Compile Data Set for Download or QSAR

Found 33 hits of ic50 data for polymerid = 50007276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521058 (CHEMBL4456548) Show SMILES O=C(Nc1nnc(o1)C1CCCCC1)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C21H21N3O2/c25-19(18-13-7-12-17(14-18)15-8-3-1-4-9-15)22-21-24-23-20(26-21)16-10-5-2-6-11-16/h1,3-4,7-9,12-14,16H,2,5-6,10-11H2,(H,22,24,25)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521074 (CHEMBL4467742) Show SMILES CCc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C21H21N3O2/c1-2-14-7-9-16(10-8-14)19(25)22-21-24-23-20(26-21)18-12-11-15-5-3-4-6-17(15)13-18/h7-13H,2-6H2,1H3,(H,22,24,25)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521109 (CHEMBL4585588) Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C21H18F3N3O2/c1-12-8-16(11-17(9-12)21(22,23)24)18(28)25-20-27-26-19(29-20)15-7-6-13-4-2-3-5-14(13)10-15/h6-11H,2-5H2,1H3,(H,25,27,28)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521096 (CHEMBL4537053) Show SMILES Clc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C19H16ClN3O2/c20-16-9-7-13(8-10-16)17(24)21-19-23-22-18(25-19)15-6-5-12-3-1-2-4-14(12)11-15/h5-11H,1-4H2,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521093 (CHEMBL4457916) Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H11F4N3O2/c1-9-6-11(8-12(7-9)17(19,20)21)14(25)22-16-24-23-15(26-16)10-2-4-13(18)5-3-10/h2-8H,1H3,(H,22,24,25)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521061 (CHEMBL4464131) Show SMILES Fc1cccc(c1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C19H16FN3O2/c20-16-7-3-6-14(11-16)17(24)21-19-23-22-18(25-19)15-9-8-12-4-1-2-5-13(12)10-15/h3,6-11H,1-2,4-5H2,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521071 (CHEMBL2093209 | TDR77394) Show SMILES COc1cccc(c1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C20H19N3O3/c1-25-17-8-4-7-15(12-17)18(24)21-20-23-22-19(26-20)16-10-9-13-5-2-3-6-14(13)11-16/h4,7-12H,2-3,5-6H2,1H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521067 (CHEMBL4452051) Show SMILES COc1ccc(cc1)-c1nnc(NC(=O)c2cc(nc3ccccc23)-c2cccs2)o1 Show InChI InChI=1S/C23H16N4O3S/c1-29-15-10-8-14(9-11-15)22-26-27-23(30-22)25-21(28)17-13-19(20-7-4-12-31-20)24-18-6-3-2-5-16(17)18/h2-13H,1H3,(H,25,27,28)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521100 (CHEMBL4575792) Show SMILES Fc1ccc(cc1)-c1nnc(NC(=O)c2cccc(c2)-c2ccccc2)o1 Show InChI InChI=1S/C21H14FN3O2/c22-18-11-9-15(10-12-18)20-24-25-21(27-20)23-19(26)17-8-4-7-16(13-17)14-5-2-1-3-6-14/h1-13H,(H,23,25,26)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521056 (CHEMBL4543838) Show SMILES Cc1ccc(cc1C(F)(F)F)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C17H18F3N3O2/c1-10-7-8-12(9-13(10)17(18,19)20)14(24)21-16-23-22-15(25-16)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521087 (CHEMBL4549401) Show SMILES Fc1ccc(cc1)-c1nnc(NC(=O)c2ccc(cc2)-c2ccccc2)o1 Show InChI InChI=1S/C21H14FN3O2/c22-18-12-10-17(11-13-18)20-24-25-21(27-20)23-19(26)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-13H,(H,23,25,26)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521072 (CHEMBL4437081) Show SMILES Cc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C20H19N3O2/c1-13-6-8-15(9-7-13)18(24)21-20-23-22-19(25-20)17-11-10-14-4-2-3-5-16(14)12-17/h6-12H,2-5H2,1H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521057 (CHEMBL4467466) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C20H16F3N3O2/c21-20(22,23)16-7-3-6-14(11-16)17(27)24-19-26-25-18(28-19)15-9-8-12-4-1-2-5-13(12)10-15/h3,6-11H,1-2,4-5H2,(H,24,26,27)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521103 (CHEMBL4466580) Show SMILES Cc1ccc(cc1C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H11F4N3O2/c1-9-2-3-11(8-13(9)17(19,20)21)14(25)22-16-24-23-15(26-16)10-4-6-12(18)7-5-10/h2-8H,1H3,(H,22,24,25)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521059 (CHEMBL4449979) Show SMILES COc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C17H18F3N3O3/c1-25-13-8-11(7-12(9-13)17(18,19)20)14(24)21-16-23-22-15(26-16)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521111 (CHEMBL4464808) Show SMILES CSc1cccc(c1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C20H19N3O2S/c1-26-17-8-4-7-15(12-17)18(24)21-20-23-22-19(25-20)16-10-9-13-5-2-3-6-14(13)11-16/h4,7-12H,2-3,5-6H2,1H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521092 (CHEMBL4438060) Show SMILES COc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C21H18F3N3O3/c1-29-17-10-15(9-16(11-17)21(22,23)24)18(28)25-20-27-26-19(30-20)14-7-6-12-4-2-3-5-13(12)8-14/h6-11H,2-5H2,1H3,(H,25,27,28)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521070 (CHEMBL4547217) Show SMILES CC(C)Oc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C22H23N3O3/c1-14(2)27-19-11-9-16(10-12-19)20(26)23-22-25-24-21(28-22)18-8-7-15-5-3-4-6-17(15)13-18/h7-14H,3-6H2,1-2H3,(H,23,25,26)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521110 (CHEMBL4541956) Show SMILES CCOc1cccc2cc(oc12)-c1nnc(NC(=O)c2ccccc2SC)o1 Show InChI InChI=1S/C20H17N3O4S/c1-3-25-14-9-6-7-12-11-15(26-17(12)14)19-22-23-20(27-19)21-18(24)13-8-4-5-10-16(13)28-2/h4-11H,3H2,1-2H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM64573 (MLS000529919 | N-(5-tetralin-6-yl-1,3,4-oxadiazol-...) Show SMILES O=C(Nc1nnc(o1)-c1ccc2CCCCc2c1)c1ccccc1 Show InChI InChI=1S/C19H17N3O2/c23-17(14-7-2-1-3-8-14)20-19-22-21-18(24-19)16-11-10-13-6-4-5-9-15(13)12-16/h1-3,7-8,10-12H,4-6,9H2,(H,20,22,23)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521102 (CHEMBL4582554) Show SMILES Cc1ccc(cc1C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C21H18F3N3O2/c1-12-6-7-15(11-17(12)21(22,23)24)18(28)25-20-27-26-19(29-20)16-9-8-13-4-2-3-5-14(13)10-16/h6-11H,2-5H2,1H3,(H,25,27,28)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521078 (CHEMBL4518661) Show SMILES Cc1ccc(cc1C)C(=O)Nc1nnc(o1)-c1ccc2OCCOc2c1 Show InChI InChI=1S/C19H17N3O4/c1-11-3-4-13(9-12(11)2)17(23)20-19-22-21-18(26-19)14-5-6-15-16(10-14)25-8-7-24-15/h3-6,9-10H,7-8H2,1-2H3,(H,20,22,23)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521104 (CHEMBL4531260) Show SMILES Cc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C17H18F3N3O2/c1-10-7-12(9-13(8-10)17(18,19)20)14(24)21-16-23-22-15(25-16)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521065 (CHEMBL4438010) Show SMILES Brc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C19H16BrN3O2/c20-16-9-7-13(8-10-16)17(24)21-19-23-22-18(25-19)15-6-5-12-3-1-2-4-14(12)11-15/h5-11H,1-4H2,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521105 (CHEMBL591858 | SJ000236729) Show SMILES Fc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C19H16FN3O2/c20-16-9-7-13(8-10-16)17(24)21-19-23-22-18(25-19)15-6-5-12-3-1-2-4-14(12)11-15/h5-11H,1-4H2,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521098 (CHEMBL4449710) Show SMILES Brc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2OCCOc2c1 Show InChI InChI=1S/C17H12BrN3O4/c18-12-4-1-10(2-5-12)15(22)19-17-21-20-16(25-17)11-3-6-13-14(9-11)24-8-7-23-13/h1-6,9H,7-8H2,(H,19,21,22)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521088 (CHEMBL4566535) Show SMILES Brc1ccc(cc1)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C15H16BrN3O2/c16-12-8-6-10(7-9-12)13(20)17-15-19-18-14(21-15)11-4-2-1-3-5-11/h6-9,11H,1-5H2,(H,17,19,20)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521099 (CHEMBL1630682) Show SMILES Fc1ccc(cc1)-c1nnc(NC(=O)c2cccc(c2)C(F)(F)F)o1 Show InChI InChI=1S/C16H9F4N3O2/c17-12-6-4-9(5-7-12)14-22-23-15(25-14)21-13(24)10-2-1-3-11(8-10)16(18,19)20/h1-8H,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521094 (CHEMBL4574197) Show SMILES COc1cc(cc(c1)C(F)(F)F)C(=O)Nc1nnc(o1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H11F4N3O3/c1-26-13-7-10(6-11(8-13)17(19,20)21)14(25)22-16-24-23-15(27-16)9-2-4-12(18)5-3-9/h2-8H,1H3,(H,22,24,25)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521097 (CHEMBL4453190) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nnc(o1)-c1ccc2OCCOc2c1 Show InChI InChI=1S/C18H12F3N3O4/c19-18(20,21)12-3-1-2-10(8-12)15(25)22-17-24-23-16(28-17)11-4-5-13-14(9-11)27-7-6-26-13/h1-5,8-9H,6-7H2,(H,22,24,25)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521116 (CHEMBL4463572) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C16H16F3N3O2/c17-16(18,19)12-8-4-7-11(9-12)13(23)20-15-22-21-14(24-15)10-5-2-1-3-6-10/h4,7-10H,1-3,5-6H2,(H,20,22,23)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521101 (CHEMBL4519442) Show SMILES Cc1ccc(cc1C)C(=O)Nc1nnc(o1)C1CCCCC1 Show InChI InChI=1S/C17H21N3O2/c1-11-8-9-14(10-12(11)2)15(21)18-17-20-19-16(22-17)13-6-4-3-5-7-13/h8-10,13H,3-7H2,1-2H3,(H,18,20,21)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair
Adenylate cyclase type 8 (Homo sapiens (Human))	BDBM50521073 (CHEMBL2098245 | GSK293721A | TCMDC-142518) Show SMILES COc1ccc(cc1)C(=O)Nc1nnc(o1)-c1ccc2CCCCc2c1 Show InChI InChI=1S/C20H19N3O3/c1-25-17-10-8-14(9-11-17)18(24)21-20-23-22-19(26-20)16-7-6-13-4-2-3-5-15(13)12-16/h6-12H,2-5H2,1H3,(H,21,23,24)	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.18E+5	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A2...				Eur J Med Chem 162: 568-585 (2019) Article DOI: 10.1016/j.ejmech.2018.11.036
					More data for this Ligand-Target Pair