Found 4 hits of ec50 for UniProtKB: A0A090N8Q6 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
AMPK alpha1/beta1/gamma2
(Homo sapiens-Homo sapiens (Human)) | BDBM50246120
(CHEMBL4082745)Show SMILES Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O Show InChI InChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32) | PDB
Reactome pathway
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc
Curated by ChEMBL
| Assay Description
Agonist activity at human recombinant phosphorylated AMPK complex 2 alpha1/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos... |
J Med Chem 60: 9040-9052 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01344
BindingDB Entry DOI: 10.7270/Q2V69N0Q |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase catalytic subunit alpha-2/beta-1/gamma-2
(Homo sapiens (Human)) | BDBM50246120
(CHEMBL4082745)Show SMILES Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O Show InChI InChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32) | PDB
Reactome pathway
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc
Curated by ChEMBL
| Assay Description
Agonist activity at human recombinant phosphorylated AMPK complex 8 alpha2/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos... |
J Med Chem 60: 9040-9052 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01344
BindingDB Entry DOI: 10.7270/Q2V69N0Q |
More data for this
Ligand-Target Pair | |
AMP-activated protein kinase alpha-2/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50246120
(CHEMBL4082745)Show SMILES Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O Show InChI InChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32) | PDB
Reactome pathway
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc
Curated by ChEMBL
| Assay Description
Agonist activity at human recombinant phosphorylated AMPK complex 11 alpha2/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as pho... |
J Med Chem 60: 9040-9052 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01344
BindingDB Entry DOI: 10.7270/Q2V69N0Q |
More data for this
Ligand-Target Pair | |
5'-AMP-activated protein kinase subunit gamma-2
(Homo sapiens) | BDBM50246120
(CHEMBL4082745)Show SMILES Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O Show InChI InChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32) | Reactome pathway
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 118 | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc
Curated by ChEMBL
| Assay Description
Agonist activity at human recombinant phosphorylated AMPK complex 5 alpha1/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos... |
J Med Chem 60: 9040-9052 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01344
BindingDB Entry DOI: 10.7270/Q2V69N0Q |
More data for this
Ligand-Target Pair | |
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