-13,18,23,26,28,30,35,39H,14-17,19-22,24-25H2/t35-/m1/s1
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n/an/an/a 7n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019844
PNG
(CHEMBL3286910)
Show SMILES CC(C)c1nc2ccccc2n1[C@H](COC(=O)C1CCN(CC1)c1nc2ccccc2n1Cc1ccsc1)C1CCNCC1
Show InChI InChI=1S/C35H42N6O2S/c1-24(2)33-37-29-8-4-6-10-31(29)41(33)32(26-11-16-36-17-12-26)22-43-34(42)27-13-18-39(19-14-27)35-38-28-7-3-5-9-30(28)40(35)21-25-15-20-44-23-25/h3-10,15,20,23-24,26-27,32,36H,11-14,16-19,21-22H2,1-2H3/t32-/m1/s1
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n/an/an/a 8n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249990
PNG
(CHEMBL4090022)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CCCCCN1C(Nc2ccccc2C1=O)c1ccccc1F
Show InChI InChI=1S/C33H30F2N4O2/c34-26-16-6-2-12-22(26)30-36-28-18-8-4-14-24(28)32(40)38(30)20-10-1-11-21-39-31(23-13-3-7-17-27(23)35)37-29-19-9-5-15-25(29)33(39)41/h2-9,12-19,30-31,36-37H,1,10-11,20-21H2
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n/an/an/a 8n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249989
PNG
(CHEMBL1387422)
Show SMILES CC(CNC(=O)CCCn1nc(C)c2c(C)n(nc2c1=O)-c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C27H31N5O2/c1-18-12-14-23(15-13-18)32-21(4)25-20(3)29-31(27(34)26(25)30-32)16-8-11-24(33)28-17-19(2)22-9-6-5-7-10-22/h5-7,9-10,12-15,19H,8,11,16-17H2,1-4H3,(H,28,33)
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n/an/an/a 8n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019846
PNG
(CHEMBL3286912)
Show SMILES CCc1nc2ccccc2n1[C@H](COC(=O)C1CCN(CC1)c1nc2ccccc2n1Cc1ccsc1)C1CCNCC1
Show InChI InChI=1S/C34H40N6O2S/c1-2-32-36-28-8-4-6-10-30(28)40(32)31(25-11-16-35-17-12-25)22-42-33(41)26-13-18-38(19-14-26)34-37-27-7-3-5-9-29(27)39(34)21-24-15-20-43-23-24/h3-10,15,20,23,25-26,31,35H,2,11-14,16-19,21-22H2,1H3/t31-/m1/s1
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n/an/an/a 9n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019822
PNG
(CHEMBL3286902)
Show SMILES O=C(OCC(C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccsc1
Show InChI InChI=1S/C38H40N6O2S/c45-37(30-16-21-42(22-17-30)38-41-31-10-4-6-12-33(31)43(38)24-27-18-23-47-26-27)46-25-35(28-14-19-39-20-15-28)44-34-13-7-5-11-32(34)40-36(44)29-8-2-1-3-9-29/h1-13,18,23,26,28,30,35,39H,14-17,19-22,24-25H2
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n/an/an/a 9n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256251
PNG
(CHEMBL4100698)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CCOc1ccc(cc1)-c1nc2ccccc2n1Cc1ccncc1
Show InChI InChI=1S/C35H28FN5O2/c36-29-9-3-1-7-27(29)34-38-30-10-4-2-8-28(30)35(42)40(34)21-22-43-26-15-13-25(14-16-26)33-39-31-11-5-6-12-32(31)41(33)23-24-17-19-37-20-18-24/h1-20,34,38H,21-23H2
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n/an/an/a 9n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249980
PNG
(CHEMBL4091313)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CCCCCCCN1C(Nc2ccccc2C1=O)c1ccccc1F
Show InChI InChI=1S/C35H34F2N4O2/c36-28-18-8-4-14-24(28)32-38-30-20-10-6-16-26(30)34(42)40(32)22-12-2-1-3-13-23-41-33(25-15-5-9-19-29(25)37)39-31-21-11-7-17-27(31)35(41)43/h4-11,14-21,32-33,38-39H,1-3,12-13,22-23H2
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n/an/an/a 9n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256249
PNG
(CHEMBL4099759)
Show SMILES Cc1ccc2NC(N(CCOc3ccc(cc3)-c3nc4ccccc4n3Cc3ccncc3)C(=O)c2c1)c1ccccc1F
Show InChI InChI=1S/C36H30FN5O2/c1-24-10-15-31-29(22-24)36(43)41(35(39-31)28-6-2-3-7-30(28)37)20-21-44-27-13-11-26(12-14-27)34-40-32-8-4-5-9-33(32)42(34)23-25-16-18-38-19-17-25/h2-19,22,35,39H,20-21,23H2,1H3
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n/an/an/a 9.30n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256247
PNG
(CHEMBL4077104)
Show SMILES COc1ccc2C(=O)N(CCOc3ccc(cc3)-c3nc4ccccc4n3Cc3ccncc3)C(Nc2c1)c1ccccc1F
Show InChI InChI=1S/C36H30FN5O3/c1-44-27-14-15-29-32(22-27)40-35(28-6-2-3-7-30(28)37)41(36(29)43)20-21-45-26-12-10-25(11-13-26)34-39-31-8-4-5-9-33(31)42(34)23-24-16-18-38-19-17-24/h2-19,22,35,40H,20-21,23H2,1H3
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n/an/an/a 9.80n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019813
PNG
(CHEMBL3286897)
Show SMILES O=C(OCC(C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C40H42N6O2/c47-39(32-21-25-44(26-22-32)40-43-33-15-7-9-17-35(33)45(40)27-29-11-3-1-4-12-29)48-28-37(30-19-23-41-24-20-30)46-36-18-10-8-16-34(36)42-38(46)31-13-5-2-6-14-31/h1-18,30,32,37,41H,19-28H2
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n/an/an/a 10n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019824
PNG
(CHEMBL3286904)
Show SMILES O=C(OCC(C1CCCNC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C40H42N6O2/c47-39(31-21-24-44(25-22-31)40-43-33-17-7-9-19-35(33)45(40)27-29-12-3-1-4-13-29)48-28-37(32-16-11-23-41-26-32)46-36-20-10-8-18-34(36)42-38(46)30-14-5-2-6-15-30/h1-10,12-15,17-20,31-32,37,41H,11,16,21-28H2
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n/an/an/a 11n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019845
PNG
(CHEMBL3286911)
Show SMILES O=C(OC[C@H](C1CCNCC1)n1c(nc2ccccc12)C1CC1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccsc1
Show InChI InChI=1S/C35H40N6O2S/c42-34(27-13-18-39(19-14-27)35-38-28-5-1-3-7-30(28)40(35)21-24-15-20-44-23-24)43-22-32(25-11-16-36-17-12-25)41-31-8-4-2-6-29(31)37-33(41)26-9-10-26/h1-8,15,20,23,25-27,32,36H,9-14,16-19,21-22H2/t32-/m1/s1
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n/an/an/a 12n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256250
PNG
(CHEMBL4102432)
Show SMILES Fc1ccccc1C1Nc2ccc(Cl)cc2C(=O)N1CCOc1ccc(cc1)-c1nc2ccccc2n1Cc1ccncc1
Show InChI InChI=1S/C35H27ClFN5O2/c36-25-11-14-30-28(21-25)35(43)41(34(39-30)27-5-1-2-6-29(27)37)19-20-44-26-12-9-24(10-13-26)33-40-31-7-3-4-8-32(31)42(33)22-23-15-17-38-18-16-23/h1-18,21,34,39H,19-20,22H2
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n/an/an/a 12n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256248
PNG
(CHEMBL4087332)
Show SMILES Fc1ccc2C(=O)N(CCOc3ccc(cc3)-c3nc4ccccc4n3Cc3ccncc3)C(Nc2c1)c1ccccc1F
Show InChI InChI=1S/C35H27F2N5O2/c36-25-11-14-28-31(21-25)40-34(27-5-1-2-6-29(27)37)41(35(28)43)19-20-44-26-12-9-24(10-13-26)33-39-30-7-3-4-8-32(30)42(33)22-23-15-17-38-18-16-23/h1-18,21,34,40H,19-20,22H2
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n/an/an/a 12n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249982
PNG
(CHEMBL4092911)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CCN1CCC(CC1)N1C(Nc2ccccc2C1=O)c1ccccc1F
Show InChI InChI=1S/C35H33F2N5O2/c36-28-13-5-1-9-24(28)32-38-30-15-7-3-11-26(30)34(43)41(32)22-21-40-19-17-23(18-20-40)42-33(25-10-2-6-14-29(25)37)39-31-16-8-4-12-27(31)35(42)44/h1-16,23,32-33,38-39H,17-22H2
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n/an/an/a 12n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019825
PNG
(CHEMBL3286905)
Show SMILES O=C(OCC(C1CCNC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C39H40N6O2/c46-38(30-20-23-43(24-21-30)39-42-32-15-7-9-17-34(32)44(39)26-28-11-3-1-4-12-28)47-27-36(31-19-22-40-25-31)45-35-18-10-8-16-33(35)41-37(45)29-13-5-2-6-14-29/h1-18,30-31,36,40H,19-27H2
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n/an/an/a 13n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019826
PNG
(CHEMBL3286906)
Show SMILES O=C(OCC(CC1CCNCC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C41H44N6O2/c48-40(33-21-25-45(26-22-33)41-44-35-15-7-9-17-37(35)46(41)28-31-11-3-1-4-12-31)49-29-34(27-30-19-23-42-24-20-30)47-38-18-10-8-16-36(38)43-39(47)32-13-5-2-6-14-32/h1-18,30,33-34,42H,19-29H2
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n/an/an/a 14n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019825
PNG
(CHEMBL3286905)
Show SMILES O=C(OCC(C1CCNC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C39H40N6O2/c46-38(30-20-23-43(24-21-30)39-42-32-15-7-9-17-34(32)44(39)26-28-11-3-1-4-12-28)47-27-36(31-19-22-40-25-31)45-35-18-10-8-16-33(35)41-37(45)29-13-5-2-6-14-29/h1-18,30-31,36,40H,19-27H2
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n/an/an/a 14n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019851
PNG
(CHEMBL3286916)
Show SMILES O=C(OCCn1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C35H33N5O2/c41-34(42-24-23-39-31-17-9-7-15-29(31)36-33(39)27-13-5-2-6-14-27)28-19-21-38(22-20-28)35-37-30-16-8-10-18-32(30)40(35)25-26-11-3-1-4-12-26/h1-18,28H,19-25H2
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n/an/an/a 14n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249991
PNG
(CHEMBL4069561)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CC1CCC(CN2C(Nc3ccccc3C2=O)c2ccccc2F)CC1
Show InChI InChI=1S/C36H34F2N4O2/c37-29-13-5-1-9-25(29)33-39-31-15-7-3-11-27(31)35(43)41(33)21-23-17-19-24(20-18-23)22-42-34(26-10-2-6-14-30(26)38)40-32-16-8-4-12-28(32)36(42)44/h1-16,23-24,33-34,39-40H,17-22H2
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n/an/an/a 15n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256258
PNG
(CHEMBL4105186)
Show SMILES Fc1ccccc1C1Nc2cc(Cl)ccc2C(=O)N1CCOc1ccc(cc1)-c1nc2ccccc2n1Cc1ccncc1
Show InChI InChI=1S/C35H27ClFN5O2/c36-25-11-14-28-31(21-25)40-34(27-5-1-2-6-29(27)37)41(35(28)43)19-20-44-26-12-9-24(10-13-26)33-39-30-7-3-4-8-32(30)42(33)22-23-15-17-38-18-16-23/h1-18,21,34,40H,19-20,22H2
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n/an/an/a 16n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249981
PNG
(CHEMBL4072582)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CCOc1ccc(cc1)N1C(Nc2ccccc2C1=O)c1ccccc1F
Show InChI InChI=1S/C36H28F2N4O3/c37-29-13-5-1-9-25(29)33-39-31-15-7-3-11-27(31)35(43)41(33)21-22-45-24-19-17-23(18-20-24)42-34(26-10-2-6-14-30(26)38)40-32-16-8-4-12-28(32)36(42)44/h1-20,33-34,39-40H,21-22H2
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n/an/an/a 16n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019794
PNG
(CHEMBL3286886)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1)C(C1CCCCC1)n1c(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C41H38N4O/c1-4-14-30(15-5-1)28-44-37-22-12-10-20-35(37)42-40(44)33-24-26-34(27-25-33)46-29-39(31-16-6-2-7-17-31)45-38-23-13-11-21-36(38)43-41(45)32-18-8-3-9-19-32/h1,3-5,8-15,18-27,31,39H,2,6-7,16-17,28-29H2
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n/an/an/a 16n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019823
PNG
(CHEMBL3286903)
Show SMILES O=C(OCC(C1CCCCC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccsc1
Show InChI InChI=1S/C39H41N5O2S/c45-38(31-19-22-42(23-20-31)39-41-32-15-7-9-17-34(32)43(39)25-28-21-24-47-27-28)46-26-36(29-11-3-1-4-12-29)44-35-18-10-8-16-33(35)40-37(44)30-13-5-2-6-14-30/h2,5-10,13-18,21,24,27,29,31,36H,1,3-4,11-12,19-20,22-23,25-26H2
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n/an/an/a 16n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019859
PNG
(CHEMBL3286923)
Show SMILES CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C37H42FN3O5/c1-25(2)35-34(37(45)39-29-11-7-4-8-12-29)33(26-9-5-3-6-10-26)36(27-13-15-28(38)16-14-27)41(35)18-17-30(42)23-31(43)24-32(44)40-19-21-46-22-20-40/h3-16,25,30-31,42-43H,17-24H2,1-2H3,(H,39,45)/t30-,31-/m1/s1
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n/an/an/a 16n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019815
PNG
(CHEMBL3286899)
Show SMILES CC(C)C(COC(=O)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1)n1c(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C38H39N5O2/c1-27(2)35(43-34-20-12-10-18-32(34)39-36(43)29-15-7-4-8-16-29)26-45-37(44)30-21-23-41(24-22-30)38-40-31-17-9-11-19-33(31)42(38)25-28-13-5-3-6-14-28/h3-20,27,30,35H,21-26H2,1-2H3
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n/an/an/a 17n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019853
PNG
(CHEMBL3286918)
Show SMILES Cc1nc2ccccc2n1CCOc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C30H26N4O/c1-22-31-26-11-5-7-13-28(26)33(22)19-20-35-25-17-15-24(16-18-25)30-32-27-12-6-8-14-29(27)34(30)21-23-9-3-2-4-10-23/h2-18H,19-21H2,1H3
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n/an/an/a 17n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019824
PNG
(CHEMBL3286904)
Show SMILES O=C(OCC(C1CCCNC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C40H42N6O2/c47-39(31-21-24-44(25-22-31)40-43-33-17-7-9-19-35(33)45(40)27-29-12-3-1-4-13-29)48-28-37(32-16-11-23-41-26-32)46-36-20-10-8-18-34(36)42-38(46)30-14-5-2-6-15-30/h1-10,12-15,17-20,31-32,37,41H,11,16,21-28H2
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n/an/an/a 18n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019793
PNG
(CHEMBL3286885)
Show SMILES CC(C)C(COc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1)n1c(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C38H34N4O/c1-27(2)36(42-35-20-12-10-18-33(35)40-38(42)29-15-7-4-8-16-29)26-43-31-23-21-30(22-24-31)37-39-32-17-9-11-19-34(32)41(37)25-28-13-5-3-6-14-28/h3-24,27,36H,25-26H2,1-2H3
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n/an/an/a 20n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256256
PNG
(CHEMBL4075625)
Show SMILES O=C1N(C(Nc2ccccc12)c1ccccn1)c1ccc(OCCn2ccnc2-c2ccccc2)cc1
Show InChI InChI=1S/C30H25N5O2/c36-30-25-10-4-5-11-26(25)33-29(27-12-6-7-17-31-27)35(30)23-13-15-24(16-14-23)37-21-20-34-19-18-32-28(34)22-8-2-1-3-9-22/h1-19,29,33H,20-21H2
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n/an/an/a 22n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249983
PNG
(CHEMBL4060010)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1CCN1CCC(CN2C(Nc3ccccc3C2=O)c2ccccc2F)CC1
Show InChI InChI=1S/C36H35F2N5O2/c37-29-13-5-1-9-25(29)33-39-31-15-7-3-11-27(31)35(44)42(33)22-21-41-19-17-24(18-20-41)23-43-34(26-10-2-6-14-30(26)38)40-32-16-8-4-12-28(32)36(43)45/h1-16,24,33-34,39-40H,17-23H2
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n/an/an/a 22n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019865
PNG
(CHEMBL3286929)
Show SMILES C(Oc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1)[C@H](C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1
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n/an/an/a 24n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019814
PNG
(CHEMBL3286898)
Show SMILES O=C(OCC(C1CCCCC1)n1c(nc2ccccc12)-c1ccccc1)C1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C41H43N5O2/c47-40(33-24-26-44(27-25-33)41-43-34-20-10-12-22-36(34)45(41)28-30-14-4-1-5-15-30)48-29-38(31-16-6-2-7-17-31)46-37-23-13-11-21-35(37)42-39(46)32-18-8-3-9-19-32/h1,3-5,8-15,18-23,31,33,38H,2,6-7,16-17,24-29H2
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n/an/an/a 25n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019861
PNG
(CHEMBL3286925)
Show SMILES CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)NCCCOCCOCCOCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)-c1ccccc1
Show InChI InChI=1S/C53H71FN6O9S/c1-36(2)50-48(52(65)57-40-15-7-4-8-16-40)47(37-13-5-3-6-14-37)51(38-19-21-39(54)22-20-38)60(50)26-23-41(61)33-42(62)34-46(64)56-25-12-28-68-30-32-69-31-29-67-27-11-24-55-45(63)18-10-9-17-44-49-43(35-70-44)58-53(66)59-49/h3-8,13-16,19-22,36,41-44,49,61-62H,9-12,17-18,23-35H2,1-2H3,(H,55,63)(H,56,64)(H,57,65)(H2,58,59,66)/t41-,42-,43+,44+,49+/m1/s1
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n/an/an/a 26n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50256244
PNG
(CHEMBL4077358)
Show SMILES Fc1ccccc1C1Nc2ccccc2C(=O)N1c1ccc(OCCn2ccnc2-c2ccccc2)cc1
Show InChI InChI=1S/C31H25FN4O2/c32-27-12-6-4-10-25(27)30-34-28-13-7-5-11-26(28)31(37)36(30)23-14-16-24(17-15-23)38-21-20-35-19-18-33-29(35)22-8-2-1-3-9-22/h1-19,30,34H,20-21H2
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n/an/an/a 29n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma


J Med Chem 61: 2604-2610 (2018)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50249985
PNG
(CHEMBL4080394)
Show SMILES Fc1ccccc1[C@H]1Nc2ccccc2C(=O)N1CCN1CCC(CC1)N1[C@@H](Nc2ccccc2C1=O)c1ccccc1F
Show InChI InChI=1S/C35H33F2N5O2/c36-28-13-5-1-9-24(28)32-38-30-15-7-3-11-26(30)34(43)41(32)22-21-40-19-17-23(18-20-40)42-33(25-10-2-6-14-29(25)37)39-31-16-8-4-12-27(31)35(42)44/h1-16,23,32-33,38-39H,17-22H2/t32-,33+/m0/s1
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n/an/an/a 33n/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay


J Med Chem 60: 9400-9406 (2017)

More data for this
Ligand-Target Pair
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta


(Homo sapiens (Human))
BDBM50019842
PNG
(CHEMBL3286908)
Show SMILES O=C(OCC(C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1)N1CCN(CC1)c1nc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C39H41N7O2/c47-39(44-25-23-43(24-26-44)38-42-32-15-7-9-17-34(32)45(38)27-29-11-3-1-4-12-29)48-28-36(30-19-21-40-22-20-30)46-35-18-10-8-16-33(35)41-37(46)31-13-5-2-6-14-31/h1-18,30,36,40H,19-28H2
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n/an/an/a 35n/an/an/an/an/a



Max Planck Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay


J Med Chem 57: 5435-48 (2014)


Article DOI: 10.1021/jm500632s
BindingDB Entry DOI: 10.7270/Q24Q7WJP
More data for this
Ligand-Target Pair
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