BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 13 hits of ic50 data for polymerid = 50007594   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278824
PNG
(CHEMBL4164183)
Show SMILES C[C@H](CO)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C22H36O2/c1-14(13-23)18-6-7-19-17-5-4-15-12-16(24)8-10-21(15,2)20(17)9-11-22(18,19)3/h5,14-16,18-20,23-24H,4,6-13H2,1-3H3/t14-,15+,16+,18-,19+,20+,21+,22-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 0.100n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM20186
PNG
((4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-...)
Show SMILES C[C@H](CCC(=O)N(C)C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C26H43NO2/c1-17(6-11-24(29)27(4)5)21-9-10-22-20-8-7-18-16-19(28)12-14-25(18,2)23(20)13-15-26(21,22)3/h7,17,19-23,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,25+,26-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 0.700n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278863
PNG
(CHEMBL4174848)
Show SMILES C[C@H](CO)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C22H36O2/c1-14(13-23)18-6-7-19-17-5-4-15-12-16(24)8-10-21(15,2)20(17)9-11-22(18,19)3/h4,14,16-20,23-24H,5-13H2,1-3H3/t14-,16+,17+,18-,19+,20+,21+,22-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 2.5n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278872
PNG
(CHEMBL4170755)
Show SMILES [I-].C[C@H](\C=C\c1cc[n+](C)cc1)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C29H42NO.HI/c1-20(5-6-21-13-17-30(4)18-14-21)25-9-10-26-24-8-7-22-19-23(31)11-15-28(22,2)27(24)12-16-29(25,26)3;/h5-6,8,13-14,17-18,20,22-23,25-27,31H,7,9-12,15-16,19H2,1-4H3;1H/q+1;/p-1/b6-5+;/t20-,22+,23+,25-,26+,27+,28+,29-;/m1./s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 2.90n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278809
PNG
(CHEMBL4164005)
Show SMILES C[C@H](CO)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C24H38O3/c1-15(14-25)20-7-8-21-19-6-5-17-13-18(27-16(2)26)9-11-23(17,3)22(19)10-12-24(20,21)4/h6,15,17-18,20-22,25H,5,7-14H2,1-4H3/t15-,17+,18+,20-,21+,22+,23+,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 3.30n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278822
PNG
(CHEMBL4167637)
Show SMILES C[C@H](COC=O)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C25H38O4/c1-16(14-28-15-26)21-7-8-22-20-6-5-18-13-19(29-17(2)27)9-11-24(18,3)23(20)10-12-25(21,22)4/h6,15-16,18-19,21-23H,5,7-14H2,1-4H3/t16-,18+,19+,21-,22+,23+,24+,25-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 4.20n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278823
PNG
(CHEMBL4159728)
Show SMILES C[C@H](COC(=O)CN(C)C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C28H45NO4/c1-18(17-32-26(31)16-29(5)6)23-9-10-24-22-8-7-20-15-21(33-19(2)30)11-13-27(20,3)25(22)12-14-28(23,24)4/h8,18,20-21,23-25H,7,9-17H2,1-6H3/t18-,20+,21+,23-,24+,25+,27+,28-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 5.5n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278810
PNG
(CHEMBL4164428)
Show SMILES C\C=C\C(=O)OC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C28H42O4/c1-6-7-26(30)31-17-18(2)23-10-11-24-22-9-8-20-16-21(32-19(3)29)12-14-27(20,4)25(22)13-15-28(23,24)5/h6-7,9,18,20-21,23-25H,8,10-17H2,1-5H3/b7-6+/t18-,20+,21+,23-,24+,25+,27+,28-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 6.30n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278807
PNG
(CHEMBL4167452)
Show SMILES C[C@H](CN)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C24H39NO2/c1-15(14-25)20-7-8-21-19-6-5-17-13-18(27-16(2)26)9-11-23(17,3)22(19)10-12-24(20,21)4/h6,15,17-18,20-22H,5,7-14,25H2,1-4H3/t15-,17+,18+,20-,21+,22+,23+,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 198n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Displacement of a non-peptide radioligand from human recombinant alphaV-beta3 integrin


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278811
PNG
(CHEMBL4172305)
Show SMILES C\C=C(/C)C(=O)OC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C29H44O4/c1-7-18(2)27(31)32-17-19(3)24-10-11-25-23-9-8-21-16-22(33-20(4)30)12-14-28(21,5)26(23)13-15-29(24,25)6/h7,9,19,21-22,24-26H,8,10-17H2,1-6H3/b18-7+/t19-,21+,22+,24-,25+,26+,28+,29-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 203n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278873
PNG
(CHEMBL4173086)
Show SMILES CONC(=O)[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C25H39NO4/c1-15(23(28)26-29-5)20-8-9-21-19-7-6-17-14-18(30-16(2)27)10-12-24(17,3)22(19)11-13-25(20,21)4/h7,15,17-18,20-22H,6,8-14H2,1-5H3,(H,26,28)/t15-,17-,18-,20+,21-,22-,24-,25+/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 805n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278832
PNG
(CHEMBL4162816)
Show SMILES CNC(=O)[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C25H39NO3/c1-15(23(28)26-5)20-8-9-21-19-7-6-17-14-18(29-16(2)27)10-12-24(17,3)22(19)11-13-25(20,21)4/h7,15,17-18,20-22H,6,8-14H2,1-5H3,(H,26,28)/t15-,17-,18-,20+,21-,22-,24-,25+/m0/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 823n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair
Delta(24)-sterol reductase


(Homo sapiens)
BDBM50278808
PNG
(CHEMBL4170838)
Show SMILES CCC(=O)NC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(C)=O
Show InChI InChI=1S/C27H43NO3/c1-6-25(30)28-16-17(2)22-9-10-23-21-8-7-19-15-20(31-18(3)29)11-13-26(19,4)24(21)12-14-27(22,23)5/h8,17,19-20,22-24H,6-7,9-16H2,1-5H3,(H,28,30)/t17-,19+,20+,22-,23+,24+,26+,27-/m1/s1
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 1.69E+4n/an/an/an/an/an/a



Ludwig-Maximilians-University Munich

Curated by ChEMBL


Assay Description
Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate incorporation into newly synthesi...


Eur J Med Chem 140: 305-320 (2017)

More data for this
Ligand-Target Pair