BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 53 hits of ic50 for UniProtKB: P02554   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tubulin beta chain


(Sus scrofa)
BDBM50012278
PNG
((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)
Show SMILES CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
Show InChI InChI=1/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Ghent University

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization assessed as microtubule assembly after 15 mins by DAPI staining


Eur J Med Chem 101: 627-39 (2015)


Article DOI: 10.1016/j.ejmech.2015.06.029
BindingDB Entry DOI: 10.7270/Q2QF8VPZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin beta chain


(Sus scrofa)
BDBM50012278
PNG
((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)
Show SMILES CC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
Show InChI InChI=1/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Daiichi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...


Bioorg Med Chem Lett 12: 3191-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00568-1
BindingDB Entry DOI: 10.7270/Q2V40XCV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Sus scrofa (Pig))
BDBM50095321
PNG
(2-Methoxy-5-(3,4,5-trimethoxy-benzyloxy)-benzaldeh...)
Show SMILES COc1ccc(OCc2cc(OC)c(OC)c(OC)c2)cc1C=O
Show InChI InChI=1S/C18H20O6/c1-20-15-6-5-14(9-13(15)10-19)24-11-12-7-16(21-2)18(23-4)17(8-12)22-3/h5-10H,11H2,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



The University of Manchester

Curated by ChEMBL


Assay Description
Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.


Bioorg Med Chem Lett 11: 51-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00596-5
BindingDB Entry DOI: 10.7270/Q2C82CHT
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50154910
PNG
(CHEMBL3775353)
Show SMILES COc1ccc(cc1\C=C1\C(=O)Nc2ccc(F)cc12)C(=O)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C26H22FNO6/c1-31-21-8-5-14(24(29)16-11-22(32-2)25(34-4)23(12-16)33-3)9-15(21)10-19-18-13-17(27)6-7-20(18)28-26(19)30/h5-13H,1-4H3,(H,28,30)/b19-10+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.01E+3n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assay


Bioorg Med Chem 24: 1729-40 (2016)


Article DOI: 10.1016/j.bmc.2016.02.047
BindingDB Entry DOI: 10.7270/Q22809G0
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 1.06E+3n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assay


Bioorg Med Chem 24: 1729-40 (2016)


Article DOI: 10.1016/j.bmc.2016.02.047
BindingDB Entry DOI: 10.7270/Q22809G0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin beta chain


(Sus scrofa)
BDBM50030766
PNG
(CHEMBL3342339)
Show SMILES O=C(c1ccccc1)c1cccc(\C=c2/[nH]c(=O)\c(=C\c3ccccn3)[nH]c2=O)c1
Show InChI InChI=1S/C24H17N3O3/c28-22(17-8-2-1-3-9-17)18-10-6-7-16(13-18)14-20-23(29)27-21(24(30)26-20)15-19-11-4-5-12-25-19/h1-15H,(H,26,30)(H,27,29)/b20-14-,21-15-
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of porcine tubulin polymerization by spectrophotometry


ACS Med Chem Lett 5: 1094-8 (2014)


Article DOI: 10.1021/ml5001883
BindingDB Entry DOI: 10.7270/Q2R49SCP
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50154909
PNG
(CHEMBL3775082)
Show SMILES COc1ccc2NC(=O)\C(=C\c3cc(ccc3OC)C(=O)c3cc(OC)c(OC)c(OC)c3)c2c1
Show InChI InChI=1S/C27H25NO7/c1-31-18-7-8-21-19(14-18)20(27(30)28-21)11-16-10-15(6-9-22(16)32-2)25(29)17-12-23(33-3)26(35-5)24(13-17)34-4/h6-14H,1-5H3,(H,28,30)/b20-11+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.23E+3n/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assay


Bioorg Med Chem 24: 1729-40 (2016)


Article DOI: 10.1016/j.bmc.2016.02.047
BindingDB Entry DOI: 10.7270/Q22809G0
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50135466
PNG
(CHEMBL3752997)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]nc1-c1cc2ccccc2s1
Show InChI InChI=1S/C19H17N3O3S/c1-23-13-8-12(9-14(24-2)19(13)25-3)17-18(21-22-20-17)16-10-11-6-4-5-7-15(11)26-16/h4-10H,1-3H3,(H,20,21,22)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization by spectrophotometric analysis


Medchemcomm 6: 1535-1543 (2016)


Article DOI: 10.1039/c5md00219b
BindingDB Entry DOI: 10.7270/Q2H41T8J
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50030765
PNG
(NPI-2358 | PLINABULIN | Plinabulin)
Show SMILES CC(C)(C)c1[nH]cnc1\C=c1/[nH]c(=O)\c(=C\c2ccccc2)[nH]c1=O
Show InChI InChI=1S/C19H20N4O2/c1-19(2,3)16-13(20-11-21-16)10-15-18(25)22-14(17(24)23-15)9-12-7-5-4-6-8-12/h4-11H,1-3H3,(H,20,21)(H,22,25)(H,23,24)/b14-9-,15-10-
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Tokyo University of Pharmacy and Life Sciences

Curated by ChEMBL


Assay Description
Inhibition of porcine tubulin polymerization by spectrophotometry


ACS Med Chem Lett 5: 1094-8 (2014)


Article DOI: 10.1021/ml5001883
BindingDB Entry DOI: 10.7270/Q2R49SCP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin beta chain


(Sus scrofa)
BDBM50056777
PNG
(CHEMBL3331358)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5cnccc5c4)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H31NO2/c1-28-11-9-21-22(6-5-18-14-26(30)27(31-2)15-23(18)21)25(28)8-7-24(28)19-3-4-20-16-29-12-10-17(20)13-19/h3-4,10,12-16,21-22,24-25,30H,5-9,11H2,1-2H3/t21-,22+,24+,25-,28+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056783
PNG
(CHEMBL3331351)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC=C4c4ccc5cnccc5c4)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H29NO2/c1-28-11-9-21-22(6-5-18-14-26(30)27(31-2)15-23(18)21)25(28)8-7-24(28)19-3-4-20-16-29-12-10-17(20)13-19/h3-4,7,10,12-16,21-22,25,30H,5-6,8-9,11H2,1-2H3/t21-,22+,25-,28+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50060957
PNG
(2-Hydroxyestradol 2-methyl ether | 2-methoxy-17bet...)
Show SMILES COc1cc2[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3CCc2cc1O
Show InChI InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056779
PNG
(CHEMBL3331356)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4c4cncc5CCCCc45)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H35NO2/c1-28-12-11-20-21(8-7-17-13-26(30)27(31-2)14-22(17)20)24(28)9-10-25(28)23-16-29-15-18-5-3-4-6-19(18)23/h13-16,20-21,24-25,30H,3-12H2,1-2H3/t20-,21+,24-,25+,28-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50181051
PNG
(CHEMBL3818850)
Show SMILES COc1ccc2c(\C=C(/C)C(=O)c3cc(OC)c(OC)c(OC)c3)c[nH]c2c1
Show InChI InChI=1S/C22H23NO5/c1-13(8-15-12-23-18-11-16(25-2)6-7-17(15)18)21(24)14-9-19(26-3)22(28-5)20(10-14)27-4/h6-12,23H,1-5H3/b13-8+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.68E+3n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization measured every 60 secs for 90 mins by DAPI staining-based fluorescence assay


J Med Chem 59: 5264-83 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00021
BindingDB Entry DOI: 10.7270/Q2H41TBF
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056782
PNG
(CHEMBL3331353)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC=C4c4cccc5ncccc45)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H29NO2/c1-28-13-12-18-20(9-8-17-15-26(30)27(31-2)16-22(17)18)24(28)11-10-23(28)19-5-3-7-25-21(19)6-4-14-29-25/h3-7,10,14-16,18,20,24,30H,8-9,11-13H2,1-2H3/t18-,20+,24-,28+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50152675
PNG
(CHEMBL3780099)
Show SMILES COc1ccc(CNc2c(nc3ccc(F)cn23)-c2ccccc2O)cc1
Show InChI InChI=1S/C21H18FN3O2/c1-27-16-9-6-14(7-10-16)12-23-21-20(17-4-2-3-5-18(17)26)24-19-11-8-15(22)13-25(19)21/h2-11,13,23,26H,12H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 3.41E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Inhibition of porcine tubulin polymerization by UV-Vis microplate reader analysis


Eur J Med Chem 112: 367-72 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.004
BindingDB Entry DOI: 10.7270/Q2ZK5JHD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin beta chain


(Sus scrofa)
BDBM50181050
PNG
(CHEMBL3819590)
Show SMILES COc1ccc2c(\C=C\C(=O)c3cc(OC)c(OC)c(OC)c3)cn(C)c2c1
Show InChI InChI=1S/C22H23NO5/c1-23-13-14(17-8-7-16(25-2)12-18(17)23)6-9-19(24)15-10-20(26-3)22(28-5)21(11-15)27-4/h6-13H,1-5H3/b9-6+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.48E+3n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization measured every 60 secs for 90 mins by DAPI staining-based fluorescence assay


J Med Chem 59: 5264-83 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00021
BindingDB Entry DOI: 10.7270/Q2H41TBF
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50181053
PNG
(CHEMBL3819240)
Show SMILES COc1ccc2c(\C=C(/C)C(=O)c3cc(OC)c(OC)c(OC)c3)cn(CO)c2c1
Show InChI InChI=1S/C23H25NO6/c1-14(22(26)15-9-20(28-3)23(30-5)21(10-15)29-4)8-16-12-24(13-25)19-11-17(27-2)6-7-18(16)19/h6-12,25H,13H2,1-5H3/b14-8+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.59E+3n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization measured every 60 secs for 90 mins by DAPI staining-based fluorescence assay


J Med Chem 59: 5264-83 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00021
BindingDB Entry DOI: 10.7270/Q2H41TBF
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056775
PNG
(CHEMBL3331360)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4c4cccc5NCCCc45)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H35NO2/c1-28-13-12-18-20(9-8-17-15-26(30)27(31-2)16-22(17)18)24(28)11-10-23(28)19-5-3-7-25-21(19)6-4-14-29-25/h3,5,7,15-16,18,20,23-24,29-30H,4,6,8-14H2,1-2H3/t18-,20+,23+,24-,28+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.70E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50217543
PNG
(CHEMBL540565)
Show SMILES Cl.Cc1c(\C=C\CN2CCN(CC2)c2cc(F)cc(F)c2)cnn1-c1ccnc(N)n1
Show InChI InChI=1S/C21H23F2N7.ClH/c1-15-16(14-26-30(15)20-4-5-25-21(24)27-20)3-2-6-28-7-9-29(10-8-28)19-12-17(22)11-18(23)13-19;/h2-5,11-14H,6-10H2,1H3,(H2,24,25,27);1H/b3-2+;
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.72E+3n/an/an/an/an/an/a



Daiichi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...


Bioorg Med Chem Lett 12: 3191-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00568-1
BindingDB Entry DOI: 10.7270/Q2V40XCV
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 3.79E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Inhibition of porcine tubulin polymerization by UV-Vis microplate reader analysis


Eur J Med Chem 112: 367-72 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.004
BindingDB Entry DOI: 10.7270/Q2ZK5JHD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin beta chain


(Sus scrofa)
BDBM50216141
PNG
(CHEMBL61572)
Show SMILES COc1ccc(cc1O)[C@@H]1OCO[C@H]1c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C19H22O7/c1-21-14-6-5-11(7-13(14)20)17-18(26-10-25-17)12-8-15(22-2)19(24-4)16(9-12)23-3/h5-9,17-18,20H,10H2,1-4H3/t17-,18-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
In vitro tubulin polymerization-inhibitory activity; 4-6


Bioorg Med Chem Lett 8: 1997-2000 (1998)


Article DOI: 10.1016/s0960-894x(98)00344-8
BindingDB Entry DOI: 10.7270/Q2VH5R10
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50005480
PNG
((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Show SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
In vitro tubulin polymerization-inhibitory activity.


Bioorg Med Chem Lett 8: 1997-2000 (1998)


Article DOI: 10.1016/s0960-894x(98)00344-8
BindingDB Entry DOI: 10.7270/Q2VH5R10
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin


(Sus scrofa (Pig))
BDBM50095321
PNG
(2-Methoxy-5-(3,4,5-trimethoxy-benzyloxy)-benzaldeh...)
Show SMILES COc1ccc(OCc2cc(OC)c(OC)c(OC)c2)cc1C=O
Show InChI InChI=1S/C18H20O6/c1-20-15-6-5-14(9-13(15)10-19)24-11-12-7-16(21-2)18(23-4)17(8-12)22-3/h5-10H,11H2,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



The University of Manchester

Curated by ChEMBL


Assay Description
Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.


Bioorg Med Chem Lett 11: 51-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00596-5
BindingDB Entry DOI: 10.7270/Q2C82CHT
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056798
PNG
(CHEMBL3331347)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC=C4c4ccncc4)[C@@H]3CCc2cc1O
Show InChI InChI=1/C24H27NO2/c1-24-10-7-17-18(4-3-16-13-22(26)23(27-2)14-19(16)17)21(24)6-5-20(24)15-8-11-25-12-9-15/h5,8-9,11-14,17-18,21,26H,3-4,6-7,10H2,1-2H3/t17-,18+,21-,24+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.10E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50152676
PNG
(CHEMBL3780828)
Show SMILES COc1ccc(CNc2c(nc3ccccn23)-c2ccccc2O)cc1
Show InChI InChI=1S/C21H19N3O2/c1-26-16-11-9-15(10-12-16)14-22-21-20(17-6-2-3-7-18(17)25)23-19-8-4-5-13-24(19)21/h2-13,22,25H,14H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.35E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Inhibition of porcine tubulin polymerization by UV-Vis microplate reader analysis


Eur J Med Chem 112: 367-72 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.004
BindingDB Entry DOI: 10.7270/Q2ZK5JHD
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50181052
PNG
(CHEMBL3819618)
Show SMILES COc1ccc2c(\C=C\C(=O)c3ccc(OC)c4C=CC(C)(C)Oc34)c[nH]c2c1
Show InChI InChI=1S/C24H23NO4/c1-24(2)12-11-19-22(28-4)10-8-18(23(19)29-24)21(26)9-5-15-14-25-20-13-16(27-3)6-7-17(15)20/h5-14,25H,1-4H3/b9-5+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.39E+3n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization measured every 60 secs for 90 mins by DAPI staining-based fluorescence assay


J Med Chem 59: 5264-83 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00021
BindingDB Entry DOI: 10.7270/Q2H41TBF
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056794
PNG
(CHEMBL3331349)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC=C4c4cncc5ccccc45)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H29NO2/c1-28-12-11-20-21(8-7-17-13-26(30)27(31-2)14-22(17)20)24(28)9-10-25(28)23-16-29-15-18-5-3-4-6-19(18)23/h3-6,10,13-16,20-21,24,30H,7-9,11-12H2,1-2H3/t20-,21+,24-,28-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.80E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50181049
PNG
(CHEMBL3818763)
Show SMILES COc1ccc2[nH]cc(\C=C(/C)C(=O)c3cc(OC)c(OC)c(OC)c3)c2c1
Show InChI InChI=1S/C22H23NO5/c1-13(8-15-12-23-18-7-6-16(25-2)11-17(15)18)21(24)14-9-19(26-3)22(28-5)20(10-14)27-4/h6-12,23H,1-5H3/b13-8+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.06E+3n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization measured every 60 secs for 90 mins by DAPI staining-based fluorescence assay


J Med Chem 59: 5264-83 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00021
BindingDB Entry DOI: 10.7270/Q2H41TBF
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056781
PNG
(CHEMBL3331354)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4c4cccnc4)[C@@H]3CCc2cc1O
Show InChI InChI=1/C24H29NO2/c1-24-10-9-17-18(6-5-15-12-22(26)23(27-2)13-19(15)17)21(24)8-7-20(24)16-4-3-11-25-14-16/h3-4,11-14,17-18,20-21,26H,5-10H2,1-2H3/t17-,18+,20+,21-,24+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056780
PNG
(CHEMBL3331355)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccncc4)[C@@H]3CCc2cc1O
Show InChI InChI=1/C24H29NO2/c1-24-10-7-17-18(4-3-16-13-22(26)23(27-2)14-19(16)17)21(24)6-5-20(24)15-8-11-25-12-9-15/h8-9,11-14,17-18,20-21,26H,3-7,10H2,1-2H3/t17-,18+,20+,21-,24+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.80E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50095317
PNG
(2-Methoxy-5-(3,4,5-trimethoxy-phenoxymethyl)-pheno...)
Show SMILES COc1ccc(COc2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C17H20O6/c1-19-14-6-5-11(7-13(14)18)10-23-12-8-15(20-2)17(22-4)16(9-12)21-3/h5-9,18H,10H2,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



The University of Manchester

Curated by ChEMBL


Assay Description
Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.


Bioorg Med Chem Lett 11: 51-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00596-5
BindingDB Entry DOI: 10.7270/Q2C82CHT
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50152677
PNG
(CHEMBL3780715)
Show SMILES COc1ccc(CNc2c(nc3cnccn23)-c2ccccc2O)cc1
Show InChI InChI=1S/C20H18N4O2/c1-26-15-8-6-14(7-9-15)12-22-20-19(16-4-2-3-5-17(16)25)23-18-13-21-10-11-24(18)20/h2-11,13,22,25H,12H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.16E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Inhibition of porcine tubulin polymerization by UV-Vis microplate reader analysis


Eur J Med Chem 112: 367-72 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.004
BindingDB Entry DOI: 10.7270/Q2ZK5JHD
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056791
PNG
(CHEMBL3331350)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC=C4c4cccc5cnccc45)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H29NO2/c1-28-12-10-20-22(7-6-17-14-26(30)27(31-2)15-23(17)20)25(28)9-8-24(28)21-5-3-4-18-16-29-13-11-19(18)21/h3-5,8,11,13-16,20,22,25,30H,6-7,9-10,12H2,1-2H3/t20-,22+,25-,28+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50056778
PNG
(CHEMBL3331357)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4c4cccc5cnccc45)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H31NO2/c1-28-12-10-20-22(7-6-17-14-26(30)27(31-2)15-23(17)20)25(28)9-8-24(28)21-5-3-4-18-16-29-13-11-19(18)21/h3-5,11,13-16,20,22,24-25,30H,6-10,12H2,1-2H3/t20-,22+,24+,25-,28+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.10E+3n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50217597
PNG
(CHEMBL542447)
Show SMILES Cl.Cc1c(\C=C\CN2CCN(CC2)c2cc(F)cc(F)c2)cnn1-c1ncccn1
Show InChI InChI=1S/C21H22F2N6.ClH/c1-16-17(15-26-29(16)21-24-5-3-6-25-21)4-2-7-27-8-10-28(11-9-27)20-13-18(22)12-19(23)14-20;/h2-6,12-15H,7-11H2,1H3;1H/b4-2+;
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9.08E+3n/an/an/an/an/an/a



Daiichi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...


Bioorg Med Chem Lett 12: 3191-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00568-1
BindingDB Entry DOI: 10.7270/Q2V40XCV
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
In vitro tubulin polymerization-inhibitory activity.


Bioorg Med Chem Lett 8: 1997-2000 (1998)


Article DOI: 10.1016/s0960-894x(98)00344-8
BindingDB Entry DOI: 10.7270/Q2VH5R10
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin beta chain


(Sus scrofa)
BDBM50056776
PNG
(CHEMBL3331359)
Show SMILES COc1cc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CCc2cc1O
Show InChI InChI=1/C28H31NO2/c1-28-11-9-21-22(6-5-18-14-26(30)27(31-2)15-23(18)21)25(28)8-7-24(28)19-4-3-17-10-12-29-16-20(17)13-19/h3-4,10,12-16,21-22,24-25,30H,5-9,11H2,1-2H3/t21-,22+,24+,25-,28+/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization after 60 mins


Eur J Med Chem 85: 391-8 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.002
BindingDB Entry DOI: 10.7270/Q21V5GM9
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50217501
PNG
(CHEMBL543873)
Show SMILES Cl.Cc1c(\C=C\CN2CCN(CC2)c2cc(F)cc(F)c2)cnn1-c1nccc(N)n1
Show InChI InChI=1S/C21H23F2N7.ClH/c1-15-16(14-26-30(15)21-25-5-4-20(24)27-21)3-2-6-28-7-9-29(10-8-28)19-12-17(22)11-18(23)13-19;/h2-5,11-14H,6-10H2,1H3,(H2,24,25,27);1H/b3-2+;
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.11E+4n/an/an/an/an/an/a



Daiichi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...


Bioorg Med Chem Lett 12: 3191-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00568-1
BindingDB Entry DOI: 10.7270/Q2V40XCV
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50135464
PNG
(CHEMBL3753885)
Show SMILES COc1cc(OC)cc(c1)-c1n[nH]nc1-c1c[nH]c2ccccc12
Show InChI InChI=1S/C18H16N4O2/c1-23-12-7-11(8-13(9-12)24-2)17-18(21-22-20-17)15-10-19-16-6-4-3-5-14(15)16/h3-10,19H,1-2H3,(H,20,21,22)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.35E+4n/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization by spectrophotometric analysis


Medchemcomm 6: 1535-1543 (2016)


Article DOI: 10.1039/c5md00219b
BindingDB Entry DOI: 10.7270/Q2H41T8J
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50095326
PNG
(2-Methoxy-5-(3,4,5-trimethoxy-phenoxy)-phenol | CH...)
Show SMILES COc1ccc(Oc2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C16H18O6/c1-18-13-6-5-10(7-12(13)17)22-11-8-14(19-2)16(21-4)15(9-11)20-3/h5-9,17H,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.63E+4n/an/an/an/an/an/a



The University of Manchester

Curated by ChEMBL


Assay Description
Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.


Bioorg Med Chem Lett 11: 51-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00596-5
BindingDB Entry DOI: 10.7270/Q2C82CHT
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50135465
PNG
(CHEMBL3753880)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]nc1-c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H18N4O3/c1-24-15-8-11(9-16(25-2)19(15)26-3)17-18(22-23-21-17)13-10-20-14-7-5-4-6-12(13)14/h4-10,20H,1-3H3,(H,21,22,23)
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.85E+4n/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of porcine brain tubulin polymerization by spectrophotometric analysis


Medchemcomm 6: 1535-1543 (2016)


Article DOI: 10.1039/c5md00219b
BindingDB Entry DOI: 10.7270/Q2H41T8J
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50095320
PNG
(2-Methoxy-5-(3,4,5-trimethoxy-benzyloxy)-phenol | ...)
Show SMILES COc1ccc(OCc2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C17H20O6/c1-19-14-6-5-12(9-13(14)18)23-10-11-7-15(20-2)17(22-4)16(8-11)21-3/h5-9,18H,10H2,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.25E+4n/an/an/an/an/an/a



The University of Manchester

Curated by ChEMBL


Assay Description
Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.


Bioorg Med Chem Lett 11: 51-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00596-5
BindingDB Entry DOI: 10.7270/Q2C82CHT
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50014846
PNG
((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Show SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
Show InChI InChI=1/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 2.93E+4n/an/an/an/an/an/a



Daiichi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...


Bioorg Med Chem Lett 12: 3191-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00568-1
BindingDB Entry DOI: 10.7270/Q2V40XCV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tubulin beta chain


(Sus scrofa)
BDBM50217502
PNG
(CHEMBL554449)
Show SMILES Cl.Cc1c(\C=C\CN2CCN(CC2)c2cccc(Cl)c2)cnn1-c1ncccn1
Show InChI InChI=1S/C21H23ClN6.ClH/c1-17-18(16-25-28(17)21-23-8-4-9-24-21)5-3-10-26-11-13-27(14-12-26)20-7-2-6-19(22)15-20;/h2-9,15-16H,10-14H2,1H3;1H/b5-3+;
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.60E+4n/an/an/an/an/an/a



Daiichi Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of...


Bioorg Med Chem Lett 12: 3191-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00568-1
BindingDB Entry DOI: 10.7270/Q2V40XCV
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50095317
PNG
(2-Methoxy-5-(3,4,5-trimethoxy-phenoxymethyl)-pheno...)
Show SMILES COc1ccc(COc2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C17H20O6/c1-19-14-6-5-11(7-13(14)18)10-23-12-8-15(20-2)17(22-4)16(9-12)21-3/h5-9,18H,10H2,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.60E+4n/an/an/an/an/an/a



The University of Manchester

Curated by ChEMBL


Assay Description
Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.


Bioorg Med Chem Lett 11: 51-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00596-5
BindingDB Entry DOI: 10.7270/Q2C82CHT
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50095326
PNG
(2-Methoxy-5-(3,4,5-trimethoxy-phenoxy)-phenol | CH...)
Show SMILES COc1ccc(Oc2cc(OC)c(OC)c(OC)c2)cc1O
Show InChI InChI=1S/C16H18O6/c1-18-13-6-5-10(7-12(13)17)22-11-8-14(19-2)16(21-4)15(9-11)20-3/h5-9,17H,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.60E+4n/an/an/an/an/an/a



The University of Manchester

Curated by ChEMBL


Assay Description
Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.


Bioorg Med Chem Lett 11: 51-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00596-5
BindingDB Entry DOI: 10.7270/Q2C82CHT
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50134459
PNG
(2-(3-Hydroxy-4-methoxy-phenyl)-6,7,8-trimethoxy-ch...)
Show SMILES COc1ccc(cc1O)-c1cc(=O)c2cc(OC)c(OC)c(OC)c2o1
Show InChI InChI=1S/C19H18O7/c1-22-14-6-5-10(7-13(14)21)15-9-12(20)11-8-16(23-2)18(24-3)19(25-4)17(11)26-15/h5-9,21H,1-4H3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]colchicine to porcine tubulin


Bioorg Med Chem Lett 13: 3759-63 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.003
BindingDB Entry DOI: 10.7270/Q2G73D48
More data for this
Ligand-Target Pair
Tubulin beta chain


(Sus scrofa)
BDBM50216137
PNG
(CHEMBL303103)
Show SMILES COc1ccc(cc1O)[C@H]1OCO[C@@H]1c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C19H22O7/c1-21-14-6-5-11(7-13(14)20)17-18(26-10-25-17)12-8-15(22-2)19(24-4)16(9-12)23-3/h5-9,17-18,20H,10H2,1-4H3/t17-,18-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Tokyo

Curated by ChEMBL


Assay Description
In vitro tubulin polymerization-inhibitory activity.


Bioorg Med Chem Lett 8: 1997-2000 (1998)


Article DOI: 10.1016/s0960-894x(98)00344-8
BindingDB Entry DOI: 10.7270/Q2VH5R10
More data for this
Ligand-Target Pair
Tubulin


(Sus scrofa (Pig))
BDBM50134450
PNG
(2-[1-(3-Hydroxy-4-methoxy-phenyl)-meth-(Z)-ylidene...)
Show SMILES COc1ccc(\C=C2/Oc3c(cc(OC)c(OC)c3OC)C2=O)cc1O
Show InChI InChI=1S/C19H18O7/c1-22-13-6-5-10(7-12(13)20)8-14-16(21)11-9-15(23-2)18(24-3)19(25-4)17(11)26-14/h5-9,20H,1-4H3/b14-8-
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+4n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Ability to inhibit the binding of [3H]colchicine to porcine tubulin


Bioorg Med Chem Lett 13: 3759-63 (2003)


Article DOI: 10.1016/j.bmcl.2003.07.003
BindingDB Entry DOI: 10.7270/Q2G73D48
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 53 total )  |  Next  |  Last  >>
Jump to: